PMC:7354481 / 54227-57199 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T342","span":{"begin":359,"end":376},"obj":"Body_part"},{"id":"T343","span":{"begin":390,"end":405},"obj":"Body_part"},{"id":"T344","span":{"begin":406,"end":413},"obj":"Body_part"},{"id":"T345","span":{"begin":442,"end":449},"obj":"Body_part"},{"id":"T346","span":{"begin":469,"end":477},"obj":"Body_part"},{"id":"T347","span":{"begin":478,"end":486},"obj":"Body_part"},{"id":"T348","span":{"begin":556,"end":582},"obj":"Body_part"},{"id":"T349","span":{"begin":572,"end":582},"obj":"Body_part"},{"id":"T350","span":{"begin":577,"end":582},"obj":"Body_part"},{"id":"T351","span":{"begin":638,"end":642},"obj":"Body_part"},{"id":"T352","span":{"begin":711,"end":720},"obj":"Body_part"},{"id":"T353","span":{"begin":756,"end":760},"obj":"Body_part"},{"id":"T354","span":{"begin":799,"end":816},"obj":"Body_part"},{"id":"T355","span":{"begin":873,"end":877},"obj":"Body_part"},{"id":"T356","span":{"begin":1078,"end":1085},"obj":"Body_part"},{"id":"T357","span":{"begin":1103,"end":1120},"obj":"Body_part"},{"id":"T358","span":{"begin":1248,"end":1257},"obj":"Body_part"},{"id":"T359","span":{"begin":1488,"end":1495},"obj":"Body_part"},{"id":"T360","span":{"begin":1640,"end":1644},"obj":"Body_part"},{"id":"T361","span":{"begin":1672,"end":1679},"obj":"Body_part"},{"id":"T362","span":{"begin":1734,"end":1739},"obj":"Body_part"},{"id":"T363","span":{"begin":1778,"end":1793},"obj":"Body_part"},{"id":"T364","span":{"begin":1839,"end":1846},"obj":"Body_part"},{"id":"T365","span":{"begin":2010,"end":2017},"obj":"Body_part"},{"id":"T366","span":{"begin":2120,"end":2140},"obj":"Body_part"},{"id":"T367","span":{"begin":2174,"end":2178},"obj":"Body_part"},{"id":"T368","span":{"begin":2179,"end":2183},"obj":"Body_part"},{"id":"T369","span":{"begin":2234,"end":2237},"obj":"Body_part"},{"id":"T370","span":{"begin":2536,"end":2539},"obj":"Body_part"},{"id":"T371","span":{"begin":2587,"end":2598},"obj":"Body_part"},{"id":"T372","span":{"begin":2623,"end":2631},"obj":"Body_part"},{"id":"T373","span":{"begin":2749,"end":2752},"obj":"Body_part"},{"id":"T374","span":{"begin":2815,"end":2818},"obj":"Body_part"}],"attributes":[{"id":"A342","pred":"fma_id","subj":"T342","obj":"http://purl.org/sig/ont/fma/fma63011"},{"id":"A343","pred":"fma_id","subj":"T343","obj":"http://purl.org/sig/ont/fma/fma63023"},{"id":"A344","pred":"fma_id","subj":"T344","obj":"http://purl.org/sig/ont/fma/fma82839"},{"id":"A345","pred":"fma_id","subj":"T345","obj":"http://purl.org/sig/ont/fma/fma67408"},{"id":"A346","pred":"fma_id","subj":"T346","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A347","pred":"fma_id","subj":"T347","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A348","pred":"fma_id","subj":"T348","obj":"http://purl.org/sig/ont/fma/fma70570"},{"id":"A349","pred":"fma_id","subj":"T349","obj":"http://purl.org/sig/ont/fma/fma63368"},{"id":"A350","pred":"fma_id","subj":"T350","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A351","pred":"fma_id","subj":"T351","obj":"http://purl.org/sig/ont/fma/fma67308"},{"id":"A352","pred":"fma_id","subj":"T352","obj":"http://purl.org/sig/ont/fma/fma83358"},{"id":"A353","pred":"fma_id","subj":"T353","obj":"http://purl.org/sig/ont/fma/fma67122"},{"id":"A354","pred":"fma_id","subj":"T354","obj":"http://purl.org/sig/ont/fma/fma82814"},{"id":"A355","pred":"fma_id","subj":"T355","obj":"http://purl.org/sig/ont/fma/fma62971"},{"id":"A356","pred":"fma_id","subj":"T356","obj":"http://purl.org/sig/ont/fma/fma67408"},{"id":"A357","pred":"fma_id","subj":