PMC:7354481 / 37047-38443
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T239 | 1-18 | Body_part | denotes | Glycosaminoglycan | http://purl.org/sig/ont/fma/fma63011 |
| T240 | 32-47 | Body_part | denotes | heparan sulfate | http://purl.org/sig/ont/fma/fma63023 |
| T241 | 48-55 | Body_part | denotes | heparin | http://purl.org/sig/ont/fma/fma82839 |
| T242 | 90-119 | Body_part | denotes | Heparan sulfate proteoglycans | http://purl.org/sig/ont/fma/fma82834 |
| T243 | 90-105 | Body_part | denotes | Heparan sulfate | http://purl.org/sig/ont/fma/fma63023 |
| T244 | 90-97 | Body_part | denotes | Heparan | http://purl.org/sig/ont/fma/fma67110 |
| T245 | 303-332 | Body_part | denotes | heparan sulfate proteoglycans | http://purl.org/sig/ont/fma/fma82834 |
| T246 | 303-318 | Body_part | denotes | heparan sulfate | http://purl.org/sig/ont/fma/fma63023 |
| T247 | 344-348 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T248 | 423-438 | Body_part | denotes | heparan sulfate | http://purl.org/sig/ont/fma/fma63023 |
| T249 | 497-513 | Body_part | denotes | epithelial cells | http://purl.org/sig/ont/fma/fma66768 |
| T250 | 508-513 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T251 | 628-632 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T252 | 651-680 | Body_part | denotes | heparan sulfate proteoglycans | http://purl.org/sig/ont/fma/fma82834 |
| T253 | 651-666 | Body_part | denotes | heparan sulfate | http://purl.org/sig/ont/fma/fma63023 |
| T254 | 752-759 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T255 | 829-836 | Body_part | denotes | heparin | http://purl.org/sig/ont/fma/fma82839 |
| T256 | 841-845 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T257 | 869-876 | Body_part | denotes | heparin | http://purl.org/sig/ont/fma/fma82839 |
| T258 | 982-989 | Body_part | denotes | Heparin | http://purl.org/sig/ont/fma/fma82839 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T201 | 185-193 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T202 | 404-409 | Disease | denotes | Ebola | http://purl.obolibrary.org/obo/MONDO_0005737 |
| T203 | 526-537 | Disease | denotes | hepatitis C | http://purl.obolibrary.org/obo/MONDO_0005231 |
| T204 | 526-535 | Disease | denotes | hepatitis | http://purl.obolibrary.org/obo/MONDO_0002251 |
| T205 | 538-553 | Disease | denotes | viral infection | http://purl.obolibrary.org/obo/MONDO_0005108 |
| T206 | 544-553 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T207 | 722-733 | Disease | denotes | hepatitis E | http://purl.obolibrary.org/obo/MONDO_0005788 |
| T208 | 722-731 | Disease | denotes | hepatitis | http://purl.obolibrary.org/obo/MONDO_0002251 |
| T209 | 768-783 | Disease | denotes | viral infection | http://purl.obolibrary.org/obo/MONDO_0005108 |
| T210 | 774-783 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T211 | 903-923 | Disease | denotes | Zika virus infection | http://purl.obolibrary.org/obo/MONDO_0018661 |
| T212 | 908-923 | Disease | denotes | virus infection | http://purl.obolibrary.org/obo/MONDO_0005108 |
| T213 | 914-923 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T214 | 957-963 | Disease | denotes | Dengue | http://purl.obolibrary.org/obo/MONDO_0005502 |
| T215 | 1060-1069 | Disease | denotes | diarrhoea | http://purl.obolibrary.org/obo/MONDO_0001673 |
| T216 | 1070-1085 | Disease | denotes | virus infection | http://purl.obolibrary.org/obo/MONDO_0005108 |
| T217 | 1076-1085 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T218 | 1128-1134 | Disease | denotes | rabies | http://purl.obolibrary.org/obo/MONDO_0019173 |
