PMC:7358770 / 22091-24963
Annnotations
LitCovid_Glycan-Motif-Structure
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T37 | 570-577 | https://glytoucan.org/Structures/Glycans/G00021MO | denotes | Heparin |
| T38 | 570-577 | https://glytoucan.org/Structures/Glycans/G54161DR | denotes | Heparin |
| T39 | 581-588 | https://glytoucan.org/Structures/Glycans/G00021MO | denotes | heparin |
| T40 | 581-588 | https://glytoucan.org/Structures/Glycans/G54161DR | denotes | heparin |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T224 | 83-87 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T225 | 106-118 | Body_part | denotes | cell surface | http://purl.org/sig/ont/fma/fma67653 |
| T226 | 106-110 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T227 | 171-200 | Body_part | denotes | heparan sulfated proteoglycan | http://purl.org/sig/ont/fma/fma82834 |
| T228 | 188-200 | Body_part | denotes | proteoglycan | http://purl.org/sig/ont/fma/fma63015 |
| T229 | 208-220 | Body_part | denotes | cell surface | http://purl.org/sig/ont/fma/fma67653 |
| T230 | 208-212 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T231 | 222-237 | Body_part | denotes | Polysaccharides | http://purl.org/sig/ont/fma/fma82746 |
| T232 | 259-274 | Body_part | denotes | polysaccharides | http://purl.org/sig/ont/fma/fma82746 |
| T233 | 353-365 | Body_part | denotes | cell surface | http://purl.org/sig/ont/fma/fma67653 |
| T234 | 353-357 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T235 | 518-531 | Body_part | denotes | cell membrane | http://purl.org/sig/ont/fma/fma63841 |
| T236 | 518-522 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T237 | 570-577 | Body_part | denotes | Heparin | http://purl.org/sig/ont/fma/fma82839 |
| T238 | 581-588 | Body_part | denotes | heparin | http://purl.org/sig/ont/fma/fma82839 |
| T239 | 697-709 | Body_part | denotes | cell surface | http://purl.org/sig/ont/fma/fma67653 |
| T240 | 697-701 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T241 | 710-723 | Body_part | denotes | carbohydrates | http://purl.org/sig/ont/fma/fma82737 |
| T242 | 774-776 | Body_part | denotes | HS | http://purl.org/sig/ont/fma/fma63023 |
| T243 | 815-829 | Body_part | denotes | polysaccharide | http://purl.org/sig/ont/fma/fma82746 |
| T244 | 997-1012 | Body_part | denotes | polysaccharides | http://purl.org/sig/ont/fma/fma82746 |
| T245 | 1303-1306 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T246 | 1349-1366 | Body_part | denotes | cellular membrane | http://purl.org/sig/ont/fma/fma63841 |
| T247 | 1494-1510 | Body_part | denotes | epithelial cells | http://purl.org/sig/ont/fma/fma66768 |
| T248 | 1505-1510 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T249 | 1636-1641 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T250 | 1927-1932 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T251 | 2059-2064 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T252 | 2192-2199 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T253 | 2242-2246 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T254 | 2395-2402 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T255 | 2407-2411 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T256 | 2459-2464 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 759 | 2863-2866 | Species | denotes | HBV | Tax:10407 |
| 805 | 1673-1686 | Gene | denotes | neuraminidase | Gene:4758 |
| 806 | 1825-1829 | Gene | denotes | EGFR | Gene:1956 |
| 807 | 1831-1835 | Gene | denotes | PKCα | Gene:5578 |
| 808 | 1837-1842 | Gene | denotes | NF-κB | Gene:4790 |
| 809 | 1848-1851 | Gene | denotes | Akt | Gene:207 |
| 810 | 1890-1894 | Gene | denotes | EGFR | Gene:1956 |
| 811 | 2214-2217 | Gene | denotes | Akt | Gene:207 |
| 812 | 2218-2222 | Gene | denotes | mTOR | Gene:2475 |
| 813 | 1053-1065 | Species | denotes | dengue virus | Tax:12637 |
| 814 | 1240-1261 | Species | denotes | human metapneumovirus | Tax:162145 |
| 815 | 1263-1267 | Species | denotes | hMPV | Tax:162145 |
| 816 | 1482-1487 | Species | denotes | human | Tax:9606 |
| 817 | 2026-2032 | Species | denotes | HSV)-2 | Tax:10310 |
