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PMC:7381711 / 19931-21053 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T174 53-60 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T175 104-113 Body_part denotes Heparin’s http://purl.org/sig/ont/fma/fma82839
T176 423-439 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T177 434-439 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T178 492-504 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T179 492-496 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T180 505-520 Body_part denotes heparan sulfate http://purl.org/sig/ont/fma/fma63023
T181 528-535 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T182 569-576 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T183 650-657 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T184 856-863 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T185 867-869 Body_part denotes HS http://purl.org/sig/ont/fma/fma63023
T186 871-886 Body_part denotes heparan sulfate http://purl.org/sig/ont/fma/fma63023
T187 888-890 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T188 892-903 Body_part denotes interleukin http://purl.org/sig/ont/fma/fma86578
T189 951-957 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T190 972-978 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T191 1038-1044 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T21 951-957 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T22 972-978 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T23 1038-1044 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
708 181-197 Gene denotes antithrombin-III Gene:462
709 199-202 Gene denotes AT3 Gene:462
710 802-806 Gene denotes ACE2 Gene:59272
711 808-839 Gene denotes angiotensin-converting enzyme 2 Gene:59272
712 841-844 Gene denotes APC Gene:324
713 905-910 Gene denotes PAI-1 Gene:5054
714 912-945 Gene denotes plasminogen activator inhibitor 1 Gene:5054
715 966-970 Gene denotes TFPI Gene:7035
716 972-1003 Gene denotes tissue factor pathway inhibitor Gene:7035
717 1005-1008 Gene denotes TNF Gene:7124
718 1068-1071 Gene denotes uPA Gene:5328
719 951-964 Gene denotes tissue factor Gene:2152
720 1038-1066 Gene denotes tissue plasminogen activator Gene:100128998
721 330-377 Species denotes Severe acute respiratory syndrome coronavirus 2 Tax:2697049
722 379-389 Species denotes SARS-CoV-2 Tax:2697049
723 53-60 Chemical denotes heparin MESH:D006493
724 104-111 Chemical denotes Heparin MESH:D006493
725 505-520 Chemical denotes heparan sulfate MESH:D006497
726 528-535 Chemical denotes heparin MESH:D006493
727 569-576 Chemical denotes heparin MESH:D006493
728 650-657 Chemical denotes heparin MESH:D006493
729 871-886 Chemical denotes heparan sulfate MESH:D006497
730 64-88 Disease denotes coronavirus disease 2019 MESH:C000657245
731 90-98 Disease denotes COVID-19 MESH:C000657245
732 260-272 Disease denotes coagulopathy MESH:D001778
733 300-310 Disease denotes thrombosis MESH:D013927
734 721-729 Disease denotes COVID-19 MESH:C000657245
735 1010-1024 Disease denotes tumor necrosis MESH:D009336

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T166 64-88 Disease denotes coronavirus disease 2019 http://purl.obolibrary.org/obo/MONDO_0100096
T167 90-98 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T168 260-272 Disease denotes coagulopathy http://purl.obolibrary.org/obo/MONDO_0001531
T169 300-310 Disease denotes thrombosis http://purl.obolibrary.org/obo/MONDO_0000831
T170 330-377 Disease denotes Severe acute respiratory syndrome coronavirus 2 http://purl.obolibrary.org/obo/MONDO_0100096
T171 379-387 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T172 379-383 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T173 721-729 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T174 1010-1015 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T175 1068-1071 Disease denotes uPA http://purl.obolibrary.org/obo/MONDO_0004041

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T142 423-433 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T143 434-439 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T144 492-496 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T145 658-661 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T146 846-855 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T147 912-923 http://purl.obolibrary.org/obo/PR_000012867 denotes plasminogen
T148 924-933 http://purl.obolibrary.org/obo/CLO_0001658 denotes activator
T149 1033-1036 http://purl.obolibrary.org/obo/CLO_0053275 denotes tPA
T150 1033-1036 http://purl.obolibrary.org/obo/CLO_0053276 denotes tPA
T151 1033-1036 http://purl.obolibrary.org/obo/CLO_0053277 denotes tPA
T152 1045-1056 http://purl.obolibrary.org/obo/PR_000012867 denotes plasminogen
T153 1057-1066 http://purl.obolibrary.org/obo/CLO_0001658 denotes activator
T154 1083-1094 http://purl.obolibrary.org/obo/PR_000012867 denotes plasminogen
T155 1095-1104 http://purl.obolibrary.org/obo/CLO_0001658 denotes activator

