> top > docs > PMC:7386875 > spans > 47337-49608 > annotations

PMC:7386875 / 47337-49608 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T468 188-195 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T469 214-221 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T470 418-425 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T471 554-562 Body_part denotes heparins http://purl.org/sig/ont/fma/fma82839
T472 738-746 Body_part denotes heparins http://purl.org/sig/ont/fma/fma82839
T473 997-1006 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T474 1030-1037 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T475 1065-1080 Body_part denotes heparan sulfate http://purl.org/sig/ont/fma/fma63023
T476 1095-1109 Body_part denotes polysaccharide http://purl.org/sig/ont/fma/fma82746
T477 1121-1134 Body_part denotes cell surfaces http://purl.org/sig/ont/fma/fma67653
T478 1121-1125 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T479 1139-1159 Body_part denotes extracellular matrix http://purl.org/sig/ont/fma/fma9672
T480 1176-1188 Body_part denotes disaccharide http://purl.org/sig/ont/fma/fma82744
T481 1230-1237 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T482 1252-1259 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T483 1273-1287 Body_part denotes polysaccharide http://purl.org/sig/ont/fma/fma82746
T484 1310-1325 Body_part denotes heparan sulfate http://purl.org/sig/ont/fma/fma63023
T485 1493-1500 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T486 1553-1568 Body_part denotes heparan sulfate http://purl.org/sig/ont/fma/fma63023
T487 1635-1640 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T488 1719-1724 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T489 1726-1741 Body_part denotes heparan sulfate http://purl.org/sig/ont/fma/fma63023
T490 1840-1845 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T491 1906-1918 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T492 1906-1910 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T493 1984-1996 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T494 1984-1988 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T495 2035-2039 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T496 2109-2116 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T497 2149-2156 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T498 2190-2197 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T356 139-142 Disease denotes VTE http://purl.obolibrary.org/obo/MONDO_0005399
T357 457-465 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T358 527-539 Disease denotes coagulopathy http://purl.obolibrary.org/obo/MONDO_0001531
T359 835-850 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T360 841-850 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T361 1461-1476 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T362 1467-1476 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T363 1615-1619 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T364 2121-2129 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T365 2205-2213 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T507 64-67 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T508 1038-1041 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T509 1042-1043 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T510 1121-1125 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T511 1241-1242 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T512 1326-1329 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T513 1355-1356 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T514 1374-1375 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T515 1386-1393 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T516 1440-1445 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T517 1512-1513 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T518 1570-1573 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T519 1635-1649 http://purl.obolibrary.org/obo/CL_0001034 denotes cells in vitro
T520 1719-1724 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T521 1742-1745 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T522 1840-1845 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T523 1893-1898 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T524 1906-1910 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T525 1984-1988 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T526 2035-2039 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T527 2216-2221 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T281 188-195 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T282 214-221 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T283 418-425 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T284 554-562 Chemical denotes heparins http://purl.obolibrary.org/obo/CHEBI_24505
T285 579-593 Chemical denotes anticoagulants http://purl.obolibrary.org/obo/CHEBI_50249
T286 738-746 Chemical denotes heparins http://purl.obolibrary.org/obo/CHEBI_24505
T287 1030-1037 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T288 1065-1080 Chemical denotes heparan sulfate http://purl.obolibrary.org/obo/CHEBI_28815
T289 1065-1072 Chemical denotes heparan http://purl.obolibrary.org/obo/CHEBI_24500
T290 1073-1080 Chemical denotes sulfate http://purl.obolibrary.org/obo/CHEBI_16189
T291 1095-1109 Chemical denotes polysaccharide http://purl.obolibrary.org/obo/CHEBI_18154
T292 1176-1188 Chemical denotes disaccharide http://purl.obolibrary.org/obo/CHEBI_36233
T293 1230-1237 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T294 1252-1259 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T295 1273-1287 Chemical denotes polysaccharide http://purl.obolibrary.org/obo/CHEBI_18154
T296 1310-1325 Chemical denotes heparan sulfate http://purl.obolibrary.org/obo/CHEBI_28815
T297 1310-1317 Chemical denotes heparan http://purl.obolibrary.org/obo/CHEBI_24500
T298 1318-1325 Chemical denotes sulfate http://purl.obolibrary.org/obo/CHEBI_16189
T299 1493-1500 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T300 1553-1568 Chemical denotes heparan sulfate http://purl.obolibrary.org/obo/CHEBI_28815
T301 1553-1560 Chemical denotes heparan http://purl.obolibrary.org/obo/CHEBI_24500
T302 1561-1568 Chemical denotes sulfate http://purl.obolibrary.org/obo/CHEBI_16189
T303 1726-1741 Chemical denotes heparan sulfate http://purl.obolibrary.org/obo/CHEBI_28815
T304 1726-1733 Chemical denotes heparan http://purl.obolibrary.org/obo/CHEBI_24500
T305 1734-1741 Chemical denotes sulfate http://purl.obolibrary.org/obo/CHEBI_16189
T306 2109-2116 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T307 2149-2156 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T308 2190-2197 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T309 2247-2256 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T66 324-338 Phenotype denotes thromboembolic http://purl.obolibrary.org/obo/HP_0001907
T67 483-499 Phenotype denotes elevated D-dimer http://purl.obolibrary.org/obo/HP_0033106
T68 512-518 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T69 527-539 Phenotype denotes coagulopathy http://purl.obolibrary.org/obo/HP_0003256

