PMC:7376974 / 88471-91024 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7376974","sourcedb":"PMC","sourceid":"7376974","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7376974","text":"Other HNMs including AuNPs (two subcutaneous injections in guinea pigs) and nanodiamonds (three subcutaneous injections in Balb/C mice) were explored as carriers of viral proteins for immunization of swine transmissible gastroenteritis virus and H7N9 influenza, respectively, with good preliminary results.146,147 In these cases, the vaccine formulation relies on the adsorption of the viral antigen onto the surface of the nanoparticles. However, an effective vaccination depends on several factors. First of all, the size of the NPs plays a key role on the immune system. For instance, size-dependent vaccination efficacy has been reported in mice immunization against the foot-and-mouth disease virus (intraperitoneal and subcutaneous injection, every 7 days for 7 weeks) using AuNPs as antigen carriers. In this study, the most effective activity to stimulate the immune system was exerted by particles with a diameter in the range of 8 nm.148 Both smaller or bigger particles evidenced a drop-off of the immunization effect. This aspect cannot be ascribed to the antigen concentration, but must be associated only to the nanoparticle size; however, the mechanism of interaction remains unknown. The selected antigen plays also a crucial role in the preparation of wide spectrum vaccines. For instance, in the case of influenza, two major membrane glycoproteins, hemagglutinin and neuraminidase, are generally used as antigens. However, the antibodies produced by this vaccination strategy are selective to the dominant epitope which has a low effectiveness or is totally ineffective against other epitopes or other kinds of influenza viruses. M2 (a viral protein responsible for the budding and scission of the influenza virus) is commonly expressed in different types of influenza viruses with a high rate of conservation but with low antigenicity. It has been shown that AuNPs functionalized with M2e protein have a high immunization capacity in comparison to the antigen alone. Mice immunized with AuNPs (two intranasal injections), and then challenged, showed a survival rate higher than 90% to California-H1N1pdm, Victoria-H3N2, and Vietnam-H5N1 infections.149 This strategy shows that HNMs can be used to boost the immune response of low immunogenic molecules, providing a wide spectrum vaccination potential. Unfortunately, it has not been determined if the budding process in SARS-Cov-2 is mediated by viral proteins or via the host cell’s endosomal sorting complex, thus more research on the SARS-Cov-2 viral machinery is highly desirable.","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T423","span":{"begin":171,"end":179},"obj":"Body_part"},{"id":"T424","span":{"begin":559,"end":572},"obj":"Body_part"},{"id":"T425","span":{"begin":675,"end":679},"obj":"Body_part"},{"id":"T426","span":{"begin":684,"end":689},"obj":"Body_part"},{"id":"T427","span":{"begin":868,"end":881},"obj":"Body_part"},{"id":"T428","span":{"begin":1352,"end":1365},"obj":"Body_part"},{"id":"T429","span":{"begin":1660,"end":1667},"obj":"Body_part"},{"id":"T430","span":{"begin":1908,"end":1915},"obj":"Body_part"},{"id":"T431","span":{"begin":2421,"end":2429},"obj":"Body_part"},{"id":"T432","span":{"begin":2446,"end":2452},"obj":"Body_part"},{"id":"T433","span":{"begin":2453,"end":2462},"obj":"Body_part"}],"attributes":[{"id":"A423","pred":"fma_id","subj":"T423","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A424","pred":"fma_id","subj":"T424","obj":"http://purl.org/sig/ont/fma/fma9825"},{"id":"A425","pred":"fma_id","subj":"T425","obj":"http://purl.org/sig/ont/fma/fma9664"},{"id":"A426","pred":"fma_id","subj":"T426","obj":"http://purl.org/sig/ont/fma/fma49184"},{"id":"A427","pred":"fma_id","subj":"T427","obj":"http://purl.org/sig/ont/fma/fma9825"},{"id":"A428","pred":"fma_id","subj":"T428","obj":"http://purl.org/sig/ont/fma/fma62925"},{"id":"A429","pred":"fma_id","subj":"T429","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A430","pred":"fma_id","subj":"T430","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A431","pred":"fma_id","subj":"T431","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A432","pred":"fma_id","subj":"T432","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A433","pred":"fma_id","subj":"T433","obj":"http://purl.org/sig/ont/fma/fma67180"},{"subj":"T423","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T424","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T425","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T426","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