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T221 53-60 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T222 137-150 Chemical denotes anticoagulant http://purl.obolibrary.org/obo/CHEBI_50249
T223 505-520 Chemical denotes heparan sulfate http://purl.obolibrary.org/obo/CHEBI_28815
T224 505-512 Chemical denotes heparan http://purl.obolibrary.org/obo/CHEBI_24500
T225 513-520 Chemical denotes sulfate http://purl.obolibrary.org/obo/CHEBI_16189
T226 528-535 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T227 569-576 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T228 582-587 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T229 650-657 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T230 808-819 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T231 841-844 Chemical denotes APC http://purl.obolibrary.org/obo/CHEBI_80551
T232 856-863 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T233 867-869 Chemical denotes HS http://purl.obolibrary.org/obo/CHEBI_74056|http://purl.obolibrary.org/obo/CHEBI_28815
T235 871-886 Chemical denotes heparan sulfate http://purl.obolibrary.org/obo/CHEBI_28815
T236 871-878 Chemical denotes heparan http://purl.obolibrary.org/obo/CHEBI_24500
T237 879-886 Chemical denotes sulfate http://purl.obolibrary.org/obo/CHEBI_16189
T238 888-890 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T240 934-943 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T241 947-949 Chemical denotes TF http://purl.obolibrary.org/obo/CHEBI_74862
T242 986-1003 Chemical denotes pathway inhibitor http://purl.obolibrary.org/obo/CHEBI_76932
T243 994-1003 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T41 912-933 http://purl.obolibrary.org/obo/GO_0031639 denotes plasminogen activator
T42 1016-1024 http://purl.obolibrary.org/obo/GO_0070265 denotes necrosis
T43 1016-1024 http://purl.obolibrary.org/obo/GO_0019835 denotes necrosis
T44 1016-1024 http://purl.obolibrary.org/obo/GO_0008219 denotes necrosis
T45 1016-1024 http://purl.obolibrary.org/obo/GO_0001906 denotes necrosis
T46 1045-1066 http://purl.obolibrary.org/obo/GO_0031639 denotes plasminogen activator
T47 1083-1104 http://purl.obolibrary.org/obo/GO_0031639 denotes plasminogen activator

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T120 0-7 Sentence denotes Fig. 3.
T121 9-100 Sentence denotes Summary of potential therapeutic effects of heparin in coronavirus disease 2019 (COVID-19).
T122 101-326 Sentence denotes 1) Heparin’s classic function as an anticoagulant, through its interaction with antithrombin-III (AT3), may prove beneficial because of the high prevalence of coagulopathy and clinically significant thrombosis in the disease.
T123 327-640 Sentence denotes 2) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) entry into both endothelial and epithelial cells is believed to be dependent on its interaction with cell surface heparan sulfate; thus, heparin (or carefully designed synthetic heparin-like drugs) may inhibit this interaction and block viral entry.
T124 641-730 Sentence denotes 3) Last, heparin has known anti-inflammatory effects that may confer benefit in COVID-19.
T125 731-801 Sentence denotes This illustration was created with BioRender (https://biorender.com/).
T126 802-1122 Sentence denotes ACE2, angiotensin-converting enzyme 2; APC, activated protein C; HS, heparan sulfate; IL, interleukin; PAI-1, plasminogen activator inhibitor 1; TF, tissue factor; TFPI, tissue factor pathway inhibitor; TNF, tumor necrosis factor; tPA, tissue plasminogen activator; uPA, urokinase plasminogen activator, VII, factor VII.

LitCovid-PD-GlycoEpitope

Id Subject Object Predicate Lexical cue glyco_epitope_db_id
T16 505-520 GlycoEpitope denotes heparan sulfate http://www.glycoepitope.jp/epitopes/EP0086
T17 867-869 GlycoEpitope denotes HS http://www.glycoepitope.jp/epitopes/EP0086
T18 871-886 GlycoEpitope denotes heparan sulfate http://www.glycoepitope.jp/epitopes/EP0086

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T45 260-272 Phenotype denotes coagulopathy http://purl.obolibrary.org/obo/HP_0003256
T46 1010-1015 Phenotype denotes tumor http://purl.obolibrary.org/obo/HP_0002664