PMC:7386875 / 46014-47319
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T458 | 95-103 | Body_part | denotes | Heparins | http://purl.org/sig/ont/fma/fma82839 |
| T459 | 130-137 | Body_part | denotes | heparin | http://purl.org/sig/ont/fma/fma82839 |
| T460 | 169-176 | Body_part | denotes | heparin | http://purl.org/sig/ont/fma/fma82839 |
| T461 | 403-410 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T462 | 544-559 | Body_part | denotes | heparan sulfate | http://purl.org/sig/ont/fma/fma63023 |
| T463 | 621-626 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T464 | 978-986 | Body_part | denotes | platelet | http://purl.org/sig/ont/fma/fma62851 |
| T465 | 1044-1052 | Body_part | denotes | platelet | http://purl.org/sig/ont/fma/fma62851 |
| T466 | 1169-1175 | Body_part | denotes | serine | http://purl.org/sig/ont/fma/fma82764 |
| T467 | 1241-1247 | Body_part | denotes | tissue | http://purl.org/sig/ont/fma/fma9637 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T66 | 1241-1247 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T350 | 36-60 | Disease | denotes | coronavirus disease 2019 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T351 | 62-70 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T352 | 83-93 | Disease | denotes | thrombosis | http://purl.obolibrary.org/obo/MONDO_0000831 |
| T353 | 414-461 | Disease | denotes | severe acute respiratory syndrome coronavirus 2 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T354 | 414-447 | Disease | denotes | severe acute respiratory syndrome | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T355 | 463-471 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T498 | 512-513 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T499 | 593-598 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T500 | 621-626 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T501 | 987-997 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T502 | 1236-1239 | http://purl.obolibrary.org/obo/CLO_0053275 | denotes | tPA |
| T503 | 1236-1239 | http://purl.obolibrary.org/obo/CLO_0053276 | denotes | tPA |
| T504 | 1236-1239 | http://purl.obolibrary.org/obo/CLO_0053277 | denotes | tPA |
| T505 | 1253-1264 | http://purl.obolibrary.org/obo/PR_000012867 | denotes | plasminogen |
| T506 | 1265-1274 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activator |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T270 | 130-137 | Chemical | denotes | heparin | http://purl.obolibrary.org/obo/CHEBI_28304 |
| T271 | 169-176 | Chemical | denotes | heparin | http://purl.obolibrary.org/obo/CHEBI_28304 |
| T272 | 318-327 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
| T273 | 403-410 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T274 | 544-559 | Chemical | denotes | heparan sulfate | http://purl.obolibrary.org/obo/CHEBI_28815 |
| T275 | 544-551 | Chemical | denotes | heparan | http://purl.obolibrary.org/obo/CHEBI_24500 |
| T276 | 552-559 | Chemical | denotes | sulfate | http://purl.obolibrary.org/obo/CHEBI_16189 |
| T277 | 932-944 | Chemical | denotes | dipyridamole | http://purl.obolibrary.org/obo/CHEBI_4653 |
| T278 | 946-956 | Chemical | denotes | nafamostat | http://purl.obolibrary.org/obo/CHEBI_135466 |
| T279 | 1095-1100 | Chemical | denotes | group | http://purl.obolibrary.org/obo/CHEBI_24433 |
| T280 | 1169-1175 | Chemical | denotes | serine | http://purl.obolibrary.org/obo/CHEBI_17822 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T147 | 255-266 | http://purl.obolibrary.org/obo/GO_0050817 | denotes | coagulation |
| T148 | 808-819 | http://purl.obolibrary.org/obo/GO_0050817 | denotes | coagulation |
| T149 | 978-997 | http://purl.obolibrary.org/obo/GO_0030168 | denotes | platelet activation |
| T150 | 1253-1274 | http://purl.obolibrary.org/obo/GO_0031639 | denotes | plasminogen activator |
