PMC:7402624 / 35591-36502 JSONTXT

Annnotations TAB JSON ListView MergeView

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7402624","sourcedb":"PMC","sourceid":"7402624","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7402624","text":"Fig. 5 Temporal relationships between immune responses and disease manifestation.\n(A) Global viSNE projection of non-naïve CD8 T cells, non-naïve CD4 T cells, and B cells for all subjects pooled, with cells from COVID-19 patients at D0 and D7 concatenated and overlaid. Frequencies of (B) KI67+ and HLA-DR+CD38+ CD4 T cells, (C) KI67+ and HLA-DR+CD38+ CD8 T cells, or (D) PBs as indicated for healthy donor (HD; green), recovered donor (RD; blue), or COVID-19 patients (red) with paired samples at D0 and D7 indicated by the connecting line. Significance determined by paired Wilcoxon test: *p \u003c 0.05, **p \u003c 0.01, ***p \u003c 0.001, and ****p \u003c 0.0001. Longitudinal patterns (see Methods) of (E) HLA-DR+CD38+ CD4 T cells or (F) PBs in COVID-19 patients shown as frequency and representative flow cytometry plots. (G) Spearman correlations of clinical parameters with longitudinal fold changes in immune populations.","divisions":[{"label":"label","span":{"begin":0,"end":6}},{"label":"title","span":{"begin":8,"end":82}}],"tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T327","span":{"begin":130,"end":135},"obj":"Body_part"},{"id":"T328","span":{"begin":153,"end":158},"obj":"Body_part"},{"id":"T329","span":{"begin":166,"end":171},"obj":"Body_part"},{"id":"T330","span":{"begin":202,"end":207},"obj":"Body_part"},{"id":"T331","span":{"begin":300,"end":303},"obj":"Body_part"},{"id":"T332","span":{"begin":319,"end":324},"obj":"Body_part"},{"id":"T333","span":{"begin":340,"end":343},"obj":"Body_part"},{"id":"T334","span":{"begin":359,"end":364},"obj":"Body_part"},{"id":"T335","span":{"begin":692,"end":695},"obj":"Body_part"},{"id":"T336","span":{"begin":711,"end":716},"obj":"Body_part"}],"attributes":[{"id":"A327","pred":"fma_id","subj":"T327","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A328","pred":"fma_id","subj":"T328","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A329","pred":"fma_id","subj":"T329","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A330","pred":"fma_id","subj":"T330","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A331","pred":"fma_id","subj":"T331","obj":"http://purl.org/sig/ont/fma/fma84795"},{"id":"A332","pred":"fma_id","subj":"T332","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A333","pred":"fma_id","subj":"T333","obj":"http://purl.org/sig/ont/fma/fma84795"},{"id":"A334","pred":"fma_id","subj":"T334","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A335","pred":"fma_id","subj":"T335","obj":"http://purl.org/sig/ont/fma/fma84795"},{"id":"A336","pred":"fma_id","subj":"T336","obj":"http://purl.org/sig/ont/fma/fma68646"},{"subj":"T327","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T328","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T329","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T330","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T331","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T332","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T333","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T334","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T335","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T336","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"1291","span":{"begin":124,"end":127},"obj":"Gene"},{"id":"1292","span":{"begin":147,"end":150},"obj":"Gene"},{"id":"1293","span":{"begin":307,"end":311},"obj":"Gene"},{"id":"1294","span":{"begin":313,"end":316},"obj":"Gene"},{"id":"1295","span":{"begin":347,"end":351},"obj":"Gene"},{"id":"1296","span":{"begin":353,"end":356},"obj":"Gene"},{"id":"1297","span":{"begin":699,"end":703},"obj":"Gene"},{"id":"1298","span":{"begin":705,"end":708},"obj":"Gene"},{"id":"1299","span":{"begin":222,"end":230},"obj":"Species"},{"id":"1300","span":{"begin":461,"end":469},"obj":"Species"},{"id":"1301","span":{"begin":740,"end":748},"obj":"Species"},{"id":"1302","span":{"begin":373,"end":376},"obj":"Chemical"},{"id":"1303","span":{"begin":724,"end":727},"obj":"Chemical"},{"id":"1304","span":{"begin":213,"end":221},"obj":"Disease"},{"id":"1305","span":{"begin":409,"end":411},"obj":"Disease"},{"id":"1306","span":{"begin":452,"end":460},"obj":"Disease"},{"id":"1307","span":{"begin