PMC:7402624 / 34777-35590
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7402624","sourcedb":"PMC","sourceid":"7402624","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7402624","text":"A key question for hospitalized COVID-19 patients is how immune responses change over time. Thus, we used the global tSNE projections of overall CD8 T cell, CD4 T cell, and B cell differentiation states to interrogate temporal changes in these populations between D0 and D7 of hospitalization (Fig. 5A). Combining data for all patients revealed considerable stability of the tSNE distributions between D0 and D7 in CD8 T cell, CD4 T cell, and B cell populations, particularly for key regions of interest discussed above. For example, for CD8 T cells, the region of the tSNE map containing KI67+ and CD38+HLA-DR+ CD8 T cell populations that was enriched in COVID-19 patients at D0 (Fig. 2) was preserved at D7 (Fig. 5A). A similar temporal stability of CD4 T cell and B cell activation was also observed (Fig. 5A).","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T314","span":{"begin":151,"end":155},"obj":"Body_part"},{"id":"T315","span":{"begin":163,"end":167},"obj":"Body_part"},{"id":"T316","span":{"begin":175,"end":179},"obj":"Body_part"},{"id":"T317","span":{"begin":421,"end":425},"obj":"Body_part"},{"id":"T318","span":{"begin":433,"end":437},"obj":"Body_part"},{"id":"T319","span":{"begin":445,"end":449},"obj":"Body_part"},{"id":"T320","span":{"begin":544,"end":561},"obj":"Body_part"},{"id":"T321","span":{"begin":544,"end":549},"obj":"Body_part"},{"id":"T322","span":{"begin":574,"end":577},"obj":"Body_part"},{"id":"T323","span":{"begin":604,"end":607},"obj":"Body_part"},{"id":"T324","span":{"begin":618,"end":622},"obj":"Body_part"},{"id":"T325","span":{"begin":758,"end":762},"obj":"Body_part"},{"id":"T326","span":{"begin":769,"end":773},"obj":"Body_part"}],"attributes":[{"id":"A314","pred":"fma_id","subj":"T314","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A315","pred":"fma_id","subj":"T315","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A316","pred":"fma_id","subj":"T316","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A317","pred":"fma_id","subj":"T317","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A318","pred":"fma_id","subj":"T318","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A319","pred":"fma_id","subj":"T319","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A320","pred":"fma_id","subj":"T320","obj":"http://purl.org/sig/ont/fma/fma85545"},{"id":"A321","pred":"fma_id","subj":"T321","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A322","pred":"fma_id","subj":"T322","obj":"http://purl.org/sig/ont/fma/fma67847"},{"id":"A323","pred":"fma_id","subj":"T323","obj":"http://purl.org/sig/ont/fma/fma84795"},{"id":"A324","pred":"fma_id","subj":"T324","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A325","pred":"fma_id","subj":"T325","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A326","pred":"fma_id","subj":"T326","obj":"http://purl.org/sig/ont/fma/fma68646"},{"subj":"T314","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T315","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T316","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T317","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T318","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T319","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T320","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T321","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T322","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T323","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T324","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T325","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T326","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"1261","span":{"begin":145,"end":148},"obj":"Gene"},{"id":"1262","span":{"begin":157,"end":160},"obj":"Gene"},{"id":"1263","span":{"begin":427,"end":430},"obj":"Gene"},{"id":"1264","span":{"begin":538,"end":541},"obj":"Gene"},{"id":"1265","span":{"begin":599,"end":603},"obj":"Gene"},{"id":"1266","span":{"begin":612,"end":615},"obj":"Gene"},{"id":"1267","span":{"begin":752,"end":755},"obj":"Gene"},{"id":"1268","span":{"begin":415,"end":418},"obj":"Gene"},{"id":"1269","span":{"begin":41,"end":49},"obj":"Species"},{"id":"1270","span":{"begin":327,"end":335},"obj":"Species"},{"id":"1271","span":{"begin":665,"end":673},"obj":"Species"},{"id":"1272","span":{"begin":32,"end":40},"obj":"Disease"},{"id":"1273","span":{"begin":656,"end":664},"obj":"Disease"}],"attributes":[{"id":"A1261","pred":"tao:has_database_id","subj":"1261","obj":"Gene:925"},{"id":"A1262","pred":"tao:has_database_id","subj":"1262","obj":"Gene:920"},{"id":"A1263","pred":"tao:has_database_id","subj":"1263","obj":"Gene:920"},{"id":"A1264","pred":"tao:has_database_id","subj":"1264","obj":"Gene:925"},{"id":"A1265","pred":"tao:has_database_id","subj":"1265","obj":"Gene:952"},{"id":"A1266","pred":"tao:has_database_id","subj":"1266","obj":"Gene:925"},{"id":"A1267","pred":"tao:has_database_id","subj":"1267","obj":"Gene:920"},{"id":"A1268","pred":"tao:has_database_id","subj":"1268","obj":"Gene:925"},{"id":"A1269","pred":"tao:has_database_id","subj":"1269","obj":"Tax:9606"},{"id":"A1270","pred":"tao:has_database_id","subj":"1270","obj":"Tax:9606"},{"id":"A1271","pred":"tao:has_database_id","subj":"1271","obj":"Tax:9606"},{"id":"A1272","pred":"tao:has_database_id","subj":"1272","obj":"MESH:C000657245"},{"id":"A1273","pred":"tao:has_database_id","subj":"1273","obj":"MESH:C000657245"},{"subj":"1261","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1262","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1263","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1264","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1265","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1266","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1267","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