PMC:7354481 / 39589-40965 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T268","span":{"begin":71,"end":75},"obj":"Body_part"},{"id":"T269","span":{"begin":76,"end":82},"obj":"Body_part"},{"id":"T270","span":{"begin":158,"end":162},"obj":"Body_part"},{"id":"T271","span":{"begin":330,"end":352},"obj":"Body_part"},{"id":"T272","span":{"begin":347,"end":352},"obj":"Body_part"},{"id":"T273","span":{"begin":562,"end":566},"obj":"Body_part"},{"id":"T274","span":{"begin":1039,"end":1043},"obj":"Body_part"},{"id":"T275","span":{"begin":1119,"end":1123},"obj":"Body_part"},{"id":"T276","span":{"begin":1193,"end":1213},"obj":"Body_part"},{"id":"T277","span":{"begin":1230,"end":1236},"obj":"Body_part"}],"attributes":[{"id":"A268","pred":"fma_id","subj":"T268","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A269","pred":"fma_id","subj":"T269","obj":"http://purl.org/sig/ont/fma/fma9637"},{"id":"A270","pred":"fma_id","subj":"T270","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A271","pred":"fma_id","subj":"T271","obj":"http://purl.org/sig/ont/fma/fma0326143"},{"id":"A272","pred":"fma_id","subj":"T272","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A273","pred":"fma_id","subj":"T273","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A274","pred":"fma_id","subj":"T274","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A275","pred":"fma_id","subj":"T275","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A276","pred":"fma_id","subj":"T276","obj":"http://purl.org/sig/ont/fma/fma9672"},{"id":"A277","pred":"fma_id","subj":"T277","obj":"http://purl.org/sig/ont/fma/fma9637"}],"text":"4.1.5. miR-1307-3p\nmiR-1307 has previously been shown to be one of the lung-tissue-associated miRs [94] and was reported as an especially important target in lung development in newborns. Expression of mir-1307-3p has furthermore been linked to acid metabolism in response to aspirin in human cardiac and peri-cardiac fat-derived mesenchymal stem cells (MSCs) [95]. Moreover, it was shown that several miRs, including miR-1307-3p, are involved in TGF-β and semaphorin signalling, as well as inflammatory responses. miRs play an important role, especially during lung morphogenesis in the early stages of development. Interestingly, miR-1307 has been associated with the severity of pulmonary hypertension in systemic scleroderma [96]. Persistent problems with SARS-CoV-2-infected patients, such as oxygen dependency, urgent need for mechanical ventilation, persistent wheezing, and increased risk for pulmonary infections correlate with involvement of miR-1307-3p, as indicated above, due to its role in pulmonary hypertension and chronic lung diseases. The TGF-β superfamily plays critical roles in pre- and postnatal lung development, importantly shaping alveolarisation and controlling the extracellular matrix composition and tissue homeostasis, among other functions. TGF-β signalling is therefore strongly linked to both pulmonary and cardiovascular diseases [97,98,99]."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T49","span":{"begin":71,"end":75},"obj":"Body_part"},{"id":"T50","span":{"begin":76,"end":82},"obj":"Body_part"},{"id":"T51","span":{"begin":158,"end":162},"obj":"Body_part"},{"id":"T52","span":{"begin":562,"end":566},"obj":"Body_part"},{"id":"T53","span":{"begin":1039,"end":1043},"obj":"Body_part"},{"id":"T54","span":{"begin":1119,"end":1123},"obj":"Body_part"},{"id":"T55","span":{"begin":1230,"end":1236},"obj":"Body_part"}],"attributes":[{"id":"A49","pred":"uberon_id","subj":"T49","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A50","pred":"uberon_id","subj":"T50","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"A51","pred":"uberon_id","subj":"T51","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A52","pred":"uberon_id","subj":"T52","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A53","pred":"uberon_id","subj":"T53","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A54","pred":"uberon_id","subj":"T54","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A55","pred":"uberon_id","subj":"T55","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"}],"text":"4.1.5. miR-1307-3p\nmiR-1307 has previously been shown to be one of the lung-tissue-associated miRs [94] and was reported as an especially important