PMC:7402624 / 13971-14604 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T83","span":{"begin":33,"end":36},"obj":"Body_part"},{"id":"T84","span":{"begin":40,"end":51},"obj":"Body_part"},{"id":"T85","span":{"begin":46,"end":51},"obj":"Body_part"},{"id":"T86","span":{"begin":180,"end":185},"obj":"Body_part"},{"id":"T87","span":{"begin":227,"end":232},"obj":"Body_part"},{"id":"T88","span":{"begin":369,"end":376},"obj":"Body_part"},{"id":"T89","span":{"begin":429,"end":442},"obj":"Body_part"},{"id":"T90","span":{"begin":429,"end":433},"obj":"Body_part"},{"id":"T91","span":{"begin":586,"end":591},"obj":"Body_part"}],"attributes":[{"id":"A83","pred":"fma_id","subj":"T83","obj":"http://purl.org/sig/ont/fma/fma84795"},{"id":"A84","pred":"fma_id","subj":"T84","obj":"http://purl.org/sig/ont/fma/fma0326121"},{"id":"A85","pred":"fma_id","subj":"T85","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A86","pred":"fma_id","subj":"T86","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A87","pred":"fma_id","subj":"T87","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A88","pred":"fma_id","subj":"T88","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A89","pred":"fma_id","subj":"T89","obj":"http://purl.org/sig/ont/fma/fma62807"},{"id":"A90","pred":"fma_id","subj":"T90","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A91","pred":"fma_id","subj":"T91","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"Frequencies of (E) KI67+ and (F) HLA-DR+CD38+ cells and representative flow cytometry plots; green line at upper decile of HD. (G) (Top) Global viSNE projection of non-naïve CD8 T cells for all subjects pooled, non-naïve CD8 T cells from healthy donor (HD), recovered donor (RD), and COVID-19 patients concatenated and overlaid. (Bottom) viSNE projections of indicated protein expression. (H) viSNE projection of non-naïve CD8 T cell clusters identified by FlowSOM clustering. (I) Mean fluorescence intensity (MFI) as indicated, column-scaled z-score. (J) Percentage of non-naive CD8 T cells from each cohort in each FlowSOM cluster."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T7","span":{"begin":429,"end":442},"obj":"Body_part"}],"attributes":[{"id":"A7","pred":"uberon_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/UBERON_0034922"}],"text":"Frequencies of (E) KI67+ and (F) HLA-DR+CD38+ cells and representative flow cytometry plots; green line at upper decile of HD. (G) (Top) Global viSNE projection of non-naïve CD8 T cells for all subjects pooled, non-naïve CD8 T cells from healthy donor (HD), recovered donor (RD), and COVID-19 patients concatenated and overlaid. (Bottom) viSNE projections of indicated protein expression. (H) viSNE projection of non-naïve CD8 T cell clusters identified by FlowSOM clustering. (I) Mean fluorescence intensity (MFI) as indicated, column-scaled z-score. (J) Percentage of non-naive CD8 T cells from each cohort in each FlowSOM cluster."}

{"project":"LitCovid-PubTator","denotations":[{"id":"436","span":{"begin":40,"end":44},"obj":"Gene"},{"id":"437","span":{"begin":580,"end":583},"obj":"Gene"},{"id":"441","span":{"begin":174,"end":177},"obj":"Gene"},{"id":"445","span":{"begin":123,"end":125},"obj":"Disease"}],"attributes":[{"id":"A436","pred":"tao:has_database_id","subj":"436","obj":"Gene:952"},{"id":"A437","pred":"tao:has_database_id","subj":"437","obj":"Gene:925"},{"id":"A441","pred":"tao:has_database_id","subj":"441","obj":"Gene:925"},{"id":"A445","pred":"tao:has_database_id","subj":"445","obj":"MESH:D006816"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Frequencies of (E) KI67+ and (F) HLA-DR+CD38+ cells and representative flow cytometry plots; green line at upper decile of HD. (G) (Top) Global viSNE projection of non-naïve CD8 T cells for all subjects pooled, non-naïve CD8 T cells from healthy donor (HD), recovered donor (RD), and COVID-19 patients concatenated and overlaid. (Bottom) viSNE projections of indicated protein expression. (H) viSNE projection of non-naïve CD8 T cell clusters identified by FlowSOM clustering. (I) Mean fluorescence intensity (MFI) as indicated, column-scaled z-score. (J) Percentage of non-naive CD8 T cells from each cohort in each FlowSOM cluster."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T107","span":{"begin":123,"end":125},"obj":"Disease"},{"id":"T108","span":{"begin":253,"end":255},"obj":"Disease"},{"id":"T109","span":{"begin":275,"end":277},"obj":"Disease"},{"id":"T110","span":{"begin":284,"end":292},"obj":"Disease"}],"attributes":[{"id":"A107","pred":"mondo_id","subj":"T107","obj":"http://purl.obolibrary.org/obo/MONDO_0007739"},{"id":"A108","pred":"mondo_id","subj":"T108","obj":"http://purl.obolibrary.org/obo/MONDO_0007739"},{"id":"A109","pred":"mondo_id","subj":"T109","obj":"http://purl.obolibrary.org/obo/MONDO_0009973"},{"id":"A110","pred":"mondo_id","subj":"T110","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"Frequencies of (E) KI67+ and (F) HLA-DR+CD38+ cells and representative flow cytometry plots; green line at upper decile of HD. (G) (Top) Global viSNE projection of non-naïve CD8 T cells for all subjects pooled, non-naïve CD8 T cells from healthy donor (HD), recovered donor (RD), and COVID-19 patients concatenated and overlaid. (Bottom) viSNE projections of indicated protein expression. (H) viSNE projection of non-naïve CD8 T cell clusters identified by FlowSOM clustering. (I) Mean fluorescence intensity (MFI) as indicated, column-scaled z-score. (J) Percentage of non-naive CD8 T cells from each cohort in each FlowSOM cluster."