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PMC:7402624 / 12081-13589 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T67 81-91 Body_part denotes lymphocyte http://purl.org/sig/ont/fma/fma62863
T68 668-673 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T69 691-695 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T70 776-788 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T71 776-780 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T72 1018-1023 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T73 1041-1045 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T74 1182-1187 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T75 1281-1286 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T76 1418-1422 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
372 662-665 Gene denotes CD8 Gene:925
373 685-688 Gene denotes CD8 Gene:925
374 755-759 Gene denotes CD27 Gene:939
375 761-765 Gene denotes CCR7 Gene:1236
376 771-775 Gene denotes CD95 Gene:355
377 821-825 Gene denotes CD27 Gene:939
378 826-830 Gene denotes CCR7 Gene:1236
379 831-835 Gene denotes CD95 Gene:355
380 862-866 Gene denotes CD27 Gene:939
381 867-871 Gene denotes CCR7 Gene:1236
382 904-908 Gene denotes CD27 Gene:939
383 909-913 Gene denotes CCR7 Gene:1236
384 929-933 Gene denotes CD27 Gene:939
385 934-938 Gene denotes CCR7 Gene:1236
386 954-958 Gene denotes CD27 Gene:939
387 959-963 Gene denotes CCR7 Gene:1236
388 990-994 Gene denotes CD27 Gene:939
389 995-999 Gene denotes CCR7 Gene:1236
390 1012-1015 Gene denotes CD8 Gene:925
391 1035-1038 Gene denotes CD8 Gene:925
392 1176-1180 Gene denotes CD39 Gene:953
393 1275-1279 Gene denotes PD-1 Gene:100513601
394 1318-1321 Gene denotes CD8 Gene:925
395 1412-1415 Gene denotes CD8 Gene:925
396 266-274 Species denotes patients Tax:9606
397 418-426 Species denotes patients Tax:9606
398 1214-1222 Species denotes patients Tax:9606
399 130-138 Disease denotes COVID-19 MESH:C000657245
400 257-265 Disease denotes COVID-19 MESH:C000657245
401 303-305 Disease denotes HD MESH:D006816
402 409-417 Disease denotes COVID-19 MESH:C000657245
403 458-460 Disease denotes HD MESH:D006816
404 490-492 Disease denotes HD MESH:D006816
405 572-580 Disease denotes COVID-19 MESH:C000657245
406 631-646 Disease denotes viral infection MESH:D001102
407 1205-1213 Disease denotes COVID-19 MESH:C000657245
408 1235-1237 Disease denotes HD MESH:D006816
409 1473-1475 Disease denotes HD MESH:D006816

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T90 130-138 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T91 257-265 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T92 286-288 Disease denotes RD http://purl.obolibrary.org/obo/MONDO_0009973
T93 303-305 Disease denotes HD http://purl.obolibrary.org/obo/MONDO_0007739
T94 409-417 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T95 451-453 Disease denotes RD http://purl.obolibrary.org/obo/MONDO_0009973
T96 458-460 Disease denotes HD http://purl.obolibrary.org/obo/MONDO_0007739
T97 483-485 Disease denotes RD http://purl.obolibrary.org/obo/MONDO_0009973
T98 490-492 Disease denotes HD http://purl.obolibrary.org/obo/MONDO_0007739
T99 572-580 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T100 631-646 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T101 637-646 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T102 1205-1213 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T103 1235-1237 Disease denotes HD http://purl.obolibrary.org/obo/MONDO_0007739
T104 1451-1453 Disease denotes RD http://purl.obolibrary.org/obo/MONDO_0009973
T105 1473-1475 Disease denotes HD http://purl.obolibrary.org/obo/MONDO_0007739

