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PMC:7402624 / 34703-41269 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T313 27-31 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T314 225-229 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T315 237-241 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T316 249-253 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T317 495-499 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T318 507-511 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T319 519-523 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T320 618-635 Body_part denotes cells, the region http://purl.org/sig/ont/fma/fma85545
T321 618-623 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T322 648-651 Body_part denotes map http://purl.org/sig/ont/fma/fma67847
T323 678-681 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T324 692-696 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T325 832-836 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T326 843-847 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T327 1018-1023 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T328 1041-1046 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T329 1054-1059 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T330 1090-1095 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T331 1188-1191 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T332 1207-1212 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T333 1228-1231 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T334 1247-1252 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T335 1580-1583 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T336 1599-1604 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T337 1890-1900 Body_part denotes lymphocyte http://purl.org/sig/ont/fma/fma62863
T338 2023-2027 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T339 2033-2037 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T340 2057-2069 Body_part denotes plasmablasts http://purl.org/sig/ont/fma/fma84371
T341 2100-2103 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T342 2173-2178 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T343 2695-2699 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T344 2828-2831 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T345 2857-2862 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T346 2909-2914 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T347 2993-2998 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T348 3092-3096 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T349 3250-3255 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T350 3380-3384 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T351 3457-3460 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T352 3684-3688 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T353 3797-3802 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T354 3995-3998 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T355 4059-4061 Body_part denotes PB http://purl.org/sig/ont/fma/fma84371
T356 4099-4104 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T357 4182-4186 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T358 4192-4196 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T359 4431-4435 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T360 4521-4525 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T361 4782-4787 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T362 4789-4792 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T363 4935-4939 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T364 5006-5009 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T365 5021-5026 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T366 5088-5091 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T367 5107-5111 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T368 5289-5291 Body_part denotes PB http://purl.org/sig/ont/fma/fma84371
T369 5340-5345 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T370 5412-5420 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T371 5771-5773 Body_part denotes PB http://purl.org/sig/ont/fma/fma84371