":731,"end":739},"obj":"Disease"}],"attributes":[{"id":"A1291","pred":"tao:has_database_id","subj":"1291","obj":"Gene:925"},{"id":"A1292","pred":"tao:has_database_id","subj":"1292","obj":"Gene:920"},{"id":"A1293","pred":"tao:has_database_id","subj":"1293","obj":"Gene:952"},{"id":"A1294","pred":"tao:has_database_id","subj":"1294","obj":"Gene:920"},{"id":"A1295","pred":"tao:has_database_id","subj":"1295","obj":"Gene:952"},{"id":"A1296","pred":"tao:has_database_id","subj":"1296","obj":"Gene:925"},{"id":"A1297","pred":"tao:has_database_id","subj":"1297","obj":"Gene:952"},{"id":"A1298","pred":"tao:has_database_id","subj":"1298","obj":"Gene:920"},{"id":"A1299","pred":"tao:has_database_id","subj":"1299","obj":"Tax:9606"},{"id":"A1300","pred":"tao:has_database_id","subj":"1300","obj":"Tax:9606"},{"id":"A1301","pred":"tao:has_database_id","subj":"1301","obj":"Tax:9606"},{"id":"A1302","pred":"tao:has_database_id","subj":"1302","obj":"MESH:D007854"},{"id":"A1303","pred":"tao:has_database_id","subj":"1303","obj":"MESH:D007854"},{"id":"A1304","pred":"tao:has_database_id","subj":"1304","obj":"MESH:C000657245"},{"id":"A1305","pred":"tao:has_database_id","subj":"1305","obj":"MESH:D006816"},{"id":"A1306","pred":"tao:has_database_id","subj":"1306","obj":"MESH:C000657245"},{"id":"A1307","pred":"tao:has_database_id","subj":"1307","obj":"MESH:C000657245"},{"subj":"1291","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1292","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1293","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1294","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1295","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1296","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1297","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1298","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1299","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1300","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1301","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1302","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1303","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1304","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1305","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1306","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1307","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T285","span":{"begin":213,"end":221},"obj":"Disease"},{"id":"T286","span":{"begin":409,"end":411},"obj":"Disease"},{"id":"T287","span":{"begin":438,"end":440},"obj":"Disease"},{"id":"T288","span":{"begin":452,"end":460},"obj":"Disease"},{"id":"T289","span":{"begin":731,"end":739},"obj":"Disease"}],"attributes":[{"id":"A285","pred":"mondo_id","subj":"T285","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A286","pred":"mondo_id","subj":"T286","obj":"http://purl.obolibrary.org/obo/MONDO_0007739"},{"id":"A287","pred":"mondo_id","subj":"T287","obj":"http://purl.obolibrary.org/obo/MONDO_0009973"},{"id":"A288","pred":"mondo_id","subj":"T288","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A289","pred":"mondo_id","subj":"T289","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"subj":"T285","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T286","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T287","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T288","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T289","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T596","span":{"begin":84,"end":85},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T597","span":{"begin":124,"end":127},"obj":"http://purl.obolibrary.org/obo/CLO_0053438"},{"id":"T598","span":{"begin":128,"end":135},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T599","span":{"begin":141,"end":158},"obj":"http://purl.obolibrary.org/obo/CL_0000895"},{"id":"T600","span":{"begin":164,"end":171},"obj":"http://purl.obolibrary.org/obo/CL_0000236"},{"id":"T601","span":{"begin":202,"end":207},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T602","span":{"begin":287,"end":288},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T603","span":{"begin":307,"end":311},"obj":"http://purl.obolibrary.org/obo/PR_000001408"},{"id":"T604","span":{"begin":313,"end":316},"obj":"http://purl.obolibrary.org/obo/PR_000001004"},{"id":"T605","span":{"begin":317,"end":324},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T606","span":{"begin":347,"end":351},"obj":