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LitCovid-PD-FMA-UBERON

LitCovid-PD-UBERON

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T29","span":{"begin":221,"end":225},"obj":"Body_part"},{"id":"T30","span":{"begin":226,"end":232},"obj":"Body_part"},{"id":"T31","span":{"begin":742,"end":746},"obj":"Body_part"},{"id":"T32","span":{"begin":843,"end":847},"obj":"Body_part"},{"id":"T33","span":{"begin":941,"end":945},"obj":"Body_part"}],"attributes":[{"id":"A29","pred":"uberon_id","subj":"T29","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A30","pred":"uberon_id","subj":"T30","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"A31","pred":"uberon_id","subj":"T31","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A32","pred":"uberon_id","subj":"T32","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A33","pred":"uberon_id","subj":"T33","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"}],"text":"In our current study, we found that miR-3611 is a positive hit for stem loop region and mature miRNA prediction. Because of its potential presence in SARS-CoV-2-mediated cellular responses, we have analysed data from the lung tissue biopsy database (PRJNA615032 Bioproject) to understand its function. A previous study reported altered miRNA expression in chronic obstructive pulmonary disease (COPD). COPD is an airway disorder and respiratory disease that is associated with persistent inflammation [60]. A study on miR expression analysis, conducted on COPD and healthy volunteers, showed significant down-regulation of miR-3611 expression in COPD patients [61]. The long non-coding RNA, H19, has been linked to many carcinomas, including lung cancer [62]. It has been shown that miR-3611 is significantly down-regulated in a H19 knockdown lung cancer cell line (SPC-A1), which indicated overexpression of this miR in ‘normal’ H19 intact lung cancer cell lines [63]. In our study, we identified that miR-3611 shows high similarity with all four main SARS-CoV-2 genomes and we did not detect any mutations between genomes. However, miR-3611 was strongly associated with KEGG pathways for metabolism of xenobiotics by cytochrome P450, morphine addiction and GABAergic synapse. Moreover, morphine addiction was, besides linkage with miR-3611, also linked to miR-5197-3. This KEGG pathway has been related to enhanced HIV-1 infection [30] and morphine treatment has been shown to promote HIV-1 replication in macrophages via inhibition of the TLR9 pathway [64]. Furthermore, an increased rate of HIV-1/HTLV-I infection has been observed due to morphine in injection drug users [65]. Morphine is also associated with enhanced hepatitis C virus (HCV) replicon expression [66,67]. Opioids have furthermore been shown to enhance simian acquired immunodeficiency syndrome (SAIDS) in rhesus monkeys [68], while reduced clearance of pulmonary influenza virus infection was observed in morphine-treated Lewis rats [69]. Interestingly, opioids such as morphine are also used as indirect antitussives to suppress cough, which is commonly associated with respiratory viral infections [70], including SARS-CoV-2. Indeed, morphine was used in recent cases in China during sedation and analgesia for endotracheal intubation, to avoid patients’ cough and agitation during the procedure [39]. In light of the association of morphine with promotion of viral replication, it may have effects in SARS-CoV-2 that need to be further investigated."}

