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PMC:7354481 / 32652-35176 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T204 221-225 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T205 226-232 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T206 686-689 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T207 742-746 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T208 843-847 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T209 855-859 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T210 870-872 Body_part denotes A1 http://purl.org/sig/ont/fma/fma66592
T211 941-945 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T212 953-957 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T213 1064-1071 Body_part denotes genomes http://purl.org/sig/ont/fma/fma84116
T214 1116-1123 Body_part denotes genomes http://purl.org/sig/ont/fma/fma84116
T215 1269-1276 Body_part denotes synapse http://purl.org/sig/ont/fma/fma67408
T216 1417-1420 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T217 1487-1490 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T218 1508-1519 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T219 1595-1598 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T29 221-225 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T30 226-232 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T31 742-746 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T32 843-847 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T33 941-945 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T147 150-158 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T148 356-393 Disease denotes chronic obstructive pulmonary disease http://purl.obolibrary.org/obo/MONDO_0005002
T149 376-393 Disease denotes pulmonary disease http://purl.obolibrary.org/obo/MONDO_0005275
T150 395-399 Disease denotes COPD http://purl.obolibrary.org/obo/MONDO_0005002
T151 402-406 Disease denotes COPD http://purl.obolibrary.org/obo/MONDO_0005002
T152 433-452 Disease denotes respiratory disease http://purl.obolibrary.org/obo/MONDO_0005087
T153 488-500 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T154 556-560 Disease denotes COPD http://purl.obolibrary.org/obo/MONDO_0005002
T155 646-650 Disease denotes COPD http://purl.obolibrary.org/obo/MONDO_0005002
T156 720-730 Disease denotes carcinomas http://purl.obolibrary.org/obo/MONDO_0004993
T157 742-753 Disease denotes lung cancer http://purl.obolibrary.org/obo/MONDO_0008903
T158 747-753 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T159 843-854 Disease denotes lung cancer http://purl.obolibrary.org/obo/MONDO_0008903
T160 848-854 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T161 941-952 Disease denotes lung cancer http://purl.obolibrary.org/obo/MONDO_0008903
T162 946-952 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T163 1053-1061 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T164 1423-1432 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T165 1608-1617 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T166 1724-1735 Disease denotes hepatitis C http://purl.obolibrary.org/obo/MONDO_0005231
T167 1724-1733 Disease denotes hepatitis http://purl.obolibrary.org/obo/MONDO_0002251
T168 1824-1865 Disease denotes simian acquired immunodeficiency syndrome http://purl.obolibrary.org/obo/MONDO_0025484
T169 1831-1865 Disease denotes acquired immunodeficiency syndrome http://purl.obolibrary.org/obo/MONDO_0012268
T170 1831-1856 Disease denotes acquired immunodeficiency http://purl.obolibrary.org/obo/MONDO_0017769
T171 1840-1856 Disease denotes immunodeficiency http://purl.obolibrary.org/obo/MONDO_0021094
T172 1867-1872 Disease denotes SAIDS http://purl.obolibrary.org/obo/MONDO_0025484
T173 1935-1944 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T174 1945-1960 Disease denotes virus infection http://purl.obolibrary.org/obo/MONDO_0005108
T175 1951-1960 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T176 2155-2171 Disease denotes viral infections http://purl.obolibrary.org/obo/MONDO_0005108
T177 2188-2196 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T178 2271-2280 Disease denotes analgesia http://purl.obolibrary.org/obo/MONDO_0000675
T179 2476-2484 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T334 48-49 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T335 221-225 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T336 221-225 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T337 302-303 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T338 413-419 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airway
T339 507-508 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T340 696-699 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T341 742-746 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T342 742-746 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T343 763-766 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T344 827-828 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T345 843-847 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T346 843-847 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T347 848-864 http://purl.obolibrary.org/obo/OBI_0001906 denotes cancer cell line
T348 848-864 http://www.ebi.ac.uk/cellline#cancer_cell_line denotes cancer cell line
T349 941-945 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T350 941-945 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T351 946-963 http://purl.obolibrary.org/obo/OBI_0001906 denotes cancer cell lines
T352 946-963 http://www.ebi.ac.uk/cellline#cancer_cell_line denotes cancer cell lines
T353 1388-1391 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T354 1461-1464 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T355 1618-1621 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T356 1736-1741 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T357 1884-1891 http://purl.obolibrary.org/obo/NCBITaxon_9479 denotes monkeys
T358 1945-1950 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T88 1204-1215 Chemical denotes xenobiotics http://purl.obolibrary.org/obo/CHEBI_35703
T89 1219-1234 Chemical denotes cytochrome P450 http://purl.obolibrary.org/obo/CHEBI_38559
T90 1219-1229 Chemical denotes cytochrome http://purl.obolibrary.org/obo/CHEBI_4056
T91 1236-1244 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T93 1288-1296 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T95 1442-1450 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T97 1643-1651 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T99 1665-1669 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T100 1682-1690 Chemical denotes Morphine http://purl.obolibrary.org/obo/CHEBI_17303
T101 1977-1985 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T103 2042-2050 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T105 2208-2216 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097
T107 2407-2415 Chemical denotes morphine http://purl.obolibrary.org/obo/CHEBI_17303|http://purl.obolibrary.org/obo/CHEBI_58097