T427","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T428","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T429","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T430","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T431","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T432","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T433","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T34","span":{"begin":559,"end":572},"obj":"Body_part"},{"id":"T35","span":{"begin":675,"end":679},"obj":"Body_part"},{"id":"T36","span":{"begin":684,"end":689},"obj":"Body_part"},{"id":"T37","span":{"begin":868,"end":881},"obj":"Body_part"}],"attributes":[{"id":"A34","pred":"uberon_id","subj":"T34","obj":"http://purl.obolibrary.org/obo/UBERON_0002405"},{"id":"A35","pred":"uberon_id","subj":"T35","obj":"http://purl.obolibrary.org/obo/UBERON_0002387"},{"id":"A36","pred":"uberon_id","subj":"T36","obj":"http://purl.obolibrary.org/obo/UBERON_0000165"},{"id":"A37","pred":"uberon_id","subj":"T37","obj":"http://purl.obolibrary.org/obo/UBERON_0002405"},{"subj":"T34","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T35","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T36","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T37","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"1614","span":{"begin":1385,"end":1398},"obj":"Gene"},{"id":"1615","span":{"begin":59,"end":70},"obj":"Species"},{"id":"1616","span":{"begin":130,"end":134},"obj":"Species"},{"id":"1617","span":{"begin":200,"end":205},"obj":"Species"},{"id":"1618","span":{"begin":206,"end":241},"obj":"Species"},{"id":"1619","span":{"begin":246,"end":250},"obj":"Species"},{"id":"1620","span":{"begin":645,"end":649},"obj":"Species"},{"id":"1621","span":{"begin":675,"end":703},"obj":"Species"},{"id":"1622","span":{"begin":1629,"end":1646},"obj":"Species"},{"id":"1623","span":{"begin":1716,"end":1731},"obj":"Species"},{"id":"1624","span":{"begin":1777,"end":1794},"obj":"Species"},{"id":"1625","span":{"begin":1986,"end":1990},"obj":"Species"},{"id":"1626","span":{"begin":2115,"end":2119},"obj":"Species"},{"id":"1627","span":{"begin":2389,"end":2399},"obj":"Species"},{"id":"1628","span":{"begin":2506,"end":2516},"obj":"Species"},{"id":"1629","span":{"begin":251,"end":260},"obj":"Species"},{"id":"1630","span":{"begin":1322,"end":1331},"obj":"Species"},{"id":"1631","span":{"begin":2156,"end":2166},"obj":"Disease"}],"attributes":[{"id":"A1614","pred":"tao:has_database_id","subj":"1614","obj":"Gene:4758"},{"id":"A1615","pred":"tao:has_database_id","subj":"1615","obj":"Tax:10141"},{"id":"A1616","pred":"tao:has_database_id","subj":"1616","obj":"Tax:10090"},{"id":"A1617","pred":"tao:has_database_id","subj":"1617","obj":"Tax:9823"},{"id":"A1618","pred":"tao:has_database_id","subj":"1618","obj":"Tax:11149"},{"id":"A1619","pred":"tao:has_database_id","subj":"1619","obj":"Tax:333278"},{"id":"A1620","pred":"tao:has_database_id","subj":"1620","obj":"Tax:10090"},{"id":"A1621","pred":"tao:has_database_id","subj":"1621","obj":"Tax:12110"},{"id":"A1622","pred":"tao:has_database_id","subj":"1622","obj":"Tax:11308"},{"id":"A1623","pred":"tao:has_database_id","subj":"1623","obj":"Tax:11308"},{"id":"A1624","pred":"tao:has_database_id","subj":"1624","obj":"Tax:11308"},{"id":"A1625","pred":"tao:has_database_id","subj":"1625","obj":"Tax:10090"},{"id":"A1626","pred":"tao:has_database_id","subj":"1626","obj":"Tax:114727"},{"id":"A1627","pred":"tao:has_database_id","subj":"1627","obj":"Tax:2697049"},{"id":"A1628","pred":"tao:has_database_id","subj":"1628","obj":"Tax:2697049"},{"id":"A1629","pred":"tao:has_database_id","subj":"1629","obj":"Tax:11320"},{"id":"A1630","pred":"tao:has_database_id","subj":"1630","obj":"Tax:11320"},{"id":"A1631","pred":"tao:has_database_id","subj":"1631","obj":"MESH:D007239"},{"subj":"1614","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1615","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1616","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1617","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1618","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1619","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1620","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1621","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1622","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1623","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1624","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1625","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1626","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1627","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1628","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