LitCovid-PD-MONDO

LitCovid-PD-CLO

LitCovid-PD-CHEBI

LitCovid-PD-HP

LitCovid-PD-GO-BP

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T105","span":{"begin":488,"end":500},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T106","span":{"begin":609,"end":619},"obj":"http://purl.obolibrary.org/obo/GO_0065007"},{"id":"T107","span":{"begin":1190,"end":1200},"obj":"http://purl.obolibrary.org/obo/GO_0008152"},{"id":"T108","span":{"begin":1219,"end":1229},"obj":"http://purl.obolibrary.org/obo/GO_0045158"},{"id":"T109","span":{"begin":1219,"end":1229},"obj":"http://purl.obolibrary.org/obo/GO_0045157"},{"id":"T110","span":{"begin":1219,"end":1229},"obj":"http://purl.obolibrary.org/obo/GO_0045156"},{"id":"T111","span":{"begin":1219,"end":1229},"obj":"http://purl.obolibrary.org/obo/GO_0008121"},{"id":"T112","span":{"begin":2155,"end":2171},"obj":"http://purl.obolibrary.org/obo/GO_0016032"},{"id":"T113","span":{"begin":2434,"end":2451},"obj":"http://purl.obolibrary.org/obo/GO_0019079"},{"id":"T114","span":{"begin":2434,"end":2451},"obj":"http://purl.obolibrary.org/obo/GO_0019058"}],"text":"In our current study, we found that miR-3611 is a positive hit for stem loop region and mature miRNA prediction. Because of its potential presence in SARS-CoV-2-mediated cellular responses, we have analysed data from the lung tissue biopsy database (PRJNA615032 Bioproject) to understand its function. A previous study reported altered miRNA expression in chronic obstructive pulmonary disease (COPD). COPD is an airway disorder and respiratory disease that is associated with persistent inflammation [60]. A study on miR expression analysis, conducted on COPD and healthy volunteers, showed significant down-regulation of miR-3611 expression in COPD patients [61]. The long non-coding RNA, H19, has been linked to many carcinomas, including lung cancer [62]. It has been shown that miR-3611 is significantly down-regulated in a H19 knockdown lung cancer cell line (SPC-A1), which indicated overexpression of this miR in ‘normal’ H19 intact lung cancer cell lines [63]. In our study, we identified that miR-3611 shows high similarity with all four main SARS-CoV-2 genomes and we did not detect any mutations between genomes. However, miR-3611 was strongly associated with KEGG pathways for metabolism of xenobiotics by cytochrome P450, morphine addiction and GABAergic synapse. Moreover, morphine addiction was, besides linkage with miR-3611, also linked to miR-5197-3. This KEGG pathway has been related to enhanced HIV-1 infection [30] and morphine treatment has been shown to promote HIV-1 replication in macrophages via inhibition of the TLR9 pathway [64]. Furthermore, an increased rate of HIV-1/HTLV-I infection has been observed due to morphine in injection drug users [65]. Morphine is also associated with enhanced hepatitis C virus (HCV) replicon expression [66,67]. Opioids have furthermore been shown to enhance simian acquired immunodeficiency syndrome (SAIDS) in rhesus monkeys [68], while reduced clearance of pulmonary influenza virus infection was observed in morphine-treated Lewis rats [69]. Interestingly, opioids such as morphine are also used as indirect antitussives to suppress cough, which is commonly associated with respiratory viral infections [70], including SARS-CoV-2. Indeed, morphine was used in recent cases in China during sedation and analgesia for endotracheal intubation, to avoid patients’ cough and agitation during the procedure [39]. In light of the association of morphine with promotion of viral replication, it may have effects in SARS-CoV-2 that need to be further investigated."}

LitCovid-sentences

{"project":"LitCovid-sentences","denotations":[{"id":"T215","span":{"begin":0,"end":112},"obj":"Sentence"},{"id":"T216","span":{"begin":113,"end":301},"obj":"Sentence"},{"id":"T217","span":{"begin":302,"end":401},"obj":"Sentence"},{"id":"T218","span":{"begin":402,"end":506},"obj":"Sentence"},{"id":"T219","span":{"begin":507,"end":665},"obj":"Sentence"},{"id":"T220","span":{"begin":666,"end":759},"obj":"Sentence"},{"id":"T221","span":{"begin":760,"end":969},"obj":"Sentence"},{"id":"T222","span":{"begin":970,"end":1124},"obj":"Sentence"},{"id":"T223","span":{"begin":1125,"end":1277},"obj":"Sentence"},{"id":"T224","span":{"begin":1278,"end":1369},"obj":"Sentence"},{"id":"T225","span":{"begin":1370,"end":1560},"obj":"Sentence"},{"id":"T226","span":{"begin":1561,"end":1681},"obj":"Sentence"},{"id":"T227","span":{"begin":1682,"end":1776},"obj":"Sentence"},{"id":"T228","span":{"begin":1777,"end":2010},"obj":"Sentence"},{"id":"T229","span":{"begin":2011,"end":2199},"obj":"Sentence"},{"id":"T230","span":{"begin":2200,"end":2375},"obj":"Sentence"},{"id":"T231","span":{"begin":2376,"end":2524},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"In our current study, we found that miR-3611 is a positive hit for stem loop region and mature miRNA prediction. Because of its potential presence in SARS-CoV-2-mediated cellular responses, we have analysed data from the lung tissue biopsy database (PRJNA615032 Bioproject) to understand its function. A previous study reported altered miRNA expression in chronic obstructive pulmonary disease (COPD). COPD is an airway disorder and respiratory disease that is associated with persistent inflammation [60]. A study on miR expression analysis, conducted on COPD and healthy volunteers, showed significant down-regulation of miR-3611 expression in COPD patients [61]. The long non-coding RNA, H19, has been linked to many carcinomas, including lung cancer [62]. It has been shown that miR-3611 is significantly down-regulated in a H19 knockdown lung cancer cell line (SPC-A1), which indicated overexpression of this miR in ‘normal’ H19 intact lung cancer cell lines [63]. In our study, we identified that miR-3611 shows high similarity with all four main SARS-CoV-2 genomes and we did not detect any mutations between genomes. However, miR-3611 was strongly associated with KEGG pathways for metabolism of xenobiotics by cytochrome P450, morphine addiction and GABAergic synapse. Moreover, morphine addiction was, besides linkage with miR-3611, also linked to miR-5197-3. This KEGG pathway has been related to enhanced HIV-1 infection [30] and morphine treatment has been shown to promote HIV-1 replication in macrophages via inhibition of the TLR9 pathway [64]. Furthermore, an increased rate of HIV-1/HTLV-I infection has been observed due to morphine in injection drug users [65]. Morphine is also associated with enhanced hepatitis C virus (HCV) replicon expression [66,67]. Opioids have furthermore been shown to enhance simian acquired immunodeficiency syndrome (SAIDS) in rhesus monkeys [68], while reduced clearance of pulmonary influenza virus infection was observed in morphine-treated Lewis rats [69]. Interestingly, opioids such as morphine are also used as indirect antitussives to suppress cough, which is commonly associated with respiratory viral infections [70], including SARS-CoV-2. Indeed, morphine was used in recent cases in China during sedation and analgesia for endotracheal intubation, to avoid patients’ cough and agitation during the procedure [39]. In light of the association of morphine with promotion of viral replication, it may have effects in SARS-CoV-2 that need to be further investigated."}

