PMC:7386875 / 26235-28861 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7386875","sourcedb":"PMC","sourceid":"7386875","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7386875","text":"To date, there is a relative paucity of data regarding how SARS-CoV-2 may influence platelet function and potentially contribute to the prothrombotic phenotype observed in patients with COVID-19. However, there is now a large body of evidence demonstrating that viruses can directly interact with platelets thus potentially modulating their thrombotic and inflammatory function.75,76 Indeed, platelets are endowed with a large repertoire of adhesion receptors and immune receptors such as TLRs, FcγRIIa, and CXC/CCL receptors in addition to possessing the ability to engulf virions. Influenza, like SARS-CoV-2, is a single-stranded RNA virus which has been demonstrated to activate platelets via TLR-7 and the FcγRIIa receptor. The activation of platelet TLR-7 by viral RNA can evoke a range of functional responses which support thrombus formation, including platelet degranulation, the formation of platelet-leukocyte aggregates and platelet C3 release which in turn stimulates NETosis.75–78 In addition, previous work focusing on platelet activation by viruses has demonstrated that HSV-1 (herpes simplex virus 1) can induce thrombi via FcγRIIa on platelets and that the influenza strain H1N1 can activate platelets, both in a FcγRIIa- and thrombin-dependent fashion, thus leading to platelet GPIIb/IIIa activation, arachidonic acid metabolism, and platelet microvesicle release.79,80 Corresponding mouse studies have emphasized an important role of platelets in H1N1 infection since mice infected with sublethal doses of H1N1 demonstrated large numbers of activated platelets in their lung tissue in addition to platelet-leukocyte aggregates and microvascular thrombosis.81 Interestingly, inhibition of the major platelet adhesion receptor, GPIIb/IIIa, resulted in a protection from fatal influenza and a reduction in lung inflammation and microvascular thrombosis.81 Moreover, recent studies have demonstrated that platelets from patients with influenza contain virus particles, while human platelets appear to have the ability to internalize the influenza virus.77 Thus, a key outstanding area of research regarding the effects of SARS-CoV-2 and thrombosis pertains to how this virus interacts with platelets to mediate platelet number and function. In this regard, understanding if SARS-CoV-2 can be internalized and activate platelet TLR-7 and whether the ACE-2 receptor is expressed on platelets remain core unanswered questions. This is likely to be critical to understanding the link between COVID-19 and the prothrombotic phenotype given the key role of platelets in co-ordinating the thromboinflammatory response.","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T229","span":{"begin":84,"end":92},"obj":"Body_part"},{"id":"T230","span":{"begin":226,"end":230},"obj":"Body_part"},{"id":"T231","span":{"begin":297,"end":306},"obj":"Body_part"},{"id":"T232","span":{"begin":392,"end":401},"obj":"Body_part"},{"id":"T233","span":{"begin":632,"end":635},"obj":"Body_part"},{"id":"T234","span":{"begin":682,"end":691},"obj":"Body_part"},{"id":"T235","span":{"begin":746,"end":754},"obj":"Body_part"},{"id":"T236","span":{"begin":770,"end":773},"obj":"Body_part"},{"id":"T237","span":{"begin":860,"end":868},"obj":"Body_part"},{"id":"T238","span":{"begin":901,"end":909},"obj":"Body_part"},{"id":"T239","span":{"begin":910,"end":919},"obj":"Body_part"},{"id":"T240","span":{"begin":935,"end":943},"obj":"Body_part"},{"id":"T241","span":{"begin":1033,"end":1041},"obj":"Body_part"},{"id":"T242","span":{"begin":1151,"end":1160},"obj":"Body_part"},{"id":"T243","span":{"begin":1209,"end":1218},"obj":"Body_part"},{"id":"T244","span":{"begin":1287,"end":1295},"obj":"Body_part"},{"id":"T245","span":{"begin":1352,"end":1360},"obj":"Body_part"},{"id":"T246","span":{"begin":1453,"end":1462},"obj":"Body_part"},{"id":"T247","span":{"begin":1570,"end":1579},"obj":"Body_part"},{"id":"T248","span":{"begin":1589,"end":1593},"obj":"Body_part"},{"id":"T249","span":{"begin