| T219 | 1151-1160 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T220 | 1203-1226 | Disease | denotes | Hendra virus infections | http://purl.obolibrary.org/obo/MONDO_0017942 |
| T221 | 1379-1395 | Disease | denotes | viral infections | http://purl.obolibrary.org/obo/MONDO_0005108 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T397 | 90-119 | http://purl.obolibrary.org/obo/PR_000001307 | denotes | Heparan sulfate proteoglycans |
| T398 | 254-259 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T399 | 277-280 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T400 | 303-332 | http://purl.obolibrary.org/obo/PR_000001307 | denotes | heparan sulfate proteoglycans |
| T401 | 344-348 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T402 | 384-387 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T403 | 410-415 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T404 | 439-442 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T405 | 497-507 | http://purl.obolibrary.org/obo/CL_0000066 | denotes | epithelial |
| T406 | 508-513 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T407 | 559-564 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T408 | 628-632 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T409 | 651-680 | http://purl.obolibrary.org/obo/PR_000001307 | denotes | heparan sulfate proteoglycans |
| T410 | 734-739 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T411 | 841-845 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T412 | 877-880 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T413 | 908-913 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T414 | 1070-1075 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T415 | 1135-1140 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T416 | 1210-1215 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T417 | 1348-1353 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T118 | 1-18 | Chemical | denotes | Glycosaminoglycan | http://purl.obolibrary.org/obo/CHEBI_18085 |
| T119 | 32-47 | Chemical | denotes | heparan sulfate | http://purl.obolibrary.org/obo/CHEBI_28815 |
| T120 | 32-39 | Chemical | denotes | heparan | http://purl.obolibrary.org/obo/CHEBI_24500 |
| T121 | 40-47 | Chemical | denotes | sulfate | http://purl.obolibrary.org/obo/CHEBI_16189 |
| T122 | 48-55 | Chemical | denotes | heparin | http://purl.obolibrary.org/obo/CHEBI_28304 |
| T123 | 90-105 | Chemical | denotes | Heparan sulfate | http://purl.obolibrary.org/obo/CHEBI_28815 |
| T124 | 98-105 | Chemical | denotes | sulfate | http://purl.obolibrary.org/obo/CHEBI_16189 |
| T125 | 106-119 | Chemical | denotes | proteoglycans | http://purl.obolibrary.org/obo/CHEBI_37396 |
| T126 | 303-318 | Chemical | denotes | heparan sulfate | http://purl.obolibrary.org/obo/CHEBI_28815 |
| T127 | 303-310 | Chemical | denotes | heparan | http://purl.obolibrary.org/obo/CHEBI_24500 |
| T128 | 311-318 | Chemical | denotes | sulfate | http://purl.obolibrary.org/obo/CHEBI_16189 |
| T129 | 319-332 | Chemical | denotes | proteoglycans | http://purl.obolibrary.org/obo/CHEBI_37396 |
| T130 | 423-438 | Chemical | denotes | heparan sulfate | http://purl.obolibrary.org/obo/CHEBI_28815 |
| T131 | 423-430 | Chemical | denotes | heparan | http://purl.obolibrary.org/obo/CHEBI_24500 |
| T132 | 431-438 | Chemical | denotes | sulfate | http://purl.obolibrary.org/obo/CHEBI_16189 |
| T133 | 607-621 | Chemical | denotes | apolipoprotein | http://purl.obolibrary.org/obo/CHEBI_39015 |