| 818 | 2294-2303 | Species | denotes | HCoV-NL63 | Tax:277944 |
| 819 | 2617-2628 | Species | denotes | coronavirus | Tax:11118 |
| 820 | 2629-2638 | Species | denotes | HCoV-NL63 | Tax:277944 |
| 821 | 2728-2741 | Species | denotes | coronaviruses | Tax:11118 |
| 822 | 2784-2797 | Species | denotes | coronaviruses | Tax:11118 |
| 823 | 893-896 | Species | denotes | IAV | Tax:11320 |
| 824 | 1067-1071 | Species | denotes | DENV | Tax:12637 |
| 825 | 1467-1470 | Species | denotes | HRV | Tax:169066 |
| 826 | 1695-1698 | Species | denotes | IAV | Tax:11320 |
| 827 | 1755-1758 | Species | denotes | IAV | Tax:11320 |
| 828 | 1870-1873 | Species | denotes | IAV | Tax:11320 |
| 829 | 2142-2145 | Species | denotes | HPV | Tax:10566 |
| 830 | 171-178 | Chemical | denotes | heparan | |
| 831 | 222-237 | Chemical | denotes | Polysaccharides | MESH:D011134 |
| 832 | 259-274 | Chemical | denotes | polysaccharides | MESH:D011134 |
| 833 | 570-577 | Chemical | denotes | Heparin | MESH:D006493 |
| 834 | 710-723 | Chemical | denotes | carbohydrates | MESH:D002241 |
| 835 | 774-776 | Chemical | denotes | HS | MESH:D006497 |
| 836 | 781-792 | Chemical | denotes | carrageenan | MESH:D002351 |
| 837 | 815-829 | Chemical | denotes | polysaccharide | MESH:D011134 |
| 838 | 997-1012 | Chemical | denotes | polysaccharides | MESH:D011134 |
| 839 | 1112-1128 | Chemical | denotes | Iota-carrageenan | MESH:D002351 |
| 840 | 1165-1196 | Chemical | denotes | poly (allylamine) hydrochloride | MESH:C063994 |
| 841 | 1405-1421 | Chemical | denotes | Iota-carrageenan | MESH:D002351 |
| 842 | 1545-1561 | Chemical | denotes | iota-carrageenan | MESH:D002351 |
| 843 | 1774-1782 | Chemical | denotes | fucoidan | MESH:C007789 |
| 844 | 2530-2571 | Chemical | denotes | N-(2-hydroxypropyl) -3-trimethyl chitosan | |
| 845 | 2762-2767 | Chemical | denotes | water | MESH:D014867 |
| 846 | 897-906 | Disease | denotes | infection | MESH:D007239 |
| 847 | 1280-1302 | Disease | denotes | respiratory infections | MESH:D012141 |
| 848 | 1914-1926 | Disease | denotes | IAV-infected | MESH:D007239 |
| 849 | 2480-2495 | Disease | denotes | virus infection | MESH:D001102 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T91 | 897-906 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T92 | 1053-1059 | Disease | denotes | dengue | http://purl.obolibrary.org/obo/MONDO_0005502 |
| T93 | 1280-1302 | Disease | denotes | respiratory infections | http://purl.obolibrary.org/obo/MONDO_0024355 |
| T94 | 2004-2018 | Disease | denotes | herpes simplex | http://purl.obolibrary.org/obo/MONDO_0004609 |
| T95 | 2480-2495 | Disease | denotes | virus infection | http://purl.obolibrary.org/obo/MONDO_0005108 |
| T96 | 2486-2495 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T97 | 2578-2580 | Disease | denotes | NS | http://purl.obolibrary.org/obo/MONDO_0009735 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T225 | 16-21 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T226 | 65-70 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T227 | 81-87 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a cell |
| T228 | 106-110 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T229 | 151-152 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T230 | 171-200 | http://purl.obolibrary.org/obo/PR_000001307 | denotes | heparan sulfated proteoglycan |
| T231 | 208-212 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T232 | 353-357 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T233 | 377-382 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T234 | 436-441 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T235 | 486-491 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T236 | 507-512 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T237 | 518-522 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T238 | 523-531 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T239 | 558-563 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T240 | 697-701 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T241 | 1060-1065 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T242 | 1221-1231 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activities |