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T143 92-102 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T144 286-288 http://purl.obolibrary.org/obo/CLO_0008770 denotes RD
T145 311-313 http://purl.obolibrary.org/obo/CLO_0001313 denotes 36
T146 397-399 http://purl.obolibrary.org/obo/CLO_0008933 denotes S5
T147 451-453 http://purl.obolibrary.org/obo/CLO_0008770 denotes RD
T148 483-485 http://purl.obolibrary.org/obo/CLO_0008770 denotes RD
T149 518-520 http://purl.obolibrary.org/obo/CLO_0001236 denotes 2A
T150 651-658 http://purl.obolibrary.org/obo/CLO_0009985 denotes focused
T151 662-665 http://purl.obolibrary.org/obo/CLO_0053438 denotes CD8
T152 666-673 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T153 685-688 http://purl.obolibrary.org/obo/CLO_0053438 denotes CD8
T154 689-695 http://purl.obolibrary.org/obo/CL_0000084 denotes T cell
T155 747-753 http://purl.obolibrary.org/obo/PR_000001015 denotes CD45RA
T156 755-759 http://purl.obolibrary.org/obo/PR_000001963 denotes CD27
T157 761-765 http://purl.obolibrary.org/obo/PR_000001203 denotes CCR7
T158 776-780 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T159 814-820 http://purl.obolibrary.org/obo/PR_000001015 denotes CD45RA
T160 821-825 http://purl.obolibrary.org/obo/PR_000001963 denotes CD27
T161 826-830 http://purl.obolibrary.org/obo/PR_000001203 denotes CCR7
T162 855-861 http://purl.obolibrary.org/obo/PR_000001015 denotes CD45RA
T163 862-866 http://purl.obolibrary.org/obo/PR_000001963 denotes CD27
T164 867-871 http://purl.obolibrary.org/obo/PR_000001203 denotes CCR7
T165 897-903 http://purl.obolibrary.org/obo/PR_000001015 denotes CD45RA
T166 904-908 http://purl.obolibrary.org/obo/PR_000001963 denotes CD27
T167 909-913 http://purl.obolibrary.org/obo/PR_000001203 denotes CCR7
T168 922-928 http://purl.obolibrary.org/obo/PR_000001015 denotes CD45RA
T169 929-933 http://purl.obolibrary.org/obo/PR_000001963 denotes CD27
T170 934-938 http://purl.obolibrary.org/obo/PR_000001203 denotes CCR7
T171 941-944 http://purl.obolibrary.org/obo/CLO_0002922 denotes EM2
T172 947-953 http://purl.obolibrary.org/obo/PR_000001015 denotes CD45RA
T173 954-958 http://purl.obolibrary.org/obo/PR_000001963 denotes CD27
T174 959-963 http://purl.obolibrary.org/obo/PR_000001203 denotes CCR7
T175 966-969 http://purl.obolibrary.org/obo/CLO_0002923 denotes EM3
T176 983-989 http://purl.obolibrary.org/obo/PR_000001015 denotes CD45RA
T177 990-994 http://purl.obolibrary.org/obo/PR_000001963 denotes CD27
T178 995-999 http://purl.obolibrary.org/obo/PR_000001203 denotes CCR7
T179 1012-1015 http://purl.obolibrary.org/obo/CLO_0053438 denotes CD8
T180 1016-1023 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T181 1035-1038 http://purl.obolibrary.org/obo/CLO_0053438 denotes CD8
T182 1039-1045 http://purl.obolibrary.org/obo/CL_0000084 denotes T cell
T183 1088-1091 http://purl.obolibrary.org/obo/CLO_0002922 denotes EM2
T184 1117-1118 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T185 1182-1187 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T186 1278-1286 http://purl.obolibrary.org/obo/CLO_0001757 denotes 1+ cells
T187 1318-1321 http://purl.obolibrary.org/obo/CLO_0053438 denotes CD8
T188 1412-1415 http://purl.obolibrary.org/obo/CLO_0053438 denotes CD8
T189 1416-1422 http://purl.obolibrary.org/obo/CL_0000084 denotes T cell
T190 1451-1453 http://purl.obolibrary.org/obo/CLO_0008770 denotes RD

