PMC:7388103 / 11270-11850 JSONTXT

{"project":"LitCovid_Glycan-Motif-Structure","denotations":[{"id":"T47","span":{"begin":390,"end":397},"obj":"https://glytoucan.org/Structures/Glycans/G00021MO"},{"id":"T48","span":{"begin":390,"end":397},"obj":"https://glytoucan.org/Structures/Glycans/G54161DR"}],"text":"COVID-19 infection is a highly prothrombotic state, resulting from a dysregulation of the coagulation cascade. COVID-19 and HIT are both prothrombotic and can lead to thrombocytopenia. Both entities may be complicated by DIC. Given a considerable overlap, there is potential for devastating consequences, if a diagnosis of HIT is missed. As most patients with COVID-19 receive prophylactic heparin, and those with severe disease are likely to develop venous thromboembolism and thrombocytopenia, unrelated to HIT, there could be an even greater potential for overdiagnosis of HIT."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T68","span":{"begin":390,"end":397},"obj":"Body_part"}],"attributes":[{"id":"A68","pred":"fma_id","subj":"T68","obj":"http://purl.org/sig/ont/fma/fma82839"}],"text":"COVID-19 infection is a highly prothrombotic state, resulting from a dysregulation of the coagulation cascade. COVID-19 and HIT are both prothrombotic and can lead to thrombocytopenia. Both entities may be complicated by DIC. Given a considerable overlap, there is potential for devastating consequences, if a diagnosis of HIT is missed. As most patients with COVID-19 receive prophylactic heparin, and those with severe disease are likely to develop venous thromboembolism and thrombocytopenia, unrelated to HIT, there could be an even greater potential for overdiagnosis of HIT."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T133","span":{"begin":0,"end":8},"obj":"Disease"},{"id":"T134","span":{"begin":9,"end":18},"obj":"Disease"},{"id":"T135","span":{"begin":111,"end":119},"obj":"Disease"},{"id":"T136","span":{"begin":124,"end":127},"obj":"Disease"},{"id":"T137","span":{"begin":167,"end":183},"obj":"Disease"},{"id":"T138","span":{"begin":323,"end":326},"obj":"Disease"},{"id":"T139","span":{"begin":360,"end":368},"obj":"Disease"},{"id":"T140","span":{"begin":451,"end":473},"obj":"Disease"},{"id":"T141","span":{"begin":478,"end":494},"obj":"Disease"},{"id":"T142","span":{"begin":509,"end":512},"obj":"Disease"},{"id":"T143","span":{"begin":576,"end":579},"obj":"Disease"}],"attributes":[{"id":"A133","pred":"mondo_id","subj":"T133","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A134","pred":"mondo_id","subj":"T134","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A135","pred":"mondo_id","subj":"T135","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A136","pred":"mondo_id","subj":"T136","obj":"http://purl.obolibrary.org/obo/MONDO_0018048"},{"id":"A137","pred":"mondo_id","subj":"T137","obj":"http://purl.obolibrary.org/obo/MONDO_0002049"},{"id":"A138","pred":"mondo_id","subj":"T138","obj":"http://purl.obolibrary.org/obo/MONDO_0018048"},{"id":"A139","pred":"mondo_id","subj":"T139","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A140","pred":"mondo_id","subj":"T140","obj":"http://purl.obolibrary.org/obo/MONDO_0005399"},{"id":"A141","pred":"mondo_id","subj":"T141","obj":"http://purl.obolibrary.org/obo/MONDO_0002049"},{"id":"A142","pred":"mondo_id","subj":"T142","obj":"http://purl.obolibrary.org/obo/MONDO_0018048"},{"id":"A143","pred":"mondo_id","subj":"T143","obj":"http://purl.obolibrary.org/obo/MONDO_0018048"}],"text":"COVID-19 infection is a highly prothrombotic state, resulting from a dysregulation of the coagulation cascade. COVID-19 and HIT are both prothrombotic and can lead to thrombocytopenia. Both entities may be complicated by DIC. Given a considerable overlap, there is potential for devastating consequences, if a diagnosis of HIT is missed. As most patients with COVID-19 receive prophylactic heparin, and those with severe disease are likely to develop venous thromboembolism and thrombocytopenia, unrelated to HIT, there could be an even greater potential for overdiagnosis of HIT."