| T134 | 651-666 | Chemical | denotes | heparan sulfate | http://purl.obolibrary.org/obo/CHEBI_28815 |
| T135 | 651-658 | Chemical | denotes | heparan | http://purl.obolibrary.org/obo/CHEBI_24500 |
| T136 | 659-666 | Chemical | denotes | sulfate | http://purl.obolibrary.org/obo/CHEBI_16189 |
| T137 | 667-680 | Chemical | denotes | proteoglycans | http://purl.obolibrary.org/obo/CHEBI_37396 |
| T138 | 752-759 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T139 | 829-836 | Chemical | denotes | heparin | http://purl.obolibrary.org/obo/CHEBI_28304 |
| T140 | 869-876 | Chemical | denotes | heparin | http://purl.obolibrary.org/obo/CHEBI_28304 |
| T141 | 939-948 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
| T142 | 982-989 | Chemical | denotes | Heparin | http://purl.obolibrary.org/obo/CHEBI_28304 |
| T143 | 990-998 | Chemical | denotes | sulphate | http://purl.obolibrary.org/obo/CHEBI_16189 |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T58 | 526-535 | Phenotype | denotes | hepatitis | http://purl.obolibrary.org/obo/HP_0012115 |
| T59 | 722-731 | Phenotype | denotes | hepatitis | http://purl.obolibrary.org/obo/HP_0012115 |
| T60 | 1060-1069 | Phenotype | denotes | diarrhoea | http://purl.obolibrary.org/obo/HP_0002014 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T128 | 1-31 | http://purl.obolibrary.org/obo/GO_0006024 | denotes | Glycosaminoglycan biosynthesis |
| T129 | 19-31 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | biosynthesis |
| T130 | 538-553 | http://purl.obolibrary.org/obo/GO_0016032 | denotes | viral infection |
| T131 | 607-621 | http://purl.obolibrary.org/obo/GO_0005319 | denotes | apolipoprotein |
| T132 | 768-783 | http://purl.obolibrary.org/obo/GO_0016032 | denotes | viral infection |
| T133 | 1379-1395 | http://purl.obolibrary.org/obo/GO_0016032 | denotes | viral infections |
LitCovid-PD-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glyco_epitope_db_id |
|---|---|---|---|---|---|
| T3 | 32-47 | GlycoEpitope | denotes | heparan sulfate | http://www.glycoepitope.jp/epitopes/EP0086 |
| T4 | 90-105 | GlycoEpitope | denotes | Heparan sulfate | http://www.glycoepitope.jp/epitopes/EP0086 |
| T5 | 303-318 | GlycoEpitope | denotes | heparan sulfate | http://www.glycoepitope.jp/epitopes/EP0086 |
| T6 | 423-438 | GlycoEpitope | denotes | heparan sulfate | http://www.glycoepitope.jp/epitopes/EP0086 |
| T7 | 651-666 | GlycoEpitope | denotes | heparan sulfate | http://www.glycoepitope.jp/epitopes/EP0086 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T245 | 0-89 | Sentence | denotes | “Glycosaminoglycan biosynthesis—heparan sulfate/heparin” was here related to miRs 3934-3. |
| T246 | 90-240 | Sentence | denotes | Heparan sulfate proteoglycans have previously been identified to provide the binding sites for SARS-CoV-2 invasion at the early attachment phase [76]. |
| T247 | 241-365 | Sentence | denotes | Furthermore, human coronavirus NL63 has been shown to utilise heparan sulfate proteoglycans for target cell attachment [77]. |
| T248 | 366-522 | Sentence | denotes | This KEGG pathway has been related to Ebola virus, where heparan sulfate has been identified as an important mediator in polarised epithelial cells [78,79]. |
| T249 | 523-789 | Sentence | denotes | In hepatitis C viral infection, the virus hijacks this pathway via interaction with apolipoprotein E for cell entry [63], while heparan sulfate proteoglycans are required for cellular binding of the hepatitis E virus ORF2 capsid protein and for viral infection [70]. |