"T357","obj":"http://purl.org/sig/ont/fma/fma63011"},{"id":"A358","pred":"fma_id","subj":"T358","obj":"http://purl.org/sig/ont/fma/fma63832"},{"id":"A359","pred":"fma_id","subj":"T359","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A360","pred":"fma_id","subj":"T360","obj":"http://purl.org/sig/ont/fma/fma74402"},{"id":"A361","pred":"fma_id","subj":"T361","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A362","pred":"fma_id","subj":"T362","obj":"http://purl.org/sig/ont/fma/fma9670"},{"id":"A363","pred":"fma_id","subj":"T363","obj":"http://purl.org/sig/ont/fma/fma67906"},{"id":"A364","pred":"fma_id","subj":"T364","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A365","pred":"fma_id","subj":"T365","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A366","pred":"fma_id","subj":"T366","obj":"http://purl.org/sig/ont/fma/fma67272"},{"id":"A367","pred":"fma_id","subj":"T367","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A368","pred":"fma_id","subj":"T368","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A369","pred":"fma_id","subj":"T369","obj":"http://purl.org/sig/ont/fma/fma74412"},{"id":"A370","pred":"fma_id","subj":"T370","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A371","pred":"fma_id","subj":"T371","obj":"http://purl.org/sig/ont/fma/fma74410"},{"id":"A372","pred":"fma_id","subj":"T372","obj":"http://purl.org/sig/ont/fma/fma62851"},{"id":"A373","pred":"fma_id","subj":"T373","obj":"http://pu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Pathway (A) p-Value #genes #miRNAs\nMucin type O-Glycan biosynthesis 2.52 × 10−2 7 3\nTGF-beta signaling pathway 4.96 × 10−1 12 4\nMorphine addiction 0.0001128919 14 5\nMetabolism of xenobiotics by cytochrome P450 0.0002215491 5 2\nOther types of O-glycan biosynthesis 0.0003646344 1 1\nVitamin digestion and absorption 0.001008222 2 1\nGlycosaminoglycan biosynthesis—heparan sulfate/heparin 0.00385809 1 1\nGABAergic synapse 0.01342039 13 4\nCytokine-cytokine receptor interaction 0.02096334 9 1\nSignaling pathways regulating pluripotency of stem cells 0.180299 9 1\nAmphetamine addiction 0.2150865 7 1\nAxon guidance 0.2239648 22 3\nHippo signaling pathway 0.2278356 7 1\nProlactin signaling pathway 0.2284669 5 1\nmRNA surveillance pathway 0.2795597 1 1\nGlycosphingolipid biosynthesis—lacto and neolacto series 0.3157068 1 1\nBile secretion 0.4120997 1 1\nCircadian entrainment 0.4608082 9 1\nN-Glycan biosynthesis 0.488078 2 1\nMismatch repair 0.6174557 1 1\nDrug metabolism—cytochrome P450 0.7063987 6 1\nGlutamatergic synapse 0.7319762 6 1\nGlycosaminoglycan degradation 0.7395672 2 1\nAntigen processing and presentation 0.7591685 1 1\nGO Category (B) p-Value #genes #miRNAs\norganelle 1 × 10−38 848 6\ncellular nitrogen compound metabolic process 1 × 10−12 414 7\nion binding 8 × 10−8 495 7\nbiosynthetic process 3 × 10−7 351 7\nnucleic acid binding transcription factor activity 4 × 10−2 115 6\ncellular protein modification process 2 × 101 205 7\nmolecular_function 5 × 103 1303 7\ncellular_component 1 × 105 1312 7\nenzyme binding 2 × 105 119 5\ngene expression 3 × 105 54 6\nprotein binding transcription factor activity 1 × 106 52 5\nblood coagulation 0.000176061599974 44 6\nprotein complex 0.00115693944276 290 5\npost-translational protein modification 0.00185490003064 19 5\nneurotrophin TRK receptor signaling pathway 0.00197464302174 24 5\nsynaptic transmission 0.00204631087649 42 5\ncellular protein metabolic process 0.00275618650845 39 5\nsmall molecule metabolic process 0.00275618650845 170 7\ncytoskeletal protein binding 0.00396272124679 68 