PMC:7408073 / 26140-26483 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T182","span":{"begin":278,"end":285},"obj":"Body_part"}],"attributes":[{"id":"A182","pred":"fma_id","subj":"T182","obj":"http://purl.org/sig/ont/fma/fma67257"}],"text":"Therefore, Ang (1–7) (as well as ACEIs and ARBs), preventing Ang II-mediated ACE2 downregulation, shift the Ang peptide balance in favour of Ang II metabolisation by ACE2, which, in turn, leads to further production of Ang (1–7), finally sustaining ACE2 transcription, membrane protein expression and eventually shedding and systemic activity."}

{"project":"LitCovid-PubTator","denotations":[{"id":"1027","span":{"begin":11,"end":19},"obj":"Gene"},{"id":"1028","span":{"begin":61,"end":67},"obj":"Gene"},{"id":"1029","span":{"begin":77,"end":81},"obj":"Gene"},{"id":"1030","span":{"begin":166,"end":170},"obj":"Gene"},{"id":"1031","span":{"begin":219,"end":227},"obj":"Gene"},{"id":"1032","span":{"begin":249,"end":253},"obj":"Gene"},{"id":"1060","span":{"begin":141,"end":147},"obj":"Gene"}],"attributes":[{"id":"A1027","pred":"tao:has_database_id","subj":"1027","obj":"Gene:305843"},{"id":"A1028","pred":"tao:has_database_id","subj":"1028","obj":"Gene:24179"},{"id":"A1029","pred":"tao:has_database_id","subj":"1029","obj":"Gene:302668"},{"id":"A1030","pred":"tao:has_database_id","subj":"1030","obj":"Gene:302668"},{"id":"A1031","pred":"tao:has_database_id","subj":"1031","obj":"Gene:305843"},{"id":"A1032","pred":"tao:has_database_id","subj":"1032","obj":"Gene:302668"},{"id":"A1060","pred":"tao:has_database_id","subj":"1060","obj":"Gene:24179"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Therefore, Ang (1–7) (as well as ACEIs and ARBs), preventing Ang II-mediated ACE2 downregulation, shift the Ang peptide balance in favour of Ang II metabolisation by ACE2, which, in turn, leads to further production of Ang (1–7), finally sustaining ACE2 transcription, membrane protein expression and eventually shedding and systemic activity."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T330","span":{"begin":112,"end":119},"obj":"http://purl.obolibrary.org/obo/PR_000018263"},{"id":"T331","span":{"begin":269,"end":277},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T332","span":{"begin":334,"end":342},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"}],"text":"Therefore, Ang (1–7) (as well as ACEIs and ARBs), preventing Ang II-mediated ACE2 downregulation, shift the Ang peptide balance in favour of Ang II metabolisation by ACE2, which, in turn, leads to further production of Ang (1–7), finally sustaining ACE2 transcription, membrane protein expression and eventually shedding and systemic activity."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T219","span":{"begin":11,"end":14},"obj":"Chemical"},{"id":"T220","span":{"begin":33,"end":38},"obj":"Chemical"},{"id":"T221","span":{"begin":61,"end":64},"obj":"Chemical"},{"id":"T222","span":{"begin":65,"end":67},"obj":"Chemical"},{"id":"T223","span":{"begin":108,"end":111},"obj":"Chemical"},{"id":"T224","span":{"begin":112,"end":119},"obj":"Chemical"},{"id":"T225","span":{"begin":141,"end":144},"obj":"Chemical"},{"id":"T226","span":{"begin":145,"end":147},"obj":"Chemical"},{"id":"T227","span":{"begin":219,"end":222},"obj":"Chemical"},{"id":"T228","span":{"begin":278,"end":285},"obj":"Chemical"}],"attributes":[{"id":"A219","pred":"chebi_id","subj":"T219","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"id":"A220","pred":"chebi_id","subj":"T220","obj":"http://purl.obolibrary.org/obo/CHEBI_35457"},{"id":"A221","pred":"chebi_id","subj":"T221","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"id":"A222","pred":"chebi_id","subj":"T222","obj":"http://purl.obolibrary.org/obo/CHEBI_74067"},{"id":"A223","pred":"chebi_id","subj":"T223","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"id":"A224","pred":"chebi_id","subj":"T224","obj":"http://purl.obolibrary.org/obo/CHEBI_16670"},{"id":"A225","pred":"chebi_id","subj":"T225","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"id":"A226","pred":"chebi_id","subj":"T226","obj":"http://purl.obolibrary.org/obo/CHEBI_74067"},{"id":"A227","pred":"chebi_id","subj":"T227","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"id":"A228","pred":"chebi_id","subj":"T228","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"}],"text":"Therefore, Ang (1–7) (as well as ACEIs and ARBs), preventing Ang II-mediated ACE2 downregulation, shift the Ang peptide balance in favour of Ang II metabolisation by ACE2, which, in turn, leads to further production of Ang (1–7), finally sustaining ACE2 transcription, membrane protein expression and eventually shedding and systemic activity."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T47","span":{"begin":254,"end":267},"obj":"http://purl.obolibrary.org/obo/GO_0006351"}],"text":"Therefore, Ang (1–7) (as well as ACEIs and ARBs), preventing Ang II-mediated ACE2 downregulation, shift the Ang peptide balance in favour of Ang II metabolisation by ACE2, which, in turn, leads to further production of Ang (1–7), finally sustaining ACE2 transcription, membrane protein expression and eventually shedding and systemic activity."}

{"project":"LitCovid-sentences","denotations":[{"id":"T122","span":{"begin":0,"end":343},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Therefore, Ang (1–7) (as well as ACEIs and ARBs), preventing Ang II-mediated ACE2 downregulation, shift the Ang peptide balance in favour of Ang II metabolisation by ACE2, which, in turn, leads to further production of Ang (1–7), finally sustaining ACE2 transcription, membrane protein expression and eventually shedding and systemic activity."}