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T151 600-619 http://purl.obolibrary.org/obo/GO_0050819 denotes inhibit coagulation
T152 608-619 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T153 835-850 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T154 1461-1476 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection

LitCovid-PD-GlycoEpitope

Id Subject Object Predicate Lexical cue glyco_epitope_db_id
T2 1065-1080 GlycoEpitope denotes heparan sulfate http://www.glycoepitope.jp/epitopes/EP0086
T3 1310-1325 GlycoEpitope denotes heparan sulfate http://www.glycoepitope.jp/epitopes/EP0086
T4 1553-1568 GlycoEpitope denotes heparan sulfate http://www.glycoepitope.jp/epitopes/EP0086
T5 1726-1741 GlycoEpitope denotes heparan sulfate http://www.glycoepitope.jp/epitopes/EP0086

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T165 0-679 Sentence denotes The strikingly increased prevalence of thrombotic complications has led to many hospitals instituting the routine administration of strict VTE prophylaxis with either low molecular weight heparin or unfractionated heparin and also resulting in several groups using intermediate or full-dose anticoagulation to prevent these thromboembolic phenomena.137,138 Preliminary reports have suggested that low molecular weight heparin treatment reduces mortality in COVID-19 patients with an elevated D-dimer or elevated sepsis-induced coagulopathy score.139 The heparins are widely used anticoagulants which inhibit coagulation by the antithrombin mediated inhibition of FXa or thrombin.
T166 680-1195 Sentence denotes However, aside from their effects on anticoagulation, the heparins appear to have pleiotropic effects that may provide unique advantages in the context of viral infection, including anti-inflammatory effects by way of their ability to bind to danger-associated molecular patterns, such as HMGB-1, and proinflammatory cytokines.140,141 Unfractionated heparin has a similar structure as heparan sulfate, the sulfated polysaccharide present on cell surfaces and extracellular matrix, with repeating disaccharide units.
T167 1196-1295 Sentence denotes In contrast, low molecular weight heparin is a modified heparin with shorter polysaccharide chains.
T168 1296-2271 Sentence denotes Intriguingly, heparan sulfate has previously implicated as a docking site for a number of viruses, thus facilitating cellular attachment of the virus and subsequent viral infection.142,143 Indeed, heparin, acting as a decoy receptor for naturally expressed heparan sulfate, has been shown to inhibit the binding of the SARS coronavirus to cells in vitro.144 While ACE-2 is the major receptor that mediates viral entry into cells, heparan sulfate has previously been demonstrated to play an important role in facilitating coronavirus entry into cells by functioning as an adhesion receptor for the virus on the cell surface thereby allowing the increased density of viral particles on the cell surface which then facilitates ACE-2-mediated cell entry.145 Recent studies have directly investigated the link between heparin and SARS-CoV-2 and suggest that heparin can directly bind with the spike protein of the SARS-CoV-2 virus and, therefore, may have antiviral properties.146