T372 5849-5851 Body_part denotes PB http://purl.org/sig/ont/fma/fma84371
T373 5932-5935 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T374 5946-5951 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T375 6128-6131 Body_part denotes HLA http://purl.org/sig/ont/fma/fma84795
T376 6142-6147 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T377 6308-6310 Body_part denotes PB http://purl.org/sig/ont/fma/fma84371
T378 6366-6370 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T379 6477-6481 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1247 57-65 Disease denotes COVID-19 MESH:C000657245
1261 219-222 Gene denotes CD8 Gene:925
1262 231-234 Gene denotes CD4 Gene:920
1263 501-504 Gene denotes CD4 Gene:920
1264 612-615 Gene denotes CD8 Gene:925
1265 673-677 Gene denotes CD38 Gene:952
1266 686-689 Gene denotes CD8 Gene:925
1267 826-829 Gene denotes CD4 Gene:920
1268 489-492 Gene denotes CD8 Gene:925
1269 115-123 Species denotes patients Tax:9606
1270 401-409 Species denotes patients Tax:9606
1271 739-747 Species denotes patients Tax:9606
1272 106-114 Disease denotes COVID-19 MESH:C000657245
1273 730-738 Disease denotes COVID-19 MESH:C000657245
1291 1012-1015 Gene denotes CD8 Gene:925
1292 1035-1038 Gene denotes CD4 Gene:920
1293 1195-1199 Gene denotes CD38 Gene:952
1294 1201-1204 Gene denotes CD4 Gene:920
1295 1235-1239 Gene denotes CD38 Gene:952
1296 1241-1244 Gene denotes CD8 Gene:925
1297 1587-1591 Gene denotes CD38 Gene:952
1298 1593-1596 Gene denotes CD4 Gene:920
1299 1110-1118 Species denotes patients Tax:9606
1300 1349-1357 Species denotes patients Tax:9606
1301 1628-1636 Species denotes patients Tax:9606
1302 1261-1264 Chemical denotes PBs MESH:D007854
1303 1612-1615 Chemical denotes PBs MESH:D007854
1304 1101-1109 Disease denotes COVID-19 MESH:C000657245
1305 1297-1299 Disease denotes HD MESH:D006816
1306 1340-1348 Disease denotes COVID-19 MESH:C000657245
1307 1619-1627 Disease denotes COVID-19 MESH:C000657245
1313 2009-2012 Gene denotes CD4 Gene:920
1314 2017-2020 Gene denotes CD8 Gene:925
1315 2107-2111 Gene denotes CD38 Gene:952
1316 2133-2136 Gene denotes CD4 Gene:920
1317 2167-2170 Gene denotes CD8 Gene:925
1352 2835-2839 Gene denotes CD38 Gene:952
1353 2851-2854 Gene denotes CD4 Gene:920
1354 2987-2990 Gene denotes CD8 Gene:925
1355 3086-3089 Gene denotes CD8 Gene:925
1356 3244-3247 Gene denotes CD8 Gene:925
1357 3374-3377 Gene denotes CD8 Gene:925
1358 3464-3468 Gene denotes CD38 Gene:952
1359 3480-3483 Gene denotes CD8 Gene:925
1360 3670-3673 Gene denotes CD8 Gene:925
1361 3678-3681 Gene denotes CD4 Gene:920
1362 3783-3786 Gene denotes CD8 Gene:925
1363 3791-3794 Gene denotes CD4 Gene:920
1364 2350-2358 Species denotes patients Tax:9606
1365 2444-2451 Species denotes patient Tax:9606
1366 2663-2671 Species denotes patients Tax:9606
1367 2800-2808 Species denotes patients Tax:9606
1368 2893-2901 Species denotes patients Tax:9606
1369 3171-3179 Species denotes patients Tax:9606
1370 3515-3523 Species denotes patients Tax:9606
1371 3844-3852 Species denotes smallpox Tax:10255
1372 3875-3889 Species denotes vaccinia virus Tax:10245
1373 4036-4044 Species denotes patients Tax:9606
1374 4142-4150 Species denotes patients Tax:9606
1375 4263-4271 Species denotes patients Tax:9606
1376 4318-4326 Species denotes patients Tax:9606
1377 4059-4061 Chemical denotes PB
1378 2654-2662 Disease denotes COVID-19 MESH:C000657245
1379 3313-3315 Disease denotes HD MESH:D006816
1380 3411-3420 Disease denotes infection MESH:D007239
1381 3725-3740 Disease denotes viral infection MESH:D001102
1382 3816-3832 Disease denotes viral infections MESH:D001102
1383 3919-3924 Disease denotes fever MESH:D005334
1384 3963-3978 Disease denotes virus infection MESH:D001102
1385 3989-4008 Disease denotes acute HIV infection MESH:D015658
1421 4768-4771 Gene denotes CD4 Gene:920
1422 4776-4779 Gene denotes CD8 Gene:925
1423 4796-4800 Gene denotes CD38 Gene:952
1424 4994-4997 Gene denotes CD4 Gene:920
1425 5002-5005 Gene denotes CD8 Gene:925
1426 5013-5017 Gene denotes CD38 Gene:952
1427 5095-5099 Gene denotes CD38 Gene:952