2_test

{"project":"2_test","denotations":[{"id":"32512929-9666259-144200748","span":{"begin":2173,"end":2175},"obj":"9666259"},{"id":"32512929-28534971-144200739","span":{"begin":755,"end":757},"obj":"28534971"},{"id":"32512929-26536864-144200740","span":{"begin":965,"end":967},"obj":"26536864"},{"id":"32512929-25516281-144200741","span":{"begin":1434,"end":1436},"obj":"25516281"},{"id":"32512929-25609801-144200742","span":{"begin":1556,"end":1558},"obj":"25609801"},{"id":"32512929-29026137-144200743","span":{"begin":1677,"end":1679},"obj":"29026137"},{"id":"32512929-12640199-144200744","span":{"begin":1769,"end":1771},"obj":"12640199"},{"id":"32512929-12937158-144200745","span":{"begin":1772,"end":1774},"obj":"12937158"},{"id":"32512929-17674315-144200746","span":{"begin":1893,"end":1895},"obj":"17674315"},{"id":"32512929-15769657-144200747","span":{"begin":2006,"end":2008},"obj":"15769657"}],"text":"In our current study, we found that miR-3611 is a positive hit for stem loop region and mature miRNA prediction. Because of its potential presence in SARS-CoV-2-mediated cellular responses, we have analysed data from the lung tissue biopsy database (PRJNA615032 Bioproject) to understand its function. A previous study reported altered miRNA expression in chronic obstructive pulmonary disease (COPD). COPD is an airway disorder and respiratory disease that is associated with persistent inflammation [60]. A study on miR expression analysis, conducted on COPD and healthy volunteers, showed significant down-regulation of miR-3611 expression in COPD patients [61]. The long non-coding RNA, H19, has been linked to many carcinomas, including lung cancer [62]. It has been shown that miR-3611 is significantly down-regulated in a H19 knockdown lung cancer cell line (SPC-A1), which indicated overexpression of this miR in ‘normal’ H19 intact lung cancer cell lines [63]. In our study, we identified that miR-3611 shows high similarity with all four main SARS-CoV-2 genomes and we did not detect any mutations between genomes. However, miR-3611 was strongly associated with KEGG pathways for metabolism of xenobiotics by cytochrome P450, morphine addiction and GABAergic synapse. Moreover, morphine addiction was, besides linkage with miR-3611, also linked to miR-5197-3. This KEGG pathway has been related to enhanced HIV-1 infection [30] and morphine treatment has been shown to promote HIV-1 replication in macrophages via inhibition of the TLR9 pathway [64]. Furthermore, an increased rate of HIV-1/HTLV-I infection has been observed due to morphine in injection drug users [65]. Morphine is also associated with enhanced hepatitis C virus (HCV) replicon expression [66,67]. Opioids have furthermore been shown to enhance simian acquired immunodeficiency syndrome (SAIDS) in rhesus monkeys [68], while reduced clearance of pulmonary influenza virus infection was observed in morphine-treated Lewis rats [69]. Interestingly, opioids such as morphine are also used as indirect antitussives to suppress cough, which is commonly associated with respiratory viral infections [70], including SARS-CoV-2. Indeed, morphine was used in recent cases in China during sedation and analgesia for endotracheal intubation, to avoid patients’ cough and agitation during the procedure [39]. In light of the association of morphine with promotion of viral replication, it may have effects in SARS-CoV-2 that need to be further investigated."}

LitCovid-PubTator

PMC:7354481 / 32652-35176 JSONTXT

Annnotations TAB JSON ListView MergeView

PMC:7354481 / 32652-35176 JSON TXT