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PMC:7386875 / 10407-12485 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T53 80-91 Body_part denotes endothelium http://purl.org/sig/ont/fma/fma63916
T54 266-272 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T55 310-317 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T56 386-403 Body_part denotes endothelial cells http://purl.org/sig/ont/fma/fma66772
T57 398-403 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T58 438-459 Body_part denotes von Willebrand factor http://purl.org/sig/ont/fma/fma81101
T59 492-496 Body_part denotes ICAM http://purl.org/sig/ont/fma/fma67857
T60 540-550 Body_part denotes P-selectin http://purl.org/sig/ont/fma/fma62933
T61 555-565 Body_part denotes E-selectin http://purl.org/sig/ont/fma/fma62932
T62 593-603 Body_part denotes leukocytes http://purl.org/sig/ont/fma/fma62852
T63 608-617 Body_part denotes platelets http://purl.org/sig/ont/fma/fma62851
T64 629-638 Body_part denotes platelets http://purl.org/sig/ont/fma/fma62851
T65 647-657 Body_part denotes chemokines http://purl.org/sig/ont/fma/fma241981
T66 669-677 Body_part denotes platelet http://purl.org/sig/ont/fma/fma62851
T67 751-755 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T68 801-810 Body_part denotes leukocyte http://purl.org/sig/ont/fma/fma62852
T69 824-834 Body_part denotes Leukocytes http://purl.org/sig/ont/fma/fma62852
T70 849-858 Body_part denotes platelets http://purl.org/sig/ont/fma/fma62851
T71 908-916 Body_part denotes platelet http://purl.org/sig/ont/fma/fma62851
T72 917-927 Body_part denotes P-selectin http://purl.org/sig/ont/fma/fma62933
T73 966-976 Body_part denotes P-selectin http://purl.org/sig/ont/fma/fma62933
T74 977-989 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T75 996-1006 Body_part denotes leukocytes http://purl.org/sig/ont/fma/fma62852
T76 1017-1026 Body_part denotes platelets http://purl.org/sig/ont/fma/fma62851
T77 1053-1062 Body_part denotes monocytes http://purl.org/sig/ont/fma/fma62864
T78 1067-1078 Body_part denotes neutrophils http://purl.org/sig/ont/fma/fma62860
T79 1123-1134 Body_part denotes neutrophils http://purl.org/sig/ont/fma/fma62860
T80 1146-1155 Body_part denotes platelets http://purl.org/sig/ont/fma/fma62851
T81 1277-1285 Body_part denotes monocyte http://purl.org/sig/ont/fma/fma62864
T82 1302-1310 Body_part denotes monocyte http://purl.org/sig/ont/fma/fma62864
T83 1311-1317 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T84 1422-1433 Body_part denotes Neutrophils http://purl.org/sig/ont/fma/fma62860
T85 1442-1452 Body_part denotes neutrophil http://purl.org/sig/ont/fma/fma62860
T86 1577-1586 Body_part denotes platelets http://purl.org/sig/ont/fma/fma62851
T87 1647-1657 Body_part denotes leukocytes http://purl.org/sig/ont/fma/fma62852
T88 1699-1707 Body_part denotes platelet http://purl.org/sig/ont/fma/fma62851
T89 1777-1786 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T90 1801-1816 Body_part denotes (interleukin)-1 http://purl.org/sig/ont/fma/fma86583
T91 1802-1813 Body_part denotes interleukin http://purl.org/sig/ont/fma/fma86578
T92 1839-1847 Body_part denotes monocyte http://purl.org/sig/ont/fma/fma62864
T93 1864-1871 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T94 1967-1976 Body_part denotes platelets http://purl.org/sig/ont/fma/fma62851
T95 1978-1988 Body_part denotes leukocytes http://purl.org/sig/ont/fma/fma62852
T96 1994-2005 Body_part denotes endothelium http://purl.org/sig/ont/fma/fma63916

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T11 80-91 Body_part denotes endothelium http://purl.obolibrary.org/obo/UBERON_0001986
T12 266-272 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T13 1311-1317 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T14 1994-2005 Body_part denotes endothelium http://purl.obolibrary.org/obo/UBERON_0001986

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T109 359-368 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T110 372-384 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T111 1179-1184 Disease denotes polyP http://purl.obolibrary.org/obo/MONDO_0005079
T112 1494-1504 Disease denotes thrombosis http://purl.obolibrary.org/obo/MONDO_0000831

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T82 80-91 http://purl.obolibrary.org/obo/UBERON_0001986 denotes endothelium
T83 300-309 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T84 386-403 http://purl.obolibrary.org/obo/CL_0000115 denotes endothelial cells
T85 619-628 http://purl.obolibrary.org/obo/CLO_0001658 denotes Activated
