KEGG Pathway (A) p-Value #genes #miRNAs Mucin type O-Glycan biosynthesis 2.52 × 10−2 7 3 TGF-beta signaling pathway 4.96 × 10−1 12 4 Morphine addiction 0.0001128919 14 5 Metabolism of xenobiotics by cytochrome P450 0.0002215491 5 2 Other types of O-glycan biosynthesis 0.0003646344 1 1 Vitamin digestion and absorption 0.001008222 2 1 Glycosaminoglycan biosynthesis—heparan sulfate/heparin 0.00385809 1 1 GABAergic synapse 0.01342039 13 4 Cytokine-cytokine receptor interaction 0.02096334 9 1 Signaling pathways regulating pluripotency of stem cells 0.180299 9 1 Amphetamine addiction 0.2150865 7 1 Axon guidance 0.2239648 22 3 Hippo signaling pathway 0.2278356 7 1 Prolactin signaling pathway 0.2284669 5 1 mRNA surveillance pathway 0.2795597 1 1 Glycosphingolipid biosynthesis—lacto and neolacto series 0.3157068 1 1 Bile secretion 0.4120997 1 1 Circadian entrainment 0.4608082 9 1 N-Glycan biosynthesis 0.488078 2 1 Mismatch repair 0.6174557 1 1 Drug metabolism—cytochrome P450 0.7063987 6 1 Glutamatergic synapse 0.7319762 6 1 Glycosaminoglycan degradation 0.7395672 2 1 Antigen processing and presentation 0.7591685 1 1 GO Category (B) p-Value #genes #miRNAs organelle 1 × 10−38 848 6 cellular nitrogen compound metabolic process 1 × 10−12 414 7 ion binding 8 × 10−8 495 7 biosynthetic process 3 × 10−7 351 7 nucleic acid binding transcription factor activity 4 × 10−2 115 6 cellular protein modification process 2 × 101 205 7 molecular_function 5 × 103 1303 7 cellular_component 1 × 105 1312 7 enzyme binding 2 × 105 119 5 gene expression 3 × 105 54 6 protein binding transcription factor activity 1 × 106 52 5 blood coagulation 0.000176061599974 44 6 protein complex 0.00115693944276 290 5 post-translational protein modification 0.00185490003064 19 5 neurotrophin TRK receptor signaling pathway 0.00197464302174 24 5 synaptic transmission 0.00204631087649 42 5 cellular protein metabolic process 0.00275618650845 39 5 small molecule metabolic process 0.00275618650845 170 7 cytoskeletal protein binding 0.00396272124679 68 4 cell-cell signaling 0.00396272124679 60 5 transcription, DNA-templated 0.00450420995446 208 6 symbiosis, encompassing mutualism through parasitism 0.0140041886634 41 5 catabolic process 0.0141620388146 142 6 Fc-epsilon receptor signaling pathway 0.0222360628043 15 6 cellular component assembly 0.02375306792 99 5 transcription initiation from RNA polymerase II promoter 0.0250016205995 24 5 nucleoplasm 0.0335128910566 92 6 platelet activation 0.0350801245107 20 5 positive regulation of telomere maintenance via telomerase 0.0370638891992 3 3 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription 0.0448871926331 32 5 O-glycan processing 0.0449415771561 8 5