ack loop.

4. COVID-19 Can Induce RAS-mediated Positive Feedback Loops at Different Levels
Intriguingly, the binding affinity of ACE2 to SARS-CoV-2 binding domain has been reported to be either equal to or 10- to 20-fold higher than ACE2 binding to SARS-CoV [27,32]. The affinity of spike protein for ACE2 has been shown to correlate with the severity of disease