4\ncell-cell signaling 0.00396272124679 60 5\ntranscription, DNA-templated 0.00450420995446 208 6\nsymbiosis, encompassing mutualism through parasitism 0.0140041886634 41 5\ncatabolic process 0.0141620388146 142 6\nFc-epsilon receptor signaling pathway 0.0222360628043 15 6\ncellular component assembly 0.02375306792 99 5\ntranscription initiation from RNA polymerase II promoter 0.0250016205995 24 5\nnucleoplasm 0.0335128910566 92 6\nplatelet activation 0.0350801245107 20 5\npositive regulation of telomere maintenance via telomerase 0.0370638891992 3 3\nRNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription 0.0448871926331 32 5\nO-glycan processing 0.0449415771561 8 5"}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T70","span":{"begin":873,"end":877},"obj":"Body_part"},{"id":"T71","span":{"begin":1734,"end":1739},"obj":"Body_part"}],"attributes":[{"id":"A70","pred":"uberon_id","subj":"T70","obj":"http://purl.obolibrary.org/obo/UBERON_0001970"},{"id":"A71","pred":"uberon_id","subj":"T71","obj":"http://purl.obolibrary.org/obo/UBERON_0000178"}],"text":"KEGG Pathway (A) p-Value #genes #miRNAs\nMucin type O-Glycan biosynthesis 2.52 × 10−2 7 3\nTGF-beta signaling pathway 4.96 × 10−1 12 4\nMorphine addiction 0.0001128919 14 5\nMetabolism of xenobiotics by cytochrome P450 0.0002215491 5 2\nOther types of O-glycan biosynthesis 0.0003646344 1 1\nVitamin digestion and absorption 0.001008222 2 1\nGlycosaminoglycan biosynthesis—heparan sulfate/heparin 0.00385809 1 1\nGABAergic synapse 0.01342039 13 4\nCytokine-cytokine receptor interaction 0.02096334 9 1\nSignaling pathways regulating pluripotency of stem cells 0.180299 9 1\nAmphetamine addiction 0.2150865 7 1\nAxon guidance 0.2239648 22 3\nHippo signaling pathway 0.2278356 7 1\nProlactin signaling pathway 0.2284669 5 1\nmRNA surveillance pathway 0.2795597 1 1\nGlycosphingolipid biosynthesis—lacto and neolacto series 0.3157068 1 1\nBile secretion 0.4120997 1 1\nCircadian entrainment 0.4608082 9 1\nN-Glycan biosynthesis 0.488078 2 1\nMismatch repair 0.6174557 1 1\nDrug metabolism—cytochrome P450 0.7063987 6 1\nGlutamatergic synapse 0.7319762 6 1\nGlycosaminoglycan degradation 0.7395672 2 1\nAntigen processing and presentation 0.7591685 1 1\nGO Category (B) p-Value #genes #miRNAs\norganelle 1 × 10−38 848 6\ncellular nitrogen compound metabolic process 1 × 10−12 414 7\nion binding 8 × 10−8 495 7\nbiosynthetic process 3 × 10−7 351 7\nnucleic acid binding transcription factor activity 4 × 10−2 115 6\ncellular protein modification process 2 × 101 205 7\nmolecular_function 5 × 103 1303 7\ncellular_component 1 × 105 1312 7\nenzyme binding 2 × 105 119 5\ngene expression 3 × 105 54 6\nprotein binding transcription factor activity 1 × 106 52 5\nblood coagulation 0.000176061599974 44 6\nprotein complex 0.00115693944276 290 5\npost-translational protein modification 0.00185490003064 19 5\nneurotrophin TRK receptor signaling pathway 0.00197464302174 24 5\nsynaptic transmission 0.00204631087649 42 5\ncellular protein metabolic process 0.00275618650845 39 5\nsmall molecule metabolic process 0.00275618650845 170 7\ncytoskeletal protein binding 0.00396272124679 68 4\ncell-cell signaling 0.00396272124679 60 5\ntranscription, DNA-templated 0.00450420995446 208 6\nsymbiosis, encompassing mutualism through parasitism 0.0140041886634 41 5\ncatabolic process 0.0141620388146 142 6\nFc-epsilon receptor signaling pathway 0.0222360628043 15 6\ncellular component assembly 0.02375306792 99 5\ntranscription initiation from RNA polymerase II promoter 0.0250016205995 24 5\nnucleoplasm 0.0335128910566 