":1594,"end":1600},"obj":"Body_part"},{"id":"T250","span":{"begin":1616,"end":1624},"obj":"Body_part"},{"id":"T251","span":{"begin":1625,"end":1634},"obj":"Body_part"},{"id":"T252","span":{"begin":1717,"end":1725},"obj":"Body_part"},{"id":"T253","span":{"begin":1822,"end":1826},"obj":"Body_part"},{"id":"T254","span":{"begin":1920,"end":1929},"obj":"Body_part"},{"id":"T255","span":{"begin":1996,"end":2005},"obj":"Body_part"},{"id":"T256","span":{"begin":2205,"end":2214},"obj":"Body_part"},{"id":"T257","span":{"begin":2226,"end":2234},"obj":"Body_part"},{"id":"T258","span":{"begin":2333,"end":2341},"obj":"Body_part"},{"id":"T259","span":{"begin":2395,"end":2404},"obj":"Body_part"},{"id":"T260","span":{"begin":2566,"end":2575},"obj":"Body_part"}],"attributes":[{"id":"A229","pred":"fma_id","subj":"T229","obj":"http://purl.org/sig/ont/fma/fma62851"},{"id":"A230","pred":"fma_id","subj":"T230","obj":"http://purl.org/sig/ont/fma/fma256135"},{"id":"A231","pred":"fma_id","subj":"T231","obj":"http://purl.org/sig/ont/fma/fma62851"},{"id":"A232","pred":"fma_id","subj":"T232","obj":"http://purl.org/sig/ont/fma/fma62851"},{"id":"A233","pred":"fma_id","subj":"T233","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A234","pred":"fma_id","subj":"T234","obj":"http://purl.org/sig/ont/fma/fma62851"},{"id":"A235","pred":"fma_id","subj":"T235","obj":"http://purl.org/sig/ont/fma/fma62851"},{"id":"A236","pred":"fma_id","subj":"T236","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A237","pred":"fma_id","subj":"T237","obj":"http://purl.org/sig/ont/fma/fma62851"},{"id":"A238","pred":"fma_id","subj":"T238","obj":"http://purl.org/sig/ont/fma/fma62851"},{"id":"A239","pred":"fma_id","subj":"T239","obj":"http://purl.org/sig/ont/fma/fma62852"},{"id":"A240","pred":"fma_id","subj":"T240","obj":"http://purl.org/sig/ont/fma/fma62851"},{"id":"A241","pred":"fma_id","subj":"T241","obj":"http://purl.org/sig/ont/fma/fma62851"},{"id":"A242","pred":"fma_id","subj":"T242","obj":"http://purl.org/sig/ont/fma/fma62851"},{"id":"A243","pred":"fma_id","subj":"T243","obj":"http://purl.org/sig/ont/fma/fma62851"},{"id":"A244","pred":"fma_id","subj":"T244","obj":"http://purl.org/sig/ont/fma/fma62851"},{"id":"A245","pred":"fma_id","subj":"T245","obj":"http://purl.org/sig/ont/fma/fma62851"},{"id":"A246","pred":"fma_id","subj":"T246","obj":"http://purl.org/sig/ont/fma/fma62851"},{"id":"A247","pred":"fma_id","subj":"T247","obj":"http://purl.org/sig/ont/fma/fma62851"},{"id":"A248","pred":"fma_id","subj":"T248","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A249","pred":"fma_id","subj":"T249","obj":"http://purl.org/sig/ont/fma/fma9637"},{"id":"A250","pred":"fma_id","subj":"T250","obj":"http://purl.org/sig/ont/fma/fma62851"},{"id":"A251","pred":"fma_id","subj":"T251","obj":"http://purl.org/sig/ont/fma/fma62852"},{"id":"A252","pred":"fma_id","subj":"T252","obj":"http://purl.org/sig/ont/fma/fma62851"},{"id":"A253","pred":"fma_id","subj":"T253","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A254","pred":"fma_id","subj":"T254","obj":"http://purl.org/sig/ont/fma/fma62851"},{"id":"A255","pred":"fma_id","subj":"T255","obj":"http://purl.org/sig/ont/fma/fma62851"},{"id":"A256","pred":"fma_id","subj":"T256","obj":"http://purl.org/sig/ont/fma/fma62851"},{"id":"A257","pred":"fma_id","subj":"T257","obj":"http://purl.org/sig/ont/fma/fma62851"},{"id":"A258","pred":"fma_id","subj":"T258","obj":"http://purl.org/sig/ont/fma/fma62851"},{"id":"A259","pred":"fma_id","subj":"T259","obj":"http://purl.org/sig/ont/fma/fma62851"},{"id":"A260","pred":"fma_id","subj":"T260","obj":"http://purl.org/sig/ont/fma/fma62851"},{"subj":"T229","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T230","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T231","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T232","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T233","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T234","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T235","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T236","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T237","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T