PMC:7376845 / 27721-29374
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T203 | 601-608 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T204 | 685-692 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T205 | 873-880 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T206 | 984-989 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T207 | 1083-1090 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T208 | 1285-1307 | Body_part | denotes | cytotoxic T-lymphocyte | http://purl.org/sig/ont/fma/fma70573 |
| T209 | 1295-1307 | Body_part | denotes | T-lymphocyte | http://purl.org/sig/ont/fma/fma62870 |
| T210 | 1309-1312 | Body_part | denotes | CTL | http://purl.org/sig/ont/fma/fma70573 |
| T211 | 1437-1440 | Body_part | denotes | CTL | http://purl.org/sig/ont/fma/fma70573 |
| T212 | 1596-1600 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 711 | 170-174 | Gene | denotes | ACE2 | Gene:59272 |
| 712 | 479-483 | Gene | denotes | ACE2 | Gene:59272 |
| 713 | 47-55 | Species | denotes | SARS-CoV | Tax:694009 |
| 714 | 140-148 | Species | denotes | SARS-CoV | Tax:694009 |
| 715 | 155-165 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 716 | 221-229 | Species | denotes | SARS-CoV | Tax:694009 |
| 717 | 275-285 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 718 | 366-373 | Species | denotes | patient | Tax:9606 |
| 719 | 407-417 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 720 | 612-622 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 721 | 1180-1190 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 722 | 1394-1402 | Species | denotes | SARS-CoV | Tax:694009 |
| 723 | 1627-1635 | Species | denotes | SARS-CoV | Tax:694009 |
| 724 | 1642-1652 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 725 | 314-320 | Chemical | denotes | CR3022 | |
| 726 | 964-983 | Disease | denotes | SARS-CoV-2-infected | MESH:C000657245 |
| 727 | 1007-1016 | Disease | denotes | infection | MESH:D007239 |
| 728 | 1098-1107 | Disease | denotes | infection | MESH:D007239 |
| 729 | 1253-1261 | Disease | denotes | COVID-19 | MESH:C000657245 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T260 | 47-55 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T261 | 47-51 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T262 | 140-148 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T263 | 140-144 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T264 | 155-163 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T265 | 155-159 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T266 | 221-229 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T267 | 221-225 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T268 | 275-283 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T269 | 275-279 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T270 | 348-352 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T271 | 407-415 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T272 | 407-411 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T273 | 612-620 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T274 | 612-616 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T275 | 964-972 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T276 | 964-968 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T277 | 1007-1016 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T278 | 1098-1107 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T279 | 1180-1188 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T280 | 1180-1184 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T281 | 1253-1261 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T282 | 1394-1402 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T283 | 1394-1398 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T284 | 1627-1635 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T285 | 1627-1631 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T286 | 1642-1650 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T287 | 1642-1646 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T297 | 114-116 | http://purl.obolibrary.org/obo/CLO_0050050 | denotes | S1 |
| T298 | 178-179 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T299 | 346-347 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T300 | 375-377 | http://purl.obolibrary.org/obo/CLO_0050507 | denotes | 22 |
| T301 | 523-529 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | tested |
| T302 | 696-697 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T303 | 759-761 | http://purl.obolibrary.org/obo/CLO_0008922 | denotes | S2 |
| T304 | 759-761 | http://purl.obolibrary.org/obo/CLO_0050052 | denotes | S2 |
| T305 | 792-794 | http://purl.obolibrary.org/obo/CLO_0050050 | denotes | S1 |
| T306 | 939-940 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T307 | 984-989 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T308 | 1380-1382 | http://purl.obolibrary.org/obo/CLO_0008922 | denotes | S2 |
