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PMC:7381711 / 2953-4886 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T16 0-7 Body_part denotes HEPARIN http://purl.org/sig/ont/fma/fma82839
T17 31-38 Body_part denotes Heparin http://purl.org/sig/ont/fma/fma82839
T18 102-117 Body_part denotes heparan sulfate http://purl.org/sig/ont/fma/fma63023
T19 119-121 Body_part denotes HS http://purl.org/sig/ont/fma/fma63023
T20 123-141 Body_part denotes glycosaminoglycans http://purl.org/sig/ont/fma/fma63011
T21 164-174 Body_part denotes intestines http://purl.org/sig/ont/fma/fma7199
T22 228-230 Body_part denotes HS http://purl.org/sig/ont/fma/fma63023
T23 231-248 Body_part denotes glycosaminoglycan http://purl.org/sig/ont/fma/fma63011
T24 264-271 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T25 363-370 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T26 434-442 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T27 488-494 Body_part denotes serine http://purl.org/sig/ont/fma/fma82764
T28 688-690 Body_part denotes HS http://purl.org/sig/ont/fma/fma63023
T29 793-800 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T30 801-808 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T31 961-968 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T32 1036-1043 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T33 1045-1053 Body_part denotes Heparins http://purl.org/sig/ont/fma/fma82839
T34 1081-1096 Body_part denotes heparan sulfate http://purl.org/sig/ont/fma/fma63023
T35 1098-1100 Body_part denotes HS http://purl.org/sig/ont/fma/fma63023
T36 1102-1120 Body_part denotes glycosaminoglycans http://purl.org/sig/ont/fma/fma63011
T37 1127-1129 Body_part denotes HS http://purl.org/sig/ont/fma/fma63023
T38 1162-1174 Body_part denotes disaccharide http://purl.org/sig/ont/fma/fma82744
T39 1184-1203 Body_part denotes N-acetylglucosamine http://purl.org/sig/ont/fma/fma82787
T40 1217-1232 Body_part denotes glucuronic acid http://purl.org/sig/ont/fma/fma82798
T41 1234-1238 Body_part denotes GlcA http://purl.org/sig/ont/fma/fma82798
T42 1370-1377 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T43 1393-1395 Body_part denotes HS http://purl.org/sig/ont/fma/fma63023
T44 1468-1475 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T45 1488-1490 Body_part denotes HS http://purl.org/sig/ont/fma/fma63023
T46 1557-1564 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T47 1662-1669 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T48 1673-1679 Body_part denotes serine http://purl.org/sig/ont/fma/fma82764
T49 1819-1826 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T50 1924-1932 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 164-174 Body_part denotes intestines http://purl.obolibrary.org/obo/UBERON_0000160

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
83 0-7 Chemical denotes HEPARIN MESH:D006493
97 532-535 Gene denotes AT3 Gene:462
98 714-717 Gene denotes AT3 Gene:462
99 753-756 Gene denotes AT3 Gene:462
100 514-530 Gene denotes antithrombin-III Gene:462
101 31-38 Chemical denotes Heparin MESH:D006493
102 102-141 Chemical denotes heparan sulfate (HS) glycosaminoglycans
103 228-248 Chemical denotes HS glycosaminoglycan
104 264-271 Chemical denotes heparin MESH:D006493
105 363-370 Chemical denotes heparin MESH:D006493
106 488-494 Chemical denotes serine MESH:D012694
107 649-664 Chemical denotes pentasaccharide
108 793-800 Chemical denotes heparin MESH:D006493
109 961-968 Chemical denotes heparin MESH:D006493
131 1699-1715 Gene denotes antithrombin-III Gene:462
132 1717-1720 Gene denotes AT3 Gene:462
133 1036-1043 Chemical denotes heparin MESH:D006493
134 1045-1053 Chemical denotes Heparins MESH:D006493
135 1081-1096 Chemical denotes heparan sulfate MESH:D006497
136 1098-1120 Chemical denotes HS) glycosaminoglycans
137 1162-1174 Chemical denotes disaccharide MESH:D004187
138 1184-1203 Chemical denotes N-acetylglucosamine MESH:D000117
139 1205-1211 Chemical denotes GlcNAc MESH:D000117
140 1217-1232 Chemical denotes glucuronic acid MESH:D020723
141 1234-1238 Chemical denotes GlcA MESH:D020723
142 1243-1256 Chemical denotes iduronic acid MESH:D007067
143 1258-1262 Chemical denotes IdoA MESH:D007067
144 1265-1271 Chemical denotes GlcNAc MESH:D000117
145 1370-1377 Chemical denotes heparin MESH:D006493
146 1447-1475 Chemical denotes low-molecular weight heparin MESH:D006495
147 1557-1564 Chemical denotes heparin MESH:D006493
148 1605-1620 Chemical denotes pentasaccharide
149 1662-1669 Chemical denotes heparin MESH:D006493
150 1673-1679 Chemical denotes serine MESH:D012694
151 1819-1826 Chemical denotes heparin MESH:D006493

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T32 1319-1321 Disease denotes NS http://purl.obolibrary.org/obo/MONDO_0009735