| T243 | 1240-1245 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T244 | 1270-1271 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T245 | 1307-1312 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T246 | 1326-1331 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T247 | 1358-1366 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T248 | 1382-1387 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T249 | 1482-1487 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T250 | 1494-1504 | http://purl.obolibrary.org/obo/CL_0000066 | denotes | epithelial |
| T251 | 1505-1510 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T252 | 1636-1641 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T253 | 1716-1724 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T254 | 1811-1821 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T255 | 1841-1842 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T256 | 1927-1932 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T257 | 2019-2024 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T258 | 2059-2064 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T259 | 2066-2068 | http://purl.obolibrary.org/obo/CLO_0001527 | denotes | 94 |
| T260 | 2146-2156 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activities |
| T261 | 2242-2246 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T262 | 2307-2308 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T263 | 2407-2411 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T264 | 2459-2464 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T265 | 2480-2485 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T266 | 2581-2583 | http://purl.obolibrary.org/obo/CLO_0007874 | denotes | MS |
| T267 | 2652-2657 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T351 | 171-178 | Chemical | denotes | heparan | http://purl.obolibrary.org/obo/CHEBI_24500 |
| T352 | 188-200 | Chemical | denotes | proteoglycan | http://purl.obolibrary.org/obo/CHEBI_37396 |
| T353 | 259-274 | Chemical | denotes | polysaccharides | http://purl.obolibrary.org/obo/CHEBI_18154 |
| T354 | 570-577 | Chemical | denotes | Heparin | http://purl.obolibrary.org/obo/CHEBI_28304 |
| T355 | 581-588 | Chemical | denotes | heparin | http://purl.obolibrary.org/obo/CHEBI_28304 |
| T356 | 624-633 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
| T357 | 710-723 | Chemical | denotes | carbohydrates | http://purl.obolibrary.org/obo/CHEBI_16646 |
| T358 | 774-776 | Chemical | denotes | HS | http://purl.obolibrary.org/obo/CHEBI_74056|http://purl.obolibrary.org/obo/CHEBI_28815 |
| T360 | 781-792 | Chemical | denotes | carrageenan | http://purl.obolibrary.org/obo/CHEBI_3435 |
| T361 | 815-829 | Chemical | denotes | polysaccharide | http://purl.obolibrary.org/obo/CHEBI_18154 |
| T362 | 968-977 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
| T363 | 997-1012 | Chemical | denotes | polysaccharides | http://purl.obolibrary.org/obo/CHEBI_18154 |
| T364 | 1117-1128 | Chemical | denotes | carrageenan | http://purl.obolibrary.org/obo/CHEBI_3435 |
| T365 | 1183-1196 | Chemical | denotes | hydrochloride | http://purl.obolibrary.org/obo/CHEBI_36807 |
| T366 | 1211-1220 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
| T367 | 1410-1421 | Chemical | denotes | carrageenan | http://purl.obolibrary.org/obo/CHEBI_3435 |
| T368 | 1545-1561 | Chemical | denotes | iota-carrageenan | http://purl.obolibrary.org/obo/CHEBI_37168 |
| T369 | 1550-1561 | Chemical | denotes | carrageenan | http://purl.obolibrary.org/obo/CHEBI_3435 |
| T370 | 1688-1690 | Chemical | denotes | NA | http://purl.obolibrary.org/obo/CHEBI_33696 |
| T371 | 1728-1730 | Chemical | denotes | NA | http://purl.obolibrary.org/obo/CHEBI_33696 |
| T372 | 1774-1782 | Chemical | denotes | fucoidan | http://purl.obolibrary.org/obo/CHEBI_5181 |
| T373 | 1837-1839 | Chemical | denotes | NF | http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224 |
| T376 | 1943-1952 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
| T377 | 2106-2114 | Chemical | denotes | chitosan | http://purl.obolibrary.org/obo/CHEBI_16261|http://purl.obolibrary.org/obo/CHEBI_57704 |
