PMC:7386875 / 28862-30801
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T261 | 272-276 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T262 | 627-636 | Body_part | denotes | platelets | http://purl.org/sig/ont/fma/fma62851 |
| T263 | 766-775 | Body_part | denotes | Platelets | http://purl.org/sig/ont/fma/fma62851 |
| T264 | 815-819 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T265 | 867-880 | Body_part | denotes | T lymphocytes | http://purl.org/sig/ont/fma/fma62870 |
| T266 | 935-944 | Body_part | denotes | platelets | http://purl.org/sig/ont/fma/fma62851 |
| T267 | 955-959 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T268 | 1019-1028 | Body_part | denotes | platelets | http://purl.org/sig/ont/fma/fma62851 |
| T269 | 1037-1069 | Body_part | denotes | major histocompatibility complex | http://purl.org/sig/ont/fma/fma84079 |
| T270 | 1128-1133 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T271 | 1140-1172 | Body_part | denotes | major histocompatibility complex | http://purl.org/sig/ont/fma/fma84079 |
| T272 | 1207-1215 | Body_part | denotes | platelet | http://purl.org/sig/ont/fma/fma62851 |
| T273 | 1233-1242 | Body_part | denotes | serotonin | http://purl.org/sig/ont/fma/fma67245 |
| T274 | 1285-1289 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T275 | 1354-1363 | Body_part | denotes | platelets | http://purl.org/sig/ont/fma/fma62851 |
| T276 | 1379-1383 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T277 | 1454-1463 | Body_part | denotes | platelets | http://purl.org/sig/ont/fma/fma62851 |
| T278 | 1511-1528 | Body_part | denotes | cytotoxic T cells | http://purl.org/sig/ont/fma/fma70573 |
| T279 | 1523-1528 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T280 | 1548-1553 | Body_part | denotes | organ | http://purl.org/sig/ont/fma/fma67498 |
| T281 | 1655-1664 | Body_part | denotes | platelets | http://purl.org/sig/ont/fma/fma62851 |
| T282 | 1675-1684 | Body_part | denotes | leukocyte | http://purl.org/sig/ont/fma/fma62852 |
| T283 | 1714-1719 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T284 | 1730-1738 | Body_part | denotes | platelet | http://purl.org/sig/ont/fma/fma62851 |
| T285 | 1810-1815 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T50 | 1548-1553 | Body_part | denotes | organ | http://purl.obolibrary.org/obo/UBERON_0000062 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T236 | 39-47 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T237 | 246-254 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T238 | 290-298 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T239 | 444-454 | Disease | denotes | thrombosis | http://purl.obolibrary.org/obo/MONDO_0000831 |
| T240 | 495-505 | Disease | denotes | thrombosis | http://purl.obolibrary.org/obo/MONDO_0000831 |
| T241 | 542-550 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T242 | 742-764 | Disease | denotes | inflammatory disorders | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T243 | 902-908 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T244 | 912-921 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T245 | 1589-1604 | Disease | denotes | viral hepatitis | http://purl.obolibrary.org/obo/MONDO_0006011 |
| T246 | 1595-1604 | Disease | denotes | hepatitis | http://purl.obolibrary.org/obo/MONDO_0002251 |
| T247 | 1838-1855 | Disease | denotes | venous thrombosis | http://purl.obolibrary.org/obo/MONDO_0008559 |
| T248 | 1845-1855 | Disease | denotes | thrombosis | http://purl.obolibrary.org/obo/MONDO_0000831 |
| T249 | 1914-1922 | Disease | denotes | thrombus | http://purl.obolibrary.org/obo/MONDO_0000831 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T280 | 0-1 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T281 | 270-276 | http://purl.obolibrary.org/obo/CL_0000236 | denotes | B-cell |
| T282 | 731-732 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T283 | 813-819 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T-cell |
| T284 | 953-959 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T-cell |
| T285 | 1117-1125 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activate |
| T286 | 1126-1133 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cells |
| T287 | 1233-1242 | http://purl.obolibrary.org/obo/CHEBI_28790 | denotes | serotonin |
| T288 | 1277-1289 | http://purl.obolibrary.org/obo/CL_0000898 | denotes | naïve T-cell |
| T289 | 1290-1300 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T290 | 1377-1383 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T-cell |
| T291 | 1469-1470 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T292 | 1521-1528 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cells |
| T293 | 1534-1539 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T294 | 1548-1553 | http://purl.obolibrary.org/obo/UBERON_0003103 | denotes | organ |
| T295 | 1565-1566 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T296 | 1698-1708 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T297 | 1712-1719 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cells |
| T298 | 1808-1815 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cells |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T141 | 1078-1087 | Chemical | denotes | molecules | http://purl.obolibrary.org/obo/CHEBI_25367 |
| T142 | 1224-1226 | Chemical | denotes | PF | http://purl.obolibrary.org/obo/CHEBI_74795|http://purl.obolibrary.org/obo/CHEBI_90284 |