92 6\nplatelet activation 0.0350801245107 20 5\npositive regulation of telomere maintenance via telomerase 0.0370638891992 3 3\nRNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription 0.0448871926331 32 5\nO-glycan processing 0.0449415771561 8 5"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T324","span":{"begin":2316,"end":2326},"obj":"Disease"}],"attributes":[{"id":"A324","pred":"mondo_id","subj":"T324","obj":"http://purl.obolibrary.org/obo/MONDO_0005135"}],"text":"KEGG Pathway (A) p-Value #genes #miRNAs\nMucin type O-Glycan biosynthesis 2.52 × 10−2 7 3\nTGF-beta signaling pathway 4.96 × 10−1 12 4\nMorphine addiction 0.0001128919 14 5\nMetabolism of xenobiotics by cytochrome P450 0.0002215491 5 2\nOther types of O-glycan biosynthesis 0.0003646344 1 1\nVitamin digestion and absorption 0.001008222 2 1\nGlycosaminoglycan biosynthesis—heparan sulfate/heparin 0.00385809 1 1\nGABAergic synapse 0.01342039 13 4\nCytokine-cytokine receptor interaction 0.02096334 9 1\nSignaling pathways regulating pluripotency of stem cells 0.180299 9 1\nAmphetamine addiction 0.2150865 7 1\nAxon guidance 0.2239648 22 3\nHippo signaling pathway 0.2278356 7 1\nProlactin signaling pathway 0.2284669 5 1\nmRNA surveillance pathway 0.2795597 1 1\nGlycosphingolipid biosynthesis—lacto and neolacto series 0.3157068 1 1\nBile secretion 0.4120997 1 1\nCircadian entrainment 0.4608082 9 1\nN-Glycan biosynthesis 0.488078 2 1\nMismatch repair 0.6174557 1 1\nDrug metabolism—cytochrome P450 0.7063987 6 1\nGlutamatergic synapse 0.7319762 6 1\nGlycosaminoglycan degradation 0.7395672 2 1\nAntigen processing and presentation 0.7591685 1 1\nGO Category (B) p-Value #genes #miRNAs\norganelle 1 × 10−38 848 6\ncellular nitrogen compound metabolic process 1 × 10−12 414 7\nion binding 8 × 10−8 495 7\nbiosynthetic process 3 × 10−7 351 7\nnucleic acid binding transcription factor activity 4 × 10−2 115 6\ncellular protein modification process 2 × 101 205 7\nmolecular_function 5 × 103 1303 7\ncellular_component 1 × 105 1312 7\nenzyme binding 2 × 105 119 5\ngene expression 3 × 105 54 6\nprotein binding transcription factor activity 1 × 106 52 5\nblood coagulation 0.000176061599974 44 6\nprotein complex 0.00115693944276 290 5\npost-translational protein modification 0.00185490003064 19 5\nneurotrophin TRK receptor signaling pathway 0.00197464302174 24 5\nsynaptic transmission 0.00204631087649 42 5\ncellular protein metabolic process 0.00275618650845 39 5\nsmall molecule metabolic process 0.00275618650845 170 7\ncytoskeletal protein binding 0.00396272124679 68 4\ncell-cell signaling 0.00396272124679 60 5\ntranscription, DNA-templated 0.00450420995446 208 6\nsymbiosis, encompassing mutualism through parasitism 0.0140041886634 41 5\ncatabolic process 0.0141620388146 142 6\nFc-epsilon receptor signaling pathway 0.0222360628043 15 6\ncellular component assembly 0.02375306792 99 5\ntranscription initiation from RNA polymerase II promoter 0.0250016205995 24 5\nnucleoplasm 0.0335128910566 92 6\nplatelet activation 0.0350801245107 20 5\npositive regulation of telomere maintenance via telomerase 0.0370638891992 3 3\nRNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription 0.0448871926331 32 5\nO-glycan processing 0.0449415771561 8 