PMC:7386875 / 2766-3685 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T10","span":{"begin":220,"end":237},"obj":"Body_part"}],"attributes":[{"id":"A10","pred":"fma_id","subj":"T10","obj":"http://purl.org/sig/ont/fma/fma265130"}],"text":"vaccine for COVID-19, the enormous number of cases and deaths due to COVID-19 is likely to continue to increase. In this regard, although the adverse effects of COVID-19 were initially considered to primarily affect the respiratory tract by causing pneumonia and acute respiratory distress syndrome (ARDS), it has now become apparent that COVID-19 is associated with a prothrombotic state, which can manifest as microvascular thrombosis, venous, or arterial thrombosis, the presence of which usually portends an adverse prognosis. Thus, there is an urgent need to understand how SARS-CoV-2 induces a prothrombotic state to develop effective therapeutic approaches for COVID-19-associated thrombosis. This review will detail the significant emerging clinical findings of the prothrombotic status of patients suffering from COVID-19. We then provide an overview of the inherent links between the immune response and throm"}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T3","span":{"begin":220,"end":237},"obj":"Body_part"}],"attributes":[{"id":"A3","pred":"uberon_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/UBERON_0000065"}],"text":"vaccine for COVID-19, the enormous number of cases and deaths due to COVID-19 is likely to continue to increase. In this regard, although the adverse effects of COVID-19 were initially considered to primarily affect the respiratory tract by causing pneumonia and acute respiratory distress syndrome (ARDS), it has now become apparent that COVID-19 is associated with a prothrombotic state, which can manifest as microvascular thrombosis, venous, or arterial thrombosis, the presence of which usually portends an adverse prognosis. Thus, there is an urgent need to understand how SARS-CoV-2 induces a prothrombotic state to develop effective therapeutic approaches for COVID-19-associated thrombosis. This review will detail the significant emerging clinical findings of the prothrombotic status of patients suffering from COVID-19. We then provide an overview of the inherent links between the immune response and throm"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T37","span":{"begin":12,"end":20},"obj":"Disease"},{"id":"T38","span":{"begin":69,"end":77},"obj":"Disease"},{"id":"T39","span":{"begin":161,"end":169},"obj":"Disease"},{"id":"T40","span":{"begin":249,"end":258},"obj":"Disease"},{"id":"T41","span":{"begin":263,"end":298},"obj":"Disease"},{"id":"T42","span":{"begin":269,"end":298},"obj":"Disease"},{"id":"T43","span":{"begin":300,"end":304},"obj":"Disease"},{"id":"T44","span":{"begin":339,"end":347},"obj":"Disease"},{"id":"T45","span":{"begin":426,"end":436},"obj":"Disease"},{"id":"T46","span":{"begin":458,"end":468},"obj":"Disease"},{"id":"T47","span":{"begin":579,"end":587},"obj":"Disease"},{"id":"T48","span":{"begin":668,"end":676},"obj":"Disease"},{"id":"T49","span":{"begin":688,"end":698},"obj":"Disease"},{"id":"T50","span":{"begin":822,"end":830},"obj":"Disease"}],"attributes":[{"id":"A37","pred":"mondo_id","subj":"T37","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A38","pred":"mondo_id","subj":"T38","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A39","pred":"mondo_id","subj":"T39","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A40","pred":"mondo_id","subj":"T40","obj":"http://purl.obolibrary.org/obo/MONDO_0005249"},{"id":"A41","pred":"mondo_id","subj":"T41","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A42","pred":"mondo_id","subj":"T42","obj":"http://purl.obolibrary.org/obo/MONDO_0009971"},{"id":"A43","pred":"mondo_id","subj":"T43","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A44","pred":"mondo_id","subj":"T44","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A45","pred":"mondo_id","subj":"T45","obj":"http://purl.obolibrary.org/obo/MONDO_0000831"},{"id":"A46","pred":"mondo_id","subj":"T46","obj":"http://purl.obolibrary.org/obo/MONDO_0000831"},{"id":"A47","pred":"mondo_id","subj":"T47","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A48","pred":"mondo_id","subj":"T48","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A49","pred":"mondo_id","subj":"T49","obj":"http://purl.obolibrary.org/obo/MONDO_0000831"},{"id":"A50","pred":"mondo_id","subj":"T50","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"vaccine for COVID-19, the enormous number of cases and deaths due to COVID-19 is likely to continue to increase. In this regard, although the adverse effects of COVID-19 were initially considered to primarily affect the respiratory tract by causing pneumonia and acute respiratory distress syndrome (ARDS), it has now become apparent that COVID-19 is associated with a prothrombotic state, which can manifest as microvascular thrombosis, venous, or arterial thrombosis, the presence of which usually portends an adverse prognosis. Thus, there is an urgent need to understand how SARS-CoV-2 induces a prothrombotic state to develop effective therapeutic approaches for COVID-19-associated thrombosis. This review will detail the significant emerging clinical findings of the prothrombotic status