1629","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1630","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1631","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T243","span":{"begin":200,"end":235},"obj":"Disease"},{"id":"T244","span":{"begin":220,"end":235},"obj":"Disease"},{"id":"T245","span":{"begin":251,"end":260},"obj":"Disease"},{"id":"T246","span":{"begin":675,"end":697},"obj":"Disease"},{"id":"T247","span":{"begin":684,"end":697},"obj":"Disease"},{"id":"T248","span":{"begin":1322,"end":1331},"obj":"Disease"},{"id":"T249","span":{"begin":1629,"end":1638},"obj":"Disease"},{"id":"T250","span":{"begin":1716,"end":1725},"obj":"Disease"},{"id":"T251","span":{"begin":1777,"end":1786},"obj":"Disease"},{"id":"T252","span":{"begin":2156,"end":2166},"obj":"Disease"},{"id":"T253","span":{"begin":2389,"end":2393},"obj":"Disease"},{"id":"T254","span":{"begin":2506,"end":2510},"obj":"Disease"}],"attributes":[{"id":"A243","pred":"mondo_id","subj":"T243","obj":"http://purl.obolibrary.org/obo/MONDO_0025420"},{"id":"A244","pred":"mondo_id","subj":"T244","obj":"http://purl.obolibrary.org/obo/MONDO_0002269"},{"id":"A245","pred":"mondo_id","subj":"T245","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"},{"id":"A246","pred":"mondo_id","subj":"T246","obj":"http://purl.obolibrary.org/obo/MONDO_0005765"},{"id":"A247","pred":"mondo_id","subj":"T247","obj":"http://purl.obolibrary.org/obo/MONDO_0006858"},{"id":"A248","pred":"mondo_id","subj":"T248","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"},{"id":"A249","pred":"mondo_id","subj":"T249","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"},{"id":"A250","pred":"mondo_id","subj":"T250","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"},{"id":"A251","pred":"mondo_id","subj":"T251","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"},{"id":"A252","pred":"mondo_id","subj":"T252","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A253","pred":"mondo_id","subj":"T253","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A254","pred":"mondo_id","subj":"T254","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"subj":"T243","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T244","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T245","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T246","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T247","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T248","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T249","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T250","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T251","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T252","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T253","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T254","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T812","span":{"begin":59,"end":70},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10141"},{"id":"T813","span":{"begin":236,"end":241},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T814","span":{"begin":541,"end":542},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T815","span":{"begin":559,"end":572},"obj":"http://purl.obolibrary.org/obo/UBERON_0002405"},{"id":"T816","span":{"begin":624,"end":627},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T817","span":{"begin":684,"end":689},"obj":"http://www.ebi.ac.uk/efo/EFO_0000825"},{"id":"T818","span":{"begin":698,"end":703},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T819","span":{"begin":842,"end":850},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T820","span":{"begin":868,"end":881},"obj":"http://purl.obolibrary.org/obo/UBERON_0002405"},{"id":"T821","span":{"begin":912,"end":913},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T822","span":{"begin":944,"end":947},"obj":"http://purl.obolibrary.org/obo/CLO_0001079"},{"id":"T823","span":{"begin":991,"end":992},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T824","span":{"begin":1232,"end":1233},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T825","span":{"begin":1343,"end":1351},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T826","span":{"begin":1538,"end":1541},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T827","span":{"begin":1542,"end":1543},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T828","span":{"begin":1639,"end":1646},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T829","span":{"begin":1652,"end":1653},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T830","span":{"begin":1726,"end":1731},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T831","span":{"begin":1787,"end":1794},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T832","span":{"