PMC:7394275 / 9787-11136
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7394275","sourcedb":"PMC","sourceid":"7394275","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7394275","text":"Therefore, it is necessary to have a definitive confirmation by culture or nonculture technique, including (i) direct microscopic examination with the optical brightener methods, Calcofluor or Blankophor, which may increase the sensitivity and specificity for detecting Aspergillus-like features; (ii) culture on fungal-specific media at 37 °C for 2–5 days, if positive, morphological features of Aspergillus can be identified under the microscope or the DNA sequencing may be used in reference laboratories to identify the species accurately, but usually culture yield is low and a negative result does not exclude the diagnosis of IA; (iii) molecular assays targeting ribosomal DNA (rDNA) sequences can also be used for detection of Aspergillus in tissues or BALF, especially PCR-based assays can be used to detect Aspergillus spp. and CYP51A resistance mutations in A. fumigatus, although these methods have not been standardized or limited by laboratory conditions or proven commercial reagents in some countries [30]; (iv) serum and BALF GM testing are also recommended as an early and accurate marker using less invasive techniques for the diagnosis, especially in neutropenic patients, with advantages of less injury and time-efficient, though sometimes this test in blood samples are less sensitive than cultures of respiratory samples [25].","tracks":[{"project":"LitCovid-PMC-OGER-BB","denotations":[{"id":"T163","span":{"begin":270,"end":281},"obj":"NCBITaxon:5052"},{"id":"T164","span":{"begin":313,"end":319},"obj":"NCBITaxon:4751"},{"id":"T165","span":{"begin":397,"end":408},"obj":"NCBITaxon:5052"},{"id":"T166","span":{"begin":670,"end":679},"obj":"GO:0005840"},{"id":"T167","span":{"begin":735,"end":746},"obj":"NCBITaxon:5052"},{"id":"T168","span":{"begin":750,"end":757},"obj":"UBERON:0000479"},{"id":"T169","span":{"begin":761,"end":765},"obj":"BV_4"},{"id":"T170","span":{"begin":817,"end":828},"obj":"NCBITaxon:5052"},{"id":"T171","span":{"begin":829,"end":832},"obj":"NCBITaxon:species"},{"id":"T172","span":{"begin":838,"end":844},"obj":"PR:000006147"},{"id":"T173","span":{"begin":869,"end":870},"obj":"NCBITaxon:8296"},{"id":"T174","span":{"begin":870,"end":881},"obj":"NCBITaxon:31032"},{"id":"T175","span":{"begin":990,"end":998},"obj":"CHEBI:33893;CHEBI:33893"},{"id":"T176","span":{"begin":1028,"end":1033},"obj":"UBERON:0001977"},{"id":"T177","span":{"begin":1038,"end":1042},"obj":"BV_4"},{"id":"T178","span":{"begin":1274,"end":1279},"obj":"UBERON:0000178"},{"id":"T179","span":{"begin":1324,"end":1335},"obj":"UBERON:0001004"},{"id":"T71196","span":{"begin":270,"end":281},"obj":"NCBITaxon:5052"},{"id":"T95830","span":{"begin":313,"end":319},"obj":"NCBITaxon:4751"},{"id":"T31042","span":{"begin":397,"end":408},"obj":"NCBITaxon:5052"},{"id":"T44167","span":{"begin":670,"end":679},"obj":"GO:0005840"},{"id":"T80438","span":{"begin":735,"end":746},"obj":"NCBITaxon:5052"},{"id":"T62724","span":{"begin":750,"end":757},"obj":"UBERON:0000479"},{"id":"T23730","span":{"begin":761,"end":765},"obj":"BV_4"},{"id":"T49081","span":{"begin":817,"end":828},"obj":"NCBITaxon:5052"},{"id":"T81108","span":{"begin":829,"end":832},"obj":"NCBITaxon:species"},{"id":"T34970","span":{"begin":838,"end":844},"obj":"PR:000006147"},{"id":"T26672","span":{"begin":869,"end":870},"obj":"NCBITaxon:8296"},{"id":"T47994","span":{"begin":870,"end":881},"obj":"NCBITaxon:31032"},{"id":"T85259","span":{"begin":990,"end":998},"obj":"CHEBI:33893;CHEBI:33893"},{"id":"T55352","span":{"begin":1028,"end":1033},"obj":"UBERON:0001977"},{"id":"T62010","span":{"begin":1038,"end":1042},"obj":"BV_4"},{"id":"T90815","span":{"begin":1274,"end":1279},"obj":"UBERON:0000178"},{"id":"T48524","span":{"begin":1324,"end":1335},"obj":"UBERON:0001004"}],"attributes":[{"subj":"T163","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T164","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T165","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T166","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T167","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T168","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T169","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T170","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T171","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T172","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