"http://purl.obolibrary.org/obo/PR_000001408"},{"id":"T607","span":{"begin":353,"end":356},"obj":"http://purl.obolibrary.org/obo/CLO_0053438"},{"id":"T608","span":{"begin":357,"end":364},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T609","span":{"begin":438,"end":440},"obj":"http://purl.obolibrary.org/obo/CLO_0008770"},{"id":"T610","span":{"begin":586,"end":590},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T611","span":{"begin":699,"end":703},"obj":"http://purl.obolibrary.org/obo/PR_000001408"},{"id":"T612","span":{"begin":705,"end":708},"obj":"http://purl.obolibrary.org/obo/PR_000001004"},{"id":"T613","span":{"begin":709,"end":716},"obj":"http://purl.obolibrary.org/obo/CL_0000084"}],"attributes":[{"subj":"T596","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T597","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T598","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T599","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T600","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T601","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T602","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T603","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T604","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T605","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T606","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T607","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T608","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T609","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T610","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T611","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T612","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T613","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T257","span":{"begin":304,"end":306},"obj":"Chemical"},{"id":"T258","span":{"begin":344,"end":346},"obj":"Chemical"},{"id":"T259","span":{"begin":402,"end":407},"obj":"Chemical"},{"id":"T260","span":{"begin":409,"end":411},"obj":"Chemical"},{"id":"T261","span":{"begin":431,"end":436},"obj":"Chemical"},{"id":"T262","span":{"begin":438,"end":440},"obj":"Chemical"},{"id":"T263","span":{"begin":696,"end":698},"obj":"Chemical"}],"attributes":[{"id":"A257","pred":"chebi_id","subj":"T257","obj":"http://purl.obolibrary.org/obo/CHEBI_73445"},{"id":"A258","pred":"chebi_id","subj":"T258","obj":"http://purl.obolibrary.org/obo/CHEBI_73445"},{"id":"A259","pred":"chebi_id","subj":"T259","obj":"http://purl.obolibrary.org/obo/CHEBI_17891"},{"id":"A260","pred":"chebi_id","subj":"T260","obj":"http://purl.obolibrary.org/obo/CHEBI_73925"},{"id":"A261","pred":"chebi_id","subj":"T261","obj":"http://purl.obolibrary.org/obo/CHEBI_17891"},{"id":"A262","pred":"chebi_id","subj":"T262","obj":"http://purl.obolibrary.org/obo/CHEBI_73812"},{"id":"A263","pred":"chebi_id","subj":"T263","obj":"http://purl.obolibrary.org/obo/CHEBI_73445"},{"subj":"T257","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T258","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T259","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T260","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T261","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T262","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T263","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T78","span":{"begin":39,"end":55},"obj":"http://purl.obolibrary.org/obo/GO_0006955"}],"attributes":[{"subj":"T78","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T206","span":{"begin":0,"end":82},"obj":"Sentence"},{"id":"T207","span":{"begin":83,"end":270},"obj":"Sentence"},{"id":"T208","span":{"begin":271,"end":542},"obj":"Sentence"},{"id":"T209","span":{"begin":543,"end":648},"obj":"Sentence"},{"id":"T210","span":{"begin":649,"end":911},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T206","pred":"source","obj":"LitCovid-sentences"},{"subj":"T207","pred":"source","obj":"LitCovid-sentences"},{"subj":"T208","pred":"source","obj":"LitCovid-sentences"},{"subj":"T209","pred":"source","obj":"LitCovid-sentences"},{"subj":"T210","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#d893ec","default":true},{"id":"LitCovid-PubTator","color":"#93ecbe"},{"id":"LitCovid-PD-MONDO","color":"#eca493"},{"id":"LitCovid-PD-CLO","color":"#939bec"},{"id":"LitCovid-PD-CHEBI","color":"#b5ec93"},{"id":"LitCovid-PD-GO-BP","color":"#ec93cf"},{"id":"LitCovid-sentences","color":"#93e9ec"}]}]}}