| T379 | 2192-2199 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T380 | 2354-2361 | Chemical | denotes | polymer | http://purl.obolibrary.org/obo/CHEBI_33839|http://purl.obolibrary.org/obo/CHEBI_60027 |
| T382 | 2395-2402 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T383 | 2563-2571 | Chemical | denotes | chitosan | http://purl.obolibrary.org/obo/CHEBI_16261|http://purl.obolibrary.org/obo/CHEBI_57704 |
| T385 | 2578-2580 | Chemical | denotes | NS | http://purl.obolibrary.org/obo/CHEBI_73426 |
| T386 | 2581-2583 | Chemical | denotes | MS | http://purl.obolibrary.org/obo/CHEBI_73613 |
| T387 | 2762-2767 | Chemical | denotes | water | http://purl.obolibrary.org/obo/CHEBI_15377 |
| T388 | 2843-2851 | Chemical | denotes | chitosan | http://purl.obolibrary.org/obo/CHEBI_16261|http://purl.obolibrary.org/obo/CHEBI_57704 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T34 | 471-482 | http://purl.obolibrary.org/obo/GO_0006897 | denotes | endocytosis |
| T35 | 1825-1829 | http://purl.obolibrary.org/obo/GO_0005006 | denotes | EGFR |
| T36 | 1874-1885 | http://purl.obolibrary.org/obo/GO_0006897 | denotes | endocytosis |
| T37 | 1890-1894 | http://purl.obolibrary.org/obo/GO_0005006 | denotes | EGFR |
| T38 | 2209-2213 | http://purl.obolibrary.org/obo/GO_0016303 | denotes | PI3K |
| T39 | 2247-2256 | http://purl.obolibrary.org/obo/GO_0016236 | denotes | autophagy |
| T40 | 2247-2256 | http://purl.obolibrary.org/obo/GO_0006914 | denotes | autophagy |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32679328-29654857-48281303 | 407-409 | 29654857 | denotes | 12 |
| 32679328-29654857-48281304 | 565-567 | 29654857 | denotes | 12 |
| 32679328-20394070-48281305 | 647-649 | 20394070 | denotes | 87 |
| 32679328-19447134-48281306 | 653-655 | 19447134 | denotes | 88 |
| 32679328-16127029-48281307 | 659-661 | 16127029 | denotes | 89 |
| 32679328-22197247-48281308 | 959-961 | 22197247 | denotes | 91 |
| 32679328-22652218-48281309 | 1107-1109 | 22652218 | denotes | 92 |
| 32679328-18817582-48281310 | 1643-1645 | 18817582 | denotes | 85 |
| 32679328-30093007-48281311 | 2268-2270 | 30093007 | denotes | 95 |
| 32679328-28482585-48281312 | 2799-2801 | 28482585 | denotes | 97 |
| 32679328-30093007-48281313 | 2868-2870 | 30093007 | denotes | 95 |
| T78657 | 407-409 | 29654857 | denotes | 12 |
| T64060 | 565-567 | 29654857 | denotes | 12 |
| T36608 | 647-649 | 20394070 | denotes | 87 |
| T81775 | 653-655 | 19447134 | denotes | 88 |
| T20509 | 659-661 | 16127029 | denotes | 89 |
| T51780 | 959-961 | 22197247 | denotes | 91 |
| T22710 | 1107-1109 | 22652218 | denotes | 92 |
| T43498 | 1643-1645 | 18817582 | denotes | 85 |
| T47034 | 2268-2270 | 30093007 | denotes | 95 |
| T38579 | 2799-2801 | 28482585 | denotes | 97 |
| T64039 | 2868-2870 | 30093007 | denotes | 95 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T137 | 0-45 | Sentence | denotes | 3.2 Inhibiting virus adsorption and invasion |
| T138 | 46-221 | Sentence | denotes | The first step for virus to invade a cell is to bind to the cell surface by electrostatic interaction or a receptor, such as heparan sulfated proteoglycan on the cell surface. |
| T139 | 222-411 | Sentence | denotes | Polysaccharides, especially sulfated polysaccharides, have strong polyanionic properties, and can block the positive charge on the cell surface to prevent virus adsorption or invasion [12]. |
| T140 | 412-569 | Sentence | denotes | The invasion process of virus is often associated with the endocytosis of virus, the fusion of virus with cell membrane, and the translocation of virus [12]. |
| T141 | 570-801 | Sentence | denotes | Heparin or heparin-like materials with broad-spectrum antiviral properties [[87], [88], [89]] have been developed to mimic the cell surface carbohydrates responsible for initial viral attachment, such as HS and carrageenan [34,90]. |
| T142 | 802-963 | Sentence | denotes | The sulfated polysaccharide derived from marine microalga showed strong inhibition against IAV infection via the viral adsorption and internalization steps [91]. |
