PMC:7402624 / 41401-42375 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T381","span":{"begin":394,"end":398},"obj":"Body_part"},{"id":"T382","span":{"begin":540,"end":545},"obj":"Body_part"},{"id":"T383","span":{"begin":578,"end":583},"obj":"Body_part"},{"id":"T384","span":{"begin":711,"end":715},"obj":"Body_part"},{"id":"T385","span":{"begin":722,"end":726},"obj":"Body_part"},{"id":"T386","span":{"begin":827,"end":830},"obj":"Body_part"},{"id":"T387","span":{"begin":846,"end":851},"obj":"Body_part"},{"id":"T388","span":{"begin":878,"end":881},"obj":"Body_part"},{"id":"T389","span":{"begin":897,"end":902},"obj":"Body_part"}],"attributes":[{"id":"A381","pred":"fma_id","subj":"T381","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A382","pred":"fma_id","subj":"T382","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A383","pred":"fma_id","subj":"T383","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A384","pred":"fma_id","subj":"T384","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A385","pred":"fma_id","subj":"T385","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A386","pred":"fma_id","subj":"T386","obj":"http://purl.org/sig/ont/fma/fma84795"},{"id":"A387","pred":"fma_id","subj":"T387","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A388","pred":"fma_id","subj":"T388","obj":"http://purl.org/sig/ont/fma/fma84795"},{"id":"A389","pred":"fma_id","subj":"T389","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"To further investigate the relationship between immune responses and COVID-19 disease trajectory, we stratified the COVID-19 patients (n = 125) into eight different categories according to the NIH Ordinal Severity Scale ranging from COVID 1 (death) and COVID 2 (requiring maximal clinical intervention) to COVID 8 (at home with no required care) (Fig. 6A). We then asked how changes in T and B cell populations defined above on D0 were related to disease severity. More severe disease was associated with lower frequencies of CD8 and CD4 T cells, with a greater effect on CD8 T cells in less severe disease (Fig. 6B). Taking all patients together, there were no statistically significant changes in the major T cell and B cell subsets related to disease severity though some trends were present (fig. S7, A to C). In contrast, HLA-DR+CD38+ CD8 T cells as well as both KI67+ and HLA-DR+CD38+ CD4 T cells were increased in patients with more severe disease (fig. S7, D and E)."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T17","span":{"begin":214,"end":219},"obj":"Body_part"}],"attributes":[{"id":"A17","pred":"uberon_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/UBERON_0002542"}],"text":"To further investigate the relationship between immune responses and COVID-19 disease trajectory, we stratified the COVID-19 patients (n = 125) into eight different categories according to the NIH Ordinal Severity Scale ranging from COVID 1 (death) and COVID 2 (requiring maximal clinical intervention) to COVID 8 (at home with no required care) (Fig. 6A). We then asked how changes in T and B cell populations defined above on D0 were related to disease severity. More severe disease was associated with lower frequencies of CD8 and CD4 T cells, with a greater effect on CD8 T cells in less severe disease (Fig. 6B). Taking all patients together, there were no statistically significant changes in the major T cell and B cell subsets related to disease severity though some trends were present (fig. S7, A to C). In contrast, HLA-DR+CD38+ CD8 T cells as well as both KI67+ and HLA-DR+CD38+ CD4 T cells were increased in patients with more severe disease (fig. S7, D and E)."}

{"project":"LitCovid-PubTator","denotations":[{"id":"1474","span":{"begin":526,"end":529},"obj":"Gene"},{"id":"1475","span":{"begin":534,"end":537},"obj":"Gene"},{"id":"1476","span":{"begin":572,"end":575},"obj":"Gene"},{"id":"1477","span":{"begin":834,"end":838},"obj":"Gene"},{"id":"1478","span":{"begin":840,"end":843},"obj":"Gene"},{"id":"1479","span":{"begin":885,"end":889},"obj":"Gene"},{"id":"1480","span":{"begin":891,"end":894},"obj":"Gene"},{"id":"1481","span":{"begin":125,"end":133},"obj":"Species"},{"id":"1482","span":{"begin":629,"end":637},"obj":"Species"},{"id":"1483","span":{"begin":921,"end":929},"obj":"Species"},{"id":"1484","span":{"begin":69,"end":77},"obj":"Disease"},{"id":"1485","span":{"begin":116,"end":124},"obj":"Disease"},{"id":"1486","span":{"begin":233,"end":238},"obj":"Disease"},{"id":"1487","span":{"begin":242,"end":247},"obj":"Disease"},{"id":"1488","span":{"begin":253,"end":258},"obj":"Disease"},{"id":"1489","span":{"begin":306,"end":311},"obj":"Disease"}],"attributes":[{"id":"A1474","pred":"tao:has_database_id","subj":"1474","obj":"Gene:925"},{"id":"A1475","pred":"tao:has_database_id","subj":"1475","obj":"Gene:920"},{"id":"A1476","pred":"tao:has_database_id","subj":"1476","obj":"Gene:925"},{"id":"A1477","pred":"tao:has_database_id","subj":"1477","obj":"Gene:952"},{"id":"A1478","pred":"tao:has_database_id","subj":"1478","obj":"Gene:925"},{"id":"A1479","pred":"tao:has_database_id","subj":"1479","obj":"Gene:952"},{"id":"A1480","pred":"tao:has_database_id","subj":"1480","obj":"Gene:920"},{"id":"A1481","pred":"tao:has_database_id","subj":"1481","obj":"Tax:9606"},{"id":"A1482","pred":"tao:has_database_id","subj":"1482","obj":"Tax:9606"},{"id":"A1483","pred":"tao:has_database_id","subj":"1483","obj":"Tax:9606"},{"id":"A1484","pred":"tao:has_database_id","subj":"1484","obj":"MESH:C000657245"},{"id":"A1485","pred":"tao:has_database_id","subj":"1485","obj":"MESH:C000657245"},{"id":"A1486","pred":"tao:has_database_id","subj":"1486","obj":"MESH:C000657245"},{"id":"A1487","pred":"tao:has_database_id","subj":"1487","obj":"MESH:D003643"},{"id":"A1488","pred":"tao:has_database_id","subj":"1488","obj":"MESH:C000657245"},{"id":"A1489","pred":"tao:has_database_id","subj":"1489","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"To further investigate the relationship between immune responses and COVID-19 disease trajectory, we stratified the COVID-19 patients (n = 125) into eight different categories according to the NIH Ordinal Severity Scale ranging from COVID 1 (death) and COVID 2 (requiring maximal clinical intervention) to COVID 8 (at home with no required care) (Fig. 6A). We then asked how changes in T and B cell populations defined above on D0 were related to disease severity. More severe disease was associated with lower frequencies of CD8 and CD4 T cells, with a greater effect on CD8 T cells in less severe disease (Fig. 6B). Taking all patients together, there were no statistically significant changes in the major T cell and B cell subsets related to disease severity though some trends were present (fig. S7, A to C). In contrast, HLA-DR+CD38+ CD8 T cells as well as both KI67+ and HLA-DR+CD38+ CD4 T cells were increased in patients with more severe disease (fig. S7, D and E)."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T317","span":{"begin":69,"end":77},"obj":"Disease"},{"id":"T318","span":{"begin":116,"end":124},"obj":"Disease"}],"attributes":[{"id":"A317","pred":"mondo_id","subj":"T317","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A318","pred":"mondo_id","subj":"T318","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"To further investigate the relationship between immune responses and COVID-19 disease trajectory, we stratified the COVID-19 patients (n = 125) into eight different categories according to the NIH Ordinal Severity Scale ranging from COVID 1 (death) and COVID 2 (requiring maximal clinical intervention) to COVID 8 (at home with no required care) (Fig. 6A). We then asked how changes in T and B cell populations defined above on D0 were related to disease severity. More severe disease was associated with lower frequencies of CD8 and CD4 T cells, with a greater effect on CD8 T cells in less severe disease (Fig. 6B). Taking all patients together, there were no statistically significant changes in the major T cell and B cell subsets related to disease severity though some trends were present (fig. S7, A to C). In contrast, HLA-DR+CD38+ CD8 T cells as well as both KI67+ and HLA-DR+CD38+ CD4 T cells were increased in patients with more severe disease (fig. S7, D and E)."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T690","span":{"begin":392,"end":398},"obj":"http://purl.obolibrary.org/obo/CL_0000236"},{"id":"T691","span":{"begin":526,"end":529},"obj":"http://purl.obolibrary.org/obo/CLO_0053438"},{"id":"T692","span":{"begin":534,"end":537},"obj":"http://purl.obolibrary.org/obo/PR_000001004"},{"id":"T693","span":{"begin":538,"end":545},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T694","span":{"begin":552,"end":553},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T695","span":{"begin":572,"end":575},"obj":"http://purl.obolibrary.org/obo/CLO_0053438"},{"id":"T696","span":{"begin":576,"end":583},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T697","span":{"begin":709,"end":715},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T698","span":{"begin":720,"end":726},"obj":"http://purl.obolibrary.org/obo/CL_0000236"},{"id":"T699","span":{"begin":805,"end":806},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T700","span":{"begin":834,"end":838},"obj":"http://purl.obolibrary.org/obo/PR_000001408"},{"id":"T701","span":{"begin":840,"end":843},"obj":"http://purl.obolibrary.org/obo/CLO_0053438"},{"id":"T702","span":{"begin":844,"end":851},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T703","span":{"begin":885,"end":889},"obj":"http://purl.obolibrary.org/obo/PR_000001408"},{"id":"T704","span":{"begin":891,"end":894},"obj":"http://purl.obolibrary.org/obo/PR_000001004"},{"id":"T705","span":{"begin":895,"end":902},"obj":"http://purl.obolibrary.org/obo/CL_0000084"}],"text":"To