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T36 356-393 Phenotype denotes chronic obstructive pulmonary disease http://purl.obolibrary.org/obo/HP_0006510
T37 395-399 Phenotype denotes COPD http://purl.obolibrary.org/obo/HP_0006510
T38 402-406 Phenotype denotes COPD http://purl.obolibrary.org/obo/HP_0006510
T39 556-560 Phenotype denotes COPD http://purl.obolibrary.org/obo/HP_0006510
T40 646-650 Phenotype denotes COPD http://purl.obolibrary.org/obo/HP_0006510
T41 720-730 Phenotype denotes carcinomas http://purl.obolibrary.org/obo/HP_0030731
T42 742-753 Phenotype denotes lung cancer http://purl.obolibrary.org/obo/HP_0100526
T43 843-854 Phenotype denotes lung cancer http://purl.obolibrary.org/obo/HP_0100526
T44 941-952 Phenotype denotes lung cancer http://purl.obolibrary.org/obo/HP_0100526
T45 1724-1733 Phenotype denotes hepatitis http://purl.obolibrary.org/obo/HP_0012115
T46 1840-1856 Phenotype denotes immunodeficiency http://purl.obolibrary.org/obo/HP_0002721
T47 2102-2107 Phenotype denotes cough http://purl.obolibrary.org/obo/HP_0012735
T48 2329-2334 Phenotype denotes cough http://purl.obolibrary.org/obo/HP_0012735
T49 2339-2348 Phenotype denotes agitation http://purl.obolibrary.org/obo/HP_0000713

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T105 488-500 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T106 609-619 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T107 1190-1200 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolism
T108 1219-1229 http://purl.obolibrary.org/obo/GO_0045158 denotes cytochrome
T109 1219-1229 http://purl.obolibrary.org/obo/GO_0045157 denotes cytochrome
T110 1219-1229 http://purl.obolibrary.org/obo/GO_0045156 denotes cytochrome
T111 1219-1229 http://purl.obolibrary.org/obo/GO_0008121 denotes cytochrome
T112 2155-2171 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infections
T113 2434-2451 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T114 2434-2451 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T215 0-112 Sentence denotes In our current study, we found that miR-3611 is a positive hit for stem loop region and mature miRNA prediction.
T216 113-301 Sentence denotes Because of its potential presence in SARS-CoV-2-mediated cellular responses, we have analysed data from the lung tissue biopsy database (PRJNA615032 Bioproject) to understand its function.
T217 302-401 Sentence denotes A previous study reported altered miRNA expression in chronic obstructive pulmonary disease (COPD).
T218 402-506 Sentence denotes COPD is an airway disorder and respiratory disease that is associated with persistent inflammation [60].
T219 507-665 Sentence denotes A study on miR expression analysis, conducted on COPD and healthy volunteers, showed significant down-regulation of miR-3611 expression in COPD patients [61].
T220 666-759 Sentence denotes The long non-coding RNA, H19, has been linked to many carcinomas, including lung cancer [62].
T221 760-969 Sentence denotes It has been shown that miR-3611 is significantly down-regulated in a H19 knockdown lung cancer cell line (SPC-A1), which indicated overexpression of this miR in ‘normal’ H19 intact lung cancer cell lines [63].
T222 970-1124 Sentence denotes In our study, we identified that miR-3611 shows high similarity with all four main SARS-CoV-2 genomes and we did not detect any mutations between genomes.
T223 1125-1277 Sentence denotes However, miR-3611 was strongly associated with KEGG pathways for metabolism of xenobiotics by cytochrome P450, morphine addiction and GABAergic synapse.
T224 1278-1369 Sentence denotes Moreover, morphine addiction was, besides linkage with miR-3611, also linked to miR-5197-3.
T225 1370-1560 Sentence denotes This KEGG pathway has been related to enhanced HIV-1 infection [30] and morphine treatment has been shown to promote HIV-1 replication in macrophages via inhibition of the TLR9 pathway [64].
T226 1561-1681 Sentence denotes Furthermore, an increased rate of HIV-1/HTLV-I infection has been observed due to morphine in injection drug users [65].
T227 1682-1776 Sentence denotes Morphine is also associated with enhanced hepatitis C virus (HCV) replicon expression [66,67].
T228 1777-2010 Sentence denotes Opioids have furthermore been shown to enhance simian acquired immunodeficiency syndrome (SAIDS) in rhesus monkeys [68], while reduced clearance of pulmonary influenza virus infection was observed in morphine-treated Lewis rats [69].
T229 2011-2199 Sentence denotes Interestingly, opioids such as morphine are also used as indirect antitussives to suppress cough, which is commonly associated with respiratory viral infections [70], including SARS-CoV-2.
T230 2200-2375 Sentence denotes Indeed, morphine was used in recent cases in China during sedation and analgesia for endotracheal intubation, to avoid patients’ cough and agitation during the procedure [39].
T231 2376-2524 Sentence denotes In light of the association of morphine with promotion of viral replication, it may have effects in SARS-CoV-2 that need to be further investigated.