| T143 | 964-1111 | Sentence | denotes | The antiviral effect of sulfated polysaccharides from seaweeds was mainly exerted during dengue virus (DENV)-2 adsorption and internalization [92]. |
| T144 | 1112-1404 | Sentence | denotes | Iota-carrageenan and its N-sulfonated derivatives of poly (allylamine) hydrochloride showed strong antiviral activities against human metapneumovirus (hMPV), a kind of respiratory infections RNA virus, by blocking virus release from the cellular membrane and inhibiting virus adsorption [93]. |
| T145 | 1405-1522 | Sentence | denotes | Iota-carrageenan also effectively prevents the replication of HRV in primary human nasal epithelial cells in culture. |
| T146 | 1523-1647 | Sentence | denotes | The data suggest that iota-carrageenan acts primarily by preventing the binding or the entry of virions into the cells [85]. |
| T147 | 1648-1759 | Sentence | denotes | Fucoidan can bind to the neuraminidase (NA) of IAV, and inhibit the activity of NA to block the release of IAV. |
| T148 | 1760-1938 | Sentence | denotes | Additionally, fucoidan can also interfere with the activation of EGFR, PKCα, NF-κB, and Akt, and inhibit both IAV endocytosis and EGFR internalization in IAV-infected cells [73]. |
| T149 | 1939-2070 | Sentence | denotes | The antiviral mechanism of the fucoidans may be through blocking herpes simplex virus (HSV)-2 virion adsorption to host cells [94]. |
| T150 | 2071-2272 | Sentence | denotes | Our team found that 3,6-O-sulfated chitosan (36S) possessed broad anti-HPV activities by directly targeting viral capsid protein and host PI3K/Akt/mTOR pathway to inhibit cell autophagy (Fig. 6 ) [95]. |
| T151 | 2273-2504 | Sentence | denotes | Interestingly, using HCoV-NL63 as a model system, it can be determined that HTCC polymer blocks the interaction between S protein and cell receptor, consequently blocking its entry into cells and preventing virus infection [68,96]. |
| T152 | 2505-2670 | Sentence | denotes | The nano/microspheres of N-(2-hydroxypropyl) -3-trimethyl chitosan (HTCC-NS/MS) were used for adsorption of the coronavirus HCoV-NL63 from aqueous virus suspensions. |
| T153 | 2671-2803 | Sentence | denotes | This nano/microspheres can be applied for the removal of coronaviruses and purification of water from pathogenic coronaviruses [97]. |
| T154 | 2804-2872 | Sentence | denotes | Fig. 6 The mechanism of 3,6-O-sulfated chitosan inhibiting HBV [95]. |
LitCovid-PD-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glyco_epitope_db_id |
|---|---|---|---|---|---|
| T15 | 774-776 | GlycoEpitope | denotes | HS | http://www.glycoepitope.jp/epitopes/EP0086 |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T10 | 1280-1302 | Phenotype | denotes | respiratory infections | http://purl.obolibrary.org/obo/HP_0011947 |
LitCovid-PMC-OGER-BB
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T607 | 16-21 | NCBITaxon:10239 | denotes | virus |
| T608 | 65-70 | NCBITaxon:10239 | denotes | virus |
| T609 | 106-118 | GO:0009986 | denotes | cell surface |
| T610 | 171-200 | CHEBI:24499;CHEBI:24499 | denotes | heparan sulfated proteoglycan |
| T611 | 208-220 | GO:0009986 | denotes | cell surface |
| T612 | 222-237 | CHEBI:18154;CHEBI:18154 | denotes | Polysaccharides |
| T613 | 259-274 | CHEBI:18154;CHEBI:18154 | denotes | polysaccharides |
| T614 | 353-365 | GO:0009986 | denotes | cell surface |
| T615 | 377-382 | NCBITaxon:10239 | denotes | virus |
| T616 | 436-441 | NCBITaxon:10239 | denotes | virus |
| T617 | 471-482 | GO:0006897 | denotes | endocytosis |
| T618 | 486-491 | NCBITaxon:10239 | denotes | virus |
| T619 | 497-503 | GO:0061025 | denotes | fusion |
| T620 | 507-512 | NCBITaxon:10239 | denotes | virus |
| T621 | 518-531 | GO:0005886 | denotes | cell membrane |
| T622 | 558-563 | NCBITaxon:10239 | denotes | virus |
| T623 | 570-577 | CHEBI:24505;CHEBI:24505 | denotes | Heparin |
| T624 | 581-588 | CHEBI:24505;CHEBI:24505 | denotes | heparin |
| T625 | 697-709 | GO:0009986 | denotes | cell surface |
| T626 | 710-723 | CHEBI:16646;CHEBI:16646 | denotes | carbohydrates |
| T627 | 748-753 | NCBITaxon:10239 | denotes | viral |