| T144 | 1233-1242 | Chemical | denotes | serotonin | http://purl.obolibrary.org/obo/CHEBI_28790|http://purl.obolibrary.org/obo/CHEBI_350546 |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T47 | 1589-1604 | Phenotype | denotes | viral hepatitis | http://purl.obolibrary.org/obo/HP_0006562 |
| T48 | 1838-1855 | Phenotype | denotes | venous thrombosis | http://purl.obolibrary.org/obo/HP_0004936 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T73 | 218-242 | http://purl.obolibrary.org/obo/GO_0002250 | denotes | adaptive immune response |
| T74 | 227-242 | http://purl.obolibrary.org/obo/GO_0006955 | denotes | immune response |
| T75 | 514-538 | http://purl.obolibrary.org/obo/GO_0002250 | denotes | adaptive immune response |
| T76 | 523-538 | http://purl.obolibrary.org/obo/GO_0006955 | denotes | immune response |
| T77 | 1037-1069 | http://purl.obolibrary.org/obo/GO_0046776 | denotes | major histocompatibility complex |
| T78 | 1140-1172 | http://purl.obolibrary.org/obo/GO_0046776 | denotes | major histocompatibility complex |
| T79 | 1283-1300 | http://purl.obolibrary.org/obo/GO_0042110 | denotes | T-cell activation |
| T80 | 1285-1300 | http://purl.obolibrary.org/obo/GO_0001775 | denotes | cell activation |
| T81 | 1730-1750 | http://purl.obolibrary.org/obo/GO_0070527 | denotes | platelet aggregation |
| T82 | 1877-1898 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammatory response |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T104 | 0-580 | Sentence | denotes | A prominent clinical feature of severe COVID-19 is the occurrence of respiratory decompensation typically 1 week after initial symptom onset.82 This clinical trajectory appears to correlate with the time course of the adaptive immune response to SARS-CoV-2, with T- and B-cell responses to SARS-CoV-2 being detected ≈1 week after symptom onset.46 Given it is postulated that this respiratory decompensation is driven by pulmonary microvascular thrombosis, understanding the intersection between thrombosis and the adaptive immune response to SARS-CoV-2 is of significant interest. |
| T105 | 581-765 | Sentence | denotes | These interactions are likely important since platelets have previously been demonstrated to be key modulators of adaptive immunity in the context of a range of inflammatory disorders. |
| T106 | 766-1005 | Sentence | denotes | Platelets play an important role in regulating T-cell trafficking by facilitating the recruitment of T lymphocytes to sites of vascular injury or infection.83 Moreover, platelets enhance T-cell functional responses via multiple mechanisms. |
| T107 | 1006-1335 | Sentence | denotes | For example, platelets express major histocompatibility complex class 1 molecules and can, therefore, directly activate T cells in an major histocompatibility complex class 1 dependent manner,84 while platelet-derived PF-4 and serotonin can regulate Th17 expansion85 and naïve T-cell activation and proliferation,86 respectively. |
| T108 | 1336-1939 | Sentence | denotes | The importance of platelets in mediating T-cell recruitment and trafficking is underscored by data demonstrating that platelets play a fundamental role in the accumulation of cytotoxic T cells, and virus-induced organ damage, in a murine model of acute viral hepatitis.87 Akin to the bidirectional relationship between platelets and other leukocyte subsets, the activation of T cells amplifies platelet aggregation with more recent data highlighting an important role for T cells recruited to sites of venous thrombosis in orchestrating the inflammatory response and subsequent thrombus resolution.88,89 |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32586214-32346093-21597743 | 344-346 | 32346093 | denotes | 46 |
| 32586214-20838746-21597744 | 922-924 | 20838746 | denotes | 83 |
| 32586214-22706078-21597745 | 1198-1200 | 22706078 | denotes | 84 |
| 32586214-24463452-21597746 | 1270-1272 | 24463452 | denotes | 85 |
| 32586214-17158224-21597747 | 1319-1321 | 17158224 | denotes | 86 |
| 32586214-16258538-21597748 | 1605-1607 | 16258538 | denotes | 87 |
| 32586214-16634758-21597749 | 1934-1936 | 16634758 | denotes | 88 |
| 32586214-27707800-21597750 | 1937-1939 | 27707800 | denotes | 89 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 1033 | 1224-1228 | Gene | denotes | PF-4 | Gene:5196 |
| 1034 | 246-256 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 1035 | 290-300 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 1036 | 542-552 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 1037 | 1567-1573 | Species | denotes | murine | Tax:10090 |
| 1038 | 1233-1242 | Chemical | denotes | serotonin | MESH:D012701 |
| 1039 | 39-47 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 1040 | 420-454 | Disease | denotes | pulmonary microvascular thrombosis | MESH:D013927 |
| 1041 | 495-505 | Disease | denotes | thrombosis | MESH:D013927 |
| 1042 | 742-764 | Disease | denotes | inflammatory disorders | MESH:D007249 |
| 1043 | 893-908 | Disease | denotes | vascular injury | MESH:D057772 |
| 1044 | 912-921 | Disease | denotes | infection | MESH:D007239 |
| 1045 | 1548-1560 | Disease | denotes | organ damage | MESH:D019965 |
| 1046 | 1589-1604 | Disease | denotes | viral hepatitis | MESH:D006525 |
| 1047 | 1730-1750 | Disease | denotes | platelet aggregation | MESH:D001791 |
| 1048 | 1838-1855 | Disease | denotes | venous thrombosis | MESH:D020246 |
| 1049 | 1914-1922 | Disease | denotes | thrombus | MESH:D013927 |