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T38 192-195 Chemical denotes PCA http://purl.obolibrary.org/obo/CHEBI_36751|http://purl.obolibrary.org/obo/CHEBI_62248
T40 286-288 Chemical denotes RD http://purl.obolibrary.org/obo/CHEBI_73812
T41 303-305 Chemical denotes HD http://purl.obolibrary.org/obo/CHEBI_73925
T42 397-399 Chemical denotes S5 http://purl.obolibrary.org/obo/CHEBI_29386
T43 451-453 Chemical denotes RD http://purl.obolibrary.org/obo/CHEBI_73812
T44 458-460 Chemical denotes HD http://purl.obolibrary.org/obo/CHEBI_73925
T45 464-467 Chemical denotes PCA http://purl.obolibrary.org/obo/CHEBI_36751|http://purl.obolibrary.org/obo/CHEBI_62248
T47 483-485 Chemical denotes RD http://purl.obolibrary.org/obo/CHEBI_73812
T48 490-492 Chemical denotes HD http://purl.obolibrary.org/obo/CHEBI_73925
T49 880-888 Chemical denotes effector http://purl.obolibrary.org/obo/CHEBI_35224
T50 1235-1237 Chemical denotes HD http://purl.obolibrary.org/obo/CHEBI_73925
T51 1275-1277 Chemical denotes PD http://purl.obolibrary.org/obo/CHEBI_74756
T52 1451-1453 Chemical denotes RD http://purl.obolibrary.org/obo/CHEBI_73812
T53 1473-1475 Chemical denotes HD http://purl.obolibrary.org/obo/CHEBI_73925

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T31 81-102 http://purl.obolibrary.org/obo/GO_0046649 denotes lymphocyte activation
T32 631-646 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T33 847-853 http://purl.obolibrary.org/obo/GO_0007613 denotes memory
T34 889-895 http://purl.obolibrary.org/obo/GO_0007613 denotes memory
T35 1429-1435 http://purl.obolibrary.org/obo/GO_0007613 denotes memory

LitCovid-PD-GlycoEpitope

Id Subject Object Predicate Lexical cue glyco_epitope_db_id
T1 916-919 GlycoEpitope denotes EM1 http://www.glycoepitope.jp/epitopes/AN0701
T2 941-944 GlycoEpitope denotes EM2 http://www.glycoepitope.jp/epitopes/AN0703
T3 1088-1091 GlycoEpitope denotes EM2 http://www.glycoepitope.jp/epitopes/AN0703
T4 1131-1134 GlycoEpitope denotes EM1 http://www.glycoepitope.jp/epitopes/AN0701
T5 1377-1380 GlycoEpitope denotes EM1 http://www.glycoepitope.jp/epitopes/AN0701

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T81 0-147 Sentence denotes We next applied high-dimensional flow cytometric analysis to further investigate lymphocyte activation and differentiation during COVID-19 disease.
T82 148-408 Sentence denotes We first used principal component analysis (PCA) to examine the general distribution of immune profiles from COVID-19 patients (n = 118), RD (n = 60), and HD (n = 36) using 193 immune parameters identified by high-dimensional flow cytometry (tables S5 and S6).
T83 409-522 Sentence denotes COVID-19 patients clearly segregated from RD and HD in PCA space, whereas RD and HD largely overlapped (Fig. 2A).
T84 523-598 Sentence denotes We investigated the immune features driving this COVID-19 immune signature.
T85 599-674 Sentence denotes Given their role in response to viral infection, we focused on CD8 T cells.
T86 675-1024 Sentence denotes Six major CD8 T cell populations were examined using the combination of CD45RA, CD27, CCR7, and CD95 cell surface markers to define naïve (CD45RA+CD27+CCR7+CD95−), central memory (CD45RA−CD27+CCR7+ [CM]), effector memory (CD45RA−CD27+CCR7− [EM1], CD45RA−CD27−CCR7+ [EM2], CD45RA−CD27−CCR7− [EM3]), and EMRA (CD45RA+CD27−CCR7−) (Fig. 2B) CD8 T cells.
T87 1025-1145 Sentence denotes Among the CD8 T cell populations, there was an increase in the EM2 and EMRA populations and a decrease in EM1 (Fig. 2C).
T88 1146-1248 Sentence denotes Furthermore, the frequency of CD39+ cells was increased in COVID-19 patients compared to HD (Fig. 2D).
T89 1249-1392 Sentence denotes Although the frequency of PD-1+ cells was not different in the total CD8 population (Fig. 2D), it was increased for both CM and EM1 (fig. S2A).
T90 1393-1508 Sentence denotes Finally, all major CD8 T cell naive/memory populations in RD were comparable to HD (Fig. 2, C and D, and fig. S2A).