PMC:7371427 / 22062-22913 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T259","span":{"begin":35,"end":40},"obj":"Body_part"},{"id":"T260","span":{"begin":48,"end":53},"obj":"Body_part"},{"id":"T261","span":{"begin":56,"end":78},"obj":"Body_part"},{"id":"T262","span":{"begin":73,"end":78},"obj":"Body_part"},{"id":"T263","span":{"begin":84,"end":97},"obj":"Body_part"},{"id":"T264","span":{"begin":340,"end":344},"obj":"Body_part"},{"id":"T265","span":{"begin":515,"end":520},"obj":"Body_part"},{"id":"T266","span":{"begin":544,"end":561},"obj":"Body_part"}],"attributes":[{"id":"A259","pred":"fma_id","subj":"T259","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A260","pred":"fma_id","subj":"T260","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A261","pred":"fma_id","subj":"T261","obj":"http://purl.org/sig/ont/fma/fma70585"},{"id":"A262","pred":"fma_id","subj":"T262","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A263","pred":"fma_id","subj":"T263","obj":"http://purl.org/sig/ont/fma/fma62879"},{"id":"A264","pred":"fma_id","subj":"T264","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A265","pred":"fma_id","subj":"T265","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A266","pred":"fma_id","subj":"T266","obj":"http://purl.org/sig/ont/fma/fma76489"}],"text":"Conversely, pancreatic polypeptide cells (gamma cells), pancreatic alpha cells, and keratinocytes show similarly robust ACE2 expression but have not been strongly associated with ACE2 in the literature. This combination suggests either a biological novelty or an experimental artifact. We note that the strong ACE2 expression in pancreatic cell types is derived from only one murine study (Figure 2—figure supplement 1; Tabula Muris Consortium et al., 2018), while ACE2 expression is not observed in gamma or alpha cells from scRNAseq of human pancreatic islets (Figure 2—figure supplement 1; Segerstolpe et al., 2016; Grün et al., 2016; Muraro et al., 2016). While we cannot determine the validity of either observation, this example demonstrates how knowledge synthesis can automatically surface discordant biological signals for further evaluation."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T454","span":{"begin":35,"end":40},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T455","span":{"begin":48,"end":53},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T456","span":{"begin":73,"end":78},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T457","span":{"begin":84,"end":97},"obj":"http://purl.obolibrary.org/obo/CL_0000312"},{"id":"T458","span":{"begin":236,"end":237},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T459","span":{"begin":340,"end":350},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T460","span":{"begin":452,"end":456},"obj":"http://purl.obolibrary.org/obo/CLO_0001185"},{"id":"T461","span":{"begin":515,"end":520},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T462","span":{"begin":538,"end":543},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T463","span":{"begin":544,"end":561},"obj":"http://purl.obolibrary.org/obo/UBERON_0000006"},{"id":"T464","span":{"begin":820,"end":827},"obj":"http://purl.obolibrary.org/obo/SO_0000418"}],"text":"Conversely, pancreatic polypeptide cells (gamma cells), pancreatic alpha cells, and keratinocytes show similarly robust ACE2 expression but have not been strongly associated with ACE2 in the literature. This combination suggests either a biological novelty or an experimental artifact. We note that the strong ACE2 expression in pancreatic cell types is derived from only one murine study (Figure 2—figure supplement 1; Tabula Muris Consortium et al., 2018), while ACE2 expression is not observed in gamma or alpha cells from scRNAseq of human pancreatic islets (Figure 2—figure supplement 1; Segerstolpe et al., 2016; Grün et al., 2016; Muraro et al., 2016). While we cannot determine the validity of either observation, this example demonstrates how knowledge synthesis can automatically surface discordant biological signals for further evaluation."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T39","span":{"begin":12,"end":34},"obj":"Chemical"},{"id":"T40","span":{"begin":23,"end":34},"obj":"Chemical"},{"id":"T41","span":{"begin":42,"end":47},"obj":"Chemical"},{"id":"T42","span":{"begin":67,"end":72},"obj":"Chemical"},{"id":"T43","span":{"begin":500,"end":505},"obj":"Chemical"},{"id":"T44","span":{"begin":509,"end":514},"obj":"Chemical"}],"attributes":[{"id":"A39","pred":"chebi_id","subj":"T39","obj":"http://purl.obolibrary.org/obo/CHEBI_80329"},{"id":"A40","pred":"chebi_id","subj":"T40","obj":"http://purl.obolibrary.org/obo/CHEBI_15841"},{"id":"A41","pred":"chebi_id","subj":"T41","obj":"http://purl.obolibrary.org/obo/CHEBI_30212"},{"id":"A42","pred":"chebi_id","subj":"T42","obj":"http://purl.obolibrary.org/obo/CHEBI_30216"},{"id":"A43","pred":"chebi_id","subj":"T43","obj":"http://purl.obolibrary.org/obo/CHEBI_30212"},{"id":"A44","pred":"chebi_id","subj":"T44","obj":"http://purl.obolibrary.org/obo/CHEBI_30216"}],"text":"Conversely, pancreatic polypeptide cells (gamma cells), pancreatic alpha cells, and keratinocytes show similarly robust ACE2 expression but have not been strongly associated with ACE2 in the literature. This combination suggests either a biological novelty or an experimental artifact. We note that the strong ACE2 expression in pancreatic cell types is derived from only one murine study (Figure 2—figure supplement 1; Tabula Muris Consortium et al., 2018), while ACE2 expression is not observed in gamma or alpha cells from scRNAseq of human pancreatic islets (Figure 2—figure supplement 1; Segerstolpe et al., 2016; Grün et al., 2016; Muraro et al., 2016). While we cannot determine the validity of either observation, this example demonstrates how knowledge synthesis can automatically surface discordant biological signals for further evaluation."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T20","span":{"begin":762,"end":771},"obj":"http://purl.obolibrary.org/obo/GO_0009058"},{"id":"T21","span":{"begin":809,"end":827},"obj":"http://purl.obolibrary.org/obo/GO_0023052"}],"text":"Conversely, pancreatic polypeptide cells (gamma cells), pancreatic alpha cells, and keratinocytes show similarly robust ACE2 expression but have not been strongly associated with ACE2 in the literature. This combination suggests either a biological novelty or an experimental artifact. We note that the strong ACE2 expression in pancreatic cell types is derived from only one murine study (Figure 2—figure supplement 1; Tabula Muris Consortium et al., 2018), while ACE2 expression is not observed in gamma or alpha cells from scRNAseq of human pancreatic islets (Figure 2—figure supplement 1; Segerstolpe et al., 2016; Grün et al., 2016; Muraro et al., 2016). While we cannot determine the validity of either observation, this example demonstrates how knowledge synthesis can automatically surface discordant biological signals for further evaluation."}