begin":1800,"end":1801},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T833","span":{"begin":1858,"end":1861},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T834","span":{"begin":1921,"end":1922},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T835","span":{"begin":2069,"end":2070},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T836","span":{"begin":2282,"end":2283},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T837","span":{"begin":2339,"end":2342},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T838","span":{"begin":2446,"end":2452},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"attributes":[{"subj":"T812","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T813","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T814","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T815","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T816","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T817","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T818","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T819","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T820","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T821","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T822","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T823","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T824","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T825","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T826","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T827","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T828","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T829","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T830","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T831","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T832","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T833","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T834","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T835","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T836","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T837","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T838","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T465","span":{"begin":153,"end":161},"obj":"Chemical"},{"id":"T10690","span":{"begin":171,"end":179},"obj":"Chemical"},{"id":"T98587","span":{"begin":392,"end":399},"obj":"Chemical"},{"id":"T89560","span":{"begin":424,"end":437},"obj":"Chemical"},{"id":"T74794","span":{"begin":790,"end":797},"obj":"Chemical"},{"id":"T54879","span":{"begin":798,"end":806},"obj":"Chemical"},{"id":"T471","span":{"begin":1068,"end":1075},"obj":"Chemical"},{"id":"T58098","span":{"begin":1126,"end":1138},"obj":"Chemical"},{"id":"T98344","span":{"begin":1213,"end":1220},"obj":"Chemical"},{"id":"T74311","span":{"begin":1352,"end":1365},"obj":"Chemical"},{"id":"T73611","span":{"begin":1422,"end":1430},"obj":"Chemical"},{"id":"T10437","span":{"begin":1524,"end":1531},"obj":"Chemical"},{"id":"T56763","span":{"begin":1648,"end":1650},"obj":"Chemical"},{"id":"T27712","span":{"begin":1660,"end":1667},"obj":"Chemical"},{"id":"T79982","span":{"begin":1908,"end":1915},"obj":"Chemical"},{"id":"T1331","span":{"begin":1971,"end":1978},"obj":"Chemical"},{"id":"T88129","span":{"begin":2261,"end":2270},"obj":"Chemical"},{"id":"T82544","span":{"begin":2421,"end":2429},"obj":"Chemical"}],"attributes":[{"id":"A18971","pred":"chebi_id","subj":"T465","obj":"http://purl.obolibrary.org/obo/CHEBI_78059"},{"id":"A63673","pred":"chebi_id","subj":"T10690","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A40788","pred":"chebi_id","subj":"T98587","obj":"http://purl.obolibrary.org/obo/CHEBI_59132"},{"id":"A5854","pred":"chebi_id","subj":"T89560","obj":"http://purl.obolibrary.org/obo/CHEBI_50803"},{"id":"A21660","pred":"chebi_id","subj":"T74794","obj":"http://purl.obolibrary.org/obo/CHEBI_59132"},{"id":"A9255","pred":"chebi_id","subj":"T54879","obj":"http://purl.obolibrary.org/obo/CHEBI_78059"},{"id":"A20446","pred":"chebi_id","subj":"T471","obj":"http://purl.obolibrary.org/obo/CHEBI_59132"},{"id":"A4899","pred":"chebi_id","subj":"T58098","obj":"http://purl.obolibrary.org/obo/CHEBI_50803"},{"id":"A35444","pred":"chebi_id","subj":"T98344","obj":"http://purl.obolibrary.org/obo/CHEBI_59132"},{"id":"A38407","pred":"chebi_id","subj":"T74311","obj":"http://purl.obolibrary.org/obo/CHEBI_17089"},{"id":"A84267","pred":"chebi_id","subj":"T73611","obj":"http://purl.obolibrary.org/obo/CHEBI_59132"},{"id":"A54189","pred":"chebi_id","subj":"T10437","obj":"http://purl.obolibrary.org/obo/CHEBI_53000"},{"id":"A7661","pred":"chebi_id","subj":"T56763","obj":"http://purl.obolibrary.org