PMC:7354481 / 37047-38443 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T239","span":{"begin":1,"end":18},"obj":"Body_part"},{"id":"T240","span":{"begin":32,"end":47},"obj":"Body_part"},{"id":"T241","span":{"begin":48,"end":55},"obj":"Body_part"},{"id":"T242","span":{"begin":90,"end":119},"obj":"Body_part"},{"id":"T243","span":{"begin":90,"end":105},"obj":"Body_part"},{"id":"T244","span":{"begin":90,"end":97},"obj":"Body_part"},{"id":"T245","span":{"begin":303,"end":332},"obj":"Body_part"},{"id":"T246","span":{"begin":303,"end":318},"obj":"Body_part"},{"id":"T247","span":{"begin":344,"end":348},"obj":"Body_part"},{"id":"T248","span":{"begin":423,"end":438},"obj":"Body_part"},{"id":"T249","span":{"begin":497,"end":513},"obj":"Body_part"},{"id":"T250","span":{"begin":508,"end":513},"obj":"Body_part"},{"id":"T251","span":{"begin":628,"end":632},"obj":"Body_part"},{"id":"T252","span":{"begin":651,"end":680},"obj":"Body_part"},{"id":"T253","span":{"begin":651,"end":666},"obj":"Body_part"},{"id":"T254","span":{"begin":752,"end":759},"obj":"Body_part"},{"id":"T255","span":{"begin":829,"end":836},"obj":"Body_part"},{"id":"T256","span":{"begin":841,"end":845},"obj":"Body_part"},{"id":"T257","span":{"begin":869,"end":876},"obj":"Body_part"},{"id":"T258","span":{"begin":982,"end":989},"obj":"Body_part"}],"attributes":[{"id":"A239","pred":"fma_id","subj":"T239","obj":"http://purl.org/sig/ont/fma/fma63011"},{"id":"A240","pred":"fma_id","subj":"T240","obj":"http://purl.org/sig/ont/fma/fma63023"},{"id":"A241","pred":"fma_id","subj":"T241","obj":"http://purl.org/sig/ont/fma/fma82839"},{"id":"A242","pred":"fma_id","subj":"T242","obj":"http://purl.org/sig/ont/fma/fma82834"},{"id":"A243","pred":"fma_id","subj":"T243","obj":"http://purl.org/sig/ont/fma/fma63023"},{"id":"A244","pred":"fma_id","subj":"T244","obj":"http://purl.org/sig/ont/fma/fma67110"},{"id":"A245","pred":"fma_id","subj":"T245","obj":"http://purl.org/sig/ont/fma/fma82834"},{"id":"A246","pred":"fma_id","subj":"T246","obj":"http://purl.org/sig/ont/fma/fma63023"},{"id":"A247","pred":"fma_id","subj":"T247","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A248","pred":"fma_id","subj":"T248","obj":"http://purl.org/sig/ont/fma/fma63023"},{"id":"A249","pred":"fma_id","subj":"T249","obj":"http://purl.org/sig/ont/fma/fma66768"},{"id":"A250","pred":"fma_id","subj":"T250","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A251","pred":"fma_id","subj":"T251","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A252","pred":"fma_id","subj":"T252","obj":"http://purl.org/sig/ont/fma/fma82834"},{"id":"A253","pred":"fma_id","subj":"T253","obj":"http://purl.org/sig/ont/fma/fma63023"},{"id":"A254","pred":"fma_id","subj":"T254","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A255","pred":"fma_id","subj":"T255","obj":"http://purl.org/sig/ont/fma/fma82839"},{"id":"A256","pred":"fma_id","subj":"T256","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A257","pred":"fma_id","subj":"T257","obj":"http://purl.org/sig/ont/fma/fma82839"},{"id":"A258","pred":"fma_id","subj":"T258","obj":"http://purl.org/sig/ont/fma/fma82839"}],"text":"“Glycosaminoglycan biosynthesis—heparan sulfate/heparin” was here related to miRs 3934-3. Heparan sulfate proteoglycans have previously been identified to provide the binding sites for SARS-CoV-2 invasion at the early attachment phase [76]. Furthermore, human coronavirus NL63 has been shown to utilise heparan sulfate proteoglycans for target cell attachment [77]. This KEGG pathway has been related to Ebola virus, where heparan sulfate has been identified as an important mediator in