238","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T239","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T240","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T241","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T242","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T243","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T244","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T245","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T246","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T247","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T248","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T249","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T250","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T251","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T252","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T253","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T254","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T255","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T256","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T257","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T258","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T259","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T260","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T47","span":{"begin":1589,"end":1593},"obj":"Body_part"},{"id":"T48","span":{"begin":1594,"end":1600},"obj":"Body_part"},{"id":"T49","span":{"begin":1822,"end":1826},"obj":"Body_part"}],"attributes":[{"id":"A47","pred":"uberon_id","subj":"T47","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A48","pred":"uberon_id","subj":"T48","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"A49","pred":"uberon_id","subj":"T49","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"subj":"T47","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T48","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T49","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T218","span":{"begin":59,"end":67},"obj":"Disease"},{"id":"T219","span":{"begin":186,"end":194},"obj":"Disease"},{"id":"T220","span":{"begin":583,"end":592},"obj":"Disease"},{"id":"T221","span":{"begin":599,"end":607},"obj":"Disease"},{"id":"T222","span":{"begin":830,"end":838},"obj":"Disease"},{"id":"T223","span":{"begin":1093,"end":1107},"obj":"Disease"},{"id":"T224","span":{"begin":1174,"end":1183},"obj":"Disease"},{"id":"T225","span":{"begin":1471,"end":1480},"obj":"Disease"},{"id":"T226","span":{"begin":1664,"end":1674},"obj":"Disease"},{"id":"T227","span":{"begin":1793,"end":1802},"obj":"Disease"},{"id":"T228","span":{"begin":1827,"end":1839},"obj":"Disease"},{"id":"T229","span":{"begin":1858,"end":1868},"obj":"Disease"},{"id":"T230","span":{"begin":1949,"end":1958},"obj":"Disease"},{"id":"T231","span":{"begin":2052,"end":2061},"obj":"Disease"},{"id":"T232","span":{"begin":2137,"end":2145},"obj":"Disease"},{"id":"T233","span":{"begin":2152,"end":2162},"obj":"Disease"},{"id":"T234","span":{"begin":2289,"end":2297},"obj":"Disease"},{"id":"T235","span":{"begin":2503,"end":2511},"obj":"Disease"}],"attributes":[{"id":"A218","pred":"mondo_id","subj":"T218","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A219","pred":"mondo_id","subj":"T219","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A220","pred":"mondo_id","subj":"T220","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"},{"id":"A221","pred":"mondo_id","subj":"T221","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A222","pred":"mondo_id","subj":"T222","obj":"http://purl.obolibrary.org/obo/MONDO_0000831"},{"id":"A223","pred":"mondo_id","subj":"T223","obj":"http://purl.obolibrary.org/obo/MONDO_0004609"},{"id":"A224","pred":"mondo_id","subj":"T224","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"},{"id":"A225","pred":"mondo_id","subj":"T225","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A226","pred":"mondo_id","subj":"T226","obj":"http://purl.obolibrary.org/obo/MONDO_0000831"},{"id":"A227","pred":"mondo_id","subj":"T227","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"},{"id":"A228","pred":"mondo_id","subj":"T228","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"id":"A229","pred":"mondo_id","subj":"T229","obj":"http://purl.obolibrary.org/obo/MONDO_0000831"},{"id":"A230","pred":"mondo_id","subj":"T230","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"},{"id":"A231","pred":"mondo_id","subj":"T231","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"},{"id":"A232","pred":"mondo_id","subj":"T232","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A233","pred":"mondo_id","subj":"T233","obj":"http://purl.obolibrary.org/obo/MONDO_0000831"},{"id":"A234","pred":"mondo_id","subj":"T234","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A235","pred":"mondo_id","subj":"T235","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"subj":"T218","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T219","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T220","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T221","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T222","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T223","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T224","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T225","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T226","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T227","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T228","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T229","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T230","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T231","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T232","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T233","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T234","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T235","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T244","span":{"begin":18,"end":19},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T245","span":{"begin":218,"end":219},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T246","span":{"begin":262,"end":269},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T247","span":{"begin":419,"end":420},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T248","span":{"begin":495,"end":497},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T249","span":{"begin":614,"end":615},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T250","span":{"begin":636,"end":641},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T251","span":{"begin":648,"end":651},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T252","span":{"begin":673,"end":681},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T253","span":{"begin":710,"end":712},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T254","span":{"begin":732,"end":742},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T255","span":{"begin":784,"end":785},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T256","span":{"begin":1021,"end":1029},"obj":"http://purl.obolibrary.org/obo/CLO_0009985"},{"id":"T257","span":{"begin":1042,"end":1052},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T258","span":{"begin":1056,"end":1063},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T259","span":{"begin":1064,"end":1067},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T260","span":{"begin":1108,"end":1113},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T261","span":{"begin":1140,"end":1142},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T262","span":{"begin":1200,"end":1208},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T263","span":{"begin":1228,"end":1229},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T264","span":{"begin":1230,"end":1232},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T265","span":{"begin":1307,"end":1317},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T266","span":{"begin":1402,"end":1407},"obj":"http://purl.obolibrary.org/obo/CLO_0007836"},{"id":"T267","span":{"begin":1560,"end":1569},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T268","span":{"begin":1589,"end":1593},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T269","span":{"begin":1589,"end":1593},