PMC:7388103 / 4628-5462 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T33","span":{"begin":243,"end":251},"obj":"Body_part"},{"id":"T34","span":{"begin":267,"end":275},"obj":"Body_part"},{"id":"T35","span":{"begin":568,"end":572},"obj":"Body_part"}],"attributes":[{"id":"A33","pred":"fma_id","subj":"T33","obj":"http://purl.org/sig/ont/fma/fma62851"},{"id":"A34","pred":"fma_id","subj":"T34","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A35","pred":"fma_id","subj":"T35","obj":"http://purl.org/sig/ont/fma/fma50723"}],"text":"We encountered 4 additional patients admitted to our ICU with a diagnosis of acute respiratory distress syndrome secondary to COVID-19 infection with thrombocytopenia, and an intermediate to high pretest probability for HIT. Due to a positive platelet factor 4 (PF4) antibody, they were started on an argatroban, pending send out results of OD levels and functional assay. However, the SRA was negative. Interestingly, their clinical characteristics (reported in Table 1) were similar to those of our patients with true HIT. Two of these patients had a confirmed deep vein thrombosis, and one with suspected pulmonary embolism. Also, 2 patients met International Society on Thrombosis and Haemostasis criteria for disseminated intravascular coagulation (DIC). All the patients were in hypotensive shock, requiring vasopressor support."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T8","span":{"begin":563,"end":572},"obj":"Body_part"},{"id":"T9","span":{"begin":568,"end":572},"obj":"Body_part"}],"attributes":[{"id":"A8","pred":"uberon_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/UBERON_0035552"},{"id":"A9","pred":"uberon_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/UBERON_0001638"}],"text":"We encountered 4 additional patients admitted to our ICU with a diagnosis of acute respiratory distress syndrome secondary to COVID-19 infection with thrombocytopenia, and an intermediate to high pretest probability for HIT. Due to a positive platelet factor 4 (PF4) antibody, they were started on an argatroban, pending send out results of OD levels and functional assay. However, the SRA was negative. Interestingly, their clinical characteristics (reported in Table 1) were similar to those of our patients with true HIT. Two of these patients had a confirmed deep vein thrombosis, and one with suspected pulmonary embolism. Also, 2 patients met International Society on Thrombosis and Haemostasis criteria for disseminated intravascular coagulation (DIC). All the patients were in hypotensive shock, requiring vasopressor support."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T55","span":{"begin":77,"end":112},"obj":"Disease"},{"id":"T56","span":{"begin":83,"end":112},"obj":"Disease"},{"id":"T57","span":{"begin":126,"end":134},"obj":"Disease"},{"id":"T58","span":{"begin":135,"end":144},"obj":"Disease"},{"id":"T59","span":{"begin":150,"end":166},"obj":"Disease"},{"id":"T60","span":{"begin":220,"end":223},"obj":"Disease"},{"id":"T61","span":{"begin":341,"end":343},"obj":"Disease"},{"id":"T62","span":{"begin":520,"end":523},"obj":"Disease"},{"id":"T63","span":{"begin":573,"end":583},"obj":"Disease"},{"id":"T64","span":{"begin":608,"end":626},"obj":"Disease"},{"id":"T65","span":{"begin":674,"end":684},"obj":"Disease"},{"id":"T66","span":{"begin":714,"end":758},"obj":"Disease"}],"attributes":[{"id":"A55","pred":"mondo_id","subj":"T55","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A56","pred":"mondo_id","subj":"T56","obj":"http://purl.obolibrary.org/obo/MONDO_0009971"},{"id":"A57","pred":"mondo_id","subj":"T57","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A58","pred":"mondo_id","subj":"T58","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A59","pred":"mondo_id","subj":"T59","obj":"http://purl.obolibrary.org/obo/MONDO_0002049"},{"id":"A60","pred":"mondo_id","subj":"T60","obj":"http://purl.obolibrary.org/obo/MONDO_0018048"},{"id":"A61","pred":"mondo_id","subj":"T61","obj":"http://purl.obolibrary.org/obo/MONDO_0017178"},{"id":"A62","pred":"mondo_id","subj":"T62","obj":"http://purl.obolibrary.org/obo/MONDO_0018048"},{"id":"A63","pred":"mondo_id","subj":"T63","obj":"http://purl.obolibrary.org/obo/MONDO_0000831"},{"id":"A64","pred":"mondo_id","subj":"T64","obj":"http://purl.obolibrary.org/obo/MONDO_0005279"},{"id":"A65","pred":"mondo_id","subj":"T65","obj":"http://purl.obolibrary.org/obo/MONDO_0000831"},{"id":"A66","pred":"mondo_id","subj":"T66","obj":"http://purl.obolibrary.org/obo/MONDO_0001243"}],"text":"We