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LitCovid-PD-FMA-UBERON

LitCovid-PD-UBERON

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T63","span":{"begin":316,"end":322},"obj":"Body_part"},{"id":"T64","span":{"begin":1923,"end":1932},"obj":"Body_part"},{"id":"T65","span":{"begin":1928,"end":1932},"obj":"Body_part"}],"attributes":[{"id":"A63","pred":"uberon_id","subj":"T63","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"A64","pred":"uberon_id","subj":"T64","obj":"http://purl.obolibrary.org/obo/UBERON_0035552"},{"id":"A65","pred":"uberon_id","subj":"T65","obj":"http://purl.obolibrary.org/obo/UBERON_0001638"}],"text":"Proposed role of thrombin in coronavirus disease 2019 (COVID-19)-associated immunothrombosis. Infection of endothelial cells by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and liberation of viral danger-associated molecular pattern (DAMPs) results in endothelial activation with the upregulation of tissue factor (TF) and adhesion molecule expression in addition to endothelial cytokine production. This leads to the recruitment and activation of leukocytes and platelets. Activated leukocytes release neutrophil extracellular traps (NETs) and monocyte-derived, TF-bearing microvesicles (MV). Activated platelets release polyP from dense granules. This initiates intravascular thrombin generation via the TF and contact pathways of coagulation. Thrombin exerts its thrombotic effect by activating platelets through the platelet PAR (protease-activated receptor)-1/4 in addition to mediating the cleavage of fibrinogen to fibrin. Furthermore, thrombin possesses proinflammatory functions due to its ability to activate endothelial cells and leukocytes. Thrombin activates endothelial cells via the endothelial PAR-1 receptor, leading to upregulation of IL-6, IL-8, PAF (platelet-activating factor), and MCP (monocyte chemoattractant protein)-1 in addition to the adhesion molecules P-selectin, E-selectin and ICAM (intercellular adhesion molecule)-1, all of which serve to increase leukocyte recruitment and activation. Similarly, monocyte and T-cell functions are enhanced by thrombin activation of monocyte and T-cell expressed PAR-1 and PAR-3. The resultant endothelial cell, platelet, and leukocyte interactions establish a positive feedback loop, which further promulgates ongoing thrombin generation leading to immunothrombosis. This thrombotic phenotype likely results in the clinical manifestations seen in COVID-19, including pulmonary embolism (PE), microvascular thrombosis, ischemic stroke, and deep vein thrombosis (DVT)."}

LitCovid-PD-MONDO

LitCovid-PD-CLO

LitCovid-PD-CHEBI

LitCovid-PD-HP

{"project":"LitCovid-PD-HP","denotations":[{"id":"T62","span":{"begin":1851,"end":1869},"obj":"Phenotype"},{"id":"T63","span":{"begin":1871,"end":1873},"obj":"Phenotype"},{"id":"T64","span":{"begin":1902,"end":1917},"obj":"Phenotype"},{"id":"T65","span":{"begin":1923,"end":1943},"obj":"Phenotype"}],"attributes":[{"id":"A62","pred":"hp_id","subj":"T62","obj":"http://purl.obolibrary.org/obo/HP_0002204"},{"id":"A63","pred":"hp_id","subj":"T63","obj":"http://purl.obolibrary.org/obo/HP_0002204"},{"id":"A64","pred":"hp_id","subj":"T64","obj":"http://purl.obolibrary.org/obo/HP_0002140"},{"id":"A65","pred":"hp_id","subj":"T65","obj":"http://purl.obolibrary.org/obo/HP_0002625"}],"text":"Proposed role of thrombin in coronavirus disease 2019 (COVID-19)-associated immunothrombosis. Infection of endothelial cells by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and liberation of viral danger-associated molecular pattern (DAMPs) results in endothelial activation with the upregulation of tissue factor (TF) and adhesion molecule expression in addition to endothelial cytokine production. This leads to the recruitment and activation of leukocytes and platelets. Activated leukocytes release neutrophil extracellular traps (NETs) and monocyte-derived, TF-bearing microvesicles (MV). Activated platelets release polyP from dense granules. This initiates intravascular thrombin generation via the TF and contact pathways of coagulation. Thrombin exerts its thrombotic effect by activating platelets through the platelet PAR (protease-activated receptor)-1/4 in addition to mediating the cleavage of fibrinogen to fibrin. Furthermore, thrombin possesses proinflammatory functions due to its ability to activate endothelial cells and leukocytes. Thrombin activates endothelial cells via the endothelial PAR-1 receptor, leading to upregulation of IL-6, IL-8, PAF (platelet-activating factor), and MCP (monocyte chemoattractant protein)-1 in addition to the adhesion molecules P-selectin, E-selectin and ICAM (intercellular adhesion molecule)-1, all of which serve to increase leukocyte recruitment and activation. Similarly, monocyte and T-cell functions are enhanced by thrombin activation of monocyte and T-cell expressed PAR-1 and PAR-3. The resultant endothelial cell, platelet, and leukocyte interactions establish a positive feedback loop, which further promulgates ongoing thrombin generation leading to immunothrombosis. This thrombotic phenotype likely results in the clinical manifestations seen in COVID-19, including pulmonary embolism (PE), microvascular thrombosis, ischemic stroke, and deep vein thrombosis (DVT)."}