| T309 | 1380-1382 | http://purl.obolibrary.org/obo/CLO_0050052 | denotes | S2 |
| T310 | 1514-1516 | http://purl.obolibrary.org/obo/CLO_0008922 | denotes | S2 |
| T311 | 1514-1516 | http://purl.obolibrary.org/obo/CLO_0050052 | denotes | S2 |
| T312 | 1596-1600 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T243 | 440-447 | Chemical | denotes | epitope | http://purl.obolibrary.org/obo/CHEBI_53000 |
| T244 | 601-608 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T245 | 685-692 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T246 | 759-761 | Chemical | denotes | S2 | http://purl.obolibrary.org/obo/CHEBI_29387 |
| T247 | 873-880 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T248 | 1083-1090 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T249 | 1380-1382 | Chemical | denotes | S2 | http://purl.obolibrary.org/obo/CHEBI_29387 |
| T250 | 1441-1448 | Chemical | denotes | epitope | http://purl.obolibrary.org/obo/CHEBI_53000 |
| T251 | 1467-1474 | Chemical | denotes | epitope | http://purl.obolibrary.org/obo/CHEBI_53000 |
| T252 | 1514-1516 | Chemical | denotes | S2 | http://purl.obolibrary.org/obo/CHEBI_29387 |
| T253 | 1551-1558 | Chemical | denotes | antigen | http://purl.obolibrary.org/obo/CHEBI_59132 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T4 | 1596-1618 | http://purl.obolibrary.org/obo/GO_0002456 | denotes | cell-mediated immunity |
| T5 | 1596-1618 | http://purl.obolibrary.org/obo/GO_0002449 | denotes | cell-mediated immunity |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T218 | 0-125 | Sentence | denotes | Recent cross-reactivity studies have evaluated SARS-CoV-1 neutralising antibodies that bind to the RBD-containing S1 subunit. |
| T219 | 126-298 | Sentence | denotes | Although both SARS-CoV-1 and SARS-CoV-2 use ACE2 as a receptor for viral entry [3,16], several SARS-CoV-1 RBD-directed mAbs did not cross-react with SARS-CoV-2 RBD [28,29]. |
| T220 | 299-502 | Sentence | denotes | Interestingly, CR3022, which was isolated from a SARS convalescent patient [22], showed cross-reactivity to SARS-CoV-2 RBD and recognises an epitope that does not overlap with the ACE2 binding site [28]. |
| T221 | 503-635 | Sentence | denotes | Among the four mAbs tested in this study, indirect ELISA showed that 1A9 binds strongest to the S protein of SARS-CoV-2 (Figure 3B). |
| T222 | 636-803 | Sentence | denotes | To determine if 1A9 is useful for detection of S protein in a sandwich ELISA, it was paired with CR3022 since 1A9 binds to S2 subunit while CR3022 binds to S1 subunit. |
| T223 | 804-909 | Sentence | denotes | As would be expected, these two antibodies can be paired to detect S protein from 15.6 ng/mL (Figure 4A). |
| T224 | 910-1120 | Sentence | denotes | In addition, mAb 1A9 stained a considerable number of SARS-CoV-2-infected cells at 24 hours post-infection showing that it is sensitive enough to detect the expression of S protein during infection (Figure 4B). |
| T225 | 1121-1262 | Sentence | denotes | Thus, mAbs 1A9 will be useful for studying the kinetics of SARS-CoV-2 replication in vitro and development of diagnostic assays for COVID-19. |
| T226 | 1263-1410 | Sentence | denotes | It is noteworthy that cytotoxic T-lymphocyte (CTL) epitopes also reside at residues 884–891 and 1116–1123 within the S2 subunit of SARS-CoV-1 [30]. |
| T227 | 1411-1502 | Sentence | denotes | Interestingly, the latter CTL epitope overlaps with the epitope recognised by mAb 1A9 [21]. |
| T228 | 1503-1653 | Sentence | denotes | Hence, the S2 subunit may serve as an important antigen for inducing both humoral as well as cell-mediated immunity against SARS-CoV-1 and SARS-CoV-2. |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32700671-32015507-29327483 | 206-207 | 32015507 | denotes | 3 |
| 32700671-14647384-29327484 | 208-210 | 14647384 | denotes | 16 |
| 32700671-32065055-29327485 | 291-293 | 32065055 | denotes | 28 |
| 32700671-32075877-29327486 | 294-296 | 32075877 | denotes | 29 |
| 32700671-16796401-29327487 | 375-377 | 16796401 | denotes | 22 |
| 32700671-32065055-29327488 | 498-500 | 32065055 | denotes | 28 |
| 32700671-19475608-29327489 | 1406-1408 | 19475608 | denotes | 30 |
| 32700671-25019613-29327490 | 1498-1500 | 25019613 | denotes | 21 |
MyTest
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32700671-32015507-29327483 | 206-207 | 32015507 | denotes | 3 |
| 32700671-14647384-29327484 | 208-210 | 14647384 | denotes | 16 |
| 32700671-32065055-29327485 | 291-293 | 32065055 | denotes | 28 |
| 32700671-32075877-29327486 | 294-296 | 32075877 | denotes | 29 |
| 32700671-16796401-29327487 | 375-377 | 16796401 | denotes | 22 |
| 32700671-32065055-29327488 | 498-500 | 32065055 | denotes | 28 |
| 32700671-19475608-29327489 | 1406-1408 | 19475608 | denotes | 30 |
| 32700671-25019613-29327490 | 1498-1500 | 25019613 | denotes | 21 |