polarised epithelial cells [78,79]. In hepatitis C viral infection, the virus hijacks this pathway via interaction with apolipoprotein E for cell entry [63], while heparan sulfate proteoglycans are required for cellular binding of the hepatitis E virus ORF2 capsid protein and for viral infection [70]. Endogenous HERV-K furthermore binds to heparin for cell entry [80], and, while heparin has been found to further Zika virus infection, it acts as an antiviral against Dengue replication [81]. Heparin sulphate is identified as an inhibitory regulator of porcine epidemic diarrhoea virus infection [82] and acts as an attachment factor for rabies virus entry and infection [83], as well as an enhancer of Nipah and Hendra virus infections, which are highly pathogenic, zoonotic paramyxoviruses [84]. This highlights the importance of this KEGG pathway both in human, zoonotic and veterinary viral infections."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T201","span":{"begin":185,"end":193},"obj":"Disease"},{"id":"T202","span":{"begin":404,"end":409},"obj":"Disease"},{"id":"T203","span":{"begin":526,"end":537},"obj":"Disease"},{"id":"T204","span":{"begin":526,"end":535},"obj":"Disease"},{"id":"T205","span":{"begin":538,"end":553},"obj":"Disease"},{"id":"T206","span":{"begin":544,"end":553},"obj":"Disease"},{"id":"T207","span":{"begin":722,"end":733},"obj":"Disease"},{"id":"T208","span":{"begin":722,"end":731},"obj":"Disease"},{"id":"T209","span":{"begin":768,"end":783},"obj":"Disease"},{"id":"T210","span":{"begin":774,"end":783},"obj":"Disease"},{"id":"T211","span":{"begin":903,"end":923},"obj":"Disease"},{"id":"T212","span":{"begin":908,"end":923},"obj":"Disease"},{"id":"T213","span":{"begin":914,"end":923},"obj":"Disease"},{"id":"T214","span":{"begin":957,"end":963},"obj":"Disease"},{"id":"T215","span":{"begin":1060,"end":1069},"obj":"Disease"},{"id":"T216","span":{"begin":1070,"end":1085},"obj":"Disease"},{"id":"T217","span":{"begin":1076,"end":1085},"obj":"Disease"},{"id":"T218","span":{"begin":1128,"end":1134},"obj":"Disease"},{"id":"T219","span":{"begin":1151,"end":1160},"obj":"Disease"},{"id":"T220","span":{"begin":1203,"end":1226},"obj":"Disease"},{"id":"T221","span":{"begin":1379,"end":1395},"obj":"Disease"}],"attributes":[{"id":"A201","pred":"mondo_id","subj":"T201","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A202","pred":"mondo_id","subj":"T202","obj":"http://purl.obolibrary.org/obo/MONDO_0005737"},{"id":"A203","pred":"mondo_id","subj":"T203","obj":"http://purl.obolibrary.org/obo/MONDO_0005231"},{"id":"A204","pred":"mondo_id","subj":"T204","obj":"http://purl.obolibrary.org/obo/MONDO_0002251"},{"id":"A205","pred":"mondo_id","subj":"T205","obj":"http://purl.obolibrary.org/obo/MONDO_0005108"},{"id":"A206","pred":"mondo_id","subj":"T206","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A207","pred":"mondo_id","subj":"T207","obj":"http://purl.obolibrary.org/obo/MONDO_0005788"},{"id":"A208","pred":"mondo_id","subj":"T208","obj":"http://purl.obolibrary.org/obo/MONDO_0002251"},{"id":"A209","pred":"mondo_id","subj":"T209","obj":"http://purl.obolibrary.org/obo/MONDO_0005108"},{"id":"A210","pred":"mondo_id","subj":"T210","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A211","pred":"mondo_id","subj":"T211","obj":"http://purl.obolibrary.org/obo/MONDO_0018661"},{"id":"A212","pred":"mondo_id","subj":"T212","obj":"http://purl.obolibrary.org/obo/MONDO_0005108"},{"id":"A213","pred":"mondo_id","subj":"T213","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A214","pred":"mondo_id","subj":"T214","obj":"http://purl.obolibrary.org/obo/MONDO_0005502"},{