encountered 4 additional patients admitted to our ICU with a diagnosis of acute respiratory distress syndrome secondary to COVID-19 infection with thrombocytopenia, and an intermediate to high pretest probability for HIT. Due to a positive platelet factor 4 (PF4) antibody, they were started on an argatroban, pending send out results of OD levels and functional assay. However, the SRA was negative. Interestingly, their clinical characteristics (reported in Table 1) were similar to those of our patients with true HIT. Two of these patients had a confirmed deep vein thrombosis, and one with suspected pulmonary embolism. Also, 2 patients met International Society on Thrombosis and Haemostasis criteria for disseminated intravascular coagulation (DIC). All the patients were in hypotensive shock, requiring vasopressor support."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T56","span":{"begin":62,"end":63},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T57","span":{"begin":232,"end":233},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T58","span":{"begin":551,"end":552},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T59","span":{"begin":568,"end":572},"obj":"http://purl.obolibrary.org/obo/UBERON_0001638"},{"id":"T60","span":{"begin":568,"end":572},"obj":"http://www.ebi.ac.uk/efo/EFO_0000816"}],"text":"We encountered 4 additional patients admitted to our ICU with a diagnosis of acute respiratory distress syndrome secondary to COVID-19 infection with thrombocytopenia, and an intermediate to high pretest probability for HIT. Due to a positive platelet factor 4 (PF4) antibody, they were started on an argatroban, pending send out results of OD levels and functional assay. However, the SRA was negative. Interestingly, their clinical characteristics (reported in Table 1) were similar to those of our patients with true HIT. Two of these patients had a confirmed deep vein thrombosis, and one with suspected pulmonary embolism. Also, 2 patients met International Society on Thrombosis and Haemostasis criteria for disseminated intravascular coagulation (DIC). All the patients were in hypotensive shock, requiring vasopressor support."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T22","span":{"begin":301,"end":311},"obj":"Chemical"},{"id":"T23","span":{"begin":754,"end":757},"obj":"Chemical"}],"attributes":[{"id":"A22","pred":"chebi_id","subj":"T22","obj":"http://purl.obolibrary.org/obo/CHEBI_48720"},{"id":"A23","pred":"chebi_id","subj":"T23","obj":"http://purl.obolibrary.org/obo/CHEBI_4305"},{"id":"A24","pred":"chebi_id","subj":"T23","obj":"http://purl.obolibrary.org/obo/CHEBI_53092"}],"text":"We encountered 4 additional patients admitted to our ICU with a diagnosis of acute respiratory distress syndrome secondary to COVID-19 infection with thrombocytopenia, and an intermediate to high pretest probability for HIT. Due to a positive platelet factor 4 (PF4) antibody, they were started on an argatroban, pending send out results of OD levels and functional assay. However, the SRA was negative. Interestingly, their clinical characteristics (reported in Table 1) were similar to those of our patients with true HIT. Two of these patients had a confirmed deep vein thrombosis, and one with suspected pulmonary embolism. Also, 2 patients met International Society on Thrombosis and Haemostasis criteria for disseminated intravascular coagulation (DIC). All the patients were in hypotensive shock, requiring vasopressor support."