> top > docs > PMC:7371427 > spans > 37754-39310 > annotations

PMC:7371427 / 37754-39310 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T473 21-24 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T474 122-128 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T475 148-163 Body_part denotes small intestine http://purl.org/sig/ont/fma/fma7200
T476 228-234 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T477 328-368 Body_part denotes epithelial cells of the proximal tubules http://purl.org/sig/ont/fma/fma70973
T478 328-344 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T479 339-344 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T480 472-477 Body_part denotes urine http://purl.org/sig/ont/fma/fma12274
T481 621-626 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T482 658-674 Body_part denotes small intestinal http://purl.org/sig/ont/fma/fma7200
T483 675-686 Body_part denotes enterocytes http://purl.org/sig/ont/fma/fma62122
T484 750-754 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T485 833-849 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T486 844-849 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T487 1091-1097 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T488 1123-1126 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T489 1183-1187 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T490 1363-1379 Body_part denotes small intestinal http://purl.org/sig/ont/fma/fma7200
T491 1533-1540 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T492 1545-1549 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T199 122-128 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T200 148-163 Body_part denotes small intestine http://purl.obolibrary.org/obo/UBERON_0002108
T201 154-163 Body_part denotes intestine http://purl.obolibrary.org/obo/UBERON_0000160
T202 228-234 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T203 352-368 Body_part denotes proximal tubules http://purl.obolibrary.org/obo/UBERON_0004134
T204 472-477 Body_part denotes urine http://purl.obolibrary.org/obo/UBERON_0001088
T205 658-674 Body_part denotes small intestinal http://purl.obolibrary.org/obo/UBERON_0002108
T206 817-832 Body_part denotes proximal tubule http://purl.obolibrary.org/obo/UBERON_0004134
T207 1091-1097 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T208 1363-1379 Body_part denotes small intestinal http://purl.obolibrary.org/obo/UBERON_0002108

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
105 281-285 Chemical denotes DPP4
106 526-530 Chemical denotes DPP4
107 1086-1097 Disease denotes GTEx kidney MESH:D007674

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T76 438-446 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T77 438-442 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T711 122-128 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T712 122-128 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T713 122-128 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T714 148-163 http://purl.obolibrary.org/obo/UBERON_0002108 denotes small intestine
T715 211-216 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T716 228-234 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T717 228-234 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T718 228-234 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T719 328-338 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T720 339-344 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T721 352-368 http://purl.obolibrary.org/obo/UBERON_0004134 denotes proximal tubules
T722 621-626 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T723 658-674 http://purl.obolibrary.org/obo/UBERON_0002108 denotes small intestinal
T724 750-754 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T725 811-816 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T726 817-832 http://purl.obolibrary.org/obo/UBERON_0004134 denotes proximal tubule
T727 833-843 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T728 844-849 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T729 923-928 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T730 1091-1097 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T731 1091-1097 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T732 1091-1097 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T733 1183-1187 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T734 1227-1232 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T735 1363-1379 http://purl.obolibrary.org/obo/UBERON_0002108 denotes small intestinal
T736 1527-1532 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T737 1545-1555 http://purl.obolibrary.org/obo/CL_0000000 denotes cell types

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T73 1257-1260 Chemical denotes TPM http://purl.obolibrary.org/obo/CHEBI_63631

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T49 750-765 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T50 1051-1066 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T51 1424-1439 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T222 0-400 Sentence denotes Our analyses of bulk RNA-seq, proteomics, and IHC demonstrated that all coronavirus receptors are highly expressed in the kidney in addition to the small intestine (Figure 2—figure supplements 2,6). scRNAseq of human and murine kidney corroborates this finding, showing that ACE2, DPP4, and ANPEP are each robustly expressed in epithelial cells of the proximal tubules (Figure 2—figure supplement 5).
T223 401-687 Sentence denotes Although clinical data suggests that SARS-CoV-2 does not reside in the urine (Wang et al., 2020c), we wondered whether ACE2, DPP4, and ANPEP show an overlapping pattern of expression heterogeneity among proximal tubular cells similar to that observed among small intestinal enterocytes.
T224 688-1010 Sentence denotes To address this, we computed cosine similarity scores between gene expression vectors specifically among ~27,000 recovered human proximal tubule epithelial cells (Stewart et al., 2019) and found that again DPP4 and ANPEP are among the genes with the most similar expression profiles to ACE2 (Figure 2—figure supplement 3).
T225 1011-1292 Sentence denotes This is further supported by the strong transcriptional correlations among GTEx kidney samples (n = 85) by bulk RNA-seq, where DPP4 and ANPEP are again among the top 1% of gene correlations to ACE2 among the ~16,600 genes with mean expression >1 TPM (Figure 2—figure supplement 6).
T226 1293-1556 Sentence denotes These observations are quite consistent with our previous analysis of small intestinal data and together may suggest an underlying transcriptional network which coordinates the expression of coronavirus entry receptors across diverse human tissues and cell types.

MyTest

Id Subject Object Predicate Lexical cue
32463365-31604275-27519128 867-871 31604275 denotes 2019

2_test

Id Subject Object Predicate Lexical cue
32463365-31604275-27519128 867-871 31604275 denotes 2019