further investigate the relationship between immune responses and COVID-19 disease trajectory, we stratified the COVID-19 patients (n = 125) into eight different categories according to the NIH Ordinal Severity Scale ranging from COVID 1 (death) and COVID 2 (requiring maximal clinical intervention) to COVID 8 (at home with no required care) (Fig. 6A). We then asked how changes in T and B cell populations defined above on D0 were related to disease severity. More severe disease was associated with lower frequencies of CD8 and CD4 T cells, with a greater effect on CD8 T cells in less severe disease (Fig. 6B). Taking all patients together, there were no statistically significant changes in the major T cell and B cell subsets related to disease severity though some trends were present (fig. S7, A to C). In contrast, HLA-DR+CD38+ CD8 T cells as well as both KI67+ and HLA-DR+CD38+ CD4 T cells were increased in patients with more severe disease (fig. S7, D and E)."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T293","span":{"begin":831,"end":833},"obj":"Chemical"},{"id":"T294","span":{"begin":882,"end":884},"obj":"Chemical"}],"attributes":[{"id":"A293","pred":"chebi_id","subj":"T293","obj":"http://purl.obolibrary.org/obo/CHEBI_73445"},{"id":"A294","pred":"chebi_id","subj":"T294","obj":"http://purl.obolibrary.org/obo/CHEBI_73445"}],"text":"To further investigate the relationship between immune responses and COVID-19 disease trajectory, we stratified the COVID-19 patients (n = 125) into eight different categories according to the NIH Ordinal Severity Scale ranging from COVID 1 (death) and COVID 2 (requiring maximal clinical intervention) to COVID 8 (at home with no required care) (Fig. 6A). We then asked how changes in T and B cell populations defined above on D0 were related to disease severity. More severe disease was associated with lower frequencies of CD8 and CD4 T cells, with a greater effect on CD8 T cells in less severe disease (Fig. 6B). Taking all patients together, there were no statistically significant changes in the major T cell and B cell subsets related to disease severity though some trends were present (fig. S7, A to C). In contrast, HLA-DR+CD38+ CD8 T cells as well as both KI67+ and HLA-DR+CD38+ CD4 T cells were increased in patients with more severe disease (fig. S7, D and E)."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T89","span":{"begin":48,"end":64},"obj":"http://purl.obolibrary.org/obo/GO_0006955"}],"text":"To further investigate the relationship between immune responses and COVID-19 disease trajectory, we stratified the COVID-19 patients (n = 125) into eight different categories according to the NIH Ordinal Severity Scale ranging from COVID 1 (death) and COVID 2 (requiring maximal clinical intervention) to COVID 8 (at home with no required care) (Fig. 6A). We then asked how changes in T and B cell populations defined above on D0 were related to disease severity. More severe disease was associated with lower frequencies of CD8 and CD4 T cells, with a greater effect on CD8 T cells in less severe disease (Fig. 6B). Taking all patients together, there were no statistically significant changes in the major T cell and B cell subsets related to disease severity though some trends were present (fig. S7, A to C). In contrast, HLA-DR+CD38+ CD8 T cells as well as both KI67+ and HLA-DR+CD38+ CD4 T cells were increased in patients with more severe disease (fig. S7, D and E)."}

{"project":"LitCovid-sentences","denotations":[{"id":"T240","span":{"begin":0,"end":356},"obj":"Sentence"},{"id":"T241","span":{"begin":357,"end":464},"obj":"Sentence"},{"id":"T242","span":{"begin":465,"end":617},"obj":"Sentence"},{"id":"T243","span":{"begin":618,"end":813},"obj":"Sentence"},{"id":"T244","span":{"begin":814,"end":974},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"To further investigate the relationship between immune responses and COVID-19 disease trajectory, we stratified the COVID-19 patients (n = 125) into eight different categories according to the NIH Ordinal Severity Scale ranging from COVID 1 (death) and COVID 2 (requiring maximal clinical intervention) to COVID 8 (at home with no required care) (Fig. 6A). We then asked how changes in T and B cell populations defined above on D0 were related to disease severity. More severe disease was associated with lower frequencies of CD8 and CD4 T cells, with a greater effect on CD8 T cells in less severe disease (Fig. 6B). Taking all patients together, there were no statistically significant changes in the major T cell and B cell subsets related to disease severity though some trends were present (fig. S7, A to C). In contrast, HLA-DR+CD38+ CD8 T cells as well as both KI67+ and HLA-DR+CD38+ CD4 T cells were increased in patients with more severe disease (fig. S7, D and E)."}