2_test

Id Subject Object Predicate Lexical cue
32586214-32311448-21597810 349-352 32311448 denotes 137
32586214-32339221-21597811 353-356 32339221 denotes 138
32586214-32220112-21597812 546-549 32220112 denotes 139
32586214-32188725-21597813 1007-1010 32188725 denotes 140
32586214-27975101-21597814 1011-1014 27975101 denotes 141
32586214-11746174-21597815 1477-1480 11746174 denotes 142
32586214-11518721-21597816 1481-1484 11518721 denotes 143
32586214-21887302-21597817 1650-1653 21887302 denotes 144
32586214-25187545-21597818 2046-2049 25187545 denotes 145

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1605 627-639 Gene denotes antithrombin Gene:462
1606 663-666 Gene denotes FXa Gene:2159
1607 670-678 Gene denotes thrombin Gene:2147
1608 969-975 Gene denotes HMGB-1 Gene:3146
1609 1660-1665 Gene denotes ACE-2 Gene:59272
1610 2020-2025 Gene denotes ACE-2 Gene:59272
1611 2184-2189 Gene denotes spike Gene:43740568
1612 466-474 Species denotes patients Tax:9606
1613 1615-1631 Species denotes SARS coronavirus Tax:694009
1614 1817-1828 Species denotes coronavirus Tax:11118
1615 2121-2131 Species denotes SARS-CoV-2 Tax:2697049
1616 2205-2215 Species denotes SARS-CoV-2 Tax:2697049
1617 167-195 Chemical denotes low molecular weight heparin MESH:D006495
1618 214-221 Chemical denotes heparin MESH:D006493
1619 397-425 Chemical denotes low molecular weight heparin MESH:D006495
1620 554-562 Chemical denotes heparins MESH:D006493
1621 738-746 Chemical denotes heparins MESH:D006493
1622 1030-1037 Chemical denotes heparin MESH:D006493
1623 1065-1080 Chemical denotes heparan sulfate MESH:D006497
1624 1095-1109 Chemical denotes polysaccharide MESH:D011134
1625 1176-1188 Chemical denotes disaccharide MESH:D004187
1626 1209-1237 Chemical denotes low molecular weight heparin MESH:D006495
1627 1252-1259 Chemical denotes heparin MESH:D006493
1628 1273-1287 Chemical denotes polysaccharide MESH:D011134
1629 1310-1325 Chemical denotes heparan sulfate MESH:D006497
1630 1493-1500 Chemical denotes heparin MESH:D006493
1631 1553-1568 Chemical denotes heparan sulfate MESH:D006497
1632 1726-1741 Chemical denotes heparan sulfate MESH:D006497
1633 2109-2116 Chemical denotes heparin MESH:D006493
1634 2149-2156 Chemical denotes heparin MESH:D006493
1635 39-63 Disease denotes thrombotic complications MESH:D013927
1636 139-142 Disease denotes VTE MESH:D054556
1637 324-348 Disease denotes thromboembolic phenomena MESH:D013923
1638 444-453 Disease denotes mortality MESH:D003643
1639 457-465 Disease denotes COVID-19 MESH:C000657245
1640 512-518 Disease denotes sepsis MESH:D018805
1641 527-539 Disease denotes coagulopathy MESH:D001778
1642 835-850 Disease denotes viral infection MESH:D001102
1643 1461-1476 Disease denotes viral infection MESH:D001102