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PMC:7408073 / 43825-46217 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T272 124-130 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T273 797-803 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T274 853-862 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T275 873-877 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T276 921-930 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T277 1121-1130 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T278 1270-1278 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T279 1292-1301 Body_part denotes monocytes http://purl.org/sig/ont/fma/fma62864
T280 1322-1326 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T281 1514-1519 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T282 1520-1525 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T283 1619-1628 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T284 1640-1644 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T285 1691-1699 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T286 1727-1745 Body_part denotes pulmonary arterial http://purl.org/sig/ont/fma/fma66326
T287 1831-1835 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T288 1838-1842 Body_part denotes IL-2 http://purl.org/sig/ont/fma/fma84051
T289 1869-1874 Body_part denotes IL-12 http://purl.org/sig/ont/fma/fma86579
T290 2107-2115 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T101 402-405 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T102 1514-1519 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T103 1727-1745 Body_part denotes pulmonary arterial http://purl.obolibrary.org/obo/UBERON_0002012

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1699 245-249 Gene denotes ACE2 Gene:59272
1700 254-257 Gene denotes ACE Gene:59272
1701 873-878 Gene denotes IL-1β Gene:3552
1702 880-884 Gene denotes IL-6 Gene:3569
1703 886-890 Gene denotes IL-8 Gene:3576
1704 895-900 Gene denotes TNF-α Gene:7124
1705 1004-1009 Gene denotes TNF-α Gene:7124
1706 1038-1042 Gene denotes IL-6 Gene:3569
1707 1047-1051 Gene denotes IL-8 Gene:3576
1708 1640-1645 Gene denotes IL-1β Gene:3552
1709 1647-1651 Gene denotes IL-6 Gene:3569
1710 1653-1657 Gene denotes IL-8 Gene:3576
1711 1659-1664 Gene denotes TNF-α Gene:7124
1712 1700-1705 Gene denotes IL-10 Gene:3586
1713 1831-1836 Gene denotes IL-1β Gene:3552
1714 1838-1842 Gene denotes IL-2 Gene:3558
1715 1844-1848 Gene denotes IL-4 Gene:3565
1716 1850-1854 Gene denotes IL-6 Gene:3569
1717 1856-1860 Gene denotes IL-8 Gene:3576
1718 1862-1867 Gene denotes IL-10 Gene:3586
1719 1879-1884 Gene denotes TNF-α Gene:7124
1720 460-468 Species denotes patients Tax:9606
1721 977-985 Species denotes patients Tax:9606
1722 1776-1784 Species denotes SARS-CoV Tax:694009
1723 37-42 Chemical denotes ZnCl2 MESH:C016837
1724 43-63 Chemical denotes ZnO/hexachloroethane
1725 306-314 Chemical denotes chloride MESH:D002712
1726 483-488 Chemical denotes metal MESH:D008670
1727 738-748 Chemical denotes metal fume
1728 2357-2362 Chemical denotes ZnCl2 MESH:C016837
1729 150-154 Disease denotes ARDS MESH:D012128
1730 210-218 Disease denotes COVID-19 MESH:C000657245
1731 409-413 Disease denotes ARDS MESH:D012128
1732 451-459 Disease denotes COVID-19 MESH:C000657245
1733 494-499 Disease denotes fever MESH:D005334
1734 501-520 Disease denotes a flu-like syndrome MESH:D007251
1735 626-646 Disease denotes respiratory symptoms MESH:D012818
1736 677-686 Disease denotes pneumonia MESH:D011014
1737 749-754 Disease denotes fever MESH:D005334
1738 781-786 Disease denotes fever MESH:D005334
1739 788-795 Disease denotes fatigue MESH:D005221
1740 797-808 Disease denotes muscle ache MESH:D063806
1741 810-815 Disease denotes cough MESH:D003371
1742 817-824 Disease denotes dyspnea MESH:D004417
1743 968-976 Disease denotes COVID-19 MESH:C000657245
1744 1403-1411 Disease denotes COVID-19 MESH:C000657245
1745 1727-1758 Disease denotes pulmonary arterial hypertension MESH:D000081029
1746 2007-2011 Disease denotes ARDS MESH:D012128
1747 2021-2040 Disease denotes SARS-CoV infections MESH:C000657245