{"project":"LitCovid-sentences","denotations":[{"id":"T135","span":{"begin":0,"end":202},"obj":"Sentence"},{"id":"T136","span":{"begin":203,"end":285},"obj":"Sentence"},{"id":"T137","span":{"begin":286,"end":659},"obj":"Sentence"},{"id":"T138","span":{"begin":660,"end":851},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Conversely, pancreatic polypeptide cells (gamma cells), pancreatic alpha cells, and keratinocytes show similarly robust ACE2 expression but have not been strongly associated with ACE2 in the literature. This combination suggests either a biological novelty or an experimental artifact. We note that the strong ACE2 expression in pancreatic cell types is derived from only one murine study (Figure 2—figure supplement 1; Tabula Muris Consortium et al., 2018), while ACE2 expression is not observed in gamma or alpha cells from scRNAseq of human pancreatic islets (Figure 2—figure supplement 1; Segerstolpe et al., 2016; Grün et al., 2016; Muraro et al., 2016). While we cannot determine the validity of either observation, this example demonstrates how knowledge synthesis can automatically surface discordant biological signals for further evaluation."}

{"project":"MyTest","denotations":[{"id":"32463365-30283141-27519104","span":{"begin":452,"end":456},"obj":"30283141"},{"id":"32463365-27667667-27519105","span":{"begin":613,"end":617},"obj":"27667667"},{"id":"32463365-27345837-27519106","span":{"begin":632,"end":636},"obj":"27345837"},{"id":"32463365-27693023-27519107","span":{"begin":653,"end":657},"obj":"27693023"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"text":"Conversely, pancreatic polypeptide cells (gamma cells), pancreatic alpha cells, and keratinocytes show similarly robust ACE2 expression but have not been strongly associated with ACE2 in the literature. This combination suggests either a biological novelty or an experimental artifact. We note that the strong ACE2 expression in pancreatic cell types is derived from only one murine study (Figure 2—figure supplement 1; Tabula Muris Consortium et al., 2018), while ACE2 expression is not observed in gamma or alpha cells from scRNAseq of human pancreatic islets (Figure 2—figure supplement 1; Segerstolpe et al., 2016; Grün et al., 2016; Muraro et al., 2016). While we cannot determine the validity of either observation, this example demonstrates how knowledge synthesis can automatically surface discordant biological signals for further evaluation."}

{"project":"2_test","denotations":[{"id":"32463365-30283141-27519104","span":{"begin":452,"end":456},"obj":"30283141"},{"id":"32463365-27667667-27519105","span":{"begin":613,"end":617},"obj":"27667667"},{"id":"32463365-27345837-27519106","span":{"begin":632,"end":636},"obj":"27345837"},{"id":"32463365-27693023-27519107","span":{"begin":653,"end":657},"obj":"27693023"}],"text":"Conversely, pancreatic polypeptide cells (gamma cells), pancreatic alpha cells, and keratinocytes show similarly robust ACE2 expression but have not been strongly associated with ACE2 in the literature. This combination suggests either a biological novelty or an experimental artifact. We note that the strong ACE2 expression in pancreatic cell types is derived from only one murine study (Figure 2—figure supplement 1; Tabula Muris Consortium et al., 2018), while ACE2 expression is not observed in gamma or alpha cells from scRNAseq of human pancreatic islets (Figure 2—figure supplement 1; Segerstolpe et al., 2016; Grün et al., 2016; Muraro et al., 2016). While we cannot determine the validity of either observation, this example demonstrates how knowledge synthesis can automatically surface discordant biological signals for further evaluation."}