target in lung development in newborns. Expression of mir-1307-3p has furthermore been linked to acid metabolism in response to aspirin in human cardiac and peri-cardiac fat-derived mesenchymal stem cells (MSCs) [95]. Moreover, it was shown that several miRs, including miR-1307-3p, are involved in TGF-β and semaphorin signalling, as well as inflammatory responses. miRs play an important role, especially during lung morphogenesis in the early stages of development. Interestingly, miR-1307 has been associated with the severity of pulmonary hypertension in systemic scleroderma [96]. Persistent problems with SARS-CoV-2-infected patients, such as oxygen dependency, urgent need for mechanical ventilation, persistent wheezing, and increased risk for pulmonary infections correlate with involvement of miR-1307-3p, as indicated above, due to its role in pulmonary hypertension and chronic lung diseases. The TGF-β superfamily plays critical roles in pre- and postnatal lung development, importantly shaping alveolarisation and controlling the extracellular matrix composition and tissue homeostasis, among other functions. TGF-β signalling is therefore strongly linked to both pulmonary and cardiovascular diseases [97,98,99]."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T237","span":{"begin":682,"end":704},"obj":"Disease"},{"id":"T238","span":{"begin":692,"end":704},"obj":"Disease"},{"id":"T239","span":{"begin":708,"end":728},"obj":"Disease"},{"id":"T240","span":{"begin":717,"end":728},"obj":"Disease"},{"id":"T241","span":{"begin":760,"end":768},"obj":"Disease"},{"id":"T242","span":{"begin":911,"end":921},"obj":"Disease"},{"id":"T243","span":{"begin":1004,"end":1026},"obj":"Disease"},{"id":"T244","span":{"begin":1014,"end":1026},"obj":"Disease"},{"id":"T245","span":{"begin":1039,"end":1052},"obj":"Disease"},{"id":"T246","span":{"begin":1341,"end":1364},"obj":"Disease"}],"attributes":[{"id":"A237","pred":"mondo_id","subj":"T237","obj":"http://purl.obolibrary.org/obo/MONDO_0005149"},{"id":"A238","pred":"mondo_id","subj":"T238","obj":"http://purl.obolibrary.org/obo/MONDO_0005044"},{"id":"A239","pred":"mondo_id","subj":"T239","obj":"http://purl.obolibrary.org/obo/MONDO_0005100"},{"id":"A240","pred":"mondo_id","subj":"T240","obj":"http://purl.obolibrary.org/obo/MONDO_0019340"},{"id":"A241","pred":"mondo_id","subj":"T241","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A242","pred":"mondo_id","subj":"T242","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A243","pred":"mondo_id","subj":"T243","obj":"http://purl.obolibrary.org/obo/MONDO_0005149"},{"id":"A244","pred":"mondo_id","subj":"T244","obj":"http://purl.obolibrary.org/obo/MONDO_0005044"},{"id":"A245","pred":"mondo_id","subj":"T245","obj":"http://purl.obolibrary.org/obo/MONDO_0005275"},{"id":"A246","pred":"mondo_id","subj":"T246","obj":"http://purl.obolibrary.org/obo/MONDO_0004995"}],"text":"4.1.5. miR-1307-3p\nmiR-1307 has previously been shown to be one of the lung-tissue-associated miRs [94] and was reported as an especially important target in lung development in newborns. Expression of mir-1307-3p has furthermore been linked to acid metabolism in response to aspirin in human cardiac and peri-cardiac fat-derived mesenchymal stem cells (MSCs) [95]. Moreover, it was shown that several miRs, including miR-1307-3p, are involved in TGF-β and semaphorin signalling, as well as inflammatory responses. miRs play an important role, especially during lung morphogenesis in the early stages of development. Interestingly, miR-1307 has been associated with the severity of pulmonary hypertension in systemic scleroderma [96]. Persistent problems with SARS-CoV-2-infected patients, such as oxygen dependency, urgent need for mechanical ventilation, persistent wheezing, and increased risk for pulmonary infections correlate with involvement of miR-1307-3p, as indicated above, due to its role in pulmonary hypertension and chronic lung diseases. The TGF-β superfamily plays critical roles in pre- and postnatal lung development, importantly shaping alveolarisation and controlling the extracellular matrix composition and tissue homeostasis, among other functions. TGF-β signalling is therefore strongly linked to both pulmonary and cardiovascular diseases [97,98,99]."