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T264 150-154 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T265 210-218 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T266 409-413 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T267 451-459 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T268 503-506 Disease denotes flu http://purl.obolibrary.org/obo/MONDO_0005812
T269 677-686 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T270 968-976 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T271 1403-1411 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T272 1727-1758 Disease denotes pulmonary arterial hypertension http://purl.obolibrary.org/obo/MONDO_0015924|http://purl.obolibrary.org/obo/MONDO_0024533
T274 1746-1758 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T275 1760-1763 Disease denotes PAH http://purl.obolibrary.org/obo/MONDO_0015924
T276 1776-1784 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T277 1776-1780 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T278 2007-2011 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T279 2013-2016 Disease denotes PAH http://purl.obolibrary.org/obo/MONDO_0015924
T280 2021-2029 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T281 2021-2025 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T282 2030-2040 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T537 124-130 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T538 270-279 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T539 371-381 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T540 390-394 http://www.ebi.ac.uk/efo/EFO_0001410 denotes arms
T541 501-502 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T542 591-592 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T543 755-758 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T544 797-803 http://purl.obolibrary.org/obo/UBERON_0001630 denotes muscle
T545 797-803 http://purl.obolibrary.org/obo/UBERON_0005090 denotes muscle
T546 797-803 http://www.ebi.ac.uk/efo/EFO_0000801 denotes muscle
T547 797-803 http://www.ebi.ac.uk/efo/EFO_0001949 denotes muscle
T548 886-890 http://purl.obolibrary.org/obo/CLO_0053704 denotes IL-8
T549 1047-1051 http://purl.obolibrary.org/obo/CLO_0053704 denotes IL-8
T550 1080-1081 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T551 1292-1301 http://purl.obolibrary.org/obo/CL_0000576 denotes monocytes
T552 1320-1326 http://purl.obolibrary.org/obo/CL_0000084 denotes T cell
T553 1343-1346 http://purl.obolibrary.org/obo/CLO_0054060 denotes 102
T554 1376-1379 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T555 1490-1493 http://purl.obolibrary.org/obo/CLO_0054060 denotes 102
T556 1514-1525 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood cells
T557 1566-1567 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T558 1653-1657 http://purl.obolibrary.org/obo/CLO_0053704 denotes IL-8
T559 1727-1745 http://purl.obolibrary.org/obo/UBERON_0002012 denotes pulmonary arterial
T560 1727-1745 http://www.ebi.ac.uk/efo/EFO_0001399 denotes pulmonary arterial
T561 1791-1795 http://www.ebi.ac.uk/efo/EFO_0001410 denotes arms
T562 1838-1842 http://purl.obolibrary.org/obo/PR_000001379 denotes IL-2
T563 1856-1860 http://purl.obolibrary.org/obo/CLO_0053704 denotes IL-8
T564 1946-1947 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T565 1975-1985 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T566 2141-2142 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T452 37-42 Chemical denotes ZnCl2 http://purl.obolibrary.org/obo/CHEBI_49976
T453 43-46 Chemical denotes ZnO http://purl.obolibrary.org/obo/CHEBI_36560
T454 47-63 Chemical denotes hexachloroethane http://purl.obolibrary.org/obo/CHEBI_39227
T455 141-145 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T457 306-314 Chemical denotes chloride http://purl.obolibrary.org/obo/CHEBI_17996
T458 319-328 Chemical denotes zinc ions http://purl.obolibrary.org/obo/CHEBI_27365
T459 319-323 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T461 324-328 Chemical denotes ions http://purl.obolibrary.org/obo/CHEBI_24870
T462 402-405 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T463 578-582 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T465 873-875 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T467 880-882 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T469 886-888 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T471 1038-1040 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T473 1047-1049 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T475 1210-1214 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T477 1640-1642 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T479 1647-1649 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T481 1653-1655 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T483 1700-1702 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T485 1760-1763 Chemical denotes PAH http://purl.obolibrary.org/obo/CHEBI_104011|http://purl.obolibrary.org/obo/CHEBI_31204|http://purl.obolibrary.org/obo/CHEBI_33848|http://purl.obolibrary.org/obo/CHEBI_53305
T489 1831-1833 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T491 1838-1840 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T493 1844-1846 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T495 1850-1852 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T497 1856-1858 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T499 1862-1864 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T501 1869-1871 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T503 2013-2016 Chemical denotes PAH http://purl.obolibrary.org/obo/CHEBI_104011|http://purl.obolibrary.org/obo/CHEBI_31204|http://purl.obolibrary.org/obo/CHEBI_33848|http://purl.obolibrary.org/obo/CHEBI_53305
T507 2076-2080 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T509 2170-2174 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T511 2241-2245 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T513 2322-2326 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T515 2357-2362 Chemical denotes ZnCl2 http://purl.obolibrary.org/obo/CHEBI_49976

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T75 1270-1288 http://purl.obolibrary.org/obo/GO_0001816 denotes cytokine secretion
T76 1279-1288 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T77 1468-1483 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T78 2241-2257 http://purl.obolibrary.org/obo/GO_0055069 denotes zinc homeostasis
T79 2241-2257 http://purl.obolibrary.org/obo/GO_0006882 denotes zinc homeostasis
T80 2246-2257 http://purl.obolibrary.org/obo/GO_0042592 denotes homeostasis

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T211 0-233 Sentence denotes Intriguingly, inhalation exposure to ZnCl2/ZnO/hexachloroethane (the main ingredients in smoke bombs) induces both elevated plasma levels of zinc and ARDS with clinical pictures that strongly resemble those of COVID-19 [100,101,102].
T212 234-469 Sentence denotes Since both ACE2 and ACE enzymes are activated by high concentrations of chloride and zinc ions [79,90], it is possible to hypothesise an activation of both arms of the RAS in ARDS induced by smoke bombs as well as in COVID-19 patients.
T213 470-721 Sentence denotes In addition, metal fume fever, a flu-like syndrome caused by inhalation of welding fumes (mainly containing zinc) can be a predictor for the development of respiratory symptoms and welders have an increased pneumonia and cardiovascular risk [103,104].
T214 722-994 Sentence denotes In this regard, metal fume fever has been shown to produce fever, fatigue, muscle ache, cough, dyspnea, and an increase of several cytokines including IL-1β, IL-6, IL-8 and TNF-α [103], symptoms and cytokines that have already been described for COVID-19 patients [2,8,9].
T215 995-1180 Sentence denotes Notably, TNF-α was upregulated early while IL-6 and IL-8 increased later, suggesting a subsequent involvement of these latter cytokines in response to inhalation of welding fumes [103].
T216 1181-1349 Sentence denotes Moreover, elevated levels of zinc have been shown not only to stimulate pro-inflammatory cytokine secretion by monocytes, but also inhibit T cell functions (see [102]).
T217 1350-1712 Sentence denotes Zinc supplementation that has also been proposed for COVID-19 treatment [105,106,107], is able to suppress allogeneic immune response (see [102]) and incubation of blood cells with welding fume particles resulted in a considerable increase not only of pro-inflammatory cytokines (including IL-1β, IL-6, IL-8, TNF-α) but also the tolerogenic cytokine IL-10 [104].
T218 1713-2041 Sentence denotes Similarly, in pulmonary arterial hypertension (PAH) as well as SARS-CoV, both arms of the inflammatory system (namely IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12 and TNF-α) have been shown to be upregulated [108,109,110], suggesting a common systemic pathway of activation in welding syndrome, ARDS, PAH and SARS-CoV infections.
T219 2042-2211 Sentence denotes Finally, the correlations between zinc exposure (metal fume) and cytokine storm [103,104] suggests a possible link between free zinc increase and these type of diseases.
T220 2212-2392 Sentence denotes More information on systemic zinc homeostasis and multiorgan effects of elevated levels of extracellular free zinc (such as in subjects inhaling ZnCl2 smoke) is available in Box 4.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T71 494-499 Phenotype denotes fever http://purl.obolibrary.org/obo/HP_0001945
T72 677-686 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T73 749-754 Phenotype denotes fever http://purl.obolibrary.org/obo/HP_0001945
T74 781-786 Phenotype denotes fever http://purl.obolibrary.org/obo/HP_0001945
T75 788-795 Phenotype denotes fatigue http://purl.obolibrary.org/obo/HP_0012378
T76 797-808 Phenotype denotes muscle ache http://purl.obolibrary.org/obo/HP_0003326
T77 810-815 Phenotype denotes cough http://purl.obolibrary.org/obo/HP_0012735
T78 817-824 Phenotype denotes dyspnea http://purl.obolibrary.org/obo/HP_0002094
T79 1727-1758 Phenotype denotes pulmonary arterial hypertension http://purl.obolibrary.org/obo/HP_0002092
T80 2107-2121 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041

2_test

Id Subject Object Predicate Lexical cue
32708755-28953660-20678799 220-223 28953660 denotes 100
32708755-20617034-20678800 228-231 20617034 denotes 102
32708755-32276440-20678801 712-715 32276440 denotes 103
32708755-30718726-20678802 716-719 30718726 denotes 104
32708755-32276440-20678803 902-905 32276440 denotes 103
32708755-32161940-20678804 987-988 32161940 denotes 2
32708755-31986264-20678805 989-990 31986264 denotes 8
32708755-32297671-20678806 991-992 32297671 denotes 9
32708755-32276440-20678807 1175-1178 32276440 denotes 103
32708755-20617034-20678808 1343-1346 20617034 denotes 102
32708755-32408070-20678809 1431-1434 32408070 denotes 107
32708755-20617034-20678810 1490-1493 20617034 denotes 102
32708755-30718726-20678811 1707-1710 30718726 denotes 104
32708755-29903860-20678812 1921-1924 29903860 denotes 108
32708755-20713898-20678813 1925-1928 20713898 denotes 109
32708755-18832706-20678814 1929-1932 18832706 denotes 110
32708755-32276440-20678815 2123-2126 32276440 denotes 103
32708755-30718726-20678816 2127-2130 30718726 denotes 104