PMC:7402624 / 41401-42375
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T381 | 394-398 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T382 | 540-545 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T383 | 578-583 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T384 | 711-715 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T385 | 722-726 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T386 | 827-830 | Body_part | denotes | HLA | http://purl.org/sig/ont/fma/fma84795 |
| T387 | 846-851 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T388 | 878-881 | Body_part | denotes | HLA | http://purl.org/sig/ont/fma/fma84795 |
| T389 | 897-902 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T17 | 214-219 | Body_part | denotes | Scale | http://purl.obolibrary.org/obo/UBERON_0002542 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 1474 | 526-529 | Gene | denotes | CD8 | Gene:925 |
| 1475 | 534-537 | Gene | denotes | CD4 | Gene:920 |
| 1476 | 572-575 | Gene | denotes | CD8 | Gene:925 |
| 1477 | 834-838 | Gene | denotes | CD38 | Gene:952 |
| 1478 | 840-843 | Gene | denotes | CD8 | Gene:925 |
| 1479 | 885-889 | Gene | denotes | CD38 | Gene:952 |
| 1480 | 891-894 | Gene | denotes | CD4 | Gene:920 |
| 1481 | 125-133 | Species | denotes | patients | Tax:9606 |
| 1482 | 629-637 | Species | denotes | patients | Tax:9606 |
| 1483 | 921-929 | Species | denotes | patients | Tax:9606 |
| 1484 | 69-77 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 1485 | 116-124 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 1486 | 233-238 | Disease | denotes | COVID | MESH:C000657245 |
| 1487 | 242-247 | Disease | denotes | death | MESH:D003643 |
| 1488 | 253-258 | Disease | denotes | COVID | MESH:C000657245 |
| 1489 | 306-311 | Disease | denotes | COVID | MESH:C000657245 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T317 | 69-77 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T318 | 116-124 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T690 | 392-398 | http://purl.obolibrary.org/obo/CL_0000236 | denotes | B cell |
| T691 | 526-529 | http://purl.obolibrary.org/obo/CLO_0053438 | denotes | CD8 |
| T692 | 534-537 | http://purl.obolibrary.org/obo/PR_000001004 | denotes | CD4 |
| T693 | 538-545 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cells |
| T694 | 552-553 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T695 | 572-575 | http://purl.obolibrary.org/obo/CLO_0053438 | denotes | CD8 |
| T696 | 576-583 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cells |
| T697 | 709-715 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cell |
| T698 | 720-726 | http://purl.obolibrary.org/obo/CL_0000236 | denotes | B cell |
| T699 | 805-806 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T700 | 834-838 | http://purl.obolibrary.org/obo/PR_000001408 | denotes | CD38 |
| T701 | 840-843 | http://purl.obolibrary.org/obo/CLO_0053438 | denotes | CD8 |
| T702 | 844-851 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cells |
| T703 | 885-889 | http://purl.obolibrary.org/obo/PR_000001408 | denotes | CD38 |
| T704 | 891-894 | http://purl.obolibrary.org/obo/PR_000001004 | denotes | CD4 |
| T705 | 895-902 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cells |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T293 | 831-833 | Chemical | denotes | DR | http://purl.obolibrary.org/obo/CHEBI_73445 |
| T294 | 882-884 | Chemical | denotes | DR | http://purl.obolibrary.org/obo/CHEBI_73445 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T89 | 48-64 | http://purl.obolibrary.org/obo/GO_0006955 | denotes | immune responses |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T240 | 0-356 | Sentence | denotes | To further investigate the relationship between immune responses and COVID-19 disease trajectory, we stratified the COVID-19 patients (n = 125) into eight different categories according to the NIH Ordinal Severity Scale ranging from COVID 1 (death) and COVID 2 (requiring maximal clinical intervention) to COVID 8 (at home with no required care) (Fig. 6A). |
| T241 | 357-464 | Sentence | denotes | We then asked how changes in T and B cell populations defined above on D0 were related to disease severity. |
| T242 | 465-617 | Sentence | denotes | More severe disease was associated with lower frequencies of CD8 and CD4 T cells, with a greater effect on CD8 T cells in less severe disease (Fig. 6B). |
| T243 | 618-813 | Sentence | denotes | Taking all patients together, there were no statistically significant changes in the major T cell and B cell subsets related to disease severity though some trends were present (fig. S7, A to C). |
| T244 | 814-974 | Sentence | denotes | In contrast, HLA-DR+CD38+ CD8 T cells as well as both KI67+ and HLA-DR+CD38+ CD4 T cells were increased in patients with more severe disease (fig. S7, D and E). |