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T440","span":{"begin":28,"end":31},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T441","span":{"begin":71,"end":75},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T442","span":{"begin":71,"end":75},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T443","span":{"begin":100,"end":102},"obj":"http://purl.obolibrary.org/obo/CLO_0001527"},{"id":"T444","span":{"begin":158,"end":162},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T445","span":{"begin":158,"end":162},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T446","span":{"begin":214,"end":217},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T447","span":{"begin":287,"end":292},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T448","span":{"begin":318,"end":321},"obj":"http://purl.obolibrary.org/obo/UBERON_0001013"},{"id":"T449","span":{"begin":330,"end":352},"obj":"http://purl.obolibrary.org/obo/CL_0000134"},{"id":"T450","span":{"begin":468,"end":478},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T451","span":{"begin":562,"end":566},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T452","span":{"begin":562,"end":566},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T453","span":{"begin":641,"end":644},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T454","span":{"begin":1039,"end":1043},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T455","span":{"begin":1039,"end":1043},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T456","span":{"begin":1119,"end":1123},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T457","span":{"begin":1119,"end":1123},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T458","span":{"begin":1279,"end":1289},"obj":"http://purl.obolibrary.org/obo/SO_0000418"}],"text":"4.1.5. miR-1307-3p\nmiR-1307 has previously been shown to be one of the lung-tissue-associated miRs [94] and was reported as an especially important target in lung development in newborns. Expression of mir-1307-3p has furthermore been linked to acid metabolism in response to aspirin in human cardiac and peri-cardiac fat-derived mesenchymal stem cells (MSCs) [95]. Moreover, it was shown that several miRs, including miR-1307-3p, are involved in TGF-β and semaphorin signalling, as well as inflammatory responses. miRs play an important role, especially during lung morphogenesis in the early stages of development. Interestingly, miR-1307 has been associated with the severity of pulmonary hypertension in systemic scleroderma [96]. Persistent problems with SARS-CoV-2-infected patients, such as oxygen dependency, urgent need for mechanical ventilation, persistent wheezing, and increased risk for pulmonary infections correlate with involvement of miR-1307-3p, as indicated above, due to its role in pulmonary hypertension and chronic lung diseases. The TGF-β superfamily plays critical roles in pre- and postnatal lung development, importantly shaping alveolarisation and controlling the extracellular matrix composition and tissue homeostasis, among other functions. TGF-β signalling is therefore strongly linked to both pulmonary and cardiovascular diseases [97,98,99]."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T159","span":{"begin":245,"end":249},"obj":"Chemical"},{"id":"T160","span":{"begin":798,"end":804},"obj":"Chemical"}],"attributes":[{"id":"A159","pred":"chebi_id","subj":"T159","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A160","pred":"chebi_id","subj":"T160","obj":"http://purl.obolibrary.org/obo/CHEBI_25805"}],"text":"4.1.5. miR-1307-3p\nmiR-1307 has previously been shown to be one of the lung-tissue-associated miRs [94] and was reported as an especially important target in lung development in newborns. Expression of mir-1307-3p has furthermore been linked to acid metabolism in response to aspirin in human cardiac and peri-cardiac fat-derived mesenchymal stem cells (MSCs) [95]. Moreover, it was shown that several miRs, including miR-1307-3p, are involved in TGF-β and semaphorin signalling, as well as inflammatory responses. miRs play an important role, especially during lung morphogenesis in the early stages of development. Interestingly, miR-1307 has been associated with the severity of pulmonary hypertension in systemic scleroderma [96]. Persistent problems with SARS-CoV-2-infected patients, such as oxygen dependency, urgent need for mechanical ventilation, persistent wheezing, and increased risk for pulmonary infections correlate with involvement of miR-1307-3p, as indicated above, due to its role in pulmonary hypertension and chronic lung diseases. The TGF-β superfamily plays critical roles in pre- and postnatal lung development, importantly shaping alveolarisation and controlling the extracellular matrix composition and tissue homeostasis, among other functions. TGF-β signalling is therefore strongly linked to both pulmonary and cardiovascular diseases [97,98,99]."