PMC:7386875 / 2766-3685 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7386875","sourcedb":"PMC","sourceid":"7386875","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7386875","text":"vaccine for COVID-19, the enormous number of cases and deaths due to COVID-19 is likely to continue to increase. In this regard, although the adverse effects of COVID-19 were initially considered to primarily affect the respiratory tract by causing pneumonia and acute respiratory distress syndrome (ARDS), it has now become apparent that COVID-19 is associated with a prothrombotic state, which can manifest as microvascular thrombosis, venous, or arterial thrombosis, the presence of which usually portends an adverse prognosis. Thus, there is an urgent need to understand how SARS-CoV-2 induces a prothrombotic state to develop effective therapeutic approaches for COVID-19-associated thrombosis. This review will detail the significant emerging clinical findings of the prothrombotic status of patients suffering from COVID-19. We then provide an overview of the inherent links between the immune response and throm","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T10","span":{"begin":220,"end":237},"obj":"Body_part"}],"attributes":[{"id":"A10","pred":"fma_id","subj":"T10","obj":"http://purl.org/sig/ont/fma/fma265130"},{"subj":"T10","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T3","span":{"begin":220,"end":237},"obj":"Body_part"}],"attributes":[{"id":"A3","pred":"uberon_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/UBERON_0000065"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T37","span":{"begin":12,"end":20},"obj":"Disease"},{"id":"T38","span":{"begin":69,"end":77},"obj":"Disease"},{"id":"T39","span":{"begin":161,"end":169},"obj":"Disease"},{"id":"T40","span":{"begin":249,"end":258},"obj":"Disease"},{"id":"T41","span":{"begin":263,"end":298},"obj":"Disease"},{"id":"T42","span":{"begin":269,"end":298},"obj":"Disease"},{"id":"T43","span":{"begin":300,"end":304},"obj":"Disease"},{"id":"T44","span":{"begin":339,"end":347},"obj":"Disease"},{"id":"T45","span":{"begin":426,"end":436},"obj":"Disease"},{"id":"T46","span":{"begin":458,"end":468},"obj":"Disease"},{"id":"T47","span":{"begin":579,"end":587},"obj":"Disease"},{"id":"T48","span":{"begin":668,"end":676},"obj":"Disease"},{"id":"T49","span":{"begin":688,"end":698},"obj":"Disease"},{"id":"T50","span":{"begin":822,"end":830},"obj":"Disease"}],"attributes":[{"id":"A37","pred":"mondo_id","subj":"T37","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A38","pred":"mondo_id","subj":"T38","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A39","pred":"mondo_id","subj":"T39","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A40","pred":"mondo_id","subj":"T40","obj":"http://purl.obolibrary.org/obo/MONDO_0005249"},{"id":"A41","pred":"mondo_id","subj":"T41","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A42","pred":"mondo_id","subj":"T42","obj":"http://purl.obolibrary.org/obo/MONDO_0009971"},{"id":"A43","pred":"mondo_id","subj":"T43","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A44","pred":"mondo_id","subj":"T44","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A45","pred":"mondo_id","subj":"T45","obj":"http://purl.obolibrary.org/obo/MONDO_0000831"},{"id":"A46","pred":"mondo_id","subj":"T46","obj":"http://purl.obolibrary.org/obo/MONDO_0000831"},{"id":"A47","pred":"mondo_id","subj":"T47","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A48","pred":"mondo_id","subj":"T48","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A49","pred":"mondo_id","subj":"T49","obj":"http://purl.obolibrary.org/obo/MONDO_0000831"},{"id":"A50","pred":"mondo_id","subj":"T50","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"subj":"T37","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T38","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T39","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T40","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T41","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T42","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T43","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T44","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T45","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T46","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T47","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T48","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T49","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T50","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T12","span":{"begin":310,"end":313},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T13","span":{"begin":367,"end":368},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T14","span":{"begin":449,"end":457},"obj":"http://purl.obolibrary.org/obo/UBERON_0001637"},{"id":"T15","span":{"begin":449,"end":457},"obj":"http://www.ebi.ac.