PMC:7408073 / 27619-27981 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T185","span":{"begin":289,"end":296},"obj":"Body_part"}],"attributes":[{"id":"A185","pred":"fma_id","subj":"T185","obj":"http://purl.org/sig/ont/fma/fma67257"}],"text":"ack loop.\n\n4. COVID-19 Can Induce RAS-mediated Positive Feedback Loops at Different Levels\nIntriguingly, the binding affinity of ACE2 to SARS-CoV-2 binding domain has been reported to be either equal to or 10- to 20-fold higher than ACE2 binding to SARS-CoV [27,32]. The affinity of spike protein for ACE2 has been shown to correlate with the severity of disease"}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T57","span":{"begin":34,"end":37},"obj":"Body_part"}],"attributes":[{"id":"A57","pred":"uberon_id","subj":"T57","obj":"http://purl.obolibrary.org/obo/UBERON_0018229"}],"text":"ack loop.\n\n4. COVID-19 Can Induce RAS-mediated Positive Feedback Loops at Different Levels\nIntriguingly, the binding affinity of ACE2 to SARS-CoV-2 binding domain has been reported to be either equal to or 10- to 20-fold higher than ACE2 binding to SARS-CoV [27,32]. The affinity of spike protein for ACE2 has been shown to correlate with the severity of disease"}

{"project":"LitCovid-PubTator","denotations":[{"id":"1071","span":{"begin":14,"end":22},"obj":"Disease"},{"id":"1231","span":{"begin":129,"end":133},"obj":"Gene"},{"id":"1232","span":{"begin":233,"end":237},"obj":"Gene"},{"id":"1233","span":{"begin":301,"end":305},"obj":"Gene"},{"id":"1261","span":{"begin":283,"end":288},"obj":"Gene"},{"id":"1262","span":{"begin":137,"end":147},"obj":"Species"},{"id":"1263","span":{"begin":249,"end":257},"obj":"Species"}],"attributes":[{"id":"A1071","pred":"tao:has_database_id","subj":"1071","obj":"MESH:C000657245"},{"id":"A1231","pred":"tao:has_database_id","subj":"1231","obj":"Gene:59272"},{"id":"A1232","pred":"tao:has_database_id","subj":"1232","obj":"Gene:59272"},{"id":"A1233","pred":"tao:has_database_id","subj":"1233","obj":"Gene:59272"},{"id":"A1261","pred":"tao:has_database_id","subj":"1261","obj":"Gene:43740568"},{"id":"A1262","pred":"tao:has_database_id","subj":"1262","obj":"Tax:2697049"},{"id":"A1263","pred":"tao:has_database_id","subj":"1263","obj":"Tax:694009"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"ack loop.\n\n4. COVID-19 Can Induce RAS-mediated Positive Feedback Loops at Different Levels\nIntriguingly, the binding affinity of ACE2 to SARS-CoV-2 binding domain has been reported to be either equal to or 10- to 20-fold higher than ACE2 binding to SARS-CoV [27,32]. The affinity of spike protein for ACE2 has been shown to correlate with the severity of disease"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T178","span":{"begin":14,"end":22},"obj":"Disease"},{"id":"T179","span":{"begin":137,"end":145},"obj":"Disease"},{"id":"T180","span":{"begin":137,"end":141},"obj":"Disease"},{"id":"T181","span":{"begin":249,"end":257},"obj":"Disease"},{"id":"T182","span":{"begin":249,"end":253},"obj":"Disease"}],"attributes":[{"id":"A178","pred":"mondo_id","subj":"T178","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A179","pred":"mondo_id","subj":"T179","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A180","pred":"mondo_id","subj":"T180","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A181","pred":"mondo_id","subj":"T181","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A182","pred":"mondo_id","subj":"T182","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"ack loop.\n\n4. COVID-19 Can Induce RAS-mediated Positive Feedback Loops at Different Levels\nIntriguingly, the binding affinity of ACE2 to SARS-CoV-2 binding domain has been reported to be either equal to or 10- to 20-fold higher than ACE2 binding to SARS-CoV [27,32]. The affinity of spike protein for ACE2 has been shown to correlate with the severity of disease"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T347","span":{"begin":163,"end":166},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T348","span":{"begin":306,"end":309},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"}],"text":"ack loop.\n\n4. COVID-19 Can Induce RAS-mediated Positive Feedback Loops at Different Levels\nIntriguingly, the binding affinity of ACE2 to SARS-CoV-2 binding domain has been reported to be either equal to or 10- to 20-fold higher than ACE2 binding to SARS-CoV [27,32]. The affinity of spike protein for ACE2 has been shown to correlate with the severity of disease"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T242","span":{"begin":34,"end":37},"obj":"Chemical"},{"id":"T243","span":{"begin":289,"end":296},"obj":"Chemical"}],"attributes":[{"id":"A242","pred":"chebi_id","subj":"T242","obj":"http://purl.obolibrary.org/obo/CHEBI_63620"},{"id":"A243","pred":"chebi_id","subj":"T243","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"}],"text":"ack loop.\n\n4. COVID-19 Can Induce RAS-mediated Positive Feedback Loops at Different Levels\nIntriguingly, the binding affinity of ACE2 to SARS-CoV-2 binding domain has been reported to be either equal to or 10- to 20-fold higher than ACE2 binding to SARS-CoV [27,32]. The affinity of spike protein for ACE2 has been shown to correlate with the severity of disease"}

{"project":"LitCovid-sentences","denotations":[{"id":"T128","span":{"begin":11,"end":13},"obj":"Sentence"},{"id":"T129","span":{"begin":14,"end":90},"obj":"Sentence"},{"id":"T130","span":{"begin":91,"end":266},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"ack loop.\n\n4. COVID-19 Can Induce RAS-mediated Positive Feedback Loops at Different Levels\nIntriguingly, the binding affinity of ACE2 to SARS-CoV-2 binding domain has been reported to be either equal to or 10- to 20-fold higher than ACE2 binding to SARS-CoV [27,32]. The affinity of spike protein for ACE2 has been shown to correlate with the severity of disease"}

{"project":"2_test","denotations":[{"id":"32708755-32075877-20678738","span":{"begin":259,"end":261},"obj":"32075877"},{"id":"32708755-32065055-20678739","span":{"begin":262,"end":264},"obj":"32065055"}],"text":"ack loop.\n\n4. COVID-19 Can Induce RAS-mediated Positive Feedback Loops at Different Levels\nIntriguingly, the binding affinity of ACE2 to SARS-CoV-2 binding domain has been reported to be either equal to or 10- to 20-fold higher than ACE2 binding to SARS-CoV [27,32]. The affinity of spike protein for ACE2 has been shown to correlate with the severity of disease"}