"id":"A215","pred":"mondo_id","subj":"T215","obj":"http://purl.obolibrary.org/obo/MONDO_0001673"},{"id":"A216","pred":"mondo_id","subj":"T216","obj":"http://purl.obolibrary.org/obo/MONDO_0005108"},{"id":"A217","pred":"mondo_id","subj":"T217","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A218","pred":"mondo_id","subj":"T218","obj":"http://purl.obolibrary.org/obo/MONDO_0019173"},{"id":"A219","pred":"mondo_id","subj":"T219","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A220","pred":"mondo_id","subj":"T220","obj":"http://purl.obolibrary.org/obo/MONDO_0017942"},{"id":"A221","pred":"mondo_id","subj":"T221","obj":"http://purl.obolibrary.org/obo/MONDO_0005108"}],"text":"“Glycosaminoglycan biosynthesis—heparan sulfate/heparin” was here related to miRs 3934-3. Heparan sulfate proteoglycans have previously been identified to provide the binding sites for SARS-CoV-2 invasion at the early attachment phase [76]. Furthermore, human coronavirus NL63 has been shown to utilise heparan sulfate proteoglycans for target cell attachment [77]. This KEGG pathway has been related to Ebola virus, where heparan sulfate has been identified as an important mediator in polarised epithelial cells [78,79]. In hepatitis C viral infection, the virus hijacks this pathway via interaction with apolipoprotein E for cell entry [63], while heparan sulfate proteoglycans are required for cellular binding of the hepatitis E virus ORF2 capsid protein and for viral infection [70]. Endogenous HERV-K furthermore binds to heparin for cell entry [80], and, while heparin has been found to further Zika virus infection, it acts as an antiviral against Dengue replication [81]. Heparin sulphate is identified as an inhibitory regulator of porcine epidemic diarrhoea virus infection [82] and acts as an attachment factor for rabies virus entry and infection [83], as well as an enhancer of Nipah and Hendra virus infections, which are highly pathogenic, zoonotic paramyxoviruses [84]. This highlights the importance of this KEGG pathway both in human, zoonotic and veterinary viral infections."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T397","span":{"begin":90,"end":119},"obj":"http://purl.obolibrary.org/obo/PR_000001307"},{"id":"T398","span":{"begin":254,"end":259},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T399","span":{"begin":277,"end":280},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T400","span":{"begin":303,"end":332},"obj":"http://purl.obolibrary.org/obo/PR_000001307"},{"id":"T401","span":{"begin":344,"end":348},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T402","span":{"begin":384,"end":387},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T403","span":{"begin":410,"end":415},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T404","span":{"begin":439,"end":442},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T405","span":{"begin":497,"end":507},"obj":"http://purl.obolibrary.org/obo/CL_0000066"},{"id":"T406","span":{"begin":508,"end":513},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T407","span":{"begin":559,"end":564},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T408","span":{"begin":628,"end":632},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T409","span":{"begin":651,"end":680},"obj":"http://purl.obolibrary.org/obo/PR_000001307"},{"id":"T410","span":{"begin":734,"end":739},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T411","span":{"begin":841,"end":845},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T412","span":{"begin":877,"end":880},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T413","span":{"begin":908,"end":913},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T414","span":{"begin":1070,"end":1075},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T415","span":{"begin":1135,"end":1140},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T416","span":{"begin":1210,"end":1215},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T417","span":{"begin":1348,"end":1353},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"}],"text":"“Glycosaminoglycan