1268","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1269","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1270","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1271","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1272","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1273","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T283","span":{"begin":32,"end":40},"obj":"Disease"},{"id":"T284","span":{"begin":656,"end":664},"obj":"Disease"}],"attributes":[{"id":"A283","pred":"mondo_id","subj":"T283","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A284","pred":"mondo_id","subj":"T284","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"subj":"T283","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T284","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T575","span":{"begin":0,"end":1},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T576","span":{"begin":145,"end":148},"obj":"http://purl.obolibrary.org/obo/CLO_0053438"},{"id":"T577","span":{"begin":149,"end":155},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T578","span":{"begin":157,"end":160},"obj":"http://purl.obolibrary.org/obo/PR_000001004"},{"id":"T579","span":{"begin":161,"end":167},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T580","span":{"begin":173,"end":179},"obj":"http://purl.obolibrary.org/obo/CL_0000236"},{"id":"T581","span":{"begin":415,"end":418},"obj":"http://purl.obolibrary.org/obo/CLO_0053438"},{"id":"T582","span":{"begin":419,"end":425},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T583","span":{"begin":427,"end":430},"obj":"http://purl.obolibrary.org/obo/PR_000001004"},{"id":"T584","span":{"begin":431,"end":437},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T585","span":{"begin":443,"end":449},"obj":"http://purl.obolibrary.org/obo/CL_0000236"},{"id":"T586","span":{"begin":538,"end":541},"obj":"http://purl.obolibrary.org/obo/CLO_0053438"},{"id":"T587","span":{"begin":542,"end":549},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T588","span":{"begin":599,"end":603},"obj":"http://purl.obolibrary.org/obo/PR_000001408"},{"id":"T589","span":{"begin":612,"end":615},"obj":"http://purl.obolibrary.org/obo/CLO_0053438"},{"id":"T590","span":{"begin":616,"end":622},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T591","span":{"begin":720,"end":721},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T592","span":{"begin":752,"end":755},"obj":"http://purl.obolibrary.org/obo/PR_000001004"},{"id":"T593","span":{"begin":756,"end":762},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T594","span":{"begin":767,"end":773},"obj":"http://purl.obolibrary.org/obo/CL_0000236"},{"id":"T595","span":{"begin":774,"end":784},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"}],"attributes":[{"subj":"T575","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T576","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T577","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T578","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T579","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T580","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T581","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T582","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T583","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T584","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T585","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T586","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T587","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T588","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T589","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T590","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T591","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T592","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T593","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T594","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T595","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T256","span":{"begin":608,"end":610},"obj":"Chemical"}],"attributes":[{"id":"A256","pred":"chebi_id","subj":"T256","obj":"http://purl.obolibrary.org/obo/CHEBI_73445"},{"subj":"T256","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T73","span":{"begin":57,"end":73},"obj":"http://purl.obolibrary.org/obo/GO_0006955"},{"id":"T74","span":{"begin":173,"end":195},"obj":"http://purl.obolibrary.org/obo/GO_0030183"},{"id":"T75","span":{"begin":175,"end":195},"obj":"http://purl.obolibrary.org/obo/GO_0030154"},{"id":"T76","span":{"begin":767,"end":784},"obj":"http://purl.obolibrary.org/obo/GO_0042113"},{"id":"T77","span":{"begin":769,"end":784},"obj":"http://purl.obolibrary.org/obo/GO_0001775"}],"attributes":[{"subj":"T73","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T74","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T75","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T76","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T77","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T201","span":{"begin":0,"end":91},"obj":"Sentence"},{"id":"T202","span":{"begin":92,"end":303},"obj":"Sentence"},{"id":"T203","span":{"begin":304,"end":520},"obj":"Sentence"},{"id":"T204","span":{"begin":521,"end":719},"obj":"Sentence"},{"id":"T205","span":{"begin":720,"end":813},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T201","pred":"source","obj":"LitCovid-sentences"},{"subj":"T202","pred":"source","obj":"LitCovid-sentences"},{"subj":"T203","pred":"source","obj":"LitCovid-sentences"},{"subj":"T204","pred":"source","obj":"LitCovid-sentences"},{"subj":"T205","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#93adec","default":true},{"id":"LitCovid-PubTator","color":"#c7ec93"},{"id":"LitCovid-PD-MONDO","color":"#ec93e1"},{"id":"LitCovid-PD-CLO","color":"#93ecdd"},{"id":"LitCovid-PD-CHEBI","color":"#ecc393"},{"id":"LitCovid-PD-GO-BP","color":"#a993ec"},{"id":"LitCovid-sentences","color":"#97ec93"}]}]}}