PMC:7402624 / 373-1006 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7402624","sourcedb":"PMC","sourceid":"7402624","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7402624","text":"~50 clinical features revealed activation of T cell and B cell subsets in a proportion of patients. A subgroup of patients had T cell activation characteristic of acute viral infection and plasmablast responses reaching \u003e30% of circulating B cells. However, another subgroup had lymphocyte activation comparable to uninfected subjects. Stable versus dynamic immunological signatures were identified and linked to trajectories of disease severity change. These analyses identified three “immunotypes” associated with poor clinical trajectories versus improving health. These immunotypes may have implications for the design of therape","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T1","span":{"begin":47,"end":51},"obj":"Body_part"},{"id":"T2","span":{"begin":58,"end":62},"obj":"Body_part"},{"id":"T3","span":{"begin":129,"end":133},"obj":"Body_part"},{"id":"T4","span":{"begin":189,"end":200},"obj":"Body_part"},{"id":"T5","span":{"begin":242,"end":247},"obj":"Body_part"},{"id":"T6","span":{"begin":279,"end":289},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"fma_id","subj":"T1","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A2","pred":"fma_id","subj":"T2","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A3","pred":"fma_id","subj":"T3","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A4","pred":"fma_id","subj":"T4","obj":"http://purl.org/sig/ont/fma/fma84371"},{"id":"A5","pred":"fma_id","subj":"T5","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A6","pred":"fma_id","subj":"T6","obj":"http://purl.org/sig/ont/fma/fma62863"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"14","span":{"begin":90,"end":98},"obj":"Species"},{"id":"15","span":{"begin":114,"end":122},"obj":"Species"},{"id":"18","span":{"begin":169,"end":184},"obj":"Disease"}],"attributes":[{"id":"A14","pred":"tao:has_database_id","subj":"14","obj":"Tax:9606"},{"id":"A15","pred":"tao:has_database_id","subj":"15","obj":"Tax:9606"},{"id":"A18","pred":"tao:has_database_id","subj":"18","obj":"MESH:D001102"},{"subj":"14","pred":"source","obj":"LitCovid-PubTator"},{"subj":"15","pred":"source","obj":"LitCovid-PubTator"},{"subj":"18","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T4","span":{"begin":169,"end":184},"obj":"Disease"},{"id":"T5","span":{"begin":175,"end":184},"obj":"Disease"}],"attributes":[{"id":"A4","pred":"mondo_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/MONDO_0005108"},{"id":"A5","pred":"mondo_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T4","span":{"begin":31,"end":41},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T5","span":{"begin":45,"end":51},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T6","span":{"begin":56,"end":62},"obj":"http://purl.obolibrary.org/obo/CL_0000236"},{"id":"T7","span":{"begin":74,"end":75},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T8","span":{"begin":100,"end":101},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T9","span":{"begin":127,"end":133},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T10","span":{"begin":134,"end":144},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T11","span":{"begin":240,"end":247},"obj":"http://purl.obolibrary.org/obo/CL_0000236"},{"id":"T12","span":{"begin":290,"end":300},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"}],"attributes":[{"subj":"T4","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T8","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T9","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T10","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T11","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T12","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T2","span":{"begin":127,"end":144},"obj":"http://purl.obolibrary.org/obo/GO_0042110"},{"id":"T3","span":{"begin":129,"end":144},"obj":"http://purl.obolibrary.org/obo/GO_0001775"},{"id":"T4","span":{"begin":169,"end":184},"obj":"http://purl.obolibrary.org/obo/GO_0016032"},{"id":"T5","span":{"begin":279,"end":300},"obj":"http://purl.obolibrary.org/obo/GO_0046649"}],"attributes":[{"subj":"T2","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T6","span":{"begin":100,"end":248},"obj":"Sentence"},{"id":"T7","span":{"begin":249,"end":335},"obj":"Sentence"},{"id":"T8","span":{"begin":336,"end":453},"obj":"Sentence"},{"id":"T9","span":{"begin":454,"end":567},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T6","pred":"source","obj":"LitCovid-sentences"},{"subj":"T7","pred":"source","obj":"LitCovid-sentences"},{"subj":"T8","pred":"source","obj":"LitCovid-sentences"},{"subj":"T9","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#9793ec","default":true},{"id":"LitCovid-PubTator","color":"#a8ec93"},{"id":"LitCovid-PD-MONDO","color":"#ec93c2"},{"id":"LitCovid-PD-CLO","color":"#93dcec"},{"id":"LitCovid-PD-GO-BP","color":"#ece193"},{"id":"LitCovid-sentences","color":"#c793ec"}]}]}}