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T66","span":{"begin":692,"end":704},"obj":"Phenotype"},{"id":"T67","span":{"begin":717,"end":728},"obj":"Phenotype"},{"id":"T68","span":{"begin":868,"end":876},"obj":"Phenotype"},{"id":"T69","span":{"begin":901,"end":921},"obj":"Phenotype"},{"id":"T70","span":{"begin":1014,"end":1026},"obj":"Phenotype"},{"id":"T71","span":{"begin":1031,"end":1052},"obj":"Phenotype"},{"id":"T72","span":{"begin":1341,"end":1364},"obj":"Phenotype"}],"attributes":[{"id":"A66","pred":"hp_id","subj":"T66","obj":"http://purl.obolibrary.org/obo/HP_0000822"},{"id":"A67","pred":"hp_id","subj":"T67","obj":"http://purl.obolibrary.org/obo/HP_0100324"},{"id":"A68","pred":"hp_id","subj":"T68","obj":"http://purl.obolibrary.org/obo/HP_0030828"},{"id":"A69","pred":"hp_id","subj":"T69","obj":"http://purl.obolibrary.org/obo/HP_0006532"},{"id":"A70","pred":"hp_id","subj":"T70","obj":"http://purl.obolibrary.org/obo/HP_0000822"},{"id":"A71","pred":"hp_id","subj":"T71","obj":"http://purl.obolibrary.org/obo/HP_0006528"},{"id":"A72","pred":"hp_id","subj":"T72","obj":"http://purl.obolibrary.org/obo/HP_0001626"}],"text":"4.1.5. miR-1307-3p\nmiR-1307 has previously been shown to be one of the lung-tissue-associated miRs [94] and was reported as an especially important target in lung development in newborns. Expression of mir-1307-3p has furthermore been linked to acid metabolism in response to aspirin in human cardiac and peri-cardiac fat-derived mesenchymal stem cells (MSCs) [95]. Moreover, it was shown that several miRs, including miR-1307-3p, are involved in TGF-β and semaphorin signalling, as well as inflammatory responses. miRs play an important role, especially during lung morphogenesis in the early stages of development. Interestingly, miR-1307 has been associated with the severity of pulmonary hypertension in systemic scleroderma [96]. Persistent problems with SARS-CoV-2-infected patients, such as oxygen dependency, urgent need for mechanical ventilation, persistent wheezing, and increased risk for pulmonary infections correlate with involvement of miR-1307-3p, as indicated above, due to its role in pulmonary hypertension and chronic lung diseases. The TGF-β superfamily plays critical roles in pre- and postnatal lung development, importantly shaping alveolarisation and controlling the extracellular matrix composition and tissue homeostasis, among other functions. TGF-β signalling is therefore strongly linked to both pulmonary and cardiovascular diseases [97,98,99]."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T141","span":{"begin":158,"end":174},"obj":"http://purl.obolibrary.org/obo/GO_0030324"},{"id":"T142","span":{"begin":250,"end":260},"obj":"http://purl.obolibrary.org/obo/GO_0008152"},{"id":"T143","span":{"begin":468,"end":478},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T144","span":{"begin":491,"end":513},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T145","span":{"begin":562,"end":580},"obj":"http://purl.obolibrary.org/obo/GO_0060425"},{"id":"T146","span":{"begin":567,"end":580},"obj":"http://purl.obolibrary.org/obo/GO_0009653"},{"id":"T147","span":{"begin":1119,"end":1135},"obj":"http://purl.obolibrary.org/obo/GO_0030324"},{"id":"T148","span":{"begin":1230,"end":1248},"obj":"http://purl.obolibrary.org/obo/GO_0001894"},{"id":"T149","span":{"begin":1237,"end":1248},"obj":"http://purl.obolibrary.org/obo/GO_0042592"},{"id":"T150","span":{"begin":1279,"end":1289},"obj":"http://purl.obolibrary.org/obo/GO_0023052"}],"text":"4.1.5. miR-1307-3p\nmiR-1307 has previously been shown to be one of the lung-tissue-associated miRs [94] and was reported as an especially important target in lung development in newborns. Expression