| T250 | 790-981 | Sentence | denotes | Endogenous HERV-K furthermore binds to heparin for cell entry [80], and, while heparin has been found to further Zika virus infection, it acts as an antiviral against Dengue replication [81]. |
| T251 | 982-1287 | Sentence | denotes | Heparin sulphate is identified as an inhibitory regulator of porcine epidemic diarrhoea virus infection [82] and acts as an attachment factor for rabies virus entry and infection [83], as well as an enhancer of Nipah and Hendra virus infections, which are highly pathogenic, zoonotic paramyxoviruses [84]. |
| T252 | 1288-1396 | Sentence | denotes | This highlights the importance of this KEGG pathway both in human, zoonotic and veterinary viral infections. |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32512929-31467373-144200755 | 236-238 | 31467373 | denotes | 76 |
| 32512929-21887302-144200756 | 361-363 | 21887302 | denotes | 77 |
| 32512929-25187545-144200757 | 515-517 | 25187545 | denotes | 78 |
| 32512929-30165875-144200758 | 518-520 | 30165875 | denotes | 79 |
| 32512929-26536864-144200759 | 640-642 | 26536864 | denotes | 63 |
| 32512929-9666259-144200760 | 785-787 | 9666259 | denotes | 70 |
| 32512929-19812150-144200761 | 853-855 | 19812150 | denotes | 80 |
| 32512929-30080900-144200762 | 977-979 | 30080900 | denotes | 81 |
| 32512929-30698412-144200763 | 1087-1089 | 30698412 | denotes | 82 |
| 32512929-25896095-144200764 | 1162-1164 | 25896095 | denotes | 83 |
| 32512929-29529215-144200765 | 1283-1285 | 29529215 | denotes | 84 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 872 | 607-623 | Gene | denotes | apolipoprotein E | Gene:348 |
| 873 | 740-744 | Gene | denotes | ORF2 | Gene:1494410 |
| 874 | 185-195 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 875 | 254-276 | Species | denotes | human coronavirus NL63 | Tax:277944 |
| 876 | 404-415 | Species | denotes | Ebola virus | Tax:205488 |
| 877 | 722-739 | Species | denotes | hepatitis E virus | Tax:12461 |
| 878 | 801-807 | Species | denotes | HERV-K | Tax:45617 |
| 879 | 1348-1353 | Species | denotes | human | Tax:9606 |
| 880 | 1-18 | Chemical | denotes | Glycosaminoglycan | MESH:D006025 |
| 881 | 32-47 | Chemical | denotes | heparan sulfate | MESH:D006497 |
| 882 | 48-55 | Chemical | denotes | heparin | MESH:D006493 |
| 883 | 90-105 | Chemical | denotes | Heparan sulfate | MESH:D006497 |
| 884 | 303-318 | Chemical | denotes | heparan sulfate | MESH:D006497 |
| 885 | 423-438 | Chemical | denotes | heparan sulfate | MESH:D006497 |
| 886 | 651-666 | Chemical | denotes | heparan sulfate | MESH:D006497 |
| 887 | 829-836 | Chemical | denotes | heparin | MESH:D006493 |
| 888 | 869-876 | Chemical | denotes | heparin | MESH:D006493 |
| 889 | 982-989 | Chemical | denotes | Heparin | MESH:D006493 |
| 890 | 526-553 | Disease | denotes | hepatitis C viral infection | MESH:D006526 |
| 891 | 768-783 | Disease | denotes | viral infection | MESH:D001102 |
| 892 | 908-923 | Disease | denotes | virus infection | MESH:D001102 |
| 893 | 1060-1085 | Disease | denotes | diarrhoea virus infection | MESH:D003967 |
| 894 | 1128-1146 | Disease | denotes | rabies virus entry | MESH:D011818 |
| 895 | 1151-1160 | Disease | denotes | infection | MESH:D007239 |
| 896 | 1203-1226 | Disease | denotes | Hendra virus infections | MESH:D045464 |
| 897 | 1257-1265 | Disease | denotes | zoonotic | MESH:D015047 |
| 898 | 1355-1363 | Disease | denotes | zoonotic | MESH:D015047 |
| 899 | 1379-1395 | Disease | denotes | viral infections | MESH:D001102 |