LitCovid-PD-GO-BP

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T144","span":{"begin":395,"end":414},"obj":"http://purl.obolibrary.org/obo/GO_0001816"},{"id":"T145","span":{"begin":749,"end":760},"obj":"http://purl.obolibrary.org/obo/GO_0050817"},{"id":"T146","span":{"begin":1186,"end":1205},"obj":"http://purl.obolibrary.org/obo/GO_0030168"}],"text":"Proposed role of thrombin in coronavirus disease 2019 (COVID-19)-associated immunothrombosis. Infection of endothelial cells by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and liberation of viral danger-associated molecular pattern (DAMPs) results in endothelial activation with the upregulation of tissue factor (TF) and adhesion molecule expression in addition to endothelial cytokine production. This leads to the recruitment and activation of leukocytes and platelets. Activated leukocytes release neutrophil extracellular traps (NETs) and monocyte-derived, TF-bearing microvesicles (MV). Activated platelets release polyP from dense granules. This initiates intravascular thrombin generation via the TF and contact pathways of coagulation. Thrombin exerts its thrombotic effect by activating platelets through the platelet PAR (protease-activated receptor)-1/4 in addition to mediating the cleavage of fibrinogen to fibrin. Furthermore, thrombin possesses proinflammatory functions due to its ability to activate endothelial cells and leukocytes. Thrombin activates endothelial cells via the endothelial PAR-1 receptor, leading to upregulation of IL-6, IL-8, PAF (platelet-activating factor), and MCP (monocyte chemoattractant protein)-1 in addition to the adhesion molecules P-selectin, E-selectin and ICAM (intercellular adhesion molecule)-1, all of which serve to increase leukocyte recruitment and activation. Similarly, monocyte and T-cell functions are enhanced by thrombin activation of monocyte and T-cell expressed PAR-1 and PAR-3. The resultant endothelial cell, platelet, and leukocyte interactions establish a positive feedback loop, which further promulgates ongoing thrombin generation leading to immunothrombosis. This thrombotic phenotype likely results in the clinical manifestations seen in COVID-19, including pulmonary embolism (PE), microvascular thrombosis, ischemic stroke, and deep vein thrombosis (DVT)."}

LitCovid-sentences

{"project":"LitCovid-sentences","denotations":[{"id":"T140","span":{"begin":0,"end":93},"obj":"Sentence"},{"id":"T141","span":{"begin":94,"end":415},"obj":"Sentence"},{"id":"T142","span":{"begin":416,"end":489},"obj":"Sentence"},{"id":"T143","span":{"begin":490,"end":609},"obj":"Sentence"},{"id":"T144","span":{"begin":610,"end":664},"obj":"Sentence"},{"id":"T145","span":{"begin":665,"end":761},"obj":"Sentence"},{"id":"T146","span":{"begin":762,"end":945},"obj":"Sentence"},{"id":"T147","span":{"begin":946,"end":1068},"obj":"Sentence"},{"id":"T148","span":{"begin":1069,"end":1435},"obj":"Sentence"},{"id":"T149","span":{"begin":1436,"end":1562},"obj":"Sentence"},{"id":"T150","span":{"begin":1563,"end":1750},"obj":"Sentence"},{"id":"T151","span":{"begin":1751,"end":1950},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Proposed role of thrombin in coronavirus disease 2019 (COVID-19)-associated immunothrombosis. Infection of endothelial cells by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and liberation of viral danger-associated molecular pattern (DAMPs) results in endothelial activation with the upregulation of tissue factor (TF) and adhesion molecule expression in addition to endothelial cytokine production. This leads to the recruitment and activation of leukocytes and platelets. Activated leukocytes release neutrophil extracellular traps (NETs) and monocyte-derived, TF-bearing microvesicles (MV). Activated platelets release polyP from dense granules. This initiates intravascular thrombin generation via the TF and contact pathways of coagulation. Thrombin exerts its thrombotic effect by activating platelets through the platelet PAR (protease-activated receptor)-1/4 in addition to mediating the cleavage of fibrinogen to fibrin. Furthermore, thrombin possesses proinflammatory functions due to its ability to activate endothelial cells and leukocytes. Thrombin activates endothelial cells via the endothelial PAR-1 receptor, leading to upregulation of IL-6, IL-8, PAF (platelet-activating factor), and MCP (monocyte chemoattractant protein)-1 in addition to the adhesion molecules P-selectin, E-selectin and ICAM (intercellular adhesion molecule)-1, all of which serve to increase leukocyte recruitment and activation. Similarly, monocyte and T-cell functions are enhanced by thrombin activation of monocyte and T-cell expressed PAR-1 and PAR-3. The resultant endothelial cell, platelet, and leukocyte interactions establish a positive feedback loop, which further promulgates ongoing thrombin generation leading to immunothrombosis. This thrombotic phenotype likely results in the clinical manifestations seen in COVID-19, including pulmonary embolism (PE), microvascular thrombosis, ischemic stroke, and deep vein thrombosis (DVT)."}

LitCovid-PubTator

PMC:7386875 / 43583-45533 JSONTXT

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PMC:7386875 / 43583-45533 JSON TXT