of mir-1307-3p has furthermore been linked to acid metabolism in response to aspirin in human cardiac and peri-cardiac fat-derived mesenchymal stem cells (MSCs) [95]. Moreover, it was shown that several miRs, including miR-1307-3p, are involved in TGF-β and semaphorin signalling, as well as inflammatory responses. miRs play an important role, especially during lung morphogenesis in the early stages of development. Interestingly, miR-1307 has been associated with the severity of pulmonary hypertension in systemic scleroderma [96]. Persistent problems with SARS-CoV-2-infected patients, such as oxygen dependency, urgent need for mechanical ventilation, persistent wheezing, and increased risk for pulmonary infections correlate with involvement of miR-1307-3p, as indicated above, due to its role in pulmonary hypertension and chronic lung diseases. The TGF-β superfamily plays critical roles in pre- and postnatal lung development, importantly shaping alveolarisation and controlling the extracellular matrix composition and tissue homeostasis, among other functions. TGF-β signalling is therefore strongly linked to both pulmonary and cardiovascular diseases [97,98,99]."}

{"project":"LitCovid-sentences","denotations":[{"id":"T261","span":{"begin":0,"end":18},"obj":"Sentence"},{"id":"T262","span":{"begin":19,"end":187},"obj":"Sentence"},{"id":"T263","span":{"begin":188,"end":365},"obj":"Sentence"},{"id":"T264","span":{"begin":366,"end":616},"obj":"Sentence"},{"id":"T265","span":{"begin":617,"end":734},"obj":"Sentence"},{"id":"T266","span":{"begin":735,"end":1053},"obj":"Sentence"},{"id":"T267","span":{"begin":1054,"end":1272},"obj":"Sentence"},{"id":"T268","span":{"begin":1273,"end":1376},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"4.1.5. miR-1307-3p\nmiR-1307 has previously been shown to be one of the lung-tissue-associated miRs [94] and was reported as an especially important target in lung development in newborns. Expression of mir-1307-3p has furthermore been linked to acid metabolism in response to aspirin in human cardiac and peri-cardiac fat-derived mesenchymal stem cells (MSCs) [95]. Moreover, it was shown that several miRs, including miR-1307-3p, are involved in TGF-β and semaphorin signalling, as well as inflammatory responses. miRs play an important role, especially during lung morphogenesis in the early stages of development. Interestingly, miR-1307 has been associated with the severity of pulmonary hypertension in systemic scleroderma [96]. Persistent problems with SARS-CoV-2-infected patients, such as oxygen dependency, urgent need for mechanical ventilation, persistent wheezing, and increased risk for pulmonary infections correlate with involvement of miR-1307-3p, as indicated above, due to its role in pulmonary hypertension and chronic lung diseases. The TGF-β superfamily plays critical roles in pre- and postnatal lung development, importantly shaping alveolarisation and controlling the extracellular matrix composition and tissue homeostasis, among other functions. TGF-β signalling is therefore strongly linked to both pulmonary and cardiovascular diseases [97,98,99]."}

{"project":"2_test","denotations":[{"id":"32512929-32205856-144200774","span":{"begin":100,"end":102},"obj":"32205856"},{"id":"32512929-30013141-144200775","span":{"begin":361,"end":363},"obj":"30013141"},{"id":"32512929-32044414-144200776","span":{"begin":730,"end":732},"obj":"32044414"},{"id":"32512929-23739951-144200777","span":{"begin":1366,"end":1368},"obj":"23739951"},{"id":"32512929-18095342-144200778","span":{"begin":1369,"end":1371},"obj":"18095342"},{"id":"32512929-18313409-144200779","span":{"begin":1372,"end":1374},"obj":"18313409"}],"text":"4.1.5. miR-1307-3p\nmiR-1307 has previously been shown to be one of the lung-tissue-associated miRs [94] and was reported as an especially important target in lung development in newborns. Expression of mir-1307-3p has furthermore been linked to acid metabolism in response to aspirin in human cardiac and peri-cardiac fat-derived mesenchymal stem cells (MSCs) [95]. Moreover, it was shown that several miRs, including miR-1307-3p, are involved in TGF-β and semaphorin signalling, as well as inflammatory responses. miRs play an important role, especially during lung morphogenesis in the early stages