biosynthesis—heparan sulfate/heparin” was here related to miRs 3934-3. Heparan sulfate proteoglycans have previously been identified to provide the binding sites for SARS-CoV-2 invasion at the early attachment phase [76]. Furthermore, human coronavirus NL63 has been shown to utilise heparan sulfate proteoglycans for target cell attachment [77]. This KEGG pathway has been related to Ebola virus, where heparan sulfate has been identified as an important mediator in polarised epithelial cells [78,79]. In hepatitis C viral infection, the virus hijacks this pathway via interaction with apolipoprotein E for cell entry [63], while heparan sulfate proteoglycans are required for cellular binding of the hepatitis E virus ORF2 capsid protein and for viral infection [70]. Endogenous HERV-K furthermore binds to heparin for cell entry [80], and, while heparin has been found to further Zika virus infection, it acts as an antiviral against Dengue replication [81]. Heparin sulphate is identified as an inhibitory regulator of porcine epidemic diarrhoea virus infection [82] and acts as an attachment factor for rabies virus entry and infection [83], as well as an enhancer of Nipah and Hendra virus infections, which are highly pathogenic, zoonotic paramyxoviruses [84]. This highlights the importance of this KEGG pathway both in human, zoonotic and veterinary viral infections."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T118","span":{"begin":1,"end":18},"obj":"Chemical"},{"id":"T119","span":{"begin":32,"end":47},"obj":"Chemical"},{"id":"T120","span":{"begin":32,"end":39},"obj":"Chemical"},{"id":"T121","span":{"begin":40,"end":47},"obj":"Chemical"},{"id":"T122","span":{"begin":48,"end":55},"obj":"Chemical"},{"id":"T123","span":{"begin":90,"end":105},"obj":"Chemical"},{"id":"T124","span":{"begin":98,"end":105},"obj":"Chemical"},{"id":"T125","span":{"begin":106,"end":119},"obj":"Chemical"},{"id":"T126","span":{"begin":303,"end":318},"obj":"Chemical"},{"id":"T127","span":{"begin":303,"end":310},"obj":"Chemical"},{"id":"T128","span":{"begin":311,"end":318},"obj":"Chemical"},{"id":"T129","span":{"begin":319,"end":332},"obj":"Chemical"},{"id":"T130","span":{"begin":423,"end":438},"obj":"Chemical"},{"id":"T131","span":{"begin":423,"end":430},"obj":"Chemical"},{"id":"T132","span":{"begin":431,"end":438},"obj":"Chemical"},{"id":"T133","span":{"begin":607,"end":621},"obj":"Chemical"},{"id":"T134","span":{"begin":651,"end":666},"obj":"Chemical"},{"id":"T135","span":{"begin":651,"end":658},"obj":"Chemical"},{"id":"T136","span":{"begin":659,"end":666},"obj":"Chemical"},{"id":"T137","span":{"begin":667,"end":680},"obj":"Chemical"},{"id":"T138","span":{"begin":752,"end":759},"obj":"Chemical"},{"id":"T139","span":{"begin":829,"end":836},"obj":"Chemical"},{"id":"T140","span":{"begin":869,"end":876},"obj":"Chemical"},{"id":"T141","span":{"begin":939,"end":948},"obj":"Chemical"},{"id":"T142","span":{"begin":982,"end":989},"obj":"Chemical"},{"id":"T143","span":{"begin":990,"end":998},"obj":"Chemical"}],"attributes":[{"id":"A118","pred":"chebi_id","subj":"T118","obj":"http://purl.obolibrary.org/obo/CHEBI_18085"},{"id":"A119","pred