5"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T632","span":{"begin":13,"end":20},"obj":"http://purl.obolibrary.org/obo/CLO_0001547"},{"id":"T633","span":{"begin":30,"end":35},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T634","span":{"begin":87,"end":91},"obj":"http://purl.obolibrary.org/obo/CLO_0054060"},{"id":"T635","span":{"begin":107,"end":116},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T636","span":{"begin":245,"end":249},"obj":"http://purl.obolibrary.org/obo/CLO_0001407"},{"id":"T637","span":{"begin":302,"end":306},"obj":"http://purl.obolibrary.org/obo/CLO_0053733"},{"id":"T638","span":{"begin":427,"end":431},"obj":"http://purl.obolibrary.org/obo/CLO_0053733"},{"id":"T639","span":{"begin":526,"end":535},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T640","span":{"begin":572,"end":582},"obj":"http://purl.obolibrary.org/obo/CL_0000034"},{"id":"T641","span":{"begin":633,"end":637},"obj":"http://purl.obolibrary.org/obo/CLO_0054055"},{"id":"T642","span":{"begin":664,"end":666},"obj":"http://purl.obolibrary.org/obo/CLO_0050507"},{"id":"T643","span":{"begin":676,"end":685},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T644","span":{"begin":706,"end":710},"obj":"http://purl.obolibrary.org/obo/CLO_0054055"},{"id":"T645","span":{"begin":711,"end":720},"obj":"http://purl.obolibrary.org/obo/PR_000013246"},{"id":"T646","span":{"begin":721,"end":730},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T647","span":{"begin":794,"end":798},"obj":"http://purl.obolibrary.org/obo/CLO_0053733"},{"id":"T648","span":{"begin":868,"end":872},"obj":"http://purl.obolibrary.org/obo/CLO_0053733"},{"id":"T649","span":{"begin":900,"end":904},"obj":"http://purl.obolibrary.org/obo/CLO_0053733"},{"id":"T650","span":{"begin":1010,"end":1014},"obj":"http://purl.obolibrary.org/obo/CLO_0053733"},{"id":"T651","span":{"begin":1198,"end":1202},"obj":"http://purl.obolibrary.org/obo/CLO_0053733"},{"id":"T652","span":{"begin":1216,"end":1217},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T653","span":{"begin":1232,"end":1237},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T654","span":{"begin":1403,"end":1406},"obj":"http://purl.obolibrary.org/obo/CLO_0001310"},{"id":"T655","span":{"begin":1452,"end":1460},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T656","span":{"begin":1466,"end":1470},"obj":"http://purl.obolibrary.org/obo/CLO_0054060"},{"id":"T657","span":{"begin":1591,"end":1598},"obj":"http://purl.obolibrary.org/obo/CLO_0001040"},{"id":"T658","span":{"begin":1640,"end":1644},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T659","span":{"begin":1709,"end":1717},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T660","span":{"begin":1728,"end":1730},"obj":"http://purl.obolibrary.org/obo/CLO_0001407"},{"id":"T661","span":{"begin":1734,"end":1739},"obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"T662","span":{"begin":1734,"end":1739},"obj":"http://www.ebi.ac.uk/efo/EFO_0000296"},{"id":"T663","span":{"begin":1778,"end":1793},"obj":"http://purl.obolibrary.org/obo/GO_0043234"},{"id":"T664","span":{"begin":1911,"end":1920},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T665","span":{"begin":2174,"end":2178},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T666","span":{"begin":2179,"end":2183},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T667","span":{"begin":2184,"end":2193},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T668","span":{"begin":2345,"end":2347},"obj":"http://purl.obolibrary.org/obo/CLO_0053794"},{"id":"T669","span":{"begin":2394,"end":2396},"obj":"http://purl.obolibrary.org/obo/CLO_0052676"},{"id":"T670","span":{"begin":2414,"end":2423},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T671","span":{"begin":2456,"end":2474},"obj":"http://purl.obolibrary.org/obo/GO_0005575"},{"id":"T672","span":{"begin":2632,"end":2642},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T673","span":{"begin":2848,"end":2856},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"}],"text":"KEGG