| T628 | 781-792 | CHEBI:3435;CHEBI:3435 | denotes | carrageenan |
| T629 | 815-829 | CHEBI:65212;CHEBI:65212 | denotes | polysaccharide |
| T630 | 915-920 | NCBITaxon:10239 | denotes | viral |
| T631 | 997-1012 | CHEBI:18154;CHEBI:18154 | denotes | polysaccharides |
| T632 | 1053-1059 | NCBITaxon:9793 | denotes | dengue |
| T633 | 1060-1065 | NCBITaxon:10239 | denotes | virus |
| T634 | 1117-1128 | CHEBI:37168;CHEBI:37168 | denotes | carrageenan |
| T635 | 1139-1149 | CHEBI:33543;CHEBI:33543 | denotes | sulfonated |
| T636 | 1183-1196 | CHEBI:36807;CHEBI:36807 | denotes | hydrochloride |
| T637 | 1240-1245 | SP_6;NCBITaxon:9606 | denotes | human |
| T638 | 1263-1267 | NCBITaxon:10359 | denotes | hMPV |
| T639 | 1303-1306 | BV_22 | denotes | RNA |
| T640 | 1307-1312 | BV_22;NCBITaxon:10239 | denotes | virus |
| T641 | 1326-1331 | NCBITaxon:10239 | denotes | virus |
| T642 | 1349-1366 | GO:0005886 | denotes | cellular membrane |
| T643 | 1382-1387 | NCBITaxon:10239 | denotes | virus |
| T644 | 1410-1421 | CHEBI:37168;CHEBI:37168 | denotes | carrageenan |
| T645 | 1452-1463 | GO:0006260 | denotes | replication |
| T646 | 1474-1481 | CL:0000001 | denotes | primary |
| T647 | 1482-1487 | SP_6;NCBITaxon:9606 | denotes | human |
| T648 | 1488-1493 | CL:0000082;UBERON:0001823 | denotes | nasal |
| T649 | 1494-1504 | UBERON:0001823;CL:0000066 | denotes | epithelial |
| T650 | 1505-1510 | CL:0000066 | denotes | cells |
| T651 | 1550-1561 | CHEBI:37168;CHEBI:37168 | denotes | carrageenan |
| T652 | 1610-1618 | GO:0035376 | denotes | entry of |
| T653 | 1774-1782 | CHEBI:5181;CHEBI:5181 | denotes | fucoidan |
| T654 | 1837-1839 | GO:0005883 | denotes | NF |
| T655 | 1848-1851 | PR:000002190 | denotes | Akt |
| T656 | 1874-1885 | GO:0006897 | denotes | endocytosis |
| T657 | 2004-2024 | NCBITaxon:10376 | denotes | herpes simplex virus |
| T658 | 2026-2029 | NCBITaxon:10298 | denotes | HSV |
| T659 | 2093-2094 | CHEBI:17369;CHEBI:17369 | denotes | 6 |
| T660 | 2097-2105 | CHEBI:16189;CHEBI:16189 | denotes | sulfated |
| T661 | 2106-2114 | CHEBI:16261;CHEBI:16261 | denotes | chitosan |
| T662 | 2142-2145 | NCBITaxon:11886 | denotes | HPV |
| T663 | 2179-2184 | NCBITaxon:10239 | denotes | viral |
| T664 | 2214-2217 | PR:000002190 | denotes | Akt |
| T665 | 2242-2246 | GO:0000422 | denotes | cell |
| T666 | 2247-2256 | GO:0006914 | denotes | autophagy |
| T667 | 2354-2361 | CHEBI:60027;CHEBI:60027 | denotes | polymer |
| T668 | 2393-2402 | PG_1 | denotes | S protein |
| T669 | 2448-2458 | GO:0035376 | denotes | entry into |
| T670 | 2480-2485 | NCBITaxon:10239 | denotes | virus |
| T671 | 2530-2532 | CHEBI:8502;CHEBI:8502 | denotes | N- |
| T672 | 2532-2533 | CHEBI:62946;CHEBI:62946 | denotes | ( |
| T673 | 2533-2534 | CHEBI:17824;CHEBI:17824 | denotes | 2 |
| T674 | 2534-2535 | CHEBI:8502;CHEBI:8502 | denotes | - |
| T675 | 2535-2548 | CHEBI:20067;CHEBI:20067 | denotes | hydroxypropyl |
| T676 | 2551-2552 | CHEBI:53233;CHEBI:53233 | denotes | 3 |
| T677 | 2553-2562 | CHEBI:53233;CHEBI:53233 | denotes | trimethyl |
| T678 | 2563-2571 | CHEBI:16261;CHEBI:16261 | denotes | chitosan |
| T679 | 2617-2628 | NCBITaxon:11118 | denotes | coronavirus |
| T680 | 2644-2651 | CHEBI:15377;CHEBI:15377 | denotes | aqueous |
| T681 | 2652-2657 | NCBITaxon:10239 | denotes | virus |
| T682 | 2728-2741 | NCBITaxon:11118 | denotes | coronaviruses |
| T683 | 2762-2767 | CHEBI:15377;CHEBI:15377 | denotes | water |
| T684 | 2784-2797 | NCBITaxon:11118 | denotes | coronaviruses |
| T685 | 2828-2834 | CHEBI:53233;CHEBI:53233 | denotes | 3,6-O- |
| T686 | 2834-2842 | CHEBI:16189;CHEBI:16189 | denotes | sulfated |
| T687 | 2843-2851 | CHEBI:16261;CHEBI:16261 | denotes | chitosan |
| T688 | 2863-2866 | NCBITaxon:10376 | denotes | HBV |
| T52303 | 19-24 | NCBITaxon:10239 | denotes | us ad |
| T54377 | 52-63 | CHEBI:3435;CHEBI:3435 | denotes | rst step fo |
| T60405 | 86-100 | CHEBI:65212;CHEBI:65212 | denotes | l is to bind t |
| T97116 | 186-191 | NCBITaxon:10239 | denotes | d pro |
| T17827 | 268-283 | CHEBI:18154;CHEBI:18154 | denotes | arides, have st |
| T53742 | 324-330 | NCBITaxon:9793 | denotes | k the |