2_test

Id Subject Object Predicate Lexical cue
32512929-9666259-144200748 2173-2175 9666259 denotes 70
32512929-28534971-144200739 755-757 28534971 denotes 62
32512929-26536864-144200740 965-967 26536864 denotes 63
32512929-25516281-144200741 1434-1436 25516281 denotes 30
32512929-25609801-144200742 1556-1558 25609801 denotes 64
32512929-29026137-144200743 1677-1679 29026137 denotes 65
32512929-12640199-144200744 1769-1771 12640199 denotes 66
32512929-12937158-144200745 1772-1774 12937158 denotes 67
32512929-17674315-144200746 1893-1895 17674315 denotes 68
32512929-15769657-144200747 2006-2008 15769657 denotes 69

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
706 36-44 Gene denotes miR-3611 Gene:100500890
707 623-631 Gene denotes miR-3611 Gene:100500890
708 691-694 Gene denotes H19 Gene:283120
709 783-791 Gene denotes miR-3611 Gene:100500890
710 829-832 Gene denotes H19 Gene:283120
711 1003-1011 Gene denotes miR-3611 Gene:100500890
712 1134-1142 Gene denotes miR-3611 Gene:100500890
713 1333-1341 Gene denotes miR-3611 Gene:100500890
714 1542-1546 Gene denotes TLR9 Gene:54106
715 1358-1366 Gene denotes miR-5197 Gene:100846991
716 930-933 Gene denotes H19 Gene:283120
717 150-160 Species denotes SARS-CoV-2 Tax:2697049
718 651-659 Species denotes patients Tax:9606
719 1053-1063 Species denotes SARS-CoV-2 Tax:2697049
720 1487-1492 Species denotes HIV-1 Tax:11676
721 1724-1741 Species denotes hepatitis C virus Tax:11103
722 1877-1891 Species denotes rhesus monkeys Tax:9544
723 2000-2004 Species denotes rats Tax:10116
724 2188-2198 Species denotes SARS-CoV-2 Tax:2697049
725 2319-2327 Species denotes patients Tax:9606
726 2476-2486 Species denotes SARS-CoV-2 Tax:2697049
727 1743-1746 Species denotes HCV Tax:11103
728 1236-1244 Chemical denotes morphine MESH:D009020
729 1288-1296 Chemical denotes morphine MESH:D009020
730 1442-1450 Chemical denotes morphine MESH:D009020
731 1643-1651 Chemical denotes morphine MESH:D009020
732 1682-1690 Chemical denotes Morphine MESH:D009020
733 1977-1985 Chemical denotes morphine MESH:D009020
734 2042-2050 Chemical denotes morphine MESH:D009020
735 2208-2216 Chemical denotes morphine MESH:D009020
736 2407-2415 Chemical denotes morphine MESH:D009020
737 356-393 Disease denotes chronic obstructive pulmonary disease MESH:D029424
738 395-399 Disease denotes COPD MESH:D029424
739 402-406 Disease denotes COPD MESH:D029424
740 413-428 Disease denotes airway disorder MESH:D000402
741 433-452 Disease denotes respiratory disease MESH:D012140
742 488-500 Disease denotes inflammation MESH:D007249
743 556-560 Disease denotes COPD MESH:D029424
744 646-650 Disease denotes COPD MESH:D029424
745 720-730 Disease denotes carcinomas MESH:D009369
746 742-753 Disease denotes lung cancer MESH:D008175
747 843-854 Disease denotes lung cancer MESH:D008175
748 941-952 Disease denotes lung cancer MESH:D008175
749 1417-1432 Disease denotes HIV-1 infection MESH:D015658
750 1595-1617 Disease denotes HIV-1/HTLV-I infection MESH:D015490
751 1840-1865 Disease denotes immunodeficiency syndrome MESH:D007153
752 1945-1960 Disease denotes virus infection MESH:D001102
753 2102-2107 Disease denotes cough MESH:D003371
754 2143-2171 Disease denotes respiratory viral infections
755 2329-2334 Disease denotes cough MESH:D003371
756 2339-2348 Disease denotes agitation MESH:D011595
757 866-872 CellLine denotes SPC-A1 CVCL:6955