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T8 42-43 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T9 164-174 http://purl.obolibrary.org/obo/UBERON_0000160 denotes intestines
T10 164-174 http://www.ebi.ac.uk/efo/EFO_0000834 denotes intestines
T11 569-577 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T12 598-606 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T13 639-640 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T14 849-852 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T15 1058-1059 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T16 1502-1504 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T17 1890-1898 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T21 31-38 Chemical denotes Heparin http://purl.obolibrary.org/obo/CHEBI_28304
T22 102-117 Chemical denotes heparan sulfate http://purl.obolibrary.org/obo/CHEBI_28815
T23 102-109 Chemical denotes heparan http://purl.obolibrary.org/obo/CHEBI_24500
T24 110-117 Chemical denotes sulfate http://purl.obolibrary.org/obo/CHEBI_16189
T25 119-121 Chemical denotes HS http://purl.obolibrary.org/obo/CHEBI_74056|http://purl.obolibrary.org/obo/CHEBI_28815
T27 123-141 Chemical denotes glycosaminoglycans http://purl.obolibrary.org/obo/CHEBI_18085
T28 228-230 Chemical denotes HS http://purl.obolibrary.org/obo/CHEBI_74056|http://purl.obolibrary.org/obo/CHEBI_28815
T30 231-248 Chemical denotes glycosaminoglycan http://purl.obolibrary.org/obo/CHEBI_18085
T31 264-271 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T32 363-370 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T33 434-442 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T34 488-513 Chemical denotes serine protease inhibitor http://purl.obolibrary.org/obo/CHEBI_64926
T35 488-494 Chemical denotes serine http://purl.obolibrary.org/obo/CHEBI_17822
T36 495-513 Chemical denotes protease inhibitor http://purl.obolibrary.org/obo/CHEBI_37670|http://purl.obolibrary.org/obo/CHEBI_60258
T38 504-513 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T39 555-568 Chemical denotes anticoagulant http://purl.obolibrary.org/obo/CHEBI_50249
T40 584-597 Chemical denotes anticoagulant http://purl.obolibrary.org/obo/CHEBI_50249
T41 649-664 Chemical denotes pentasaccharide http://purl.obolibrary.org/obo/CHEBI_35369
T42 688-690 Chemical denotes HS http://purl.obolibrary.org/obo/CHEBI_74056|http://purl.obolibrary.org/obo/CHEBI_28815
T44 793-800 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T45 801-808 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T46 961-968 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T47 1036-1043 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T48 1081-1096 Chemical denotes heparan sulfate http://purl.obolibrary.org/obo/CHEBI_28815
T49 1081-1088 Chemical denotes heparan http://purl.obolibrary.org/obo/CHEBI_24500
T50 1089-1096 Chemical denotes sulfate http://purl.obolibrary.org/obo/CHEBI_16189
T51 1098-1100 Chemical denotes HS http://purl.obolibrary.org/obo/CHEBI_74056|http://purl.obolibrary.org/obo/CHEBI_28815
T53 1102-1120 Chemical denotes glycosaminoglycans http://purl.obolibrary.org/obo/CHEBI_18085
T54 1127-1129 Chemical denotes HS http://purl.obolibrary.org/obo/CHEBI_74056|http://purl.obolibrary.org/obo/CHEBI_28815
T56 1162-1174 Chemical denotes disaccharide http://purl.obolibrary.org/obo/CHEBI_36233
T57 1184-1203 Chemical denotes N-acetylglucosamine http://purl.obolibrary.org/obo/CHEBI_28009|http://purl.obolibrary.org/obo/CHEBI_59640
T59 1205-1211 Chemical denotes GlcNAc http://purl.obolibrary.org/obo/CHEBI_506227|http://purl.obolibrary.org/obo/CHEBI_73685
T61 1217-1232 Chemical denotes glucuronic acid http://purl.obolibrary.org/obo/CHEBI_24298
T62 1228-1232 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T63 1234-1238 Chemical denotes GlcA http://purl.obolibrary.org/obo/CHEBI_24298
T64 1243-1256 Chemical denotes iduronic acid http://purl.obolibrary.org/obo/CHEBI_24769
T65 1252-1256 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T66 1258-1262 Chemical denotes IdoA http://purl.obolibrary.org/obo/CHEBI_24769
T67 1265-1271 Chemical denotes GlcNAc http://purl.obolibrary.org/obo/CHEBI_506227|http://purl.obolibrary.org/obo/CHEBI_73685
T69 1319-1321 Chemical denotes NS http://purl.obolibrary.org/obo/CHEBI_73426
T70 1336-1340 Chemical denotes IdoA http://purl.obolibrary.org/obo/CHEBI_24769
T71 1370-1377 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T72 1393-1395 Chemical denotes HS http://purl.obolibrary.org/obo/CHEBI_74056|http://purl.obolibrary.org/obo/CHEBI_28815
T74 1416-1427 Chemical denotes saccharides http://purl.obolibrary.org/obo/CHEBI_16646
T75 1468-1475 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T76 1488-1490 Chemical denotes HS http://purl.obolibrary.org/obo/CHEBI_74056|http://purl.obolibrary.org/obo/CHEBI_28815
T78 1505-1516 Chemical denotes saccharides http://purl.obolibrary.org/obo/CHEBI_16646
T79 1557-1564 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T80 1605-1620 Chemical denotes pentasaccharide http://purl.obolibrary.org/obo/CHEBI_35369
T81 1662-1669 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T82 1673-1698 Chemical denotes serine protease inhibitor http://purl.obolibrary.org/obo/CHEBI_64926
T83 1673-1679 Chemical denotes serine http://purl.obolibrary.org/obo/CHEBI_17822
T84 1680-1698 Chemical denotes protease inhibitor http://purl.obolibrary.org/obo/CHEBI_37670|http://purl.obolibrary.org/obo/CHEBI_60258
T86 1689-1698 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T87 1746-1759 Chemical denotes anticoagulant http://purl.obolibrary.org/obo/CHEBI_50249
T88 1819-1826 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T89 1924-1932 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 555-577 http://purl.obolibrary.org/obo/GO_0050819 denotes anticoagulant activity
T2 584-606 http://purl.obolibrary.org/obo/GO_0050819 denotes anticoagulant activity
T3 1234-1238 http://purl.obolibrary.org/obo/GO_0043879 denotes GlcA
T4 1786-1795 http://purl.obolibrary.org/obo/GO_0051923 denotes sulfation