T86 730-740 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T87 749-755 http://purl.obolibrary.org/obo/CL_0000084 denotes T-cell
T88 1053-1062 http://purl.obolibrary.org/obo/CL_0000576 denotes monocytes
T89 1136-1145 http://purl.obolibrary.org/obo/CLO_0001658 denotes Activated
T90 1193-1202 http://purl.obolibrary.org/obo/CLO_0001658 denotes activates
T91 1277-1285 http://purl.obolibrary.org/obo/CL_0000576 denotes monocyte
T92 1302-1310 http://purl.obolibrary.org/obo/CL_0000576 denotes monocyte
T93 1509-1519 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T94 1563-1573 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T95 1608-1618 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T96 1708-1718 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T97 1801-1816 http://purl.obolibrary.org/obo/PR_000001091 denotes (interleukin)-1
T98 1824-1828 http://purl.obolibrary.org/obo/CLO_0053704 denotes IL-8
T99 1839-1847 http://purl.obolibrary.org/obo/CL_0000576 denotes monocyte
T100 1953-1963 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T101 1994-2005 http://purl.obolibrary.org/obo/UBERON_0001986 denotes endothelium
T102 2025-2034 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T103 2064-2065 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T45 181-193 Chemical denotes nitric oxide http://purl.obolibrary.org/obo/CHEBI_16480
T46 188-193 Chemical denotes oxide http://purl.obolibrary.org/obo/CHEBI_25741|http://purl.obolibrary.org/obo/CHEBI_29356
T48 244-258 Chemical denotes anticoagulants http://purl.obolibrary.org/obo/CHEBI_50249
T49 280-297 Chemical denotes pathway inhibitor http://purl.obolibrary.org/obo/CHEBI_76932
T50 288-297 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T51 310-317 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T52 474-483 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T53 521-529 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T54 665-667 Chemical denotes PF http://purl.obolibrary.org/obo/CHEBI_74795|http://purl.obolibrary.org/obo/CHEBI_90284
T56 689-694 Chemical denotes CXCL5 http://purl.obolibrary.org/obo/CHEBI_138180
T57 696-701 Chemical denotes CXCL7 http://purl.obolibrary.org/obo/CHEBI_138155
T58 785-789 Chemical denotes CCL7 http://purl.obolibrary.org/obo/CHEBI_138183
T59 880-886 Chemical denotes ligand http://purl.obolibrary.org/obo/CHEBI_52214
T60 977-989 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T61 1008-1010 Chemical denotes GP http://purl.obolibrary.org/obo/CHEBI_70744
T62 1164-1177 Chemical denotes polyphosphate http://purl.obolibrary.org/obo/CHEBI_16838
T63 1179-1184 Chemical denotes polyP http://purl.obolibrary.org/obo/CHEBI_16838
T64 1248-1253 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T65 1326-1328 Chemical denotes TF http://purl.obolibrary.org/obo/CHEBI_74862
T66 1395-1397 Chemical denotes TF http://purl.obolibrary.org/obo/CHEBI_74862
T67 1674-1676 Chemical denotes TF http://purl.obolibrary.org/obo/CHEBI_74862
T68 1798-1800 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T70 1818-1820 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T72 1824-1826 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T74 1834-1837 Chemical denotes MCP http://purl.obolibrary.org/obo/CHEBI_132592|http://purl.obolibrary.org/obo/CHEBI_50099
T76 1864-1871 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T28 63-74 http://purl.obolibrary.org/obo/GO_0042592 denotes homeostasis
T29 372-384 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T30 1409-1420 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T31 1597-1618 http://purl.obolibrary.org/obo/GO_0006956 denotes complement activation
T32 1699-1718 http://purl.obolibrary.org/obo/GO_0030168 denotes platelet activation

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T48 0-9 Sentence denotes Figure 2.
T49 11-50 Sentence denotes Mechanisms regulating immunothrombosis.
T50 51-340 Sentence denotes In vascular homeostasis, the endothelium possesses anti-inflammatory and antithrombotic properties due to the expression of CD39, nitric oxide (NO), and prostacyclin in addition to the natural anticoagulants, TFPI (tissue factor pathway inhibitor), activated protein C, and thrombomodulin.
T51 341-618 Sentence denotes In the setting of infection or inflammation, endothelial cells upregulate the expression of VWF (von Willebrand factor) and adhesion molecules such as ICAM (intercellular adhesion molecule)-1, αvβ3, P-selectin and E-selectin, promoting the adhesion of leukocytes and platelets.
