PMC:7386875 / 742-1228 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/7386875","sourcedb":"PMC","sourceid":"7386875","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7386875","text":"o the ability of SARS-CoV-2 to invade endothelial cells via ACE-2 (angiotensin-converting enzyme 2), which is expressed on the endothelial cell surface. However, in patients with COVID-19 the subsequent endothelial inflammation, complement activation, thrombin generation, platelet, and leukocyte recruitment, and the initiation of innate and adaptive immune responses culminate in immunothrombosis, ultimately causing (micro)thrombotic complications, such as deep vein thrombosis, pulm","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T1","span":{"begin":38,"end":55},"obj":"Body_part"},{"id":"T2","span":{"begin":50,"end":55},"obj":"Body_part"},{"id":"T3","span":{"begin":127,"end":143},"obj":"Body_part"},{"id":"T4","span":{"begin":139,"end":143},"obj":"Body_part"},{"id":"T5","span":{"begin":273,"end":281},"obj":"Body_part"},{"id":"T6","span":{"begin":287,"end":296},"obj":"Body_part"},{"id":"T7","span":{"begin":465,"end":469},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"fma_id","subj":"T1","obj":"http://purl.org/sig/ont/fma/fma66772"},{"id":"A2","pred":"fma_id","subj":"T2","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A3","pred":"fma_id","subj":"T3","obj":"http://purl.org/sig/ont/fma/fma66772"},{"id":"A4","pred":"fma_id","subj":"T4","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A5","pred":"fma_id","subj":"T5","obj":"http://purl.org/sig/ont/fma/fma62851"},{"id":"A6","pred":"fma_id","subj":"T6","obj":"http://purl.org/sig/ont/fma/fma62852"},{"id":"A7","pred":"fma_id","subj":"T7","obj":"http://purl.org/sig/ont/fma/fma50723"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T1","span":{"begin":460,"end":469},"obj":"Body_part"},{"id":"T2","span":{"begin":465,"end":469},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/UBERON_0035552"},{"id":"A2","pred":"uberon_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/UBERON_0001638"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T15","span":{"begin":17,"end":25},"obj":"Disease"},{"id":"T16","span":{"begin":179,"end":187},"obj":"Disease"},{"id":"T17","span":{"begin":215,"end":227},"obj":"Disease"},{"id":"T18","span":{"begin":470,"end":480},"obj":"Disease"}],"attributes":[{"id":"A15","pred":"mondo_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A16","pred":"mondo_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A17","pred":"mondo_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"id":"A18","pred":"mondo_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/MONDO_0000831"},{"subj":"T15","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T16","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T17","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T18","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T5","span":{"begin":38,"end":55},"obj":"http://purl.obolibrary.org/obo/CL_0000115"},{"id":"T6","span":{"begin":127,"end":143},"obj":"http://purl.obolibrary.org/obo/CL_0000115"},{"id":"T7","span":{"begin":240,"end":250},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T8","span":{"begin":465,"end":469},"obj":"http://purl.obolibrary.org/obo/UBERON_0001638"},{"id":"T9","span":{"begin":465,"end":469},"obj":"http://www.ebi.ac.uk/efo/EFO_0000816"}],"attributes":[{"subj":"T5","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T8","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T9","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T1","span":{"begin":67,"end":78},"obj":"Chemical"}],"attributes":[{"id":"A1","pred":"chebi_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T3","span":{"begin":460,"end":480},"obj":"Phenotype"}],"attributes":[{"id":"A3","pred":"hp_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/HP_0002625"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-HP"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T1","span":{"begin":215,"end":227},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T2","span":{"begin":229,"end":250},"obj":"http://purl.obolibrary.org/obo/GO_0006956"},{"id":"T3","span":{"begin":343,"end":368},"obj":"http://purl.obolibrary.org/obo/GO_0002250"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"48","span":{"begin":60,"end":65},"obj":"Gene"},{"id":"49","span":{"begin":67,"end":98},"obj":"Gene"},{"id":"50","span":{"begin":252,"end":260},"obj":"Gene"},{"id":"53","span":{"begin":17,"end":27},"obj":"Species"},{"id":"54","span":{"begin":165,"end":173},"obj":"Species"},{"id":"72","span":{"begin":179,"end":187},"obj":"Disease"},{"id":"73","span":{"begin":215,"end":227},"obj":"Disease"},{"id":"74","span":{"begin":382,"end":398},"obj":"Disease"},{"id":"75","span":{"begin":426,"end":450},"obj":"Disease"},{"id":"76","span":{"begin":460,"end":480},"obj":"Disease"}],"attributes":[{"id":"A48","pred":"tao:has_database_id","subj":"48","obj":"Gene:59272"},{"id":"A49","pred":"tao:has_database_id","subj":"49","obj":"Gene:59272"},{"id":"A50","pred":"tao:has_database_id","subj":"50","obj":"Gene:2147"},{"id":"A53","pred":"tao:has_database_id","subj":"53","obj":"Tax:2697049"},{"id":"A54","pred":"tao:has_database_id","subj":"54","obj":"Tax:9606"},{"id":"A72","pred":"tao:has_database_id","subj":"72","obj":"MESH:C000657245"},{"id":"A73","pred":"tao:has_database_id","subj":"73","obj":"MESH:D007249"},{"id":"A75","pred":"tao:has_database_id","subj":"75","obj":"MESH:D013927"},{"id":"A76","pred":"tao:has_database_id","subj":"76","obj":"MESH:D020246"},{"subj":"48","pred":"source","obj":"LitCovid-PubTator"},{"subj":"49","pred":"source","obj":"LitCovid-PubTator"},{"subj":"50","pred":"source","obj":"LitCovid-PubTator"},{"subj":"53","pred":"source","obj":"LitCovid-PubTator"},{"subj":"54","pred":"source","obj":"LitCovid-PubTator"},{"subj":"72","pred":"source","obj":"LitCovid-PubTator"},{"subj":"73","pred":"source","obj":"LitCovid-PubTator"},{"subj":"74","pred":"source","obj":"LitCovid-PubTator"},{"subj":"75","pred":"source","obj":"LitCovid-PubTator"},{"subj":"76","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#93e1ec","default":true},{"id":"LitCovid-PD-UBERON","color":"#ecdc93"},{"id":"LitCovid-PD-MONDO","color":"#c293ec"},{"id":"LitCovid-PD-CLO","color":"#93eca8"},{"id":"LitCovid-PD-CHEBI","color":"#ec9397"},{"id":"LitCovid-PD-HP","color":"#93b1ec"},{"id":"LitCovid-PD-GO-BP","color":"#cbec93"},{"id":"LitCovid-PubTator","color":"#ec93e5"}]}]}}