1428 5101-5104 Gene denotes CD4 Gene:920
1429 5326-5329 Gene denotes CD4 Gene:920
1430 5927-5931 Gene denotes CD38 Gene:952
1431 5940-5943 Gene denotes CD8 Gene:925
1432 6123-6127 Gene denotes CD38 Gene:952
1433 6136-6139 Gene denotes CD8 Gene:925
1434 5334-5337 Gene denotes CD8 Gene:925
1435 5746-5754 Species denotes patients Tax:9606
1436 5824-5832 Species denotes patients Tax:9606
1437 5899-5907 Species denotes patients Tax:9606
1438 6088-6096 Species denotes patients Tax:9606
1439 6269-6277 Species denotes patients Tax:9606
1440 6503-6511 Species denotes patients Tax:9606
1441 5402-5411 Species denotes SARS-CoV2 Tax:2697049
1442 5207-5211 Chemical denotes cTfh
1443 5592-5602 Chemical denotes Remdesivir MESH:C000606551
1444 5607-5610 Chemical denotes HCQ MESH:D006886
1445 5771-5773 Chemical denotes PB
1446 5849-5851 Chemical denotes PB
1447 6029-6041 Chemical denotes nitric oxide MESH:D009569
1448 6204-6216 Chemical denotes nitric oxide MESH:D009569
1449 6228-6235 Chemical denotes steroid MESH:D013256
1450 4567-4575 Disease denotes COVID-19 MESH:C000657245
1451 4955-4966 Disease denotes lymphopenia MESH:D008231
1452 5138-5163 Disease denotes coagulation complications MESH:D001778
1453 5237-5249 Disease denotes co-infection MESH:D060085
1454 5788-5802 Disease denotes hyperlipidemia MESH:D006949
1455 6494-6502 Disease denotes COVID-19 MESH:C000657245

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T282 57-65 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T283 106-114 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T284 730-738 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T285 1101-1109 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T286 1297-1299 Disease denotes HD http://purl.obolibrary.org/obo/MONDO_0007739
T287 1326-1328 Disease denotes RD http://purl.obolibrary.org/obo/MONDO_0009973
T288 1340-1348 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T289 1619-1627 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T290 2654-2662 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T291 3313-3315 Disease denotes HD http://purl.obolibrary.org/obo/MONDO_0007739
T292 3320-3322 Disease denotes RD http://purl.obolibrary.org/obo/MONDO_0009973
T293 3411-3420 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T294 3725-3740 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T295 3731-3740 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T296 3816-3832 Disease denotes viral infections http://purl.obolibrary.org/obo/MONDO_0005108
T297 3844-3852 Disease denotes smallpox http://purl.obolibrary.org/obo/MONDO_0004651
T298 3875-3883 Disease denotes vaccinia http://purl.obolibrary.org/obo/MONDO_0002595
T299 3912-3924 Disease denotes yellow fever http://purl.obolibrary.org/obo/MONDO_0020502
T300 3953-3962 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T301 3963-3978 Disease denotes virus infection http://purl.obolibrary.org/obo/MONDO_0005108
T302 3969-3978 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T303 3995-4008 Disease denotes HIV infection http://purl.obolibrary.org/obo/MONDO_0005109
T304 3999-4008 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T305 4059-4061 Disease denotes PB http://purl.obolibrary.org/obo/MONDO_0019035
T306 4567-4575 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T307 4955-4966 Disease denotes lymphopenia http://purl.obolibrary.org/obo/MONDO_0003783
T308 5240-5249 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T309 5289-5291 Disease denotes PB http://purl.obolibrary.org/obo/MONDO_0019035
T310 5402-5406 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T311 5771-5773 Disease denotes PB http://purl.obolibrary.org/obo/MONDO_0019035
T312 5788-5802 Disease denotes hyperlipidemia http://purl.obolibrary.org/obo/MONDO_0021187
T313 5849-5851 Disease denotes PB http://purl.obolibrary.org/obo/MONDO_0019035
T314 6308-6310 Disease denotes PB http://purl.obolibrary.org/obo/MONDO_0019035
T315 6494-6502 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T574 27-31 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T575 74-75 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T576 219-222 http://purl.obolibrary.org/obo/CLO_0053438 denotes CD8