":"chebi_id","subj":"T119","obj":"http://purl.obolibrary.org/obo/CHEBI_28815"},{"id":"A120","pred":"chebi_id","subj":"T120","obj":"http://purl.obolibrary.org/obo/CHEBI_24500"},{"id":"A121","pred":"chebi_id","subj":"T121","obj":"http://purl.obolibrary.org/obo/CHEBI_16189"},{"id":"A122","pred":"chebi_id","subj":"T122","obj":"http://purl.obolibrary.org/obo/CHEBI_28304"},{"id":"A123","pred":"chebi_id","subj":"T123","obj":"http://purl.obolibrary.org/obo/CHEBI_28815"},{"id":"A124","pred":"chebi_id","subj":"T124","obj":"http://purl.obolibrary.org/obo/CHEBI_16189"},{"id":"A125","pred":"chebi_id","subj":"T125","obj":"http://purl.obolibrary.org/obo/CHEBI_37396"},{"id":"A126","pred":"chebi_id","subj":"T126","obj":"http://purl.obolibrary.org/obo/CHEBI_28815"},{"id":"A127","pred":"chebi_id","subj":"T127","obj":"http://purl.obolibrary.org/obo/CHEBI_24500"},{"id":"A128","pred":"chebi_id","subj":"T128","obj":"http://purl.obolibrary.org/obo/CHEBI_16189"},{"id":"A129","pred":"chebi_id","subj":"T129","obj":"http://purl.obolibrary.org/obo/CHEBI_37396"},{"id":"A130","pred":"chebi_id","subj":"T130","obj":"http://purl.obolibrary.org/obo/CHEBI_28815"},{"id":"A131","pred":"chebi_id","subj":"T131","obj":"http://purl.obolibrary.org/obo/CHEBI_24500"},{"id":"A132","pred":"chebi_id","subj":"T132","obj":"http://purl.obolibrary.org/obo/CHEBI_16189"},{"id":"A133","pred":"chebi_id","subj":"T133","obj":"http://purl.obolibrary.org/obo/CHEBI_39015"},{"id":"A134","pred":"chebi_id","subj":"T134","obj":"http://purl.obolibrary.org/obo/CHEBI_28815"},{"id":"A135","pred":"chebi_id","subj":"T135","obj":"http://purl.obolibrary.org/obo/CHEBI_24500"},{"id":"A136","pred":"chebi_id","subj":"T136","obj":"http://purl.obolibrary.org/obo/CHEBI_16189"},{"id":"A137","pred":"chebi_id","subj":"T137","obj":"http://purl.obolibrary.org/obo/CHEBI_37396"},{"id":"A138","pred":"chebi_id","subj":"T138","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A139","pred":"chebi_id","subj":"T139","obj":"http://purl.obolibrary.org/obo/CHEBI_28304"},{"id":"A140","pred":"chebi_id","subj":"T140","obj":"http://purl.obolibrary.org/obo/CHEBI_28304"},{"id":"A141","pred":"chebi_id","subj":"T141","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A142","pred":"chebi_id","subj":"T142","obj":"http://purl.obolibrary.org/obo/CHEBI_28304"},{"id":"A143","pred":"chebi_id","subj":"T143","obj":"http://purl.obolibrary.org/obo/CHEBI_16189"}],"text":"“Glycosaminoglycan biosynthesis—heparan sulfate/heparin” was here related to miRs 3934-3. Heparan sulfate proteoglycans have previously been identified to provide the binding sites for SARS-CoV-2 invasion at the early attachment phase [76]. Furthermore, human coronavirus NL63 has been shown to utilise heparan sulfate proteoglycans for target cell attachment [77]. This KEGG pathway has been related to Ebola virus, where heparan sulfate has been identified as an important mediator in polarised epithelial cells [78,79]. In hepatitis C viral infection, the virus hijacks this pathway via interaction with apolipoprotein E for cell entry [63], while heparan sulfate proteoglycans are required for cellular binding of the hepatitis E virus ORF2 capsid protein and for viral infection [70]. Endogenous HERV-K furthermore binds to heparin for cell entry [80], and, while heparin has been found to further Zika virus infection, it acts as an antiviral against Dengue replication [81]. Heparin sulphate is identified as an inhibitory regulator of porcine epidemic diarrhoea virus infection [82] and acts as an attachment factor for rabies virus entry and infection [83], as well as an enhancer of Nipah and Hendra virus infections, which are highly pathogenic, zoonotic paramyxoviruses [84]. This highlights the importance of this KEGG pathway both in human, zoonotic and veterinary viral infections."