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T270","span":{"begin":1769,"end":1770},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T271","span":{"begin":1807,"end":1808},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T272","span":{"begin":1822,"end":1826},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T273","span":{"begin":1822,"end":1826},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T274","span":{"begin":1967,"end":1972},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T275","span":{"begin":1990,"end":1995},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T276","span":{"begin":2062,"end":2067},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T277","span":{"begin":2077,"end":2078},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T278","span":{"begin":2184,"end":2189},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T279","span":{"begin":2324,"end":2332},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"}],"attributes":[{"subj":"T244","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T245","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T246","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T247","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T248","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T249","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T250","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T251","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T252","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T253","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T254","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T255","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T256","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T257","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T258","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T259","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T260","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T261","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T262","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T263","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T264","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T265","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T266","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T267","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T268","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T269","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T270","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T271","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T272","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T273","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T274","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T275","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T276","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T277","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T278","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T279","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T138","span":{"begin":512,"end":515},"obj":"Chemical"},{"id":"T139","span":{"begin":1319,"end":1335},"obj":"Chemical"},{"id":"T140","span":{"begin":1331,"end":1335},"obj":"Chemical"}],"attributes":[{"id":"A138","pred":"chebi_id","subj":"T138","obj":"http://purl.obolibrary.org/obo/CHEBI_3478"},{"id":"A139","pred":"chebi_id","subj":"T139","obj":"http://purl.obolibrary.org/obo/CHEBI_15843"},{"id":"A140","pred":"chebi_id","subj":"T140","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"subj":"T138","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T139","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T140","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T64","span":{"begin":839,"end":848},"obj":"http://purl.obolibrary.org/obo/GO_0009058"},{"id":"T65","span":{"begin":860,"end":882},"obj":"http://purl.obolibrary.org/obo/GO_0002576"},{"id":"T66","span":{"begin":888,"end":897},"obj":"http://purl.obolibrary.org/obo/GO_0009058"},{"id":"T67","span":{"begin":910,"end":930},"obj":"http://purl.obolibrary.org/obo/GO_0070486"},{"id":"T68","span":{"begin":1033,"end":1052},"obj":"http://purl.obolibrary.org/obo/GO_0030168"},{"id":"T69","span":{"begin":1319,"end":1346},"obj":"http://purl.obolibrary.org/obo/GO_0019369"},{"id":"T70","span":{"begin":1336,"end":1346},"obj":"http://purl.obolibrary.org/obo/GO_0008152"},{"id":"T71","span":{"begin":1625,"end":1645},"obj":"http://purl.obolibrary.org/obo/GO_0070486"},{"id":"T72","span":{"begin":1827,"end":1839},"obj":"http://purl.obolibrary.org/obo/GO_0006954"}],"attributes":[{"subj":"T64","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T65","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T66","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T67","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T68","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T69","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T70","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T71","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T72","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T98","span":{"begin":0,"end":195},"obj":"Sentence"},{"id":"T99","span":{"begin":196,"end":582},"obj":"Sentence"},{"id":"T100","span":{"begin":583,"end":727},"obj":"Sentence"},{"id":"T101","span":{"begin":728,"end":2255},"obj":"Sentence"},{"id":"T102","span":{"begin":2256,"end":2438},"obj":"Sentence"},{"id":"T103","span":{"begin":2439,"end":2626},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T98","pred":"source","obj":"LitCovid-sentences"},{"subj":"T99","pred":"source","obj":"LitCovid-sentences"},{"subj":"T100","pred":"source","obj":"LitCovid-sentences"},{"subj":"T101","pred":"source","obj":"LitCovid-sentences"},{"subj":"T102","pred":"source","obj":"LitCovid-sentences"},{"subj":"T103","pred":"source","obj":"LitCovid-sentences"}]},{"project":"2_test","denotations":[{"id":"32586214-29348254-21597735","span":{"begin":378,"end":380},"obj":"29348254"},{"id":"32586214-25566260-21597736","span":{"begin":381,"end":383},"obj":"25566260"},{"id":"32586214-29348254-21597737","span":{"begin":988,"end":990},"obj":"29348254"},{"id":"32586214-25566260-21597737","span":{"begin":988,"end":990},"obj":"25566260"},{"id":"32586214-30992428-21597737","span":{"begin":988,"end":990},"obj":"30992428"},{"id":"32586214-24755410-21597737","span":{"begin":988,"end":990},"obj":"24755410"},{"id":"32586214-24665136-21597738","span":{"begin":1382,"end":1384},"obj":"24665136"},{"id":"32586214-29386381-21597739","span":{"begin":1385,"end":1387},"obj":"29386381"},{"id":"32586214-25664391-21597740","span":{"begin":1675,"end":1677},"obj":"25664391"},{"id":"32586214-25664391-21597741","span":{"begin":1869,"end":1871},"obj":"25664391"},{"id":"32586214-30992428-21597742","span":{"begin":2068,"end":2070},"obj":"30992428"}],"attributes":[{"subj":"32586214-29348254-21597735","pred":"source","obj":"2_test"},{"subj":"32586214-25566260-21597736","pred":"source","obj":"2_test"},{"subj":"32586214-29348254-21597737","pred":"source","obj":"2_test"},{"subj":"32586214-25566260-21597737","pred":"source","obj":"2_test"},{"subj":"32586214-30992428-21597737","pred":"source","obj":"2_test"},{"subj":"32586214-24755410-21597737","pred":"source","obj":"2_test"},{"subj":"32586214-24665136-21597738","pred":"source","obj":"2_test"},{"subj":"32586214-29386381-21597739","pred":"source","obj":"2_test"},{"subj":"32586214-25664391-21597740","pred":"source","obj":"2_test"},{"subj":"32586214-25664391-21597741","pred":"source","obj":"2_test"},{"subj":"32586214-30992428-21597742","pred":"source","obj":"2_test"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"972","span":{"begin":696,"end":701},"obj":"Gene"},{"id":"973","span":{"begin":755,"end":760},"obj":"Gene"},{"id":"974","span":{"begin":1243,"end":1251},"obj":"Gene"},{"id":"975","span":{"begin":1296,"end":1301},"obj":"Gene"},{"id":"976","span":{"begin":1745,"end":1750},"obj":"Gene"},{"id":"977","span":{"begin":2342,"end":2347},"obj":"Gene"},{"id":"978","span":{"begin":2364,"end":2369},"obj":"Gene"},{"id":"979","span":{"begin":1230,"end":1237},"obj":"Gene"},{"id":"980","span":{"begin":1140,"end":1147},"obj":"Gene"},{"id":"981","span":{"begin":495,"end":502