T577 223-229 http://purl.obolibrary.org/obo/CL_0000084 denotes T cell
T578 231-234 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T579 235-241 http://purl.obolibrary.org/obo/CL_0000084 denotes T cell
T580 247-253 http://purl.obolibrary.org/obo/CL_0000236 denotes B cell
T581 489-492 http://purl.obolibrary.org/obo/CLO_0053438 denotes CD8
T582 493-499 http://purl.obolibrary.org/obo/CL_0000084 denotes T cell
T583 501-504 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T584 505-511 http://purl.obolibrary.org/obo/CL_0000084 denotes T cell
T585 517-523 http://purl.obolibrary.org/obo/CL_0000236 denotes B cell
T586 612-615 http://purl.obolibrary.org/obo/CLO_0053438 denotes CD8
T587 616-623 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T588 673-677 http://purl.obolibrary.org/obo/PR_000001408 denotes CD38
T589 686-689 http://purl.obolibrary.org/obo/CLO_0053438 denotes CD8
T590 690-696 http://purl.obolibrary.org/obo/CL_0000084 denotes T cell
T591 794-795 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T592 826-829 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T593 830-836 http://purl.obolibrary.org/obo/CL_0000084 denotes T cell
T594 841-847 http://purl.obolibrary.org/obo/CL_0000236 denotes B cell
T595 848-858 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T596 972-973 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T597 1012-1015 http://purl.obolibrary.org/obo/CLO_0053438 denotes CD8
T598 1016-1023 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T599 1029-1046 http://purl.obolibrary.org/obo/CL_0000895 denotes naïve CD4 T cells
T600 1052-1059 http://purl.obolibrary.org/obo/CL_0000236 denotes B cells
T601 1090-1095 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T602 1175-1176 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T603 1195-1199 http://purl.obolibrary.org/obo/PR_000001408 denotes CD38
T604 1201-1204 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T605 1205-1212 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T606 1235-1239 http://purl.obolibrary.org/obo/PR_000001408 denotes CD38
T607 1241-1244 http://purl.obolibrary.org/obo/CLO_0053438 denotes CD8
T608 1245-1252 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T609 1326-1328 http://purl.obolibrary.org/obo/CLO_0008770 denotes RD
T610 1474-1478 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T611 1587-1591 http://purl.obolibrary.org/obo/PR_000001408 denotes CD38
T612 1593-1596 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T613 1597-1604 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T614 2009-2012 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T615 2017-2020 http://purl.obolibrary.org/obo/CLO_0053438 denotes CD8
T616 2021-2027 http://purl.obolibrary.org/obo/CL_0000084 denotes T cell
T617 2031-2037 http://purl.obolibrary.org/obo/CL_0000236 denotes B cell
T618 2107-2111 http://purl.obolibrary.org/obo/PR_000001408 denotes CD38
T619 2133-2136 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T620 2167-2170 http://purl.obolibrary.org/obo/CLO_0053438 denotes CD8
T621 2171-2178 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T622 2469-2470 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T623 2695-2699 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T624 2835-2839 http://purl.obolibrary.org/obo/PR_000001408 denotes CD38
T625 2845-2862 http://purl.obolibrary.org/obo/CL_0000895 denotes naïve CD4 T cells
T626 2909-2914 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T627 2987-2990 http://purl.obolibrary.org/obo/CLO_0053438 denotes CD8
T628 2991-2998 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T629 3086-3089 http://purl.obolibrary.org/obo/CLO_0053438 denotes CD8
T630 3090-3096 http://purl.obolibrary.org/obo/CL_0000084 denotes T cell
T631 3244-3247 http://purl.obolibrary.org/obo/CLO_0053438 denotes CD8
T632 3248-3255 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T633 3320-3322 http://purl.obolibrary.org/obo/CLO_0008770 denotes RD