uk/efo/EFO_0000814"},{"id":"T16","span":{"begin":598,"end":599},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"attributes":[{"subj":"T12","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T13","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T14","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T15","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T16","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T7","span":{"begin":249,"end":258},"obj":"Phenotype"},{"id":"T8","span":{"begin":269,"end":289},"obj":"Phenotype"},{"id":"T9","span":{"begin":449,"end":468},"obj":"Phenotype"}],"attributes":[{"id":"A7","pred":"hp_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/HP_0002090"},{"id":"A8","pred":"hp_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/HP_0002098"},{"id":"A9","pred":"hp_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/HP_0004420"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T8","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T9","pred":"source","obj":"LitCovid-PD-HP"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T6","span":{"begin":894,"end":909},"obj":"http://purl.obolibrary.org/obo/GO_0006955"}],"attributes":[{"subj":"T6","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T16","span":{"begin":113,"end":530},"obj":"Sentence"},{"id":"T17","span":{"begin":531,"end":699},"obj":"Sentence"},{"id":"T18","span":{"begin":700,"end":831},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T16","pred":"source","obj":"LitCovid-sentences"},{"subj":"T17","pred":"source","obj":"LitCovid-sentences"},{"subj":"T18","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"130","span":{"begin":579,"end":589},"obj":"Species"},{"id":"131","span":{"begin":798,"end":806},"obj":"Species"},{"id":"138","span":{"begin":12,"end":20},"obj":"Disease"},{"id":"139","span":{"begin":55,"end":61},"obj":"Disease"},{"id":"140","span":{"begin":69,"end":77},"obj":"Disease"},{"id":"141","span":{"begin":161,"end":169},"obj":"Disease"},{"id":"142","span":{"begin":249,"end":258},"obj":"Disease"},{"id":"143","span":{"begin":263,"end":298},"obj":"Disease"},{"id":"144","span":{"begin":300,"end":304},"obj":"Disease"},{"id":"145","span":{"begin":339,"end":347},"obj":"Disease"},{"id":"146","span":{"begin":426,"end":436},"obj":"Disease"},{"id":"147","span":{"begin":458,"end":468},"obj":"Disease"},{"id":"148","span":{"begin":668,"end":676},"obj":"Disease"},{"id":"149","span":{"begin":688,"end":698},"obj":"Disease"},{"id":"150","span":{"begin":822,"end":830},"obj":"Disease"}],"attributes":[{"id":"A130","pred":"tao:has_database_id","subj":"130","obj":"Tax:2697049"},{"id":"A131","pred":"tao:has_database_id","subj":"131","obj":"Tax:9606"},{"id":"A138","pred":"tao:has_database_id","subj":"138","obj":"MESH:C000657245"},{"id":"A139","pred":"tao:has_database_id","subj":"139","obj":"MESH:D003643"},{"id":"A140","pred":"tao:has_database_id","subj":"140","obj":"MESH:C000657245"},{"id":"A141","pred":"tao:has_database_id","subj":"141","obj":"MESH:C000657245"},{"id":"A142","pred":"tao:has_database_id","subj":"142","obj":"MESH:D011014"},{"id":"A143","pred":"tao:has_database_id","subj":"143","obj":"MESH:D012128"},{"id":"A144","pred":"tao:has_database_id","subj":"144","obj":"MESH:D012128"},{"id":"A145","pred":"tao:has_database_id","subj":"145","obj":"MESH:C000657245"},{"id":"A146","pred":"tao:has_database_id","subj":"146","obj":"MESH:D013927"},{"id":"A147","pred":"tao:has_database_id","subj":"147","obj":"MESH:D013927"},{"id":"A148","pred":"tao:has_database_id","subj":"148","obj":"MESH:C000657245"},{"id":"A149","pred":"tao:has_database_id","subj":"149","obj":"MESH:D013927"},{"id":"A150","pred":"tao:has_database_id","subj":"150","obj":"MESH:C000657245"},{"subj":"130","pred":"source","obj":"LitCovid-PubTator"},{"subj":"131","pred":"source","obj":"LitCovid-PubTator"},{"subj":"138","pred":"source","obj":"LitCovid-PubTator"},{"subj":"139","pred":"source","obj":"LitCovid-PubTator"},{"subj":"140","pred":"source","obj":"LitCovid-PubTator"},{"subj":"141","pred":"source","obj":"LitCovid-PubTator"},{"subj":"142","pred":"source","obj":"LitCovid-PubTator"},{"subj":"143","pred":"source","obj":"LitCovid-PubTator"},{"subj":"144","pred":"source","obj":"LitCovid-PubTator"},{"subj":"145","pred":"source","obj":"LitCovid-PubTator"},{"subj":"146","pred":"source","obj":"LitCovid-PubTator"},{"subj":"147","pred":"source","obj":"LitCovid-PubTator"},{"subj":"148","pred":"source","obj":"LitCovid-PubTator"},{"subj":"149","pred":"source","obj":"LitCovid-PubTator"},{"subj":"150","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#93ecc5","default":true},{"id":"LitCovid-PD-UBERON","color":"#ecab93"},{"id":"LitCovid-PD-MONDO","color":"#9395ec"},{"id":"LitCovid-PD-CLO","color":"#afec93"},{"id":"LitCovid-PD-HP","color":"#ec93c9"},{"id":"LitCovid-PD-GO-BP","color":"#93e3ec"},{"id":"LitCovid-sentences","color":"#ecdb93"},{"id":"LitCovid-PubTator","color":"#c193ec"}]}]}}