| T39423 | 331-336 | NCBITaxon:10239 | denotes | ositi |
| T83421 | 385-396 | CHEBI:37168;CHEBI:37168 | denotes | sorption or |
| T36115 | 407-417 | CHEBI:33543;CHEBI:33543 | denotes | 12]. The i |
| T92759 | 451-464 | CHEBI:36807;CHEBI:36807 | denotes | associated wi |
| T32672 | 508-513 | SP_6;NCBITaxon:9606 | denotes | irus |
| T96885 | 529-533 | NCBITaxon:10359 | denotes | ne, |
| T18494 | 568-571 | BV_22 | denotes | . H |
| T90836 | 572-577 | BV_22;NCBITaxon:10239 | denotes | parin |
| T41255 | 591-596 | NCBITaxon:10239 | denotes | ke ma |
| T21887 | 614-631 | GO:0005886 | denotes | -spectrum antivir |
| T58956 | 647-652 | NCBITaxon:10239 | denotes | 87], |
| T30401 | 672-683 | CHEBI:37168;CHEBI:37168 | denotes | n developed |
| T55753 | 714-725 | GO:0006260 | denotes | ohydrates r |
| T42513 | 736-743 | CL:0000001 | denotes | for ini |
| T45720 | 744-749 | SP_6;NCBITaxon:9606 | denotes | ial v |
| T43477 | 750-755 | CL:0000082;UBERON:0001823 | denotes | ral a |
| T78452 | 756-765 | UBERON:0001823;CL:0000066 | denotes | tachment, |
| T90709 | 766-771 | CL:0000066 | denotes | such |
| T17731 | 808-819 | CHEBI:37168;CHEBI:37168 | denotes | lfated poly |
| T21229 | 868-876 | GO:0035376 | denotes | trong in |
| T31244 | 1032-1040 | CHEBI:5181;CHEBI:5181 | denotes | ainly ex |
| T46328 | 1095-1097 | GO:0005883 | denotes | na |
| T93483 | 1106-1109 | PR:000002190 | denotes | [92 |
| T69930 | 1135-1146 | GO:0006897 | denotes | s N-sulfona |
| T42947 | 1267-1288 | NCBITaxon:10376 | denotes | ), a kind of respirat |
| T16071 | 1290-1293 | NCBITaxon:10298 | denotes | y i |
| T58472 | 1357-1358 | CHEBI:17369;CHEBI:17369 | denotes | |
| T21845 | 1361-1369 | CHEBI:16189;CHEBI:16189 | denotes | brane an |
| T82603 | 1370-1376 | CHEBI:16261;CHEBI:16261 | denotes | inhib |
| T97586 | 1404-1410 | NCBITaxon:11886 | denotes | Iota- |
| T58220 | 1444-1449 | NCBITaxon:10239 | denotes | nts t |
| T99141 | 1477-1480 | PR:000002190 | denotes | mar |
| T24577 | 1506-1510 | GO:0000422 | denotes | ells |
| T69144 | 1511-1520 | GO:0006914 | denotes | in cultur |
| T20448 | 1621-1628 | CHEBI:60027;CHEBI:60027 | denotes | rions i |
| T31179 | 1660-1669 | PG_1 | denotes | bind to |
| T91673 | 1715-1725 | GO:0035376 | denotes | activity |
| T28428 | 1747-1752 | NCBITaxon:10239 | denotes | ease |
| T45439 | 1797-1799 | CHEBI:8502;CHEBI:8502 | denotes | fe |
| T76917 | 1799-1800 | CHEBI:62946;CHEBI:62946 | denotes | r |
| T79671 | 1800-1801 | CHEBI:17824;CHEBI:17824 | denotes | e |
| T40800 | 1801-1802 | CHEBI:8502;CHEBI:8502 | denotes | |
| T31954 | 1802-1815 | CHEBI:20067;CHEBI:20067 | denotes | with the acti |
| T45466 | 1818-1819 | CHEBI:53233;CHEBI:53233 | denotes | i |
| T82199 | 1820-1829 | CHEBI:53233;CHEBI:53233 | denotes | n of EGFR |
| T96261 | 1830-1836 | CHEBI:16261;CHEBI:16261 | denotes | PKCα, |
| T39295 | 1882-1893 | NCBITaxon:11118 | denotes | sis and EGF |
| T83146 | 1909-1916 | CHEBI:15377;CHEBI:15377 | denotes | n in IA |
| T92659 | 1917-1922 | NCBITaxon:10239 | denotes | -infe |
| T64279 | 1993-2006 | NCBITaxon:11118 | denotes | h blocking he |
| T25834 | 2027-2032 | CHEBI:15377;CHEBI:15377 | denotes | SV)-2 |
| T30740 | 2049-2062 | NCBITaxon:11118 | denotes | n to host cel |
| T65995 | 2091-2097 | CHEBI:53233;CHEBI:53233 | denotes | 3,6-O- |
| T67308 | 2097-2105 | CHEBI:16189;CHEBI:16189 | denotes | sulfated |
| T33853 | 2106-2114 | CHEBI:16261;CHEBI:16261 | denotes | chitosan |
| T6480 | 2126-2129 | NCBITaxon:10376 | denotes | sse |
| T689 | 2166-2168 | CHEBI:53233;CHEBI:53233 | denotes | ly |
| T690 | 2168-2169 | CHEBI:17369;CHEBI:17369 | denotes | |
| T691 | 2169-2172 | CHEBI:53233;CHEBI:53233 | denotes | tar |
| T692 | 2172-2180 | CHEBI:16189;CHEBI:16189 | denotes | geting v |
| T693 | 2181-2187 | CHEBI:16261;CHEBI:16261 | denotes | ral ca |
| T694 | 2201-2204 | NCBITaxon:10376 | denotes | nd |
| T3478 | 2226-2231 | NCBITaxon:10239 | denotes | hway |
| T77225 | 2250-2261 | GO:0006260 | denotes | ophagy (Fig |
| T27096 | 2262-2277 | CHEBI:18154;CHEBI:18154 | denotes | 6 ) [95]. Inte |
| T33964 | 2299-2314 | CHEBI:18154;CHEBI:18154 | denotes | NL63 as a model |