T634 3362-3363 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T635 3374-3377 http://purl.obolibrary.org/obo/CLO_0053438 denotes CD8
T636 3378-3384 http://purl.obolibrary.org/obo/CL_0000084 denotes T cell
T637 3422-3423 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T638 3464-3468 http://purl.obolibrary.org/obo/PR_000001408 denotes CD38
T639 3480-3483 http://purl.obolibrary.org/obo/CLO_0053438 denotes CD8
T640 3528-3529 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T641 3643-3652 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T642 3670-3673 http://purl.obolibrary.org/obo/CLO_0053438 denotes CD8
T643 3678-3681 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T644 3682-3688 http://purl.obolibrary.org/obo/CL_0000084 denotes T cell
T645 3783-3786 http://purl.obolibrary.org/obo/CLO_0053438 denotes CD8
T646 3791-3794 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T647 3795-3802 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T648 3884-3889 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T649 3937-3940 http://purl.obolibrary.org/obo/CLO_0001134 denotes 17D
T650 3942-3944 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T651 3963-3968 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T652 4010-4012 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T653 4097-4104 http://purl.obolibrary.org/obo/CL_0000236 denotes B cells
T654 4180-4186 http://purl.obolibrary.org/obo/CL_0000084 denotes T cell
T655 4190-4196 http://purl.obolibrary.org/obo/CL_0000236 denotes B cell
T656 4197-4207 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T657 4357-4367 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T658 4429-4435 http://purl.obolibrary.org/obo/CL_0000236 denotes B cell
T659 4436-4446 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T660 4519-4525 http://purl.obolibrary.org/obo/CL_0000236 denotes B cell
T661 4768-4771 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T662 4776-4779 http://purl.obolibrary.org/obo/CLO_0053438 denotes CD8
T663 4780-4787 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T664 4796-4800 http://purl.obolibrary.org/obo/PR_000001408 denotes CD38
T665 4813-4822 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T666 4910-4911 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T667 4933-4939 http://purl.obolibrary.org/obo/CL_0000084 denotes T cell
T668 4940-4950 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T669 4994-4997 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T670 5002-5005 http://purl.obolibrary.org/obo/CLO_0053438 denotes CD8
T671 5013-5017 http://purl.obolibrary.org/obo/PR_000001408 denotes CD38
T672 5019-5026 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T673 5095-5099 http://purl.obolibrary.org/obo/PR_000001408 denotes CD38
T674 5101-5104 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T675 5105-5111 http://purl.obolibrary.org/obo/CL_0000084 denotes T cell
T676 5197-5206 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T677 5326-5329 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T678 5334-5337 http://purl.obolibrary.org/obo/CLO_0053438 denotes CD8
T679 5338-5345 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T680 5927-5931 http://purl.obolibrary.org/obo/PR_000001408 denotes CD38
T681 5940-5943 http://purl.obolibrary.org/obo/CLO_0053438 denotes CD8
T682 5944-5951 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T683 6123-6127 http://purl.obolibrary.org/obo/PR_000001408 denotes CD38
T684 6136-6139 http://purl.obolibrary.org/obo/CLO_0053438 denotes CD8
T685 6140-6147 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T686 6364-6370 http://purl.obolibrary.org/obo/CL_0000084 denotes T cell
T687 6475-6481 http://purl.obolibrary.org/obo/CL_0000236 denotes B cell

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T256 682-684 Chemical denotes DR http://purl.obolibrary.org/obo/CHEBI_73445
T257 1192-1194 Chemical denotes DR http://purl.obolibrary.org/obo/CHEBI_73445
T258 1232-1234 Chemical denotes DR http://purl.obolibrary.org/obo/CHEBI_73445
T259 1290-1295 Chemical denotes donor http://purl.obolibrary.org/obo/CHEBI_17891
T260 1297-1299 Chemical denotes HD http://purl.obolibrary.org/obo/CHEBI_73925