},"obj":"Gene"},{"id":"982","span":{"begin":59,"end":69},"obj":"Species"},{"id":"983","span":{"begin":172,"end":180},"obj":"Species"},{"id":"984","span":{"begin":599,"end":609},"obj":"Species"},{"id":"985","span":{"begin":614,"end":641},"obj":"Species"},{"id":"986","span":{"begin":1086,"end":1091},"obj":"Species"},{"id":"987","span":{"begin":1093,"end":1115},"obj":"Species"},{"id":"988","span":{"begin":1191,"end":1195},"obj":"Species"},{"id":"989","span":{"begin":1402,"end":1407},"obj":"Species"},{"id":"990","span":{"begin":1466,"end":1470},"obj":"Species"},{"id":"991","span":{"begin":1487,"end":1491},"obj":"Species"},{"id":"992","span":{"begin":1525,"end":1529},"obj":"Species"},{"id":"993","span":{"begin":1935,"end":1943},"obj":"Species"},{"id":"994","span":{"begin":1990,"end":1995},"obj":"Species"},{"id":"995","span":{"begin":2052,"end":2067},"obj":"Species"},{"id":"996","span":{"begin":2137,"end":2147},"obj":"Species"},{"id":"997","span":{"begin":2289,"end":2299},"obj":"Species"},{"id":"998","span":{"begin":583,"end":592},"obj":"Species"},{"id":"999","span":{"begin":1174,"end":1183},"obj":"Species"},{"id":"1000","span":{"begin":1793,"end":1802},"obj":"Species"},{"id":"1001","span":{"begin":1949,"end":1958},"obj":"Species"},{"id":"1002","span":{"begin":710,"end":717},"obj":"Gene"},{"id":"1003","span":{"begin":1319,"end":1335},"obj":"Chemical"},{"id":"1004","span":{"begin":186,"end":194},"obj":"Disease"},{"id":"1005","span":{"begin":341,"end":351},"obj":"Disease"},{"id":"1006","span":{"begin":830,"end":838},"obj":"Disease"},{"id":"1007","span":{"begin":980,"end":987},"obj":"Disease"},{"id":"1008","span":{"begin":1128,"end":1135},"obj":"Disease"},{"id":"1009","span":{"begin":1471,"end":1480},"obj":"Disease"},{"id":"1010","span":{"begin":1492,"end":1500},"obj":"Disease"},{"id":"1011","span":{"begin":1664,"end":1674},"obj":"Disease"},{"id":"1012","span":{"begin":1822,"end":1839},"obj":"Disease"},{"id":"1013","span":{"begin":1858,"end":1868},"obj":"Disease"},{"id":"1014","span":{"begin":2152,"end":2162},"obj":"Disease"},{"id":"1015","span":{"begin":2503,"end":2511},"obj":"Disease"}],"attributes":[{"id":"A972","pred":"tao:has_database_id","subj":"972","obj":"Gene:51284"},{"id":"A973","pred":"tao:has_database_id","subj":"973","obj":"Gene:51284"},{"id":"A974","pred":"tao:has_database_id","subj":"974","obj":"Gene:2147"},{"id":"A975","pred":"tao:has_database_id","subj":"975","obj":"Gene:3674"},{"id":"A976","pred":"tao:has_database_id","subj":"976","obj":"Gene:3674"},{"id":"A977","pred":"tao:has_database_id","subj":"977","obj":"Gene:51284"},{"id":"A978","pred":"tao:has_database_id","subj":"978","obj":"Gene:59272"},{"id":"A979","pred":"tao:has_database_id","subj":"979","obj":"Gene:2212"},{"id":"A980","pred":"tao:has_database_id","subj":"980","obj":"Gene:2212"},{"id":"A981","pred":"tao:has_database_id","subj":"981","obj":"Gene:2212"},{"id":"A982","pred":"tao:has_database_id","subj":"982","obj":"Tax:2697049"},{"id":"A983","pred":"tao:has_database_id","subj":"983","obj":"Tax:9606"},{"id":"A984","pred":"tao:has_database_id","subj":"984","obj":"Tax:2697049"},{"id":"A985","pred":"tao:has_database_id","subj":"985","obj":"Tax:674971"},{"id":"A986","pred":"tao:has_database_id","subj":"986","obj":"Tax:10298"},{"id":"A987","pred":"tao:has_database_id","subj":"987","obj":"Tax:10298"},{"id":"A988","pred":"tao:has_database_id","subj":"988","obj":"Tax:114727"},{"id":"A989","pred":"tao:has_database_id","subj":"989","obj":"Tax:10090"},{"id":"A990","pred":"tao:has_database_id","subj":"990","obj":"Tax:114727"},{"id":"A991","pred":"tao:has_database_id","subj":"991","obj":"Tax:10090"},{"id":"A992","pred":"tao:has_database_id","subj":"992","obj":"Tax:114727"},{"id":"A993","pred":"tao:has_database_id","subj":"993","obj":"Tax:9606"},{"id":"A994","pred":"tao:has_database_id","subj":"994","obj":"Tax:9606"},{"id":"A995","pred":"tao:has_database_id","subj":"995","obj":"Tax:11309"},{"id":"A996","pred":"tao:has_database_id","subj":"996","obj":"Tax:2697049"},{"id":"A997","pred":"tao:has_database_id","subj":"997","obj":"Tax:2697049"},{"id":"A998","pred":"tao:has_database_id","subj":"998","obj":"Tax:11309"},{"id":"A999","pred":"tao:has_