PMC:7376845 / 1243-1672 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T12","span":{"begin":64,"end":71},"obj":"Body_part"},{"id":"T13","span":{"begin":246,"end":253},"obj":"Body_part"},{"id":"T14","span":{"begin":277,"end":281},"obj":"Body_part"},{"id":"T15","span":{"begin":341,"end":348},"obj":"Body_part"},{"id":"T16","span":{"begin":372,"end":377},"obj":"Body_part"}],"attributes":[{"id":"A12","pred":"fma_id","subj":"T12","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A13","pred":"fma_id","subj":"T13","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A14","pred":"fma_id","subj":"T14","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A15","pred":"fma_id","subj":"T15","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A16","pred":"fma_id","subj":"T16","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"Results\nAn immunogenic domain in the S2 subunit of SARS-CoV-1 S protein is highly conserved in SARS-CoV-2 but not in MERS and human common-cold coronaviruses. Four murine mAbs raised against this immunogenic fragment could recognise SARS-CoV-2 S protein expressed in mammalian cell lines. In particular, mAb 1A9 was demonstrated to detect S protein in SARS-CoV-2-infected cells and is suitable for use in a sandwich ELISA format."}

{"project":"LitCovid-PubTator","denotations":[{"id":"63","span":{"begin":51,"end":59},"obj":"Species"},{"id":"64","span":{"begin":95,"end":105},"obj":"Species"},{"id":"65","span":{"begin":126,"end":131},"obj":"Species"},{"id":"66","span":{"begin":144,"end":157},"obj":"Species"},{"id":"67","span":{"begin":164,"end":170},"obj":"Species"},{"id":"68","span":{"begin":233,"end":243},"obj":"Species"},{"id":"69","span":{"begin":267,"end":276},"obj":"Species"},{"id":"70","span":{"begin":117,"end":121},"obj":"Disease"},{"id":"71","span":{"begin":357,"end":371},"obj":"Disease"}],"attributes":[{"id":"A63","pred":"tao:has_database_id","subj":"63","obj":"Tax:694009"},{"id":"A64","pred":"tao:has_database_id","subj":"64","obj":"Tax:2697049"},{"id":"A65","pred":"tao:has_database_id","subj":"65","obj":"Tax:9606"},{"id":"A66","pred":"tao:has_database_id","subj":"66","obj":"Tax:11118"},{"id":"A67","pred":"tao:has_database_id","subj":"67","obj":"Tax:10090"},{"id":"A68","pred":"tao:has_database_id","subj":"68","obj":"Tax:2697049"},{"id":"A69","pred":"tao:has_database_id","subj":"69","obj":"Tax:9606"},{"id":"A70","pred":"tao:has_database_id","subj":"70","obj":"MESH:D018352"},{"id":"A71","pred":"tao:has_database_id","subj":"71","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Results\nAn immunogenic domain in the S2 subunit of SARS-CoV-1 S protein is highly conserved in SARS-CoV-2 but not in MERS and human common-cold coronaviruses. Four murine mAbs raised against this immunogenic fragment could recognise SARS-CoV-2 S protein expressed in mammalian cell lines. In particular, mAb 1A9 was demonstrated to detect S protein in SARS-CoV-2-infected cells and is suitable for use in a sandwich ELISA format."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T34","span":{"begin":51,"end":59},"obj":"Disease"},{"id":"T35","span":{"begin":51,"end":55},"obj":"Disease"},{"id":"T36","span":{"begin":95,"end":103},"obj":"Disease"},{"id":"T37","span":{"begin":95,"end":99},"obj":"Disease"},{"id":"T38","span":{"begin":132,"end":143},"obj":"Disease"},{"id":"T39","span":{"begin":233,"end":241},"obj":"Disease"},{"id":"T40","span":{"begin":233,"end":237},"obj":"Disease"},{"id":"T41","span":{"begin":352,"end":360},"obj":"Disease"},{"id":"T42","span":{"begin":352,"end":356},"obj":"Disease"}],"attributes":[{"id":"A34","pred":"mondo_id","subj":"T34","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A35","pred":"mondo_id","subj":"T35","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A36","pred":"mondo_id","subj":"T36","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A37","pred":"mondo_id","subj":"T37","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A38","pred":"mondo_id","subj":"T38","obj":"http://purl.obolibrary.org/obo/MONDO_0005709"},{"id":"A39","pred":"mondo_id","subj":"T39","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A40","pred":"mondo_id","subj":"T40","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A41","pred":"mondo_id","subj":"T41","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A42","pred":"mondo_id","subj":"T42","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"Results\nAn