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T21 0-30 Sentence denotes HEPARIN STRUCTURE AND FUNCTION
T22 31-188 Sentence denotes Heparin is a heterogeneous preparation of long, linear highly sulfated heparan sulfate (HS) glycosaminoglycans purified from porcine intestines (see Fig. 1).
T23 189-343 Sentence denotes The sulfated nature of its constituent HS glycosaminoglycan chains confers heparin with the highest negative charge density of any known biomolecule (43).
T24 344-578 Sentence denotes This charge allows heparin to strongly and selectively interact with an immense number of proteins, the most classic being its interaction with serine protease inhibitor antithrombin-III (AT3) that provides its anticoagulant activity.
T25 579-745 Sentence denotes This anticoagulant activity is dependent on the presence of a precise pentasaccharide sequence within longer HS chains that allows for AT3 binding as shown in Fig. 1.
T26 746-1000 Sentence denotes Beyond AT3, hundreds of biologically relevant, heparin-protein interactions have been described, which has led to the recognition of an immense number of potential off-target (both positive and negative) effects of heparin of unknown clinical importance.
T27 1001-1008 Sentence denotes Fig. 1.
T28 1010-1044 Sentence denotes Structure and function of heparin.
T29 1045-1121 Sentence denotes Heparins are a heterogeneous mix of heparan sulfate (HS) glycosaminoglycans.
T30 1122-1264 Sentence denotes Each HS strand is composed of repeating disaccharide units of N-acetylglucosamine (GlcNAc) and glucuronic acid (GlcA) or iduronic acid (IdoA).
T31 1265-1354 Sentence denotes GlcNAc can be sulfated at three distinct sites (-6S, -NS, and -3S) and IdoA at one (-2S).
T32 1355-1529 Sentence denotes Unfractionated heparin is composed of HS chains that are >30 saccharides in length, whereas low-molecular weight heparin constituent HS chains are 22 saccharides or less (3).
T33 1530-1767 Sentence denotes The charge distribution of heparin imparted by the presence of the precise pentasaccharide sequence shown allows for the binding of heparin to serine protease inhibitor antithrombin-III (AT3), conferring its primary anticoagulant effect.
T34 1768-1933 Sentence denotes Innumerable other sulfation sequences are found in heparin preparations, which leads to binding and biologically relevant activity modulation of many other proteins.

LitCovid-PD-GlycoEpitope

Id Subject Object Predicate Lexical cue glyco_epitope_db_id
T1 102-117 GlycoEpitope denotes heparan sulfate http://www.glycoepitope.jp/epitopes/EP0086
T2 119-121 GlycoEpitope denotes HS http://www.glycoepitope.jp/epitopes/EP0086
T3 228-230 GlycoEpitope denotes HS http://www.glycoepitope.jp/epitopes/EP0086
T4 688-690 GlycoEpitope denotes HS http://www.glycoepitope.jp/epitopes/EP0086
T5 1081-1096 GlycoEpitope denotes heparan sulfate http://www.glycoepitope.jp/epitopes/EP0086
T6 1098-1100 GlycoEpitope denotes HS http://www.glycoepitope.jp/epitopes/EP0086
T7 1127-1129 GlycoEpitope denotes HS http://www.glycoepitope.jp/epitopes/EP0086
T8 1393-1395 GlycoEpitope denotes HS http://www.glycoepitope.jp/epitopes/EP0086
T9 1488-1490 GlycoEpitope denotes HS http://www.glycoepitope.jp/epitopes/EP0086

2_test

Id Subject Object Predicate Lexical cue
32519894-28653068-2138150 339-341 28653068 denotes 43
32519894-26947929-2138151 1526-1527 26947929 denotes 3