PMC:7376974 / 90208-90931 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T430","span":{"begin":171,"end":178},"obj":"Body_part"},{"id":"T431","span":{"begin":684,"end":692},"obj":"Body_part"},{"id":"T432","span":{"begin":709,"end":715},"obj":"Body_part"}],"attributes":[{"id":"A430","pred":"fma_id","subj":"T430","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A431","pred":"fma_id","subj":"T431","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A432","pred":"fma_id","subj":"T432","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"ommonly expressed in different types of influenza viruses with a high rate of conservation but with low antigenicity. It has been shown that AuNPs functionalized with M2e protein have a high immunization capacity in comparison to the antigen alone. Mice immunized with AuNPs (two intranasal injections), and then challenged, showed a survival rate higher than 90% to California-H1N1pdm, Victoria-H3N2, and Vietnam-H5N1 infections.149 This strategy shows that HNMs can be used to boost the immune response of low immunogenic molecules, providing a wide spectrum vaccination potential. Unfortunately, it has not been determined if the budding process in SARS-Cov-2 is mediated by viral proteins or via the host cell’s endosom"}

{"project":"LitCovid-PubTator","denotations":[{"id":"1624","span":{"begin":40,"end":57},"obj":"Species"},{"id":"1625","span":{"begin":249,"end":253},"obj":"Species"},{"id":"1626","span":{"begin":378,"end":382},"obj":"Species"},{"id":"1627","span":{"begin":652,"end":662},"obj":"Species"},{"id":"1631","span":{"begin":419,"end":429},"obj":"Disease"}],"attributes":[{"id":"A1624","pred":"tao:has_database_id","subj":"1624","obj":"Tax:11308"},{"id":"A1625","pred":"tao:has_database_id","subj":"1625","obj":"Tax:10090"},{"id":"A1626","pred":"tao:has_database_id","subj":"1626","obj":"Tax:114727"},{"id":"A1627","pred":"tao:has_database_id","subj":"1627","obj":"Tax:2697049"},{"id":"A1631","pred":"tao:has_database_id","subj":"1631","obj":"MESH:D007239"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"ommonly expressed in different types of influenza viruses with a high rate of conservation but with low antigenicity. It has been shown that AuNPs functionalized with M2e protein have a high immunization capacity in comparison to the antigen alone. Mice immunized with AuNPs (two intranasal injections), and then challenged, showed a survival rate higher than 90% to California-H1N1pdm, Victoria-H3N2, and Vietnam-H5N1 infections.149 This strategy shows that HNMs can be used to boost the immune response of low immunogenic molecules, providing a wide spectrum vaccination potential. Unfortunately, it has not been determined if the budding process in SARS-Cov-2 is mediated by viral proteins or via the host cell’s endosom"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T251","span":{"begin":40,"end":49},"obj":"Disease"},{"id":"T252","span":{"begin":419,"end":429},"obj":"Disease"},{"id":"T253","span":{"begin":652,"end":656},"obj":"Disease"}],"attributes":[{"id":"A251","pred":"mondo_id","subj":"T251","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"},{"id":"A252","pred":"mondo_id","subj":"T252","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A253","pred":"mondo_id","subj":"T253","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"ommonly expressed in different types of influenza viruses with a high rate of conservation but with low antigenicity. It has been shown that AuNPs functionalized with M2e protein have a high immunization capacity in comparison to the antigen alone. Mice immunized with AuNPs (two intranasal injections), and then challenged, showed a survival rate higher than 90% to California-H1N1pdm, Victoria-H3N2, and Vietnam-H5N1 infections.149 This strategy shows that HNMs can be used to boost the immune response of low immunogenic molecules, providing a wide spectrum vaccination potential. Unfortunately, it has not been determined if the budding process in SARS-Cov-2 is mediated by viral proteins or via the host cell’s endosom"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T831","span":{"begin":50,"end":57},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T832","span":{"begin":63,"end":64},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T833","span":{"begin":121,"end":124},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T834","span":{"begin":184,"end":185},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T835","span":{"begin":332,"end":333},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T836","span":{"begin":545,"end":546},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T837","span":{"begin":602,"end":605},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T838","span":{"begin":709,"end":715},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"ommonly expressed in different types of influenza viruses with a high rate of conservation but with low antigenicity. It has been shown that AuNPs functionalized with M2e protein have a high immunization capacity in comparison to the antigen alone. Mice immunized with AuNPs (two intranasal injections), and then challenged, showed a survival rate higher than 90% to California-H1N1pdm, Victoria-H3N2, and Vietnam-H5N1 infections.149 This strategy shows that HNMs can be used to boost the immune response of low immunogenic molecules, providing a wide spectrum vaccination potential. Unfortunately, it has not been determined if the budding process in SARS-Cov-2 is mediated by viral proteins or via the host cell’s endosom"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T79982","span":{"begin":171,"end":178},"obj":"Chemical"},{"id":"T1331","span":{"begin":234,"end":241},"obj":"Chemical"},{"id":"T88129","span":{"begin":524,"end":533},"obj":"Chemical"},{"id":"T82544","span":{"begin":684,"end":692},"obj":"Chemical"}],"attributes":[{"id":"A63782","pred":"chebi_id","subj":"T79982","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A91481","pred":"chebi_id","subj":"T1331","obj":"http://purl.obolibrary.org/obo/CHEBI_59132"},{"id":"A41801","pred":"chebi_id","subj":"T88129","obj":"http://purl.obolibrary.org/obo/CHEBI_25367"},{"id":"A7636","pred":"chebi_id","subj":"T82544","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"}],"text":"ommonly expressed in different types of influenza viruses with a high rate of conservation but with low antigenicity. It has been shown that AuNPs functionalized with M2e protein have a high immunization capacity in comparison to the antigen alone. Mice immunized with AuNPs (two intranasal injections), and then challenged, showed a survival rate higher than 90% to California-H1N1pdm, Victoria-H3N2, and Vietnam-H5N1 infections.149 This strategy shows that HNMs can be used to boost the immune response of low immunogenic molecules, providing a wide spectrum vaccination potential. Unfortunately, it has not been determined if the budding process in SARS-Cov-2 is mediated by viral proteins or via the host cell’s endosom"}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T211","span":{"begin":489,"end":504},"obj":"http://purl.obolibrary.org/obo/GO_0006955"},{"id":"T212","span":{"begin":633,"end":640},"obj":"http://purl.obolibrary.org/obo/GO_0007114"}],"text":"ommonly expressed in different types of influenza viruses with a high rate of conservation but with low antigenicity. It has been shown that AuNPs functionalized with M2e protein have a high immunization capacity in comparison to the antigen alone. Mice immunized with AuNPs (two intranasal injections), and then challenged, showed a survival rate higher than 90% to California-H1N1pdm, Victoria-H3N2, and Vietnam-H5N1 infections.149 This strategy shows that HNMs can be used to boost the immune response of low immunogenic molecules, providing a wide spectrum vaccination potential. Unfortunately, it has not been determined if the budding process in SARS-Cov-2 is mediated by viral proteins or via the host cell’s endosom"}