Pathway (A) p-Value #genes #miRNAs\nMucin type O-Glycan biosynthesis 2.52 × 10−2 7 3\nTGF-beta signaling pathway 4.96 × 10−1 12 4\nMorphine addiction 0.0001128919 14 5\nMetabolism of xenobiotics by cytochrome P450 0.0002215491 5 2\nOther types of O-glycan biosynthesis 0.0003646344 1 1\nVitamin digestion and absorption 0.001008222 2 1\nGlycosaminoglycan biosynthesis—heparan sulfate/heparin 0.00385809 1 1\nGABAergic synapse 0.01342039 13 4\nCytokine-cytokine receptor interaction 0.02096334 9 1\nSignaling pathways regulating pluripotency of stem cells 0.180299 9 1\nAmphetamine addiction 0.2150865 7 1\nAxon guidance 0.2239648 22 3\nHippo signaling pathway 0.2278356 7 1\nProlactin signaling pathway 0.2284669 5 1\nmRNA surveillance pathway 0.2795597 1 1\nGlycosphingolipid biosynthesis—lacto and neolacto series 0.3157068 1 1\nBile secretion 0.4120997 1 1\nCircadian entrainment 0.4608082 9 1\nN-Glycan biosynthesis 0.488078 2 1\nMismatch repair 0.6174557 1 1\nDrug metabolism—cytochrome P450 0.7063987 6 1\nGlutamatergic synapse 0.7319762 6 1\nGlycosaminoglycan degradation 0.7395672 2 1\nAntigen processing and presentation 0.7591685 1 1\nGO Category (B) p-Value #genes #miRNAs\norganelle 1 × 10−38 848 6\ncellular nitrogen compound metabolic process 1 × 10−12 414 7\nion binding 8 × 10−8 495 7\nbiosynthetic process 3 × 10−7 351 7\nnucleic acid binding transcription factor activity 4 × 10−2 115 6\ncellular protein modification process 2 × 101 205 7\nmolecular_function 5 × 103 1303 7\ncellular_component 1 × 105 1312 7\nenzyme binding 2 × 105 119 5\ngene expression 3 × 105 54 6\nprotein binding transcription factor activity 1 × 106 52 5\nblood coagulation 0.000176061599974 44 6\nprotein complex 0.00115693944276 290 5\npost-translational protein modification 0.00185490003064 19 5\nneurotrophin TRK receptor signaling pathway 0.00197464302174 24 5\nsynaptic transmission 0.00204631087649 42 5\ncellular protein metabolic process 0.00275618650845 39 5\nsmall molecule metabolic process 0.00275618650845 170 7\ncytoskeletal protein binding 0.00396272124679 68 4\ncell-cell signaling 0.00396272124679 60 5\ntranscription, DNA-templated 0.00450420995446 208 6\nsymbiosis, encompassing mutualism through parasitism 0.0140041886634 41 5\ncatabolic process 0.0141620388146 142 6\nFc-epsilon receptor signaling pathway 0.0222360628043 15 6\ncellular component assembly 0.02375306792 99 5\ntranscription initiation from RNA polymerase II promoter 0.0250016205995 24 5\nnucleoplasm 0.0335128910566 92 6\nplatelet activation 0.0350801245107 20 5\npositive regulation of telomere maintenance via telomerase 0.0370638891992 3 3\nRNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription 0.0448871926331 32 5\nO-glycan processing 0.0449415771561 8 5"}

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Pathway (A) p-Value #genes #miRNAs\nMucin type O-Glycan biosynthesis 2.52 × 10−2 7 3\nTGF-beta signaling pathway 4.96 × 10−1 12 4\nMorphine addiction 0.0001128919 14 5\nMetabolism of xenobiotics by cytochrome P450 0.0002215491 5 2\nOther types of O-glycan biosynthesis 0.0003646344 1 1\nVitamin digestion and absorption 0.001008222 2 1\nGlycosaminoglycan biosynthesis—heparan sulfate/heparin 0.00385809 1 1\nGABAergic synapse 0.01342039 13 4\nCytokine-cytokine receptor interaction 0.02096334 9 1\nSignaling pathways regulating pluripotency of stem cells 0.180299 9 1\nAmphetamine addiction 0.2150865 7 1\nAxon guidance 0.2239648 22 3\nHippo