| T66240 | 2344-2349 | NCBITaxon:10239;GO:0006260 | denotes | that |
| T82798 | 2350-2361 | GO:0006260 | denotes | TCC polymer |
| T9741 | 2416-2427 | CHEBI:37168;CHEBI:37168 | denotes | ptor, conse |
| T57542 | 2460-2472 | NCBITaxon:28344;GO:0000003 | denotes | ells and pre |
| T48832 | 2477-2487 | GO:0045333;NCBITaxon:11886 | denotes | ng virus i |
| T67598 | 2488-2496 | NCBITaxon:11886 | denotes | fection |
| T72988 | 2497-2502 | NCBITaxon:10239 | denotes | 68,96 |
| T89206 | 2587-2595 | UBERON:0003215 | denotes | re used |
| T8863 | 2596-2607 | CL:0000583 | denotes | or adsorpti |
| T71781 | 2614-2625 | CHEBI:3435;CHEBI:3435 | denotes | he coronavi |
| T57562 | 2626-2641 | CHEBI:50699;CHEBI:50699 | denotes | us HCoV-NL63 fr |
| T39851 | 2707-2718 | GO:0006260 | denotes | d for the r |
| T91626 | 2808-2816 | CHEBI:35195;CHEBI:35195 | denotes | 6 The m |
| T67343 | 2817-2831 | CHEBI:18154;CHEBI:18154 | denotes | chanism of 3,6 |
| T78083 | 2837-2849 | NCBITaxon:61463 | denotes | fated chitos |
| T83884 | 2850-2863 | NCBITaxon:2778 | denotes | n inhibiting |
MyTest
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 759 | 2863-2866 | Species | denotes | HBV | Tax:10407 |
| 805 | 1673-1686 | Gene | denotes | neuraminidase | Gene:4758 |
| 806 | 1825-1829 | Gene | denotes | EGFR | Gene:1956 |
| 807 | 1831-1835 | Gene | denotes | PKCα | Gene:5578 |
| 808 | 1837-1842 | Gene | denotes | NF-κB | Gene:4790 |
| 809 | 1848-1851 | Gene | denotes | Akt | Gene:207 |
| 810 | 1890-1894 | Gene | denotes | EGFR | Gene:1956 |
| 811 | 2214-2217 | Gene | denotes | Akt | Gene:207 |
| 812 | 2218-2222 | Gene | denotes | mTOR | Gene:2475 |
| 813 | 1053-1065 | Species | denotes | dengue virus | Tax:12637 |
| 814 | 1240-1261 | Species | denotes | human metapneumovirus | Tax:162145 |
| 815 | 1263-1267 | Species | denotes | hMPV | Tax:162145 |
| 816 | 1482-1487 | Species | denotes | human | Tax:9606 |
| 817 | 2026-2032 | Species | denotes | HSV)-2 | Tax:10310 |
| 818 | 2294-2303 | Species | denotes | HCoV-NL63 | Tax:277944 |
| 819 | 2617-2628 | Species | denotes | coronavirus | Tax:11118 |
| 820 | 2629-2638 | Species | denotes | HCoV-NL63 | Tax:277944 |
| 821 | 2728-2741 | Species | denotes | coronaviruses | Tax:11118 |
| 822 | 2784-2797 | Species | denotes | coronaviruses | Tax:11118 |
| 823 | 893-896 | Species | denotes | IAV | Tax:11320 |
| 824 | 1067-1071 | Species | denotes | DENV | Tax:12637 |
| 825 | 1467-1470 | Species | denotes | HRV | Tax:169066 |
| 826 | 1695-1698 | Species | denotes | IAV | Tax:11320 |
| 827 | 1755-1758 | Species | denotes | IAV | Tax:11320 |
| 828 | 1870-1873 | Species | denotes | IAV | Tax:11320 |
| 829 | 2142-2145 | Species | denotes | HPV | Tax:10566 |
| 830 | 171-178 | Chemical | denotes | heparan | |
| 831 | 222-237 | Chemical | denotes | Polysaccharides | MESH:D011134 |
| 832 | 259-274 | Chemical | denotes | polysaccharides | MESH:D011134 |
| 833 | 570-577 | Chemical | denotes | Heparin | MESH:D006493 |
| 834 | 710-723 | Chemical | denotes | carbohydrates | MESH:D002241 |
| 835 | 774-776 | Chemical | denotes | HS | MESH:D006497 |
| 836 | 781-792 | Chemical | denotes | carrageenan | MESH:D002351 |
| 837 | 815-829 | Chemical | denotes | polysaccharide | MESH:D011134 |
| 838 | 997-1012 | Chemical | denotes | polysaccharides | MESH:D011134 |
| 839 | 1112-1128 | Chemical | denotes | Iota-carrageenan | MESH:D002351 |
| 840 | 1165-1196 | Chemical | denotes | poly (allylamine) hydrochloride | MESH:C063994 |
| 841 | 1405-1421 | Chemical | denotes | Iota-carrageenan | MESH:D002351 |
| 842 | 1545-1561 | Chemical | denotes | iota-carrageenan | MESH:D002351 |
| 843 | 1774-1782 | Chemical | denotes | fucoidan | MESH:C007789 |
| 844 | 2530-2571 | Chemical | denotes | N-(2-hydroxypropyl) -3-trimethyl chitosan | |
| 845 | 2762-2767 | Chemical | denotes | water | MESH:D014867 |
| 846 | 897-906 | Disease | denotes | infection | MESH:D007239 |
| 847 | 1280-1302 | Disease | denotes | respiratory infections | MESH:D012141 |
| 848 | 1914-1926 | Disease | denotes | IAV-infected | MESH:D007239 |
| 849 | 2480-2495 | Disease | denotes | virus infection | MESH:D001102 |