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T58","span":{"begin":526,"end":535},"obj":"Phenotype"},{"id":"T59","span":{"begin":722,"end":731},"obj":"Phenotype"},{"id":"T60","span":{"begin":1060,"end":1069},"obj":"Phenotype"}],"attributes":[{"id":"A58","pred":"hp_id","subj":"T58","obj":"http://purl.obolibrary.org/obo/HP_0012115"},{"id":"A59","pred":"hp_id","subj":"T59","obj":"http://purl.obolibrary.org/obo/HP_0012115"},{"id":"A60","pred":"hp_id","subj":"T60","obj":"http://purl.obolibrary.org/obo/HP_0002014"}],"text":"“Glycosaminoglycan biosynthesis—heparan sulfate/heparin” was here related to miRs 3934-3. Heparan sulfate proteoglycans have previously been identified to provide the binding sites for SARS-CoV-2 invasion at the early attachment phase [76]. Furthermore, human coronavirus NL63 has been shown to utilise heparan sulfate proteoglycans for target cell attachment [77]. This KEGG pathway has been related to Ebola virus, where heparan sulfate has been identified as an important mediator in polarised epithelial cells [78,79]. In hepatitis C viral infection, the virus hijacks this pathway via interaction with apolipoprotein E for cell entry [63], while heparan sulfate proteoglycans are required for cellular binding of the hepatitis E virus ORF2 capsid protein and for viral infection [70]. Endogenous HERV-K furthermore binds to heparin for cell entry [80], and, while heparin has been found to further Zika virus infection, it acts as an antiviral against Dengue replication [81]. Heparin sulphate is identified as an inhibitory regulator of porcine epidemic diarrhoea virus infection [82] and acts as an attachment factor for rabies virus entry and infection [83], as well as an enhancer of Nipah and Hendra virus infections, which are highly pathogenic, zoonotic paramyxoviruses [84]. This highlights the importance of this KEGG pathway both in human, zoonotic and veterinary viral infections."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T128","span":{"begin":1,"end":31},"obj":"http://purl.obolibrary.org/obo/GO_0006024"},{"id":"T129","span":{"begin":19,"end":31},"obj":"http://purl.obolibrary.org/obo/GO_0009058"},{"id":"T130","span":{"begin":538,"end":553},"obj":"http://purl.obolibrary.org/obo/GO_0016032"},{"id":"T131","span":{"begin":607,"end":621},"obj":"http://purl.obolibrary.org/obo/GO_0005319"},{"id":"T132","span":{"begin":768,"end":783},"obj":"http://purl.obolibrary.org/obo/GO_0016032"},{"id":"T133","span":{"begin":1379,"end":1395},"obj":"http://purl.obolibrary.org/obo/GO_0016032"}],"text":"“Glycosaminoglycan biosynthesis—heparan sulfate/heparin” was here related to miRs 3934-3. Heparan sulfate proteoglycans have previously been identified to provide the binding sites for SARS-CoV-2 invasion at the early attachment phase [76]. Furthermore, human coronavirus NL63 has been shown to utilise heparan sulfate proteoglycans for target cell attachment [77]. This KEGG pathway has been related to Ebola virus, where heparan sulfate has been identified as an important mediator in polarised epithelial cells [78,79]. In hepatitis C viral infection, the virus hijacks this pathway via interaction with apolipoprotein E for cell entry [63], while heparan sulfate proteoglycans are required for cellular binding of the hepatitis E virus ORF2 capsid protein and for viral infection [70]. Endogenous HERV-K furthermore binds to heparin for cell entry [80], and, while heparin has been found to further Zika virus infection, it acts as an antiviral against Dengue replication [81]. Heparin sulphate is identified as an inhibitory regulator of porcine epidemic diarrhoea virus infection [82] and acts as an attachment factor for rabies virus entry and infection [83], as well as an enhancer of Nipah and Hendra virus infections, which are highly pathogenic, zoonotic paramyxoviruses [84]. This highlights the importance of this KEGG pathway both in human, zoonotic and veterinary viral infections."}