signaling pathway 0.2278356 7 1\nProlactin signaling pathway 0.2284669 5 1\nmRNA surveillance pathway 0.2795597 1 1\nGlycosphingolipid biosynthesis—lacto and neolacto series 0.3157068 1 1\nBile secretion 0.4120997 1 1\nCircadian entrainment 0.4608082 9 1\nN-Glycan biosynthesis 0.488078 2 1\nMismatch repair 0.6174557 1 1\nDrug metabolism—cytochrome P450 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Pathway (A) p-Value #genes #miRNAs\nMucin type O-Glycan biosynthesis 2.52 × 10−2 7 3\nTGF-beta signaling pathway 4.96 × 10−1 12 4\nMorphine addiction 0.0001128919 14 5\nMetabolism of xenobiotics by cytochrome P450 0.0002215491 5 2\nOther types of O-glycan biosynthesis 0.0003646344 1 1\nVitamin digestion and absorption 0.001008222 2 1\nGlycosaminoglycan biosynthesis—heparan sulfate/heparin 0.00385809 1 1\nGABAergic synapse 0.01342039 13 4\nCytokine-cytokine receptor interaction 0.02096334 9 1\nSignaling pathways regulating pluripotency of stem cells 0.180299 9 1\nAmphetamine addiction 0.2150865 7 1\nAxon guidance 0.2239648 22 3\nHippo signaling pathway 0.2278356 7 1\nProlactin signaling pathway 0.2284669 5 1\nmRNA surveillance pathway 0.2795597 1 1\nGlycosphingolipid biosynthesis—lacto and neolacto series 0.3157068 1 1\nBile secretion 0.4120997 1 1\nCircadian entrainment 0.4608082 9 1\nN-Glycan biosynthesis 0.488078 2 1\nMismatch repair 0.6174557 1 1\nDrug metabolism—cytochrome P450 0.7063987 6 1\nGlutamatergic synapse 0.7319762 6 1\nGlycosaminoglycan degradation 0.7395672 2 1\nAntigen processing and presentation 0.7591685 1 1\nGO Category (B) p-Value #genes #miRNAs\norganelle 1 × 10−38 848 6\ncellular nitrogen compound metabolic process 1 × 10−12 414 7\nion binding 8 × 10−8 495 7\nbiosynthetic process 3 × 10−7 351 7\nnucleic acid binding transcription factor activity 4 × 10−2 115 6\ncellular protein modification process 2 × 101 205 7\nmolecular_function 5 × 103 1303 7\ncellular_component 1 × 105 1312 7\nenzyme binding 2 × 105 119 5\ngene expression 3 × 105 54 6\nprotein binding transcription factor activity 1 × 106 52 5\nblood coagulation 0.000176061599974 44 6\nprotein complex 0.00115693944276 290 5\npost-translational protein modification 0.00185490003064 19 5\nneurotrophin TRK receptor signaling pathway 0.00197464302174 24 5\nsynaptic transmission 0.00204631087649 42 5\ncellular protein metabolic process 0.00275618650845 39 5\nsmall molecule metabolic process 0.00275618650845 170 7\ncytoskeletal protein binding 0.00396272124679 68 4\ncell-cell signaling 0.00396272124679 60 5\ntranscription, DNA-templated 0.00450420995446 208 6\nsymbiosis, encompassing mutualism through parasitism 0.0140041886634 41 5\ncatabolic process 0.0141620388146 142 6\nFc-epsilon receptor signaling pathway 0.0222360628043 15 6\ncellular component assembly 0.02375306792 99 5\ntranscription initiation from RNA polymerase II promoter 0.0250016205995 24 5\nnucleoplasm 0.0335128910566 92 6\nplatelet activation 0.0350801245107 20 5\npositive regulation of telomere maintenance via telomerase 0.0370638891992 3 3\nRNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription 0.0448871926331 32 5\nO-glycan processing 0.0449415771561 8 5"}