immunogenic domain in the S2 subunit of SARS-CoV-1 S protein is highly conserved in SARS-CoV-2 but not in MERS and human common-cold coronaviruses. Four murine mAbs raised against this immunogenic fragment could recognise SARS-CoV-2 S protein expressed in mammalian cell lines. In particular, mAb 1A9 was demonstrated to detect S protein in SARS-CoV-2-infected cells and is suitable for use in a sandwich ELISA format."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T14","span":{"begin":37,"end":39},"obj":"http://purl.obolibrary.org/obo/CLO_0008922"},{"id":"T15","span":{"begin":37,"end":39},"obj":"http://purl.obolibrary.org/obo/CLO_0050052"},{"id":"T16","span":{"begin":126,"end":131},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T17","span":{"begin":277,"end":287},"obj":"http://purl.obolibrary.org/obo/CLO_0000031"},{"id":"T18","span":{"begin":372,"end":377},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T19","span":{"begin":405,"end":406},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"Results\nAn immunogenic domain in the S2 subunit of SARS-CoV-1 S protein is highly conserved in SARS-CoV-2 but not in MERS and human common-cold coronaviruses. Four murine mAbs raised against this immunogenic fragment could recognise SARS-CoV-2 S protein expressed in mammalian cell lines. In particular, mAb 1A9 was demonstrated to detect S protein in SARS-CoV-2-infected cells and is suitable for use in a sandwich ELISA format."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T12","span":{"begin":37,"end":39},"obj":"Chemical"},{"id":"T13","span":{"begin":64,"end":71},"obj":"Chemical"},{"id":"T14","span":{"begin":246,"end":253},"obj":"Chemical"},{"id":"T15","span":{"begin":341,"end":348},"obj":"Chemical"}],"attributes":[{"id":"A12","pred":"chebi_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/CHEBI_29387"},{"id":"A13","pred":"chebi_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A14","pred":"chebi_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A15","pred":"chebi_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"}],"text":"Results\nAn immunogenic domain in the S2 subunit of SARS-CoV-1 S protein is highly conserved in SARS-CoV-2 but not in MERS and human common-cold coronaviruses. Four murine mAbs raised against this immunogenic fragment could recognise SARS-CoV-2 S protein expressed in mammalian cell lines. In particular, mAb 1A9 was demonstrated to detect S protein in SARS-CoV-2-infected cells and is suitable for use in a sandwich ELISA format."}

{"project":"LitCovid-sentences","denotations":[{"id":"T13","span":{"begin":0,"end":7},"obj":"Sentence"},{"id":"T14","span":{"begin":8,"end":158},"obj":"Sentence"},{"id":"T15","span":{"begin":159,"end":288},"obj":"Sentence"},{"id":"T16","span":{"begin":289,"end":429},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Results\nAn immunogenic domain in the S2 subunit of SARS-CoV-1 S protein is highly conserved in SARS-CoV-2 but not in MERS and human common-cold coronaviruses. Four murine mAbs raised against this immunogenic fragment could recognise SARS-CoV-2 S protein expressed in mammalian cell lines. In particular, mAb 1A9 was demonstrated to detect S protein in SARS-CoV-2-infected cells and is suitable for use in a sandwich ELISA format."}