T261 1319-1324 Chemical denotes donor http://purl.obolibrary.org/obo/CHEBI_17891
T262 1326-1328 Chemical denotes RD http://purl.obolibrary.org/obo/CHEBI_73812
T263 1584-1586 Chemical denotes DR http://purl.obolibrary.org/obo/CHEBI_73445
T264 2104-2106 Chemical denotes DR http://purl.obolibrary.org/obo/CHEBI_73445
T265 2143-2145 Chemical denotes 5B http://purl.obolibrary.org/obo/CHEBI_27560
T266 2832-2834 Chemical denotes DR http://purl.obolibrary.org/obo/CHEBI_73445
T267 3313-3315 Chemical denotes HD http://purl.obolibrary.org/obo/CHEBI_73925
T268 3320-3322 Chemical denotes RD http://purl.obolibrary.org/obo/CHEBI_73812
T269 3461-3463 Chemical denotes DR http://purl.obolibrary.org/obo/CHEBI_73445
T270 4059-4061 Chemical denotes PB http://purl.obolibrary.org/obo/CHEBI_53319|http://purl.obolibrary.org/obo/CHEBI_60686
T272 4793-4795 Chemical denotes DR http://purl.obolibrary.org/obo/CHEBI_73445
T273 5010-5012 Chemical denotes DR http://purl.obolibrary.org/obo/CHEBI_73445
T274 5092-5094 Chemical denotes DR http://purl.obolibrary.org/obo/CHEBI_73445
T275 5289-5291 Chemical denotes PB http://purl.obolibrary.org/obo/CHEBI_53319|http://purl.obolibrary.org/obo/CHEBI_60686
T277 5538-5547 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T278 5771-5773 Chemical denotes PB http://purl.obolibrary.org/obo/CHEBI_53319|http://purl.obolibrary.org/obo/CHEBI_60686
T280 5849-5851 Chemical denotes PB http://purl.obolibrary.org/obo/CHEBI_53319|http://purl.obolibrary.org/obo/CHEBI_60686
T282 5936-5938 Chemical denotes DR http://purl.obolibrary.org/obo/CHEBI_73445
T283 6029-6041 Chemical denotes nitric oxide http://purl.obolibrary.org/obo/CHEBI_16480
T284 6036-6041 Chemical denotes oxide http://purl.obolibrary.org/obo/CHEBI_25741|http://purl.obolibrary.org/obo/CHEBI_29356
T286 6132-6134 Chemical denotes DR http://purl.obolibrary.org/obo/CHEBI_73445
T287 6204-6216 Chemical denotes nitric oxide http://purl.obolibrary.org/obo/CHEBI_16480
T288 6211-6216 Chemical denotes oxide http://purl.obolibrary.org/obo/CHEBI_25741|http://purl.obolibrary.org/obo/CHEBI_29356
T290 6228-6235 Chemical denotes steroid http://purl.obolibrary.org/obo/CHEBI_35341
T291 6308-6310 Chemical denotes PB http://purl.obolibrary.org/obo/CHEBI_53319|http://purl.obolibrary.org/obo/CHEBI_60686

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T73 131-147 http://purl.obolibrary.org/obo/GO_0006955 denotes immune responses
T74 247-269 http://purl.obolibrary.org/obo/GO_0030183 denotes B cell differentiation
T75 249-269 http://purl.obolibrary.org/obo/GO_0030154 denotes cell differentiation
T76 841-858 http://purl.obolibrary.org/obo/GO_0042113 denotes B cell activation
T77 843-858 http://purl.obolibrary.org/obo/GO_0001775 denotes cell activation
T78 927-943 http://purl.obolibrary.org/obo/GO_0006955 denotes immune responses
T79 3725-3740 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T80 3816-3832 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infections
T81 4190-4207 http://purl.obolibrary.org/obo/GO_0042113 denotes B cell activation
T82 4192-4207 http://purl.obolibrary.org/obo/GO_0001775 denotes cell activation
T83 4429-4446 http://purl.obolibrary.org/obo/GO_0042113 denotes B cell activation
T84 4431-4446 http://purl.obolibrary.org/obo/GO_0001775 denotes cell activation
T85 4933-4950 http://purl.obolibrary.org/obo/GO_0042110 denotes T cell activation
T86 4935-4950 http://purl.obolibrary.org/obo/GO_0001775 denotes cell activation
T87 5138-5149 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T88 5548-5563 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T10 3919-3924 Phenotype denotes fever http://purl.obolibrary.org/obo/HP_0001945
T11 4955-4966 Phenotype denotes lymphopenia http://purl.obolibrary.org/obo/HP_0001888
T12 5788-5802 Phenotype denotes hyperlipidemia http://purl.obolibrary.org/obo/HP_0003077

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T200 0-73 Sentence denotes Temporal changes in immune cell populations occur during COVID-19 disease
T201 74-165 Sentence denotes A key question for hospitalized COVID-19 patients is how immune responses change over time.