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T9","span":{"begin":741,"end":752},"obj":"http://purl.obolibrary.org/obo/GO_0050817"}],"text":"We encountered 4 additional patients admitted to our ICU with a diagnosis of acute respiratory distress syndrome secondary to COVID-19 infection with thrombocytopenia, and an intermediate to high pretest probability for HIT. Due to a positive platelet factor 4 (PF4) antibody, they were started on an argatroban, pending send out results of OD levels and functional assay. However, the SRA was negative. Interestingly, their clinical characteristics (reported in Table 1) were similar to those of our patients with true HIT. Two of these patients had a confirmed deep vein thrombosis, and one with suspected pulmonary embolism. Also, 2 patients met International Society on Thrombosis and Haemostasis criteria for disseminated intravascular coagulation (DIC). All the patients were in hypotensive shock, requiring vasopressor support."}

{"project":"LitCovid-sentences","denotations":[{"id":"T45","span":{"begin":0,"end":224},"obj":"Sentence"},{"id":"T46","span":{"begin":225,"end":372},"obj":"Sentence"},{"id":"T47","span":{"begin":373,"end":403},"obj":"Sentence"},{"id":"T48","span":{"begin":404,"end":524},"obj":"Sentence"},{"id":"T49","span":{"begin":525,"end":627},"obj":"Sentence"},{"id":"T50","span":{"begin":628,"end":759},"obj":"Sentence"},{"id":"T51","span":{"begin":760,"end":834},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"We encountered 4 additional patients admitted to our ICU with a diagnosis of acute respiratory distress syndrome secondary to COVID-19 infection with thrombocytopenia, and an intermediate to high pretest probability for HIT. Due to a positive platelet factor 4 (PF4) antibody, they were started on an argatroban, pending send out results of OD levels and functional assay. However, the SRA was negative. Interestingly, their clinical characteristics (reported in Table 1) were similar to those of our patients with true HIT. Two of these patients had a confirmed deep vein thrombosis, and one with suspected pulmonary embolism. Also, 2 patients met International Society on Thrombosis and Haemostasis criteria for disseminated intravascular coagulation (DIC). All the patients were in hypotensive shock, requiring vasopressor support."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T34","span":{"begin":83,"end":103},"obj":"Phenotype"},{"id":"T35","span":{"begin":150,"end":166},"obj":"Phenotype"},{"id":"T36","span":{"begin":220,"end":223},"obj":"Phenotype"},{"id":"T37","span":{"begin":520,"end":523},"obj":"Phenotype"},{"id":"T38","span":{"begin":563,"end":583},"obj":"Phenotype"},{"id":"T39","span":{"begin":608,"end":626},"obj":"Phenotype"},{"id":"T40","span":{"begin":714,"end":752},"obj":"Phenotype"},{"id":"T41","span":{"begin":754,"end":757},"obj":"Phenotype"},{"id":"T42","span":{"begin":797,"end":802},"obj":"Phenotype"}],"attributes":[{"id":"A34","pred":"hp_id","subj":"T34","obj":"http://purl.obolibrary.org/obo/HP_0002098"},{"id":"A35","pred":"hp_id","subj":"T35","obj":"http://purl.obolibrary.org/obo/HP_0001873"},{"id":"A36","pred":"hp_id","subj":"T36","obj":"http://purl.obolibrary.org/obo/HP_0011874"},{"id":"A37","pred":"hp_id","subj":"T37","obj":"http://purl.obolibrary.org/obo/HP_0011874"},{"id":"A38","pred":"hp_id","subj":"T38","obj":"http://purl.obolibrary.org/obo/HP_0002625"},{"id":"A39","pred":"hp_id","subj":"T39","obj":"http://purl.obolibrary.org/obo/HP_0002204"},{"id":"A40","pred":"hp_id","subj":"T40","obj":"http://purl.obolibrary.org/obo/HP_0005521"},{"id":"A41","pred":"hp_id","subj":"T41","obj":"http://purl.obolibrary.org/obo/HP_0005521"},{"id":"A42","pred":"hp_id","subj":"T42","obj":"http://purl.obolibrary.org/obo/HP_0031273"}],"text":"We encountered 4 additional patients admitted to our ICU with a diagnosis of acute respiratory distress syndrome secondary to COVID-19 infection with thrombocytopenia, and an intermediate to high pretest probability for HIT. Due to a positive platelet factor 4 (PF4) antibody, they were started on an argatroban, pending send out results of OD levels and functional assay. However, the SRA was negative. Interestingly, their clinical characteristics (reported in Table 1) were similar to those of our patients with true HIT. Two of these patients had a confirmed deep vein thrombosis, and one with suspected pulmonary embolism. Also, 2 patients met International Society on Thrombosis and Haemostasis criteria for disseminated intravascular coagulation (DIC). All the patients were in hypotensive shock, requiring vasopressor support."}