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T109","span":{"begin":22,"end":23},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T110","span":{"begin":67,"end":68},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T111","span":{"begin":232,"end":233},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T112","span":{"begin":308,"end":309},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"COVID-19 infection is a highly prothrombotic state, resulting from a dysregulation of the coagulation cascade. COVID-19 and HIT are both prothrombotic and can lead to thrombocytopenia. Both entities may be complicated by DIC. Given a considerable overlap, there is potential for devastating consequences, if a diagnosis of HIT is missed. As most patients with COVID-19 receive prophylactic heparin, and those with severe disease are likely to develop venous thromboembolism and thrombocytopenia, unrelated to HIT, there could be an even greater potential for overdiagnosis of HIT."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T63","span":{"begin":221,"end":224},"obj":"Chemical"},{"id":"T65","span":{"begin":390,"end":397},"obj":"Chemical"}],"attributes":[{"id":"A63","pred":"chebi_id","subj":"T63","obj":"http://purl.obolibrary.org/obo/CHEBI_4305"},{"id":"A64","pred":"chebi_id","subj":"T63","obj":"http://purl.obolibrary.org/obo/CHEBI_53092"},{"id":"A65","pred":"chebi_id","subj":"T65","obj":"http://purl.obolibrary.org/obo/CHEBI_28304"}],"text":"COVID-19 infection is a highly prothrombotic state, resulting from a dysregulation of the coagulation cascade. COVID-19 and HIT are both prothrombotic and can lead to thrombocytopenia. Both entities may be complicated by DIC. Given a considerable overlap, there is potential for devastating consequences, if a diagnosis of HIT is missed. As most patients with COVID-19 receive prophylactic heparin, and those with severe disease are likely to develop venous thromboembolism and thrombocytopenia, unrelated to HIT, there could be an even greater potential for overdiagnosis of HIT."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T16","span":{"begin":90,"end":101},"obj":"http://purl.obolibrary.org/obo/GO_0050817"}],"text":"COVID-19 infection is a highly prothrombotic state, resulting from a dysregulation of the coagulation cascade. COVID-19 and HIT are both prothrombotic and can lead to thrombocytopenia. Both entities may be complicated by DIC. Given a considerable overlap, there is potential for devastating consequences, if a diagnosis of HIT is missed. As most patients with COVID-19 receive prophylactic heparin, and those with severe disease are likely to develop venous thromboembolism and thrombocytopenia, unrelated to HIT, there could be an even greater potential for overdiagnosis of HIT."}

{"project":"LitCovid-sentences","denotations":[{"id":"T87","span":{"begin":0,"end":110},"obj":"Sentence"},{"id":"T88","span":{"begin":111,"end":184},"obj":"Sentence"},{"id":"T89","span":{"begin":185,"end":225},"obj":"Sentence"},{"id":"T90","span":{"begin":226,"end":337},"obj":"Sentence"},{"id":"T91","span":{"begin":338,"end":580},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"COVID-19 infection is a highly prothrombotic state, resulting from a dysregulation of the coagulation cascade. COVID-19 and HIT are both prothrombotic and can lead to thrombocytopenia. Both entities may be complicated by DIC. Given a considerable overlap, there is potential for devastating consequences, if a diagnosis of HIT is missed. As most patients with COVID-19 receive prophylactic heparin, and those with severe disease are likely to develop venous thromboembolism and thrombocytopenia, unrelated to HIT, there could be an even greater potential for overdiagnosis of HIT."