LitCovid-PD-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glyco_epitope_db_id |
|---|---|---|---|---|---|
| T1 | 544-559 | GlycoEpitope | denotes | heparan sulfate | http://www.glycoepitope.jp/epitopes/EP0086 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T155 | 0-9 | Sentence | denotes | Figure 4. |
| T156 | 11-94 | Sentence | denotes | Treatments for targeting coronavirus disease 2019 (COVID-19)-associated thrombosis. |
| T157 | 95-291 | Sentence | denotes | Heparins, including unfractionated heparin (UFH) and low molecular weight heparin (LMWH), bind antithrombin (AT), and potentiate the inhibitory effect of AT on coagulation factors Xa and thrombin. |
| T158 | 292-627 | Sentence | denotes | Furthermore, UFH may have antiviral effects by having the ability to bind the receptor-binding domain of the S protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in addition to potentially acting as a decoy for naturally expressed heparan sulfate thus reducing the ability of the virus to bind to and invade cells. |
| T159 | 628-752 | Sentence | denotes | The putative anti-inflammatory effects of UFH is related to its ability to bind danger-associated molecular pattern (DAMPs). |
| T160 | 753-902 | Sentence | denotes | Inhibitors of FXII block the contact factor pathway of coagulation, initiated by NETs, and also appear to have pleiotropic anti-inflammatory effects. |
| T161 | 903-1108 | Sentence | denotes | Antiplatelet agents, such as dipyridamole, nafamostat, and aspirin inhibit platelet activation, which can inhibit NETosis and the release of platelet-derived DAMPs such as HMGB (high mobility group box)-1. |
| T162 | 1109-1212 | Sentence | denotes | Nafamostat may inhibit the TMPRSS-2 (transmembrane protease serine 2) and therefore impede viral entry. |
| T163 | 1213-1305 | Sentence | denotes | Fibrinolytics, such as tPA (tissue-type plasminogen activator), degrade cross-linked fibrin. |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 1539 | 190-202 | Gene | denotes | antithrombin | Gene:462 |
| 1540 | 282-290 | Gene | denotes | thrombin | Gene:2147 |
| 1541 | 1081-1107 | Gene | denotes | high mobility group box)-1 | Gene:3146 |
| 1542 | 1136-1144 | Gene | denotes | TMPRSS-2 | Gene:7113 |
| 1543 | 1146-1177 | Gene | denotes | transmembrane protease serine 2 | Gene:7113 |
| 1544 | 1241-1274 | Gene | denotes | tissue-type plasminogen activator | Gene:5327 |
| 1545 | 401-402 | Gene | denotes | S | Gene:43740568 |
| 1546 | 1075-1079 | Gene | denotes | HMGB | Gene:6749 |
| 1547 | 1236-1239 | Gene | denotes | tPA | Gene:5327 |
| 1548 | 414-461 | Species | denotes | severe acute respiratory syndrome coronavirus 2 | Tax:2697049 |
| 1549 | 463-473 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 1550 | 95-103 | Chemical | denotes | Heparins | MESH:D006493 |
| 1551 | 130-137 | Chemical | denotes | heparin | MESH:D006493 |
| 1552 | 139-142 | Chemical | denotes | UFH | MESH:D006493 |
| 1553 | 148-176 | Chemical | denotes | low molecular weight heparin | MESH:D006495 |
| 1554 | 178-182 | Chemical | denotes | LMWH | MESH:D006495 |
| 1555 | 305-308 | Chemical | denotes | UFH | MESH:D006493 |
| 1556 | 544-559 | Chemical | denotes | heparan sulfate | MESH:D006497 |
| 1557 | 670-673 | Chemical | denotes | UFH | MESH:D006493 |
| 1558 | 932-944 | Chemical | denotes | dipyridamole | MESH:D004176 |
| 1559 | 946-956 | Chemical | denotes | nafamostat | MESH:C032855 |
| 1560 | 962-969 | Chemical | denotes | aspirin | MESH:D001241 |
| 1561 | 1109-1119 | Chemical | denotes | Nafamostat | MESH:C032855 |
| 1562 | 36-60 | Disease | denotes | coronavirus disease 2019 | MESH:C000657245 |
| 1563 | 62-70 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 1564 | 83-93 | Disease | denotes | thrombosis | MESH:D013927 |
| 1565 | 1017-1024 | Disease | denotes | NETosis |