/obo/CHEBI_34827"},{"id":"A25872","pred":"chebi_id","subj":"T56763","obj":"http://purl.obolibrary.org/obo/CHEBI_51112"},{"id":"A4204","pred":"chebi_id","subj":"T27712","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A63782","pred":"chebi_id","subj":"T79982","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A91481","pred":"chebi_id","subj":"T1331","obj":"http://purl.obolibrary.org/obo/CHEBI_59132"},{"id":"A41801","pred":"chebi_id","subj":"T88129","obj":"http://purl.obolibrary.org/obo/CHEBI_25367"},{"id":"A7636","pred":"chebi_id","subj":"T82544","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"subj":"T465","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T10690","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T98587","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T89560","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T74794","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T54879","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T471","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T58098","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T98344","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T74311","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T73611","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T10437","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T56763","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T27712","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T79982","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T1331","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T88129","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T82544","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T210","span":{"begin":1688,"end":1695},"obj":"http://purl.obolibrary.org/obo/GO_0007114"},{"id":"T211","span":{"begin":2226,"end":2241},"obj":"http://purl.obolibrary.org/obo/GO_0006955"},{"id":"T212","span":{"begin":2370,"end":2377},"obj":"http://purl.obolibrary.org/obo/GO_0007114"}],"attributes":[{"subj":"T210","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T211","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T212","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T537","span":{"begin":0,"end":438},"obj":"Sentence"},{"id":"T538","span":{"begin":439,"end":500},"obj":"Sentence"},{"id":"T539","span":{"begin":501,"end":573},"obj":"Sentence"},{"id":"T540","span":{"begin":574,"end":807},"obj":"Sentence"},{"id":"T541","span":{"begin":808,"end":1029},"obj":"Sentence"},{"id":"T542","span":{"begin":1030,"end":1199},"obj":"Sentence"},{"id":"T543","span":{"begin":1200,"end":1292},"obj":"Sentence"},{"id":"T544","span":{"begin":1293,"end":1431},"obj":"Sentence"},{"id":"T545","span":{"begin":1432,"end":1647},"obj":"Sentence"},{"id":"T546","span":{"begin":1648,"end":1854},"obj":"Sentence"},{"id":"T547","span":{"begin":1855,"end":1985},"obj":"Sentence"},{"id":"T548","span":{"begin":1986,"end":2320},"obj":"Sentence"},{"id":"T549","span":{"begin":2321,"end":2553},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T537","pred":"source","obj":"LitCovid-sentences"},{"subj":"T538","pred":"source","obj":"LitCovid-sentences"},{"subj":"T539","pred":"source","obj":"LitCovid-sentences"},{"subj":"T540","pred":"source","obj":"LitCovid-sentences"},{"subj":"T541","pred":"source","obj":"LitCovid-sentences"},{"subj":"T542","pred":"source","obj":"LitCovid-sentences"},{"subj":"T543","pred":"source","obj":"LitCovid-sentences"},{"subj":"T544","pred":"source","obj":"LitCovid-sentences"},{"subj":"T545","pred":"source","obj":"LitCovid-sentences"},{"subj":"T546","pred":"source","obj":"LitCovid-sentences"},{"subj":"T547","pred":"source","obj":"LitCovid-sentences"},{"subj":"T548","pred":"source","obj":"LitCovid-sentences"},{"subj":"T549","pred":"source","obj":"LitCovid-sentences"}]},{"project":"2_test","denotations":[{"id":"32667191-30402771-153402","span":{"begin":306,"end":309},"obj":"30402771"},{"id":"32667191-20400818-153403","span":{"begin":944,"end":947},"obj":"20400818"},{"id":"32667191-28161578-153404","span":{"begin":2167,"end":2170},"obj":"28161578"}],"attributes":[{"subj":"32667191-30402771-153402","pred":"source","obj":"2_test"},{"subj":"32667191-20400818-153403","pred":"source","obj":"2_test"},{"subj":"32667191-28161578-153404","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#93ecea","default":true},{"id":"LitCovid-PD-UBERON","color":"#ecd093"},{"id":"LitCovid-PubTator","color":"#b693ec"},{"id":"LitCovid-PD-MONDO","color":"#93ec9c"},{"id":"LitCovid-PD-CLO","color":"#ec93a3"},{"id":"LitCovid-PD-CHEBI","color":"#93bdec"},{"id":"LitCovid-PD-GO-BP","color":"#d8ec93"},{"id":"LitCovid-sentences","color":"#e693ec"},{"id":"2_test","color":"#93eccc"}]}]}}