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PMC:7408073 / 61707-63261 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T394 437-443 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T395 579-585 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T396 655-661 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
2229 9-13 Gene denotes ACE2 Gene:59272
2230 73-77 Gene denotes ACE2 Gene:59272
2231 83-86 Gene denotes ACE Gene:59272
2232 202-206 Gene denotes ACE2 Gene:59272
2233 212-215 Gene denotes ACE Gene:59272
2234 296-300 Gene denotes ACE2 Gene:59272
2235 598-609 Gene denotes transferrin Gene:7018
2236 1443-1450 Species denotes patient Tax:9606
2237 234-238 Chemical denotes EDTA MESH:D004492
2238 329-333 Chemical denotes EDTA MESH:D004492
2239 382-386 Chemical denotes Zn2+
2240 395-399 Chemical denotes Ca2+ MESH:D000069285
2241 404-408 Chemical denotes Fe2+
2242 450-454 Chemical denotes Ca2+ MESH:D000069285
2243 530-534 Chemical denotes Zn2+
2244 571-575 Chemical denotes iron MESH:D007501
2245 633-637 Chemical denotes iron MESH:D007501
2246 744-749 Chemical denotes metal MESH:D008670
2247 806-810 Chemical denotes EDTA MESH:D004492
2248 824-828 Chemical denotes Zn2+
2249 916-925 Chemical denotes CaNa2EDTA
2250 1397-1406 Chemical denotes CaNa2EDTA
2251 1212-1227 Disease denotes zinc deficiency MESH:C564286

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T779 240-241 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T780 259-262 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T781 301-309 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T782 354-357 http://purl.obolibrary.org/obo/CLO_0054060 denotes 102
T783 437-443 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T784 579-585 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T785 614-615 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T786 655-661 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T787 770-779 http://purl.obolibrary.org/obo/OBI_0100026 denotes organisms
T788 770-779 http://purl.obolibrary.org/obo/UBERON_0000468 denotes organisms
T789 1123-1133 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities
T790 1158-1161 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T791 1228-1231 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T792 1356-1359 http://purl.obolibrary.org/obo/CLO_0054060 denotes 102
T793 1415-1416 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T73784 118-124 Chemical denotes cation http://purl.obolibrary.org/obo/CHEBI_36916
T52408 125-130 Chemical denotes anion http://purl.obolibrary.org/obo/CHEBI_22563
T48403 181-185 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T22224 234-238 Chemical denotes EDTA http://purl.obolibrary.org/obo/CHEBI_42191|http://purl.obolibrary.org/obo/CHEBI_64755
T5627 242-248 Chemical denotes cation http://purl.obolibrary.org/obo/CHEBI_36916
T70245 249-257 Chemical denotes chelator http://purl.obolibrary.org/obo/CHEBI_38161
T22254 329-333 Chemical denotes EDTA http://purl.obolibrary.org/obo/CHEBI_42191|http://purl.obolibrary.org/obo/CHEBI_64755
T68253 382-385 Chemical denotes Zn2 http://purl.obolibrary.org/obo/CHEBI_37256
T95886 530-533 Chemical denotes Zn2 http://purl.obolibrary.org/obo/CHEBI_37256
T85661 571-575 Chemical denotes iron http://purl.obolibrary.org/obo/CHEBI_18248
T94180 633-637 Chemical denotes iron http://purl.obolibrary.org/obo/CHEBI_18248
T30043 750-754 Chemical denotes ions http://purl.obolibrary.org/obo/CHEBI_24870
T94269 806-810 Chemical denotes EDTA http://purl.obolibrary.org/obo/CHEBI_42191|http://purl.obolibrary.org/obo/CHEBI_64755
T6513 824-827 Chemical denotes Zn2 http://purl.obolibrary.org/obo/CHEBI_37256
T20754 946-950 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T40517 1020-1024 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T43428 1054-1058 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T36225 1153-1157 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T30838 1212-1216 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T125 1260-1266 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T126 1268-1288 http://purl.obolibrary.org/obo/GO_0048666 denotes neuronal development

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T296 0-217 Sentence denotes Based on ACE2 mechanism of action, there are alternative ways to inhibit ACE2 (and ACE), for example concentration of cation/anion might also targets of intervention to inhibit the zinc metalloprotease ACE2 (and ACE).
T297 218-315 Sentence denotes In this regard, EDTA, a cation chelator, has been shown to be able to inhibit ACE2 activity [79].
T298 316-610 Sentence denotes Of interest, EDTA binds with 106- and 102-fold higher affinity to Zn2+ than to Ca2+ and Fe2+, respectively [123], and in plasma, free Ca2+ concentration (1.05–1.30 mmol/L) is “only” about 103-fold higher than free Zn2+ (0.1–2.0 µmol/L), while majority of iron in plasma is bound to transferrin.
T299 611-723 Sentence denotes As a consequence, the iron concentration in plasma of healthy subjects is very low on the order of 10−18M [112].
T300 724-1031 Sentence denotes Among the essential metal ions present in the organisms, the specific affinity of EDTA for systemic Zn2+ in physiologic conditions is highlighted by the evidence that prolonged treatment with CaNa2EDTA results in specific zinc depletion that is believed to mediate the teratogenic effects of the drug [123].
T301 1032-1361 Sentence denotes As already mentioned, zinc is an important mediator/messenger involved in several cellular activities and excess of free zinc has been shown to be toxic (see also Box 4); however, zinc deficiency has also detrimental effects on growth, neuronal development, and immunity, and in severe cases its consequences can be deadly [102].
T302 1362-1554 Sentence denotes For these reasons, treatments with CaNa2EDTA require a careful monitoring of the patient for the therapeutic effects as well as possible complications, so as to titrate the appropriate dosage.

2_test

Id Subject Object Predicate Lexical cue
32708755-20717537-20678870 424-427 20717537 denotes 123
32708755-20717537-20678871 1026-1029 20717537 denotes 123
32708755-20617034-20678872 1356-1359 20617034 denotes 102