of patients suffering from COVID-19. We then provide an overview of the inherent links between the immune response and throm"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T12","span":{"begin":310,"end":313},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T13","span":{"begin":367,"end":368},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T14","span":{"begin":449,"end":457},"obj":"http://purl.obolibrary.org/obo/UBERON_0001637"},{"id":"T15","span":{"begin":449,"end":457},"obj":"http://www.ebi.ac.uk/efo/EFO_0000814"},{"id":"T16","span":{"begin":598,"end":599},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"vaccine for COVID-19, the enormous number of cases and deaths due to COVID-19 is likely to continue to increase. In this regard, although the adverse effects of COVID-19 were initially considered to primarily affect the respiratory tract by causing pneumonia and acute respiratory distress syndrome (ARDS), it has now become apparent that COVID-19 is associated with a prothrombotic state, which can manifest as microvascular thrombosis, venous, or arterial thrombosis, the presence of which usually portends an adverse prognosis. Thus, there is an urgent need to understand how SARS-CoV-2 induces a prothrombotic state to develop effective therapeutic approaches for COVID-19-associated thrombosis. This review will detail the significant emerging clinical findings of the prothrombotic status of patients suffering from COVID-19. We then provide an overview of the inherent links between the immune response and throm"}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T7","span":{"begin":249,"end":258},"obj":"Phenotype"},{"id":"T8","span":{"begin":269,"end":289},"obj":"Phenotype"},{"id":"T9","span":{"begin":449,"end":468},"obj":"Phenotype"}],"attributes":[{"id":"A7","pred":"hp_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/HP_0002090"},{"id":"A8","pred":"hp_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/HP_0002098"},{"id":"A9","pred":"hp_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/HP_0004420"}],"text":"vaccine for COVID-19, the enormous number of cases and deaths due to COVID-19 is likely to continue to increase. In this regard, although the adverse effects of COVID-19 were initially considered to primarily affect the respiratory tract by causing pneumonia and acute respiratory distress syndrome (ARDS), it has now become apparent that COVID-19 is associated with a prothrombotic state, which can manifest as microvascular thrombosis, venous, or arterial thrombosis, the presence of which usually portends an adverse prognosis. Thus, there is an urgent need to understand how SARS-CoV-2 induces a prothrombotic state to develop effective therapeutic approaches for COVID-19-associated thrombosis. This review will detail the significant emerging clinical findings of the prothrombotic status of patients suffering from COVID-19. We then provide an overview of the inherent links between the immune response and throm"}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T6","span":{"begin":894,"end":909},"obj":"http://purl.obolibrary.org/obo/GO_0006955"}],"text":"vaccine for COVID-19, the enormous number of cases and deaths due to COVID-19 is likely to continue to increase. In this regard, although the adverse effects of COVID-19 were initially considered to primarily affect the respiratory tract by causing pneumonia and acute respiratory distress syndrome (ARDS), it has now become apparent that COVID-19 is associated with a prothrombotic state, which can manifest as microvascular thrombosis, venous, or arterial thrombosis, the presence of which usually portends an adverse prognosis. Thus, there is an urgent need to understand how SARS-CoV-2 induces a prothrombotic state to develop effective therapeutic approaches for COVID-19-associated thrombosis. This review will detail the significant emerging clinical findings of the prothrombotic status of patients suffering from COVID-19. We then provide an overview of the inherent links between the immune response and throm"}

{"project":"LitCovid-sentences","denotations":[{"id":"T16","span":{"begin":113,"end":530},"obj":"Sentence"},{"id":"T17","span":{"begin":531,"end":699},"obj":"Sentence"},{"id":"T18","span":{"begin":700,"end":831},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"vaccine for COVID-19, the enormous number of cases and deaths due to COVID-19 is likely to continue to increase. In this regard, although the adverse effects of COVID-19 were initially considered to primarily affect the respiratory tract by causing pneumonia and acute respiratory distress syndrome (ARDS), it has now become apparent that COVID-19 is associated with a prothrombotic state, which can manifest as microvascular thrombosis, venous, or arterial thrombosis, the presence of which usually portends an adverse prognosis. Thus, there is an urgent need to understand how SARS-CoV-2 induces a prothrombotic state to develop effective therapeutic approaches for COVID-19-associated thrombosis. This review will detail the significant emerging clinical findings of the prothrombotic status of patients suffering from COVID-19. We then provide an overview of the inherent links between the immune response and throm"}

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