PMC:7361216 / 3102-3786 JSONTXT

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{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7361216","sourcedb":"PMC","sourceid":"7361216","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7361216","text":"A demyelinating neuropathy targeting myelin‐associated glycoprotein (MAG) has an incidence of approximately one per 100,000 (Mygland \u0026 Monstad, 2001). In this disease there is production of an IgM antibody resulting in a “monoclonal gammopathy” targeting a particular carbohydrate known as Cellular Differentiation antigen 57 (CD57) and also known as human natural killer cell‐1 (HNK‐1). The HNK‐1 antigen is found on MAG, as well as on natural killer cells, neuroectodermal tissue, retina, brain, prostate and renal proximal tubules (Pernick, 2019). CD57 belongs to a family of sialic acid‐binding Ig‐like lectins (siglecs) found on both peripheral and central nervous system 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