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T92","span":{"begin":124,"end":127},"obj":"Phenotype"},{"id":"T93","span":{"begin":167,"end":183},"obj":"Phenotype"},{"id":"T94","span":{"begin":221,"end":224},"obj":"Phenotype"},{"id":"T95","span":{"begin":323,"end":326},"obj":"Phenotype"},{"id":"T96","span":{"begin":458,"end":473},"obj":"Phenotype"},{"id":"T97","span":{"begin":478,"end":494},"obj":"Phenotype"},{"id":"T98","span":{"begin":509,"end":512},"obj":"Phenotype"},{"id":"T99","span":{"begin":576,"end":579},"obj":"Phenotype"}],"attributes":[{"id":"A92","pred":"hp_id","subj":"T92","obj":"http://purl.obolibrary.org/obo/HP_0011874"},{"id":"A93","pred":"hp_id","subj":"T93","obj":"http://purl.obolibrary.org/obo/HP_0001873"},{"id":"A94","pred":"hp_id","subj":"T94","obj":"http://purl.obolibrary.org/obo/HP_0005521"},{"id":"A95","pred":"hp_id","subj":"T95","obj":"http://purl.obolibrary.org/obo/HP_0011874"},{"id":"A96","pred":"hp_id","subj":"T96","obj":"http://purl.obolibrary.org/obo/HP_0001907"},{"id":"A97","pred":"hp_id","subj":"T97","obj":"http://purl.obolibrary.org/obo/HP_0001873"},{"id":"A98","pred":"hp_id","subj":"T98","obj":"http://purl.obolibrary.org/obo/HP_0011874"},{"id":"A99","pred":"hp_id","subj":"T99","obj":"http://purl.obolibrary.org/obo/HP_0011874"}],"text":"COVID-19 infection is a highly prothrombotic state, resulting from a dysregulation of the coagulation cascade. COVID-19 and HIT are both prothrombotic and can lead to thrombocytopenia. Both entities may be complicated by DIC. Given a considerable overlap, there is potential for devastating consequences, if a diagnosis of HIT is missed. As most patients with COVID-19 receive prophylactic heparin, and those with severe disease are likely to develop venous thromboembolism and thrombocytopenia, unrelated to HIT, there could be an even greater potential for overdiagnosis of HIT."}

{"project":"LitCovid-PubTator","denotations":[{"id":"476","span":{"begin":346,"end":354},"obj":"Species"},{"id":"477","span":{"begin":390,"end":397},"obj":"Chemical"},{"id":"478","span":{"begin":0,"end":8},"obj":"Disease"},{"id":"479","span":{"begin":9,"end":18},"obj":"Disease"},{"id":"480","span":{"begin":111,"end":119},"obj":"Disease"},{"id":"481","span":{"begin":124,"end":127},"obj":"Disease"},{"id":"482","span":{"begin":167,"end":183},"obj":"Disease"},{"id":"483","span":{"begin":221,"end":224},"obj":"Disease"},{"id":"484","span":{"begin":323,"end":326},"obj":"Disease"},{"id":"485","span":{"begin":360,"end":368},"obj":"Disease"},{"id":"486","span":{"begin":451,"end":473},"obj":"Disease"},{"id":"487","span":{"begin":478,"end":494},"obj":"Disease"},{"id":"488","span":{"begin":509,"end":512},"obj":"Disease"},{"id":"489","span":{"begin":576,"end":579},"obj":"Disease"}],"attributes":[{"id":"A476","pred":"tao:has_database_id","subj":"476","obj":"Tax:9606"},{"id":"A477","pred":"tao:has_database_id","subj":"477","obj":"MESH:D006493"},{"id":"A478","pred":"tao:has_database_id","subj":"478","obj":"MESH:C000657245"},{"id":"A479","pred":"tao:has_database_id","subj":"479","obj":"MESH:D007239"},{"id":"A480","pred":"tao:has_database_id","subj":"480","obj":"MESH:C000657245"},{"id":"A481","pred":"tao:has_database_id","subj":"481","obj":"MESH:D013921"},{"id":"A482","pred":"tao:has_database_id","subj":"482","obj":"MESH:D013921"},{"id":"A483","pred":"tao:has_database_id","subj":"483","obj":"MESH:D004211"},{"id":"A484","pred":"tao:has_database_id","subj":"484","obj":"MESH:D013921"},{"id":"A485","pred":"tao:has_database_id","subj":"485","obj":"MESH:C000657245"},{"id":"A486","pred":"tao:has_database_id","subj":"486","obj":"MESH:D054556"},{"id":"A487","pred":"tao:has_database_id","subj":"487","obj":"MESH:D013921"},{"id":"A488","pred":"tao:has_database_id","subj":"488","obj":"MESH:D013921"},{"id":"A489","pred":"tao:has_database_id","subj":"489","obj":"MESH:D013921"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"COVID-19 infection is a highly prothrombotic state, resulting from a dysregulation of the coagulation cascade. COVID-19 and HIT are both prothrombotic and can lead to thrombocytopenia. Both entities may be complicated by DIC. Given a considerable overlap, there is potential for devastating consequences, if a diagnosis of HIT is missed. As most patients with COVID-19 receive prophylactic heparin, and those with severe disease are likely to develop venous thromboembolism and thrombocytopenia, unrelated to HIT, there could be an even greater potential for overdiagnosis of HIT."}