PMC:7366549 / 22386-26331 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7366549","sourcedb":"PMC","sourceid":"7366549","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7366549","text":"Discussion\nAs per the available information, the BtCoV causing human infection belongs to α- and β-CoV genera of the Coronaviridae family. β-CoV genus has five strains known to infect humans25. The two human-infecting strains (NL63 and 229E) from α-CoV genus which cause mild-to-moderate respiratory infections are believed to have originated in bats25. Two members of the β-CoV genus (HCoV-OC43 and HCoV-HKU1) are known to cause the common cold and lower respiratory tract infections26. The other three are now shown to be pathogenic to humans (SARS-CoV-1, MERS-CoV and SARS-CoV-2). The SARS-CoV-1 and SARS-CoV-2 belong to L_B and MERS CoV belongs to L_C of β-CoV genus27.\nThe phylogenetic analysis for the partial RdRp region revealed the presence of distinct BtCoVs in both the bats. The genomic sequences retrieved from the Indian sequences form a distinct cluster. The three CoV_BtRtBetaCoV/GX2018 sequences retrieved from the Indian Rousettus bats were 5.8-6.7 per cent different from the reference sequence, which was retrieved from Rhinolophus affinis. The two CoV_BtRtBetaCoV/GX2018 sequences retrieved from different bats were 1.2 per cent different from each other. The effect of host influence on the nt usage of the virus cannot be denied; however, it needs to be explored further in detail.\nBats are reservoirs for viruses with human pathogenic potential2829, and are known to harbour a broad range of CoVs1. The global distribution of bats, along with the different types of cell receptors present within them, favours virus replication, and is a possible link to their intraspecies transmission. The interspecies spill-over of a BtCoV to humans is thought to occur through an intermediate host, in which the virus replicates through yet completely unidentified routes. In India, regions of the Western Ghats, particularly in Kerala, are reported to have habitat for diverse bat populations. The reports of pathogenic human viruses from bat specimens demand enhanced methods to monitor human exposure to various bat species. Investigations in unexplored regions/States should be focused on gaining further insights into CoV diversity within Indian bat populations.\nEarlier, we had reported the presence of pathogenic viruses such as the Nipah virus in Pteropus bats in India16. In the present scenario of changing demography and ecological manipulations, it is challenging to have checks on the encounters of bats with other animals and humans. Therefore, active and continuous surveillance remains crucial for outbreak alerts for bat-associated viral agents with epidemic potential, which would be helpful in timely interventions.\nAlthough CoVs in the subfamily Coronavirinae do not usually produce clinical symptoms in their natural hosts (bats), accidental transmission of these viruses to humans and other animals may result in respiratory, enteric, hepatic or neurologic diseases of variable severity. It is still not understood as to why only certain CoVs can infect people.\nThere is a need of proactive surveillance of zoonotic infections in bats. Detection and identifications of such aetiological agents will provide leads for the development of diagnostic along with preparedness and readiness to deal with such emergent viruses thereby quickly containing them. The detection and identification of such viruses from bats also recommends cross-sectional antibody surveys (human and domestic animals) in localities where the viruses have been detected. Similarly, if epidemiological situation demands, evidence-based surveillance should also be conducted. There is a need of developing strong mechanisms for working jointly with various stakeholders such as wildlife, poultry, animal husbandry and human health departments.\nIn conclusion, our study showed detection of pathogenic CoVs in two species of Indian bats. Continuous active surveillance is required to identify the emerging novel viruses with epidemic 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