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T202","span":{"begin":40,"end":44},"obj":"http://purl.obolibrary.org/obo/PR_000001408"},{"id":"T203","span":{"begin":46,"end":51},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T204","span":{"begin":174,"end":177},"obj":"http://purl.obolibrary.org/obo/CLO_0053438"},{"id":"T205","span":{"begin":178,"end":185},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T206","span":{"begin":221,"end":224},"obj":"http://purl.obolibrary.org/obo/CLO_0053438"},{"id":"T207","span":{"begin":225,"end":232},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T208","span":{"begin":275,"end":277},"obj":"http://purl.obolibrary.org/obo/CLO_0008770"},{"id":"T209","span":{"begin":423,"end":426},"obj":"http://purl.obolibrary.org/obo/CLO_0053438"},{"id":"T210","span":{"begin":427,"end":433},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T211","span":{"begin":580,"end":583},"obj":"http://purl.obolibrary.org/obo/CLO_0053438"},{"id":"T212","span":{"begin":584,"end":591},"obj":"http://purl.obolibrary.org/obo/CL_0000084"}],"text":"Frequencies of (E) KI67+ and (F) HLA-DR+CD38+ cells and representative flow cytometry plots; green line at upper decile of HD. (G) (Top) Global viSNE projection of non-naïve CD8 T cells for all subjects pooled, non-naïve CD8 T cells from healthy donor (HD), recovered donor (RD), and COVID-19 patients concatenated and overlaid. (Bottom) viSNE projections of indicated protein expression. (H) viSNE projection of non-naïve CD8 T cell clusters identified by FlowSOM clustering. (I) Mean fluorescence intensity (MFI) as indicated, column-scaled z-score. (J) Percentage of non-naive CD8 T cells from each cohort in each FlowSOM cluster."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T57","span":{"begin":37,"end":39},"obj":"Chemical"},{"id":"T58","span":{"begin":123,"end":125},"obj":"Chemical"},{"id":"T59","span":{"begin":246,"end":251},"obj":"Chemical"},{"id":"T60","span":{"begin":253,"end":255},"obj":"Chemical"},{"id":"T61","span":{"begin":268,"end":273},"obj":"Chemical"},{"id":"T62","span":{"begin":275,"end":277},"obj":"Chemical"},{"id":"T63","span":{"begin":369,"end":376},"obj":"Chemical"}],"attributes":[{"id":"A57","pred":"chebi_id","subj":"T57","obj":"http://purl.obolibrary.org/obo/CHEBI_73445"},{"id":"A58","pred":"chebi_id","subj":"T58","obj":"http://purl.obolibrary.org/obo/CHEBI_73925"},{"id":"A59","pred":"chebi_id","subj":"T59","obj":"http://purl.obolibrary.org/obo/CHEBI_17891"},{"id":"A60","pred":"chebi_id","subj":"T60","obj":"http://purl.obolibrary.org/obo/CHEBI_73925"},{"id":"A61","pred":"chebi_id","subj":"T61","obj":"http://purl.obolibrary.org/obo/CHEBI_17891"},{"id":"A62","pred":"chebi_id","subj":"T62","obj":"http://purl.obolibrary.org/obo/CHEBI_73812"},{"id":"A63","pred":"chebi_id","subj":"T63","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"}],"text":"Frequencies of (E) KI67+ and (F) HLA-DR+CD38+ cells and representative flow cytometry plots; green line at upper decile of HD. (G) (Top) Global viSNE projection of non-naïve CD8 T cells for all subjects pooled, non-naïve CD8 T cells from healthy donor (HD), recovered donor (RD), and COVID-19 patients concatenated and overlaid. (Bottom) viSNE projections of indicated protein expression. (H) viSNE projection of non-naïve CD8 T cell clusters identified by FlowSOM clustering. (I) Mean fluorescence intensity (MFI) as indicated, column-scaled z-score. (J) Percentage of non-naive CD8 T cells from each cohort in each FlowSOM cluster."}

{"project":"LitCovid-sentences","denotations":[{"id":"T93","span":{"begin":0,"end":633},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Frequencies of (E) KI67+ and (F) HLA-DR+CD38+ cells and representative flow cytometry plots; green line at upper decile of HD. (G) (Top) Global viSNE projection of non-naïve CD8 T cells for all subjects pooled, non-naïve CD8 T cells from healthy donor (HD), recovered donor (RD), and COVID-19 patients concatenated and overlaid. (Bottom) viSNE projections of indicated protein expression. (H) viSNE projection of non-naïve CD8 T cell clusters identified by FlowSOM clustering. (I) Mean fluorescence intensity (MFI) as indicated, column-scaled z-score. (J) Percentage of non-naive CD8 T cells from each cohort in each FlowSOM cluster."}