PMC:7386875 / 18629-19343 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T119","span":{"begin":219,"end":222},"obj":"Body_part"},{"id":"T120","span":{"begin":314,"end":324},"obj":"Body_part"},{"id":"T121","span":{"begin":329,"end":338},"obj":"Body_part"},{"id":"T122","span":{"begin":356,"end":361},"obj":"Body_part"},{"id":"T123","span":{"begin":450,"end":453},"obj":"Body_part"},{"id":"T124","span":{"begin":669,"end":677},"obj":"Body_part"}],"attributes":[{"id":"A119","pred":"fma_id","subj":"T119","obj":"http://purl.org/sig/ont/fma/fma74412"},{"id":"A120","pred":"fma_id","subj":"T120","obj":"http://purl.org/sig/ont/fma/fma241981"},{"id":"A121","pred":"fma_id","subj":"T121","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A122","pred":"fma_id","subj":"T122","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A123","pred":"fma_id","subj":"T123","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A124","pred":"fma_id","subj":"T124","obj":"http://purl.org/sig/ont/fma/fma84050"}],"text":"PRR (Pattern recognition receptors), such as TLR (Toll-like receptors), subsequently detect the release of pathogen-associated molecular patterns, and intracellular danger-associated molecular patterns, such as ATP and DNA, which evokes an intense inflammatory reaction and triggers the release of proinflammatory chemokines and cytokines from neighboring cells (Figure 1).46 Strikingly, SARS-CoV-2 has been found to contain multiple single-stranded RNA fragments that can be recognized by TLR-7 and TLR-8, similar in numbers to MERS-CoV but more than SARS-CoV.47 The recognition of SARS-CoV-2 by these receptors may contribute to innate immune hyperactivation and the cytokine storm often seen in severe COVID-19."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T184","span":{"begin":388,"end":396},"obj":"Disease"},{"id":"T185","span":{"begin":552,"end":560},"obj":"Disease"},{"id":"T186","span":{"begin":583,"end":591},"obj":"Disease"},{"id":"T187","span":{"begin":705,"end":713},"obj":"Disease"}],"attributes":[{"id":"A184","pred":"mondo_id","subj":"T184","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A185","pred":"mondo_id","subj":"T185","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A186","pred":"mondo_id","subj":"T186","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A187","pred":"mondo_id","subj":"T187","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"PRR (Pattern recognition receptors), such as TLR (Toll-like receptors), subsequently detect the release of pathogen-associated molecular patterns, and intracellular danger-associated molecular patterns, such as ATP and DNA, which evokes an intense inflammatory reaction and triggers the release of proinflammatory chemokines and cytokines from neighboring cells (Figure 1).46 Strikingly, SARS-CoV-2 has been found to contain multiple single-stranded RNA fragments that can be recognized by TLR-7 and TLR-8, similar in numbers to MERS-CoV but more than SARS-CoV.47 The recognition of SARS-CoV-2 by these receptors may contribute to innate immune hyperactivation and the cytokine storm often seen in severe COVID-19."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T158","span":{"begin":356,"end":361},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T159","span":{"begin":399,"end":402},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"}],"text":"PRR (Pattern recognition receptors), such as TLR (Toll-like receptors), subsequently detect the release of pathogen-associated molecular patterns, and intracellular danger-associated molecular patterns, such as ATP and DNA, which evokes an intense inflammatory reaction and triggers the release of proinflammatory chemokines and cytokines from neighboring cells (Figure 1).46 Strikingly, SARS-CoV-2 has been found to contain multiple single-stranded RNA fragments that can be recognized by TLR-7 and TLR-8, similar in numbers to MERS-CoV but more than SARS-CoV.47 The recognition of SARS-CoV-2 by these receptors may contribute to innate immune hyperactivation and the cytokine storm often seen in severe COVID-19."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T81","span":{"begin":211,"end":214},"obj":"Chemical"},{"id":"T83","span":{"begin":219,"end":222},"obj":"Chemical"}],"attributes":[{"id":"A81","pred":"chebi_id","subj":"T81","obj":"http://purl.obolibrary.org/obo/CHEBI_15422"},{"id":"A82","pred":"chebi_id","subj":"T81","obj":"http://purl.obolibrary.org/obo/CHEBI_30616"},{"id":"A83","pred":"chebi_id","subj":"T83","obj":"http://purl.obolibrary.org/obo/CHEBI_16991"}],"text":"PRR (Pattern recognition receptors), such as TLR (Toll-like receptors), subsequently detect the release of pathogen-associated molecular patterns, and intracellular danger-associated molecular patterns, such as ATP and DNA, which evokes an intense inflammatory reaction and triggers the release of proinflammatory chemokines and cytokines from neighboring cells (Figure 1).46 Strikingly, SARS-CoV-2 has been found to contain multiple single-stranded RNA fragments that can be recognized by TLR-7 and TLR-8, similar in numbers to MERS-CoV but more than SARS-CoV.47 The recognition of SARS-CoV-2 by these receptors may contribute to innate immune hyperactivation and the cytokine storm often seen in severe COVID-19."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T38","span":{"begin":669,"end":683},"obj":"Phenotype"}],"attributes":[{"id":"A38","pred":"hp_id","subj":"T38","obj":"http://purl.obolibrary.org/obo/HP_0033041"}],"text":"PRR (Pattern recognition receptors), such as TLR (Toll-like receptors), subsequently detect the release of pathogen-associated molecular patterns, and intracellular danger-associated molecular patterns, such as ATP and DNA, which evokes an intense inflammatory reaction and triggers the release of proinflammatory chemokines and cytokines from neighboring cells (Figure 1).46 Strikingly, SARS-CoV-2 has been found to contain multiple single-stranded RNA fragments that can be recognized by TLR-7 and TLR-8, similar in numbers to MERS-CoV but more than SARS-CoV.47 The recognition of SARS-CoV-2 by these receptors may contribute to innate immune hyperactivation and the cytokine storm often seen in severe COVID-19."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T40","span":{"begin":631,"end":644},"obj":"http://purl.obolibrary.org/obo/GO_0045087"}],"text":"PRR (Pattern recognition receptors), such as TLR (Toll-like receptors), subsequently detect the release of pathogen-associated molecular patterns, and intracellular danger-associated molecular patterns, such as ATP and DNA, which evokes an intense inflammatory reaction and triggers the release of proinflammatory chemokines and cytokines from neighboring cells (Figure 1).46 Strikingly, SARS-CoV-2 has been found to contain multiple single-stranded RNA fragments that can be recognized by TLR-7 and TLR-8, similar in numbers to MERS-CoV but more than SARS-CoV.47 The recognition of SARS-CoV-2 by these receptors may contribute to innate immune hyperactivation and the cytokine storm often seen in severe COVID-19."}

