PMC:7354481 / 39589-40965
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T268 | 71-75 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T269 | 76-82 | Body_part | denotes | tissue | http://purl.org/sig/ont/fma/fma9637 |
| T270 | 158-162 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T271 | 330-352 | Body_part | denotes | mesenchymal stem cells | http://purl.org/sig/ont/fma/fma0326143 |
| T272 | 347-352 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T273 | 562-566 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T274 | 1039-1043 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T275 | 1119-1123 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T276 | 1193-1213 | Body_part | denotes | extracellular matrix | http://purl.org/sig/ont/fma/fma9672 |
| T277 | 1230-1236 | Body_part | denotes | tissue | http://purl.org/sig/ont/fma/fma9637 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T49 | 71-75 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T50 | 76-82 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
| T51 | 158-162 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T52 | 562-566 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T53 | 1039-1043 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T54 | 1119-1123 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T55 | 1230-1236 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T237 | 682-704 | Disease | denotes | pulmonary hypertension | http://purl.obolibrary.org/obo/MONDO_0005149 |
| T238 | 692-704 | Disease | denotes | hypertension | http://purl.obolibrary.org/obo/MONDO_0005044 |
| T239 | 708-728 | Disease | denotes | systemic scleroderma | http://purl.obolibrary.org/obo/MONDO_0005100 |
| T240 | 717-728 | Disease | denotes | scleroderma | http://purl.obolibrary.org/obo/MONDO_0019340 |
| T241 | 760-768 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T242 | 911-921 | Disease | denotes | infections | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T243 | 1004-1026 | Disease | denotes | pulmonary hypertension | http://purl.obolibrary.org/obo/MONDO_0005149 |
| T244 | 1014-1026 | Disease | denotes | hypertension | http://purl.obolibrary.org/obo/MONDO_0005044 |
| T245 | 1039-1052 | Disease | denotes | lung diseases | http://purl.obolibrary.org/obo/MONDO_0005275 |
| T246 | 1341-1364 | Disease | denotes | cardiovascular diseases | http://purl.obolibrary.org/obo/MONDO_0004995 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T440 | 28-31 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T441 | 71-75 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T442 | 71-75 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T443 | 100-102 | http://purl.obolibrary.org/obo/CLO_0001527 | denotes | 94 |
| T444 | 158-162 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T445 | 158-162 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T446 | 214-217 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T447 | 287-292 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T448 | 318-321 | http://purl.obolibrary.org/obo/UBERON_0001013 | denotes | fat |
| T449 | 330-352 | http://purl.obolibrary.org/obo/CL_0000134 | denotes | mesenchymal stem cells |
| T450 | 468-478 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signalling |
| T451 | 562-566 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T452 | 562-566 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T453 | 641-644 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T454 | 1039-1043 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T455 | 1039-1043 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T456 | 1119-1123 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T457 | 1119-1123 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T458 | 1279-1289 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signalling |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T159 | 245-249 | Chemical | denotes | acid | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T160 | 798-804 | Chemical | denotes | oxygen | http://purl.obolibrary.org/obo/CHEBI_25805 |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T66 | 692-704 | Phenotype | denotes | hypertension | http://purl.obolibrary.org/obo/HP_0000822 |
| T67 | 717-728 | Phenotype | denotes | scleroderma | http://purl.obolibrary.org/obo/HP_0100324 |
| T68 | 868-876 | Phenotype | denotes | wheezing | http://purl.obolibrary.org/obo/HP_0030828 |
| T69 | 901-921 | Phenotype | denotes | pulmonary infections | http://purl.obolibrary.org/obo/HP_0006532 |