T173","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T174","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T175","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T176","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T177","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T178","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T179","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T71196","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T95830","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T31042","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T44167","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T80438","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T62724","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T23730","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T49081","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T81108","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T34970","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T26672","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T47994","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T85259","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T55352","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T62010","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T90815","pred":"source","obj":"LitCovid-PMC-OGER-BB"},{"subj":"T48524","pred":"source","obj":"LitCovid-PMC-OGER-BB"}]},{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T17","span":{"begin":455,"end":458},"obj":"Body_part"},{"id":"T18","span":{"begin":670,"end":679},"obj":"Body_part"},{"id":"T19","span":{"begin":680,"end":683},"obj":"Body_part"},{"id":"T20","span":{"begin":750,"end":757},"obj":"Body_part"},{"id":"T21","span":{"begin":1028,"end":1033},"obj":"Body_part"},{"id":"T22","span":{"begin":1274,"end":1279},"obj":"Body_part"}],"attributes":[{"id":"A17","pred":"fma_id","subj":"T17","obj":"http://purl.org/sig/ont/fma/fma74412"},{"id":"A18","pred":"fma_id","subj":"T18","obj":"http://purl.org/sig/ont/fma/fma66867"},{"id":"A19","pred":"fma_id","subj":"T19","obj":"http://purl.org/sig/ont/fma/fma74412"},{"id":"A20","pred":"fma_id","subj":"T20","obj":"http://purl.org/sig/ont/fma/fma9637"},{"id":"A21","pred":"fma_id","subj":"T21","obj":"http://purl.org/sig/ont/fma/fma63083"},{"id":"A22","pred":"fma_id","subj":"T22","obj":"http://purl.org/sig/ont/fma/fma9670"},{"subj":"T17","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T18","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T19","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T20","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T21","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T22","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T11","span":{"begin":371,"end":393},"obj":"Body_part"},{"id":"T12","span":{"begin":1028,"end":1033},"obj":"Body_part"},{"id":"T13","span":{"begin":1274,"end":1279},"obj":"Body_part"}],"attributes":[{"id":"A11","pred":"uberon_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/UBERON_0034768"},{"id":"A12","pred":"uberon_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/UBERON_0001977"},{"id":"A13","pred":"uberon_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"subj":"T11","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T12","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T13","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"348","span":{"begin":869,"end":881},"obj":"Species"},{"id":"349","span":{"begin":1183,"end":1191},"obj":"Species"},{"id":"353","span":{"begin":270,"end":281},"obj":"Species"},{"id":"354","span":{"begin":397,"end":408},"obj":"Species"},{"id":"355","span":{"begin":735,"end":746},"obj":"Species"},{"id":"356","span":{"begin":817,"end":828},"obj":"Species"},{"id":"361","span":{"begin":1043,"end":1045},"obj":"Chemical"},{"id":"373","span":{"begin":1171,"end":1182},"obj":"Disease"}],"attributes":[{"id":"A348","pred":"tao:has_database_id","subj":"348","obj":"Tax:746128"},{"id":"A349","pred":"tao:has_database_id","subj":"349","obj":"Tax:9606"},{"id":"A353","pred":"tao:has_database_id","subj":"353","obj":"Tax:746128"},{"id":"A354","pred":"tao:has_database_id","subj":"354","obj":"Tax:746128"},{"id":"A355","pred":"tao:has_database_id","subj":"355","obj":"Tax:746128"},{"id":"A356","pred":"tao:has_database_id","subj":"356","obj":"Tax:746128"},{"id":"A361","pred":"tao:has_database_id","subj":"361","obj":"MESH:C012990"},{"id":"A373","pred":"tao:has_database_id","subj":"373","obj":"MESH:D009