{"project":"LitCovid-sentences","denotations":[{"id":"T78","span":{"begin":0,"end":714},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"PRR (Pattern recognition receptors), such as TLR (Toll-like receptors), subsequently detect the release of pathogen-associated molecular patterns, and intracellular danger-associated molecular patterns, such as ATP and DNA, which evokes an intense inflammatory reaction and triggers the release of proinflammatory chemokines and cytokines from neighboring cells (Figure 1).46 Strikingly, SARS-CoV-2 has been found to contain multiple single-stranded RNA fragments that can be recognized by TLR-7 and TLR-8, similar in numbers to MERS-CoV but more than SARS-CoV.47 The recognition of SARS-CoV-2 by these receptors may contribute to innate immune hyperactivation and the cytokine storm often seen in severe COVID-19."}

{"project":"2_test","denotations":[{"id":"32586214-32346093-21597701","span":{"begin":373,"end":375},"obj":"32346093"},{"id":"32586214-32361001-21597702","span":{"begin":561,"end":563},"obj":"32361001"}],"text":"PRR (Pattern recognition receptors), such as TLR (Toll-like receptors), subsequently detect the release of pathogen-associated molecular patterns, and intracellular danger-associated molecular patterns, such as ATP and DNA, which evokes an intense inflammatory reaction and triggers the release of proinflammatory chemokines and cytokines from neighboring cells (Figure 1).46 Strikingly, SARS-CoV-2 has been found to contain multiple single-stranded RNA fragments that can be recognized by TLR-7 and TLR-8, similar in numbers to MERS-CoV but more than SARS-CoV.47 The recognition of SARS-CoV-2 by these receptors may contribute to innate immune hyperactivation and the cytokine storm often seen in severe COVID-19."}

{"project":"LitCovid-PubTator","denotations":[{"id":"709","span":{"begin":490,"end":495},"obj":"Gene"},{"id":"710","span":{"begin":500,"end":505},"obj":"Gene"},{"id":"713","span":{"begin":388,"end":398},"obj":"Species"},{"id":"714","span":{"begin":529,"end":537},"obj":"Species"},{"id":"715","span":{"begin":552,"end":560},"obj":"Species"},{"id":"716","span":{"begin":583,"end":593},"obj":"Species"},{"id":"717","span":{"begin":211,"end":214},"obj":"Chemical"},{"id":"721","span":{"begin":705,"end":713},"obj":"Disease"}],"attributes":[{"id":"A709","pred":"tao:has_database_id","subj":"709","obj":"Gene:51284"},{"id":"A710","pred":"tao:has_database_id","subj":"710","obj":"Gene:51311"},{"id":"A713","pred":"tao:has_database_id","subj":"713","obj":"Tax:2697049"},{"id":"A714","pred":"tao:has_database_id","subj":"714","obj":"Tax:1335626"},{"id":"A715","pred":"tao:has_database_id","subj":"715","obj":"Tax:694009"},{"id":"A716","pred":"tao:has_database_id","subj":"716","obj":"Tax:2697049"},{"id":"A717","pred":"tao:has_database_id","subj":"717","obj":"MESH:D000255"},{"id":"A721","pred":"tao:has_database_id","subj":"721","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"PRR (Pattern recognition receptors), such as TLR (Toll-like receptors), subsequently detect the release of pathogen-associated molecular patterns, and intracellular danger-associated molecular patterns, such as ATP and DNA, which evokes an intense inflammatory reaction and triggers the release of proinflammatory chemokines and cytokines from neighboring cells (Figure 1).46 Strikingly, SARS-CoV-2 has been found to contain multiple single-stranded RNA fragments that can be recognized by TLR-7 and TLR-8, similar in numbers to MERS-CoV but more than SARS-CoV.47 The recognition of SARS-CoV-2 by these receptors may contribute to innate immune hyperactivation and the cytokine storm often seen in severe COVID-19."}