T202 166-377 Sentence denotes Thus, we used the global tSNE projections of overall CD8 T cell, CD4 T cell, and B cell differentiation states to interrogate temporal changes in these populations between D0 and D7 of hospitalization (Fig. 5A).
T203 378-594 Sentence denotes Combining data for all patients revealed considerable stability of the tSNE distributions between D0 and D7 in CD8 T cell, CD4 T cell, and B cell populations, particularly for key regions of interest discussed above.
T204 595-793 Sentence denotes For example, for CD8 T cells, the region of the tSNE map containing KI67+ and CD38+HLA-DR+ CD8 T cell populations that was enriched in COVID-19 patients at D0 (Fig. 2) was preserved at D7 (Fig. 5A).
T205 794-887 Sentence denotes A similar temporal stability of CD4 T cell and B cell activation was also observed (Fig. 5A).
T206 888-970 Sentence denotes Fig. 5 Temporal relationships between immune responses and disease manifestation.
T207 971-1158 Sentence denotes (A) Global viSNE projection of non-naïve CD8 T cells, non-naïve CD4 T cells, and B cells for all subjects pooled, with cells from COVID-19 patients at D0 and D7 concatenated and overlaid.
T208 1159-1430 Sentence denotes Frequencies of (B) KI67+ and HLA-DR+CD38+ CD4 T cells, (C) KI67+ and HLA-DR+CD38+ CD8 T cells, or (D) PBs as indicated for healthy donor (HD; green), recovered donor (RD; blue), or COVID-19 patients (red) with paired samples at D0 and D7 indicated by the connecting line.
T209 1431-1536 Sentence denotes Significance determined by paired Wilcoxon test: *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001.
T210 1537-1799 Sentence denotes Longitudinal patterns (see Methods) of (E) HLA-DR+CD38+ CD4 T cells or (F) PBs in COVID-19 patients shown as frequency and representative flow cytometry plots. (G) Spearman correlations of clinical parameters with longitudinal fold changes in immune populations.
T211 1800-1928 Sentence denotes Given this apparent stability between D0 and D7, we next investigated temporal changes in lymphocyte subpopulations of interest.
T212 1929-2239 Sentence denotes Although there were no obvious temporal changes in major phenotypically defined CD4 and CD8 T cell or B cell subsets, including plasmablasts (Fig. 5D), the frequencies of HLA-DR+CD38+ and KI67+ non-naïve CD4 (Fig. 5B) and KI67+ non-naïve CD8 T cells were statistically increased at D7 compared to D0 (Fig. 5C).
T213 2240-2419 Sentence denotes However, in all cases, these temporal patterns were complex, with frequencies of subpopulations in individual patients appearing to increase, decrease, or stay the same over time.
T214 2420-2590 Sentence denotes To quantify these inter-patient changes, we used a previously described data set (46) to define the stability of populations of interest in healthy individuals over time.
T215 2591-2770 Sentence denotes We then used the range of this variation over time to identify COVID-19 patients with changes in immune cell subpopulations beyond that expected in healthy subjects (see methods).
T216 2771-2966 Sentence denotes Using this approach, ~50% of patients had an increase in HLA-DR+CD38+ non-naïve CD4 T cells over time, whereas in ~30% of patients, these cells were stable and, in ~20%, they decreased (Fig. 5E).
T217 2967-3057 Sentence denotes For KI67+ non-naïve CD8 T cells, there were no individuals in whom the response decreased.
T218 3058-3157 Sentence denotes Instead, this proliferative CD8 T cell response stayed stable (~70%) or increased (~30%; fig. S6A).
T219 3158-3338 Sentence denotes Notably, for patients in the stable category, the median frequency of KI67+ non-naïve CD8 T cells was ~10%, almost 5-fold higher than the ~1% detected for HD and RD subjects (Figs.
T220 3339-3421 Sentence denotes 5C and 2E), suggesting a sustained CD8 T cell proliferative response to infection.