| T70 | 1014-1026 | Phenotype | denotes | hypertension | http://purl.obolibrary.org/obo/HP_0000822 |
| T71 | 1031-1052 | Phenotype | denotes | chronic lung diseases | http://purl.obolibrary.org/obo/HP_0006528 |
| T72 | 1341-1364 | Phenotype | denotes | cardiovascular diseases | http://purl.obolibrary.org/obo/HP_0001626 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T141 | 158-174 | http://purl.obolibrary.org/obo/GO_0030324 | denotes | lung development |
| T142 | 250-260 | http://purl.obolibrary.org/obo/GO_0008152 | denotes | metabolism |
| T143 | 468-478 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signalling |
| T144 | 491-513 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammatory responses |
| T145 | 562-580 | http://purl.obolibrary.org/obo/GO_0060425 | denotes | lung morphogenesis |
| T146 | 567-580 | http://purl.obolibrary.org/obo/GO_0009653 | denotes | morphogenesis |
| T147 | 1119-1135 | http://purl.obolibrary.org/obo/GO_0030324 | denotes | lung development |
| T148 | 1230-1248 | http://purl.obolibrary.org/obo/GO_0001894 | denotes | tissue homeostasis |
| T149 | 1237-1248 | http://purl.obolibrary.org/obo/GO_0042592 | denotes | homeostasis |
| T150 | 1279-1289 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signalling |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T261 | 0-18 | Sentence | denotes | 4.1.5. miR-1307-3p |
| T262 | 19-187 | Sentence | denotes | miR-1307 has previously been shown to be one of the lung-tissue-associated miRs [94] and was reported as an especially important target in lung development in newborns. |
| T263 | 188-365 | Sentence | denotes | Expression of mir-1307-3p has furthermore been linked to acid metabolism in response to aspirin in human cardiac and peri-cardiac fat-derived mesenchymal stem cells (MSCs) [95]. |
| T264 | 366-616 | Sentence | denotes | Moreover, it was shown that several miRs, including miR-1307-3p, are involved in TGF-β and semaphorin signalling, as well as inflammatory responses. miRs play an important role, especially during lung morphogenesis in the early stages of development. |
| T265 | 617-734 | Sentence | denotes | Interestingly, miR-1307 has been associated with the severity of pulmonary hypertension in systemic scleroderma [96]. |
| T266 | 735-1053 | Sentence | denotes | Persistent problems with SARS-CoV-2-infected patients, such as oxygen dependency, urgent need for mechanical ventilation, persistent wheezing, and increased risk for pulmonary infections correlate with involvement of miR-1307-3p, as indicated above, due to its role in pulmonary hypertension and chronic lung diseases. |
| T267 | 1054-1272 | Sentence | denotes | The TGF-β superfamily plays critical roles in pre- and postnatal lung development, importantly shaping alveolarisation and controlling the extracellular matrix composition and tissue homeostasis, among other functions. |
| T268 | 1273-1376 | Sentence | denotes | TGF-β signalling is therefore strongly linked to both pulmonary and cardiovascular diseases [97,98,99]. |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32512929-32205856-144200774 | 100-102 | 32205856 | denotes | 94 |
| 32512929-30013141-144200775 | 361-363 | 30013141 | denotes | 95 |
| 32512929-32044414-144200776 | 730-732 | 32044414 | denotes | 96 |
| 32512929-23739951-144200777 | 1366-1368 | 23739951 | denotes | 97 |
| 32512929-18095342-144200778 | 1369-1371 | 18095342 | denotes | 98 |
| 32512929-18313409-144200779 | 1372-1374 | 18313409 | denotes | 99 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 977 | 19-27 | Gene | denotes | miR-1307 | Gene:100302174 |
| 978 | 447-452 | Gene | denotes | TGF-β | Gene:7039 |
| 979 | 632-640 | Gene | denotes | miR-1307 | Gene:100302174 |
| 980 | 1058-1063 | Gene | denotes | TGF-β | Gene:7039 |
| 981 | 1273-1278 | Gene | denotes | TGF-β | Gene:7039 |
| 982 | 287-292 | Species | denotes | human | Tax:9606 |
| 983 | 780-788 | Species | denotes | patients | Tax:9606 |
| 984 | 276-283 | Chemical | denotes | aspirin | MESH:D001241 |
| 985 | 682-704 | Disease | denotes | pulmonary hypertension | MESH:D006976 |
| 986 | 708-728 | Disease | denotes | systemic scleroderma | MESH:D012595 |
| 987 | 760-779 | Disease | denotes | SARS-CoV-2-infected | MESH:C000657245 |
| 988 | 901-921 | Disease | denotes | pulmonary infections | MESH:D012141 |
| 989 | 1004-1026 | Disease | denotes | pulmonary hypertension | MESH:D006976 |
| 990 | 1039-1052 | Disease | denotes | lung diseases | MESH:D008171 |
| 991 | 1341-1364 | Disease | denotes | cardiovascular diseases | MESH:D002318 |