{"project":"LitCovid-PubTator","denotations":[{"id":"190","span":{"begin":262,"end":265},"obj":"Gene"},{"id":"191","span":{"begin":28,"end":36},"obj":"Species"},{"id":"192","span":{"begin":501,"end":509},"obj":"Species"},{"id":"193","span":{"begin":538,"end":546},"obj":"Species"},{"id":"194","span":{"begin":636,"end":644},"obj":"Species"},{"id":"195","span":{"begin":768,"end":776},"obj":"Species"},{"id":"196","span":{"begin":301,"end":311},"obj":"Chemical"},{"id":"197","span":{"begin":386,"end":389},"obj":"Chemical"},{"id":"198","span":{"begin":77,"end":112},"obj":"Disease"},{"id":"199","span":{"begin":126,"end":134},"obj":"Disease"},{"id":"200","span":{"begin":135,"end":144},"obj":"Disease"},{"id":"201","span":{"begin":150,"end":166},"obj":"Disease"},{"id":"202","span":{"begin":220,"end":223},"obj":"Disease"},{"id":"203","span":{"begin":520,"end":523},"obj":"Disease"},{"id":"204","span":{"begin":563,"end":583},"obj":"Disease"},{"id":"205","span":{"begin":608,"end":626},"obj":"Disease"},{"id":"206","span":{"begin":674,"end":684},"obj":"Disease"},{"id":"207","span":{"begin":714,"end":752},"obj":"Disease"},{"id":"208","span":{"begin":754,"end":757},"obj":"Disease"},{"id":"209","span":{"begin":785,"end":802},"obj":"Disease"}],"attributes":[{"id":"A190","pred":"tao:has_database_id","subj":"190","obj":"Gene:5196"},{"id":"A191","pred":"tao:has_database_id","subj":"191","obj":"Tax:9606"},{"id":"A192","pred":"tao:has_database_id","subj":"192","obj":"Tax:9606"},{"id":"A193","pred":"tao:has_database_id","subj":"193","obj":"Tax:9606"},{"id":"A194","pred":"tao:has_database_id","subj":"194","obj":"Tax:9606"},{"id":"A195","pred":"tao:has_database_id","subj":"195","obj":"Tax:9606"},{"id":"A196","pred":"tao:has_database_id","subj":"196","obj":"MESH:C031942"},{"id":"A198","pred":"tao:has_database_id","subj":"198","obj":"MESH:D012128"},{"id":"A199","pred":"tao:has_database_id","subj":"199","obj":"MESH:C000657245"},{"id":"A200","pred":"tao:has_database_id","subj":"200","obj":"MESH:D007239"},{"id":"A201","pred":"tao:has_database_id","subj":"201","obj":"MESH:D013921"},{"id":"A202","pred":"tao:has_database_id","subj":"202","obj":"MESH:D013921"},{"id":"A203","pred":"tao:has_database_id","subj":"203","obj":"MESH:D013921"},{"id":"A204","pred":"tao:has_database_id","subj":"204","obj":"MESH:D020246"},{"id":"A205","pred":"tao:has_database_id","subj":"205","obj":"MESH:D011655"},{"id":"A206","pred":"tao:has_database_id","subj":"206","obj":"MESH:D013927"},{"id":"A207","pred":"tao:has_database_id","subj":"207","obj":"MESH:D004211"},{"id":"A208","pred":"tao:has_database_id","subj":"208","obj":"MESH:D004211"},{"id":"A209","pred":"tao:has_database_id","subj":"209","obj":"MESH:D007022"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"We encountered 4 additional patients admitted to our ICU with a diagnosis of acute respiratory distress syndrome secondary to COVID-19 infection with thrombocytopenia, and an intermediate to high pretest probability for HIT. Due to a positive platelet factor 4 (PF4) antibody, they were started on an argatroban, pending send out results of OD levels and functional assay. However, the SRA was negative. Interestingly, their clinical characteristics (reported in Table 1) were similar to those of our patients with true HIT. Two of these patients had a confirmed deep vein thrombosis, and one with suspected pulmonary embolism. Also, 2 patients met International Society on Thrombosis and Haemostasis criteria for disseminated intravascular coagulation (DIC). All the patients were in hypotensive shock, requiring vasopressor support."}