503"},{"subj":"348","pred":"source","obj":"LitCovid-PubTator"},{"subj":"349","pred":"source","obj":"LitCovid-PubTator"},{"subj":"353","pred":"source","obj":"LitCovid-PubTator"},{"subj":"354","pred":"source","obj":"LitCovid-PubTator"},{"subj":"355","pred":"source","obj":"LitCovid-PubTator"},{"subj":"356","pred":"source","obj":"LitCovid-PubTator"},{"subj":"361","pred":"source","obj":"LitCovid-PubTator"},{"subj":"373","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T131","span":{"begin":633,"end":635},"obj":"Disease"},{"id":"T132","span":{"begin":1217,"end":1223},"obj":"Disease"}],"attributes":[{"id":"A131","pred":"mondo_id","subj":"T131","obj":"http://purl.obolibrary.org/obo/MONDO_0000240"},{"id":"A132","pred":"mondo_id","subj":"T132","obj":"http://purl.obolibrary.org/obo/MONDO_0021178"},{"subj":"T131","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T132","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T51","span":{"begin":35,"end":36},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T52","span":{"begin":581,"end":582},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T53","span":{"begin":869,"end":870},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T54","span":{"begin":1046,"end":1053},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T55","span":{"begin":1266,"end":1270},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T56","span":{"begin":1274,"end":1279},"obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"T57","span":{"begin":1274,"end":1279},"obj":"http://www.ebi.ac.uk/efo/EFO_0000296"}],"attributes":[{"subj":"T51","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T52","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T53","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T54","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T55","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T56","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T57","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T46","span":{"begin":455,"end":458},"obj":"Chemical"},{"id":"T47","span":{"begin":633,"end":635},"obj":"Chemical"},{"id":"T48","span":{"begin":638,"end":641},"obj":"Chemical"},{"id":"T49","span":{"begin":680,"end":683},"obj":"Chemical"},{"id":"T50","span":{"begin":990,"end":998},"obj":"Chemical"},{"id":"T51","span":{"begin":1043,"end":1045},"obj":"Chemical"}],"attributes":[{"id":"A46","pred":"chebi_id","subj":"T46","obj":"http://purl.obolibrary.org/obo/CHEBI_16991"},{"id":"A47","pred":"chebi_id","subj":"T47","obj":"http://purl.obolibrary.org/obo/CHEBI_74062"},{"id":"A48","pred":"chebi_id","subj":"T48","obj":"http://purl.obolibrary.org/obo/CHEBI_74062"},{"id":"A49","pred":"chebi_id","subj":"T49","obj":"http://purl.obolibrary.org/obo/CHEBI_16991"},{"id":"A50","pred":"chebi_id","subj":"T50","obj":"http://purl.obolibrary.org/obo/CHEBI_33893"},{"id":"A51","pred":"chebi_id","subj":"T51","obj":"http://purl.obolibrary.org/obo/CHEBI_74120"},{"id":"A52","pred":"chebi_id","subj":"T51","obj":"http://purl.obolibrary.org/obo/CHEBI_27680"},{"subj":"T46","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T47","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T48","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T49","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T50","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T51","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GlycoEpitope","denotations":[{"id":"T4","span":{"begin":1043,"end":1045},"obj":"GlycoEpitope"}],"attributes":[{"id":"A4","pred":"glyco_epitope_db_id","subj":"T4","obj":"http://www.glycoepitope.jp/epitopes/EP0510"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-GlycoEpitope"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T56","span":{"begin":0,"end":1349},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T56","pred":"source","obj":"LitCovid-sentences"}]},{"project":"2_test","denotations":[{"id":"32737747-27365388-73473616","span":{"begin":1018,"end":1020},"obj":"27365388"}],"attributes":[{"subj":"32737747-27365388-73473616","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PMC-OGER-BB","color":"#93a1ec","default":true},{"id":"LitCovid-PD-FMA-UBERON","color":"#bbec93"},{"id":"LitCovid-PD-UBERON","color":"#ec93d5"},{"id":"LitCovid-PubTator","color":"#93ece8"},{"id":"LitCovid-PD-MONDO","color":"#ecce93"},{"id":"LitCovid-PD-CLO","color":"#b493ec"},{"id":"LitCovid-PD-CHEBI","color":"#93ec9a"},{"id":"LitCovid-PD-GlycoEpitope","color":"#ec93a5"},{"id":"LitCovid-sentences","color":"#93bfec"},{"id":"2_test","color":"#d9ec93"}]}]}}