T221 3422-3613 Sentence denotes A similar pattern was observed for HLA-DR+CD38+ non-naïve CD8 (fig. S6B), where only ~10% of patients had a decrease in this population, whereas ~65% were stable and ~25% increased over time.
T222 3614-4014 Sentence denotes The high and even increasing activated or proliferating CD8 and CD4 T cell responses over ~1 week during acute viral infection contrasted with the sharp peak of KI67 in CD8 and CD4 T cells during acute viral infections, including smallpox vaccination with live vaccinia virus (47), live attenuated yellow fever vaccine YFV-17D (48), acute influenza virus infection (49), and acute HIV infection (35).
T223 4015-4130 Sentence denotes Approximately 42% of patients had sustained PB responses, at high levels (>10% of B cells) in many cases (Fig. 5F).
T224 4131-4292 Sentence denotes Thus, some patients displayed dynamic changes in T cell or B cell activation over 1 week in the hospital, but there were also other patients who remained stable.
T225 4293-4484 Sentence denotes In the latter case, some patients remained stable without clear activation of key immune populations whereas others had stable T and or B cell activation or numerical perturbation (fig. S6C).
T226 4485-4677 Sentence denotes We next asked whether these T and B cell dynamics related to clinical measures of COVID-19 disease, by correlating changes in immune features from D0 to D7 with clinical information (Fig. 5G).
T227 4678-4724 Sentence denotes These analyses revealed distinct correlations.
T228 4725-4967 Sentence denotes Decreases in all populations of responding CD4 and CD8 T cells (HLA-DR+CD38+, KI67+, or activated cTfh) between D0 and D7 were positively correlated with PMN and WBC counts, suggesting a relationship between T cell activation and lymphopenia.
T229 4968-5071 Sentence denotes Furthermore, decreases in CD4 and CD8 HLA-DR+CD38+ T cells positively correlated with APACHE III score.
T230 5072-5177 Sentence denotes However, stable HLA-DR+CD38+ CD4 T cell responses correlated with coagulation complications and ferritin.
T231 5178-5292 Sentence denotes Whereas decreasing activated cTfh over time was related to co-infection, the opposite pattern was observed for PB.
T232 5293-5574 Sentence denotes Increases in proliferating KI67+ CD4 and CD8 T cells over time were positively correlated to increasing anti-SARS-CoV2 antibody from day 0 to day 7, suggesting that some individuals might have been hospitalized during the expansion phase of the antiviral immune response (Fig. 5G).
T233 5575-5678 Sentence denotes Finally, neither Remdesivir nor HCQ treatment correlated with any of these immune features in Fig. 5G).
T234 5679-5894 Sentence denotes Examining categorical rather than continuous clinical data, 80% of patients with decreasing PB over time had hyperlipidemia, whereas only 20% of patients with increasing PB over time had this comorbidity (fig. S6D).
T235 5895-6159 Sentence denotes All patients who had decreasing CD38+HLA-DR+ CD8 T cells from day 0 to day 7 were treated with early vasoactive medication or inhaled nitric oxide whereas these treatments were less common for patients with stable or increasing CD38+HLA-DR+ CD8 T cells (fig. S6E).
T236 6160-6322 Sentence denotes In contrast, vasoactive medication, inhaled nitric oxide, and early steroid treatment were equally common in patients with increasing or decreasing PB (fig. S6D).
T237 6323-6430 Sentence denotes Similar patterns were apparent for other T cell populations and these categorical clinical data (fig. S6F).
T238 6431-6566 Sentence denotes Thus, the trajectory of change in the T and B cell response in COVID-19 patients was strongly connected to clinical metrics of disease.

2_test

Id Subject Object Predicate Lexical cue
32669297-28397821-135105212 2502-2504 28397821 denotes 46
32669297-18468462-135105213 3891-3893 18468462 denotes 47
32669297-29236685-135105214 3942-3944 29236685 denotes 48
32669297-22286307-135105215 3980-3982 22286307 denotes 49
32669297-26362266-135105216 4010-4012 26362266 denotes 35