of development. Interestingly, miR-1307 has been associated with the severity of pulmonary hypertension in systemic scleroderma [96]. Persistent problems with SARS-CoV-2-infected patients, such as oxygen dependency, urgent need for mechanical ventilation, persistent wheezing, and increased risk for pulmonary infections correlate with involvement of miR-1307-3p, as indicated above, due to its role in pulmonary hypertension and chronic lung diseases. The TGF-β superfamily plays critical roles in pre- and postnatal lung development, importantly shaping alveolarisation and controlling the extracellular matrix composition and tissue homeostasis, among other functions. TGF-β signalling is therefore strongly linked to both pulmonary and cardiovascular diseases [97,98,99]."}

{"project":"LitCovid-PubTator","denotations":[{"id":"977","span":{"begin":19,"end":27},"obj":"Gene"},{"id":"978","span":{"begin":447,"end":452},"obj":"Gene"},{"id":"979","span":{"begin":632,"end":640},"obj":"Gene"},{"id":"980","span":{"begin":1058,"end":1063},"obj":"Gene"},{"id":"981","span":{"begin":1273,"end":1278},"obj":"Gene"},{"id":"982","span":{"begin":287,"end":292},"obj":"Species"},{"id":"983","span":{"begin":780,"end":788},"obj":"Species"},{"id":"984","span":{"begin":276,"end":283},"obj":"Chemical"},{"id":"985","span":{"begin":682,"end":704},"obj":"Disease"},{"id":"986","span":{"begin":708,"end":728},"obj":"Disease"},{"id":"987","span":{"begin":760,"end":779},"obj":"Disease"},{"id":"988","span":{"begin":901,"end":921},"obj":"Disease"},{"id":"989","span":{"begin":1004,"end":1026},"obj":"Disease"},{"id":"990","span":{"begin":1039,"end":1052},"obj":"Disease"},{"id":"991","span":{"begin":1341,"end":1364},"obj":"Disease"}],"attributes":[{"id":"A977","pred":"tao:has_database_id","subj":"977","obj":"Gene:100302174"},{"id":"A978","pred":"tao:has_database_id","subj":"978","obj":"Gene:7039"},{"id":"A979","pred":"tao:has_database_id","subj":"979","obj":"Gene:100302174"},{"id":"A980","pred":"tao:has_database_id","subj":"980","obj":"Gene:7039"},{"id":"A981","pred":"tao:has_database_id","subj":"981","obj":"Gene:7039"},{"id":"A982","pred":"tao:has_database_id","subj":"982","obj":"Tax:9606"},{"id":"A983","pred":"tao:has_database_id","subj":"983","obj":"Tax:9606"},{"id":"A984","pred":"tao:has_database_id","subj":"984","obj":"MESH:D001241"},{"id":"A985","pred":"tao:has_database_id","subj":"985","obj":"MESH:D006976"},{"id":"A986","pred":"tao:has_database_id","subj":"986","obj":"MESH:D012595"},{"id":"A987","pred":"tao:has_database_id","subj":"987","obj":"MESH:C000657245"},{"id":"A988","pred":"tao:has_database_id","subj":"988","obj":"MESH:D012141"},{"id":"A989","pred":"tao:has_database_id","subj":"989","obj":"MESH:D006976"},{"id":"A990","pred":"tao:has_database_id","subj":"990","obj":"MESH:D008171"},{"id":"A991","pred":"tao:has_database_id","subj":"991","obj":"MESH:D002318"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"4.1.5. miR-1307-3p\nmiR-1307 has previously been shown to be one of the lung-tissue-associated miRs [94] and was reported as an especially important target in lung development in newborns. Expression of mir-1307-3p has furthermore been linked to acid metabolism in response to aspirin in human cardiac and peri-cardiac fat-derived mesenchymal stem cells (MSCs) [95]. Moreover, it was shown that several miRs, including miR-1307-3p, are involved in TGF-β and semaphorin signalling, as well as inflammatory responses. miRs play an important role, especially during lung morphogenesis in the early stages of development. Interestingly, miR-1307 has been associated with the severity of pulmonary hypertension in systemic scleroderma [96]. Persistent problems with SARS-CoV-2-infected patients, such as oxygen dependency, urgent need for mechanical ventilation, persistent wheezing, and increased risk for pulmonary infections correlate with involvement of miR-1307-3p, as indicated above, due to its role in pulmonary hypertension and chronic lung diseases. The TGF-β superfamily plays critical roles in pre- and postnatal lung development, importantly shaping alveolarisation and controlling the extracellular matrix composition and tissue homeostasis, among other functions. TGF-β signalling is therefore strongly linked to both pulmonary and cardiovascular diseases [97,98,99]."}