database_id","subj":"999","obj":"Tax:11309"},{"id":"A1000","pred":"tao:has_database_id","subj":"1000","obj":"Tax:11309"},{"id":"A1001","pred":"tao:has_database_id","subj":"1001","obj":"Tax:11309"},{"id":"A1002","pred":"tao:has_database_id","subj":"1002","obj":"Gene:2212"},{"id":"A1003","pred":"tao:has_database_id","subj":"1003","obj":"MESH:D016718"},{"id":"A1004","pred":"tao:has_database_id","subj":"1004","obj":"MESH:C000657245"},{"id":"A1005","pred":"tao:has_database_id","subj":"1005","obj":"MESH:D013927"},{"id":"A1006","pred":"tao:has_database_id","subj":"1006","obj":"MESH:D013927"},{"id":"A1008","pred":"tao:has_database_id","subj":"1008","obj":"MESH:D013927"},{"id":"A1009","pred":"tao:has_database_id","subj":"1009","obj":"MESH:D007239"},{"id":"A1010","pred":"tao:has_database_id","subj":"1010","obj":"MESH:D007239"},{"id":"A1011","pred":"tao:has_database_id","subj":"1011","obj":"MESH:D013927"},{"id":"A1012","pred":"tao:has_database_id","subj":"1012","obj":"MESH:D011014"},{"id":"A1013","pred":"tao:has_database_id","subj":"1013","obj":"MESH:D013927"},{"id":"A1014","pred":"tao:has_database_id","subj":"1014","obj":"MESH:D013927"},{"id":"A1015","pred":"tao:has_database_id","subj":"1015","obj":"MESH:C000657245"},{"subj":"972","pred":"source","obj":"LitCovid-PubTator"},{"subj":"973","pred":"source","obj":"LitCovid-PubTator"},{"subj":"974","pred":"source","obj":"LitCovid-PubTator"},{"subj":"975","pred":"source","obj":"LitCovid-PubTator"},{"subj":"976","pred":"source","obj":"LitCovid-PubTator"},{"subj":"977","pred":"source","obj":"LitCovid-PubTator"},{"subj":"978","pred":"source","obj":"LitCovid-PubTator"},{"subj":"979","pred":"source","obj":"LitCovid-PubTator"},{"subj":"980","pred":"source","obj":"LitCovid-PubTator"},{"subj":"981","pred":"source","obj":"LitCovid-PubTator"},{"subj":"982","pred":"source","obj":"LitCovid-PubTator"},{"subj":"983","pred":"source","obj":"LitCovid-PubTator"},{"subj":"984","pred":"source","obj":"LitCovid-PubTator"},{"subj":"985","pred":"source","obj":"LitCovid-PubTator"},{"subj":"986","pred":"source","obj":"LitCovid-PubTator"},{"subj":"987","pred":"source","obj":"LitCovid-PubTator"},{"subj":"988","pred":"source","obj":"LitCovid-PubTator"},{"subj":"989","pred":"source","obj":"LitCovid-PubTator"},{"subj":"990","pred":"source","obj":"LitCovid-PubTator"},{"subj":"991","pred":"source","obj":"LitCovid-PubTator"},{"subj":"992","pred":"source","obj":"LitCovid-PubTator"},{"subj":"993","pred":"source","obj":"LitCovid-PubTator"},{"subj":"994","pred":"source","obj":"LitCovid-PubTator"},{"subj":"995","pred":"source","obj":"LitCovid-PubTator"},{"subj":"996","pred":"source","obj":"LitCovid-PubTator"},{"subj":"997","pred":"source","obj":"LitCovid-PubTator"},{"subj":"998","pred":"source","obj":"LitCovid-PubTator"},{"subj":"999","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1000","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1001","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1002","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1003","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1004","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1005","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1006","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1007","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1008","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1009","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1010","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1011","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1012","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1013","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1014","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1015","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#d7ec93","default":true},{"id":"LitCovid-PD-UBERON","color":"#e793ec"},{"id":"LitCovid-PD-MONDO","color":"#93eccd"},{"id":"LitCovid-PD-CLO","color":"#ecb393"},{"id":"LitCovid-PD-CHEBI","color":"#9993ec"},{"id":"LitCovid-PD-GO-BP","color":"#a6ec93"},{"id":"LitCovid-sentences","color":"#ec93c0"},{"id":"2_test","color":"#93dbec"},{"id":"LitCovid-PubTator","color":"#ece393"}]}]}}