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PMC:7386875 / 0-1313 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 780-797 Body_part denotes endothelial cells http://purl.org/sig/ont/fma/fma66772
T2 792-797 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T3 869-885 Body_part denotes endothelial cell http://purl.org/sig/ont/fma/fma66772
T4 881-885 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T5 1015-1023 Body_part denotes platelet http://purl.org/sig/ont/fma/fma62851
T6 1029-1038 Body_part denotes leukocyte http://purl.org/sig/ont/fma/fma62852
T7 1207-1211 Body_part denotes vein http://purl.org/sig/ont/fma/fma50723

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 1202-1211 Body_part denotes deep vein http://purl.obolibrary.org/obo/UBERON_0035552
T2 1207-1211 Body_part denotes vein http://purl.obolibrary.org/obo/UBERON_0001638

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 30-40 Disease denotes Thrombosis http://purl.obolibrary.org/obo/MONDO_0000831
T2 44-52 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T3 120-167 Disease denotes severe acute respiratory syndrome coronavirus 2 http://purl.obolibrary.org/obo/MONDO_0100096
T4 120-153 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T5 169-177 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T6 316-340 Disease denotes coronavirus disease 2019 http://purl.obolibrary.org/obo/MONDO_0100096
T7 342-350 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T8 445-455 Disease denotes thrombosis http://purl.obolibrary.org/obo/MONDO_0000831
T9 457-478 Disease denotes venous thromboembolic http://purl.obolibrary.org/obo/MONDO_0005399
T10 492-498 Disease denotes stroke http://purl.obolibrary.org/obo/MONDO_0005098|http://purl.obolibrary.org/obo/MONDO_0011057
T12 560-568 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T13 593-611 Disease denotes multiorgan failure http://purl.obolibrary.org/obo/MONDO_0043726
T14 724-732 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T15 759-767 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T16 921-929 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T17 957-969 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T18 1212-1222 Disease denotes thrombosis http://purl.obolibrary.org/obo/MONDO_0000831
T19 1224-1242 Disease denotes pulmonary embolism http://purl.obolibrary.org/obo/MONDO_0005279
T20 1248-1254 Disease denotes stroke http://purl.obolibrary.org/obo/MONDO_0005098|http://purl.obolibrary.org/obo/MONDO_0011057

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 213-216 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T2 227-228 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T3 295-298 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T4 371-372 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T5 780-797 http://purl.obolibrary.org/obo/CL_0000115 denotes endothelial cells
T6 869-885 http://purl.obolibrary.org/obo/CL_0000115 denotes endothelial cell
T7 982-992 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T8 1207-1211 http://purl.obolibrary.org/obo/UBERON_0001638 denotes vein
T9 1207-1211 http://www.ebi.ac.uk/efo/EFO_0000816 denotes vein
T10 1273-1283 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 809-820 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 464-486 Phenotype denotes thromboembolic disease http://purl.obolibrary.org/obo/HP_0001907
T2 492-498 Phenotype denotes stroke http://purl.obolibrary.org/obo/HP_0001297
T3 1202-1222 Phenotype denotes deep vein thrombosis http://purl.obolibrary.org/obo/HP_0002625
T4 1224-1242 Phenotype denotes pulmonary embolism http://purl.obolibrary.org/obo/HP_0002204
T5 1248-1254 Phenotype denotes stroke http://purl.obolibrary.org/obo/HP_0001297

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 957-969 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T2 971-992 http://purl.obolibrary.org/obo/GO_0006956 denotes complement activation
T3 1085-1110 http://purl.obolibrary.org/obo/GO_0002250 denotes adaptive immune responses
T4 1273-1298 http://purl.obolibrary.org/obo/GO_0050820 denotes activation of coagulation
T5 1287-1298 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T1 0-85 Sentence denotes The Emerging Threat of (Micro)Thrombosis in COVID-19 and Its Therapeutic Implications
T2 87-95 Sentence denotes Abstract
T3 96-273 Sentence denotes The recent emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the ensuing global pandemic has presented a health emergency of unprecedented magnitude.
T4 274-499 Sentence denotes Recent clinical data has highlighted that coronavirus disease 2019 (COVID-19) is associated with a significant risk of thrombotic complications ranging from microvascular thrombosis, venous thromboembolic disease, and stroke.
T5 500-636 Sentence denotes Importantly, thrombotic complications are markers of severe COVID-19 and are associated with multiorgan failure and increased mortality.
T6 637-894 Sentence denotes The evidence to date supports the concept that the thrombotic manifestations of severe COVID-19 are due to the ability of SARS-CoV-2 to invade endothelial cells via ACE-2 (angiotensin-converting enzyme 2), which is expressed on the endothelial cell surface.
T7 895-1255 Sentence denotes However, in patients with COVID-19 the subsequent endothelial inflammation, complement activation, thrombin generation, platelet, and leukocyte recruitment, and the initiation of innate and adaptive immune responses culminate in immunothrombosis, ultimately causing (micro)thrombotic complications, such as deep vein thrombosis, pulmonary embolism, and stroke.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
2 30-40 Disease denotes Thrombosis MESH:D013927
3 44-52 Disease denotes COVID-19 MESH:C000657245
48 802-807 Gene denotes ACE-2 Gene:59272
49 809-840 Gene denotes angiotensin-converting enzyme 2 Gene:59272
50 994-1002 Gene denotes thrombin Gene:2147
51 120-167 Species denotes severe acute respiratory syndrome coronavirus 2 Tax:2697049
52 169-179 Species denotes SARS-CoV-2 Tax:2697049
53 759-769 Species denotes SARS-CoV-2 Tax:2697049
54 907-915 Species denotes patients Tax:9606
60 316-340 Disease denotes coronavirus disease 2019 MESH:C000657245
61 342-350 Disease denotes COVID-19 MESH:C000657245
62 393-417 Disease denotes thrombotic complications MESH:D013927
63 445-455 Disease denotes thrombosis MESH:D013927
64 457-486 Disease denotes venous thromboembolic disease MESH:D054556
65 492-498 Disease denotes stroke MESH:D020521
66 513-537 Disease denotes thrombotic complications MESH:D013927
67 560-568 Disease denotes COVID-19 MESH:C000657245
68 593-611 Disease denotes multiorgan failure MESH:D009102
69 626-635 Disease denotes mortality MESH:D003643
70 688-698 Disease denotes thrombotic MESH:D013927
71 724-732 Disease denotes COVID-19 MESH:C000657245
72 921-929 Disease denotes COVID-19 MESH:C000657245
73 957-969 Disease denotes inflammation MESH:D007249
74 1124-1140 Disease denotes immunothrombosis
75 1168-1192 Disease denotes thrombotic complications MESH:D013927
76 1202-1222 Disease denotes deep vein thrombosis MESH:D020246
77 1224-1242 Disease denotes pulmonary embolism MESH:D011655
78 1248-1254 Disease denotes stroke MESH:D020521