{"project":"LitCovid-sentences","denotations":[{"id":"T547","span":{"begin":118,"end":248},"obj":"Sentence"},{"id":"T548","span":{"begin":249,"end":583},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"ommonly expressed in different types of influenza viruses with a high rate of conservation but with low antigenicity. It has been shown that AuNPs functionalized with M2e protein have a high immunization capacity in comparison to the antigen alone. Mice immunized with AuNPs (two intranasal injections), and then challenged, showed a survival rate higher than 90% to California-H1N1pdm, Victoria-H3N2, and Vietnam-H5N1 infections.149 This strategy shows that HNMs can be used to boost the immune response of low immunogenic molecules, providing a wide spectrum vaccination potential. Unfortunately, it has not been determined if the budding process in SARS-Cov-2 is mediated by viral proteins or via the host cell’s endosom"}

{"project":"2_test","denotations":[{"id":"32667191-28161578-153404","span":{"begin":430,"end":433},"obj":"28161578"}],"text":"ommonly expressed in different types of influenza viruses with a high rate of conservation but with low antigenicity. It has been shown that AuNPs functionalized with M2e protein have a high immunization capacity in comparison to the antigen alone. Mice immunized with AuNPs (two intranasal injections), and then challenged, showed a survival rate higher than 90% to California-H1N1pdm, Victoria-H3N2, and Vietnam-H5N1 infections.149 This strategy shows that HNMs can be used to boost the immune response of low immunogenic molecules, providing a wide spectrum vaccination potential. Unfortunately, it has not been determined if the budding process in SARS-Cov-2 is mediated by viral proteins or via the host cell’s endosom"}