{"project":"LitCovid-PubTator","denotations":[{"id":"1666","span":{"begin":48,"end":52},"obj":"Gene"},{"id":"1667","span":{"begin":99,"end":107},"obj":"Gene"},{"id":"1668","span":{"begin":712,"end":721},"obj":"Gene"},{"id":"1669","span":{"begin":407,"end":415},"obj":"Chemical"},{"id":"1670","span":{"begin":1287,"end":1295},"obj":"Chemical"},{"id":"1671","span":{"begin":1016,"end":1031},"obj":"Disease"},{"id":"1672","span":{"begin":1735,"end":1753},"obj":"Disease"},{"id":"1673","span":{"begin":2317,"end":2328},"obj":"Disease"}],"attributes":[{"id":"A1666","pred":"tao:has_database_id","subj":"1666","obj":"Gene:100508689"},{"id":"A1667","pred":"tao:has_database_id","subj":"1667","obj":"Gene:7039"},{"id":"A1668","pred":"tao:has_database_id","subj":"1668","obj":"Gene:5617"},{"id":"A1669","pred":"tao:has_database_id","subj":"1669","obj":"MESH:D006493"},{"id":"A1670","pred":"tao:has_database_id","subj":"1670","obj":"MESH:D009584"},{"id":"A1671","pred":"tao:has_database_id","subj":"1671","obj":"MESH:D065606"},{"id":"A1672","pred":"tao:has_database_id","subj":"1672","obj":"MESH:D001778"},{"id":"A1673","pred":"tao:has_database_id","subj":"1673","obj":"MESH:D010272"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"KEGG Pathway (A) p-Value #genes #miRNAs\nMucin type O-Glycan biosynthesis 2.52 × 10−2 7 3\nTGF-beta signaling pathway 4.96 × 10−1 12 4\nMorphine addiction 0.0001128919 14 5\nMetabolism of xenobiotics by cytochrome P450 0.0002215491 5 2\nOther types of O-glycan biosynthesis 0.0003646344 1 1\nVitamin digestion and absorption 0.001008222 2 1\nGlycosaminoglycan biosynthesis—heparan sulfate/heparin 0.00385809 1 1\nGABAergic synapse 0.01342039 13 4\nCytokine-cytokine receptor interaction 0.02096334 9 1\nSignaling pathways regulating pluripotency of stem cells 0.180299 9 1\nAmphetamine addiction 0.2150865 7 1\nAxon guidance 0.2239648 22 3\nHippo signaling pathway 0.2278356 7 1\nProlactin signaling pathway 0.2284669 5 1\nmRNA surveillance pathway 0.2795597 1 1\nGlycosphingolipid biosynthesis—lacto and neolacto series 0.3157068 1 1\nBile secretion 0.4120997 1 1\nCircadian entrainment 0.4608082 9 1\nN-Glycan biosynthesis 0.488078 2 1\nMismatch repair 0.6174557 1 1\nDrug metabolism—cytochrome P450 0.7063987 6 1\nGlutamatergic synapse 0.7319762 6 1\nGlycosaminoglycan degradation 0.7395672 2 1\nAntigen processing and presentation 0.7591685 1 1\nGO Category (B) p-Value #genes #miRNAs\norganelle 1 × 10−38 848 6\ncellular nitrogen compound metabolic process 1 × 10−12 414 7\nion binding 8 × 10−8 495 7\nbiosynthetic process 3 × 10−7 351 7\nnucleic acid binding transcription factor activity 4 × 10−2 115 6\ncellular protein modification process 2 × 101 205 7\nmolecular_function 5 × 103 1303 7\ncellular_component 1 × 105 1312 7\nenzyme binding 2 × 105 119 5\ngene expression 3 × 105 54 6\nprotein binding transcription factor activity 1 × 106 52 5\nblood coagulation 0.000176061599974 44 6\nprotein complex 0.00115693944276 290 5\npost-translational protein modification 0.00185490003064 19 5\nneurotrophin TRK receptor signaling pathway 0.00197464302174 24 5\nsynaptic transmission 0.00204631087649 42 5\ncellular protein metabolic process 0.00275618650845 39 5\nsmall molecule metabolic process 0.00275618650845 170 7\ncytoskeletal protein binding 0.00396272124679 68 4\ncell-cell signaling 0.00396272124679 60 5\ntranscription, DNA-templated 0.00450420995446 208 6\nsymbiosis, encompassing mutualism through parasitism 0.0140041886634 41 5\ncatabolic process 0.0141620388146 142 6\nFc-epsilon receptor signaling pathway 0.0222360628043 15 6\ncellular component assembly 0.02375306792 99 5\ntranscription initiation from RNA polymerase II promoter 0.0250016205995 24 5\nnucleoplasm 0.0335128910566 92 6\nplatelet activation 0.0350801245107 20 5\npositive regulation of telomere maintenance via telomerase 0.0370638891992 3 3\nRNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription 0.0448871926331 32 5\nO-glycan processing 0.0449415771561 8 5"}