{"project":"LitCovid-PD-GlycoEpitope","denotations":[{"id":"T3","span":{"begin":32,"end":47},"obj":"GlycoEpitope"},{"id":"T4","span":{"begin":90,"end":105},"obj":"GlycoEpitope"},{"id":"T5","span":{"begin":303,"end":318},"obj":"GlycoEpitope"},{"id":"T6","span":{"begin":423,"end":438},"obj":"GlycoEpitope"},{"id":"T7","span":{"begin":651,"end":666},"obj":"GlycoEpitope"}],"attributes":[{"id":"A3","pred":"glyco_epitope_db_id","subj":"T3","obj":"http://www.glycoepitope.jp/epitopes/EP0086"},{"id":"A4","pred":"glyco_epitope_db_id","subj":"T4","obj":"http://www.glycoepitope.jp/epitopes/EP0086"},{"id":"A5","pred":"glyco_epitope_db_id","subj":"T5","obj":"http://www.glycoepitope.jp/epitopes/EP0086"},{"id":"A6","pred":"glyco_epitope_db_id","subj":"T6","obj":"http://www.glycoepitope.jp/epitopes/EP0086"},{"id":"A7","pred":"glyco_epitope_db_id","subj":"T7","obj":"http://www.glycoepitope.jp/epitopes/EP0086"}],"text":"“Glycosaminoglycan biosynthesis—heparan sulfate/heparin” was here related to miRs 3934-3. Heparan sulfate proteoglycans have previously been identified to provide the binding sites for SARS-CoV-2 invasion at the early attachment phase [76]. Furthermore, human coronavirus NL63 has been shown to utilise heparan sulfate proteoglycans for target cell attachment [77]. This KEGG pathway has been related to Ebola virus, where heparan sulfate has been identified as an important mediator in polarised epithelial cells [78,79]. In hepatitis C viral infection, the virus hijacks this pathway via interaction with apolipoprotein E for cell entry [63], while heparan sulfate proteoglycans are required for cellular binding of the hepatitis E virus ORF2 capsid protein and for viral infection [70]. Endogenous HERV-K furthermore binds to heparin for cell entry [80], and, while heparin has been found to further Zika virus infection, it acts as an antiviral against Dengue replication [81]. Heparin sulphate is identified as an inhibitory regulator of porcine epidemic diarrhoea virus infection [82] and acts as an attachment factor for rabies virus entry and infection [83], as well as an enhancer of Nipah and Hendra virus infections, which are highly pathogenic, zoonotic paramyxoviruses [84]. This highlights the importance of this KEGG pathway both in human, zoonotic and veterinary viral infections."}

{"project":"LitCovid-sentences","denotations":[{"id":"T245","span":{"begin":0,"end":89},"obj":"Sentence"},{"id":"T246","span":{"begin":90,"end":240},"obj":"Sentence"},{"id":"T247","span":{"begin":241,"end":365},"obj":"Sentence"},{"id":"T248","span":{"begin":366,"end":522},"obj":"Sentence"},{"id":"T249","span":{"begin":523,"end":789},"obj":"Sentence"},{"id":"T250","span":{"begin":790,"end":981},"obj":"Sentence"},{"id":"T251","span":{"begin":982,"end":1287},"obj":"Sentence"},{"id":"T252","span":{"begin":1288,"end":1396},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"“Glycosaminoglycan biosynthesis—heparan sulfate/heparin” was here related to miRs 3934-3. Heparan sulfate proteoglycans have previously been identified to provide the binding sites for SARS-CoV-2 invasion at the early