T52 619-823 Sentence denotes Activated platelets release chemokines CXCL1, PF (platelet factor)-4, CXCL5, CXCL7, CCL3, RANTES (regulated on activation, normal T-cell expressed and secreted), and CCL7 to enhance leukocyte recruitment.
T53 824-893 Sentence denotes Leukocytes interact with platelets via several receptor/ligand pairs.
T54 894-1135 Sentence denotes These include platelet P-selectin binding to its cognate receptor PSGL (P-selectin glycoprotein)-1 on leukocytes, GP-Ib on platelets interacting with Mac-1 on monocytes and neutrophils, and GPIIb/IIIa binding to SLC44A2/CTL-2 on neutrophils.
T55 1136-1421 Sentence denotes Activated platelets release polyphosphate (polyP), which activates the contact pathway, and HMGB (high mobility group box)-1, which enhances monocyte recruitment and monocyte tissue factor (TF) expression, thereby amplifying thrombin generation by way of the TF pathway of coagulation.
T56 1422-1587 Sentence denotes Neutrophils release neutrophil extracellular traps (NETs) which promote thrombosis via activation of the contact pathway and the binding and activation of platelets.
T57 1588-1875 Sentence denotes Finally, complement activation leads to the recruitment of leukocytes and upregulates TF expression, amplifies platelet activation and upregulates endothelial expression of proinflammatory cytokines, including IL (interleukin)-1, IL-6, IL-8, and MCP (monocyte chemoattractant protein)-1.
T58 1876-2078 Sentence denotes These mechanisms result in excess thrombin generation, which potentiates the activation of platelets, leukocytes, and endothelium via PARs (protease-activated receptors) and culminates in a fibrin clot.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
440 175-179 Gene denotes CD39 Gene:953
441 260-264 Gene denotes TFPI Gene:7035
442 266-297 Gene denotes tissue factor pathway inhibitor Gene:7035
443 325-339 Gene denotes thrombomodulin Gene:7056
444 433-436 Gene denotes VWF Gene:7450
445 438-459 Gene denotes von Willebrand factor Gene:7450
446 498-532 Gene denotes intercellular adhesion molecule)-1 Gene:3383
447 540-550 Gene denotes P-selectin Gene:6403
448 555-565 Gene denotes E-selectin Gene:6401
449 658-663 Gene denotes CXCL1 Gene:2919
450 665-687 Gene denotes PF (platelet factor)-4 Gene:5196
451 689-694 Gene denotes CXCL5 Gene:6374
452 696-701 Gene denotes CXCL7 Gene:5473
453 703-707 Gene denotes CCL3 Gene:6348
454 709-715 Gene denotes RANTES Gene:6352
455 785-789 Gene denotes CCL7 Gene:6354
456 917-927 Gene denotes P-selectin Gene:6403
457 1044-1049 Gene denotes Mac-1 Gene:3684
458 1084-1089 Gene denotes GPIIb Gene:3674
459 1106-1113 Gene denotes SLC44A2 Gene:57153
460 1114-1119 Gene denotes CTL-2 Gene:57153
461 1228-1232 Gene denotes HMGB Gene:6749
462 1234-1260 Gene denotes high mobility group box)-1 Gene:3146
463 1311-1324 Gene denotes tissue factor Gene:2152
464 1361-1369 Gene denotes thrombin Gene:2147
465 1674-1676 Gene denotes TF Gene:2152
466 1798-1816 Gene denotes IL (interleukin)-1 Gene:3552
467 1818-1822 Gene denotes IL-6 Gene:3569
468 1824-1828 Gene denotes IL-8 Gene:3576
469 1834-1837 Gene denotes MCP Gene:4179
470 1839-1874 Gene denotes monocyte chemoattractant protein)-1 Gene:6347
471 1910-1918 Gene denotes thrombin Gene:2147
472 1395-1397 Gene denotes TF Gene:2152
473 1326-1328 Gene denotes TF Gene:2152
474 181-193 Chemical denotes nitric oxide MESH:D009569
475 204-216 Chemical denotes prostacyclin MESH:D011464
476 1164-1177 Chemical denotes polyphosphate MESH:D011122
477 1179-1184 Chemical denotes polyP MESH:D011122
478 33-49 Disease denotes immunothrombosis
479 359-368 Disease denotes infection MESH:D007239
480 372-384 Disease denotes inflammation MESH:D007249
481 1494-1504 Disease denotes thrombosis MESH:D013927