attachment phase [76]. Furthermore, human coronavirus NL63 has been shown to utilise heparan sulfate proteoglycans for target cell attachment [77]. This KEGG pathway has been related to Ebola virus, where heparan sulfate has been identified as an important mediator in polarised epithelial cells [78,79]. In hepatitis C viral infection, the virus hijacks this pathway via interaction with apolipoprotein E for cell entry [63], while heparan sulfate proteoglycans are required for cellular binding of the hepatitis E virus ORF2 capsid protein and for viral infection [70]. Endogenous HERV-K furthermore binds to heparin for cell entry [80], and, while heparin has been found to further Zika virus infection, it acts as an antiviral against Dengue replication [81]. Heparin sulphate is identified as an inhibitory regulator of porcine epidemic diarrhoea virus infection [82] and acts as an attachment factor for rabies virus entry and infection [83], as well as an enhancer of Nipah and Hendra virus infections, which are highly pathogenic, zoonotic paramyxoviruses [84]. This highlights the importance of this KEGG pathway both in human, zoonotic and veterinary viral infections."}

{"project":"2_test","denotations":[{"id":"32512929-31467373-144200755","span":{"begin":236,"end":238},"obj":"31467373"},{"id":"32512929-21887302-144200756","span":{"begin":361,"end":363},"obj":"21887302"},{"id":"32512929-25187545-144200757","span":{"begin":515,"end":517},"obj":"25187545"},{"id":"32512929-30165875-144200758","span":{"begin":518,"end":520},"obj":"30165875"},{"id":"32512929-26536864-144200759","span":{"begin":640,"end":642},"obj":"26536864"},{"id":"32512929-9666259-144200760","span":{"begin":785,"end":787},"obj":"9666259"},{"id":"32512929-19812150-144200761","span":{"begin":853,"end":855},"obj":"19812150"},{"id":"32512929-30080900-144200762","span":{"begin":977,"end":979},"obj":"30080900"},{"id":"32512929-30698412-144200763","span":{"begin":1087,"end":1089},"obj":"30698412"},{"id":"32512929-25896095-144200764","span":{"begin":1162,"end":1164},"obj":"25896095"},{"id":"32512929-29529215-144200765","span":{"begin":1283,"end":1285},"obj":"29529215"}],"text":"“Glycosaminoglycan biosynthesis—heparan sulfate/heparin” was here related to miRs 3934-3. Heparan sulfate proteoglycans have previously been identified to provide the binding sites for SARS-CoV-2 invasion at the early attachment phase [76]. Furthermore, human coronavirus NL63 has been shown to utilise heparan sulfate proteoglycans for target cell attachment [77]. This KEGG pathway has been related to Ebola virus, where heparan sulfate has been identified as an important mediator in polarised epithelial cells [78,79]. In hepatitis C viral infection, the virus hijacks this pathway via interaction with apolipoprotein E for cell entry [63], while heparan sulfate proteoglycans are required for cellular binding of the hepatitis E virus ORF2 capsid protein and for viral infection [70]. Endogenous HERV-K furthermore binds to heparin for cell entry [80], and, while heparin has been found to further Zika virus infection, it acts as an antiviral against Dengue replication [81]. Heparin sulphate is identified as an inhibitory regulator of porcine epidemic diarrhoea virus infection [82] and acts as an attachment factor for rabies virus entry and infection [83], as well as an enhancer of Nipah and Hendra virus infections, which are highly pathogenic, zoonotic paramyxoviruses [84]. This highlights the importance of this KEGG pathway both in human, zoonotic and veterinary viral infections."}

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