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PMC:7354481 / 24324-25702 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T145 29-33 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T146 201-208 Body_part denotes genomes http://purl.org/sig/ont/fma/fma84116
T147 224-230 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T148 410-417 Body_part denotes genomes http://purl.org/sig/ont/fma/fma84116
T149 483-489 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T150 946-954 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T151 1013-1019 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T152 1160-1165 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T153 1194-1203 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T154 1296-1301 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T18 1013-1019 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T90 190-198 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T91 213-221 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T92 399-407 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T93 1069-1077 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T94 1289-1295 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T95 1352-1364 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T235 29-33 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T236 121-122 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T237 163-164 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T238 255-260 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T239 307-308 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T240 364-365 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T241 426-428 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T242 483-489 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T243 651-652 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T244 695-698 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T245 894-902 http://purl.obolibrary.org/obo/CLO_0001658 denotes activate
T246 907-908 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T247 1053-1055 http://purl.obolibrary.org/obo/CLO_0053794 denotes 41
T248 1160-1165 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T249 1233-1241 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T250 1296-1301 http://purl.obolibrary.org/obo/GO_0005623 denotes cells

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T57 317-332 Chemical denotes biological role http://purl.obolibrary.org/obo/CHEBI_24432
T58 666-671 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T59 1143-1151 Chemical denotes agonists http://purl.obolibrary.org/obo/CHEBI_48705

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T21 501-507 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T22 675-681 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T23 1289-1295 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T68 955-964 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T69 1352-1364 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T167 0-117 Sentence denotes Recently, the N nucleocapsid gene-related putative miR candidates were shown through in silico prediction tools [38].
T168 118-266 Sentence denotes In a similar manner, we determined miR-8066, a mature sequence found on SARS-CoV-2 genomes, in SARS-CoV-2 genome alignment analysis with human miRs.
T169 267-430 Sentence denotes Additionally, miR-8067, which possesses a similar biological role to miR-8066, was identified as a stem loop region sequence in all SARS-CoV-2 genomes (Figure S1).
T170 431-552 Sentence denotes Previous reports showed that both miRs are found in plasma samples of sepsis patients with severe clinical outcomes [39].
T171 553-691 Sentence denotes Similar miR family members such as miR-8054, miR-8057, miR-8061, and miR-8068, were also found in a non-survivor group of sepsis patients.
T172 692-824 Sentence denotes It has been shown by in silico analysis that certain miRNAs have the core motifs of AUUGUUG, and that miR-8066 is one of these [40].
T173 825-1057 Sentence denotes When miRs have this motif, it increases their likelihood to bind and activate Nf κB-mediated TLR-8 expression and induce cytokine synthesis [40]. miR-8066 was identified at high levels in tissue biopsies as well as in exosomes [41].
T174 1058-1247 Sentence denotes Therefore, SARS-CoV-2-mediated alterations of miRs may act as autocrine or paracrine agonists of host cells to trigger pro-inflammatory cytokines, due to their increased NfKB activity [42].
T175 1248-1378 Sentence denotes Similar findings were also suggested for cancer cells, which showed miR alterations in association with inflammation markers [43].

2_test

Id Subject Object Predicate Lexical cue
32512929-27320175-144200722 820-822 27320175 denotes 40
32512929-27320175-144200723 966-968 27320175 denotes 40
32512929-31867014-144200724 1053-1055 31867014 denotes 41
32512929-31597886-144200725 1243-1245 31597886 denotes 42
32512929-23805154-144200726 1374-1376 23805154 denotes 43

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
430 51-54 Gene denotes miR
431 153-161 Gene denotes miR-8066 Gene:102465868
432 281-289 Gene denotes miR-8067 Gene:102465869
433 336-344 Gene denotes miR-8066 Gene:102465868
434 588-596 Gene denotes miR-8054 Gene:102465860
435 598-606 Gene denotes miR-8057 Gene:102466874
436 608-616 Gene denotes miR-8061 Gene:102466251
437 622-630 Gene denotes miR-8068 Gene:102466876
438 794-802 Gene denotes miR-8066 Gene:102465868
439 903-908 Gene denotes Nf κB Gene:4790
440 918-923 Gene denotes TLR-8 Gene:51311
441 971-979 Gene denotes miR-8066 Gene:102465868
442 14-15 Gene denotes N Gene:43740575
443 190-200 Species denotes SARS-CoV-2 Tax:2697049
444 213-223 Species denotes SARS-CoV-2 Tax:2697049
445 255-260 Species denotes human Tax:9606
446 399-409 Species denotes SARS-CoV-2 Tax:2697049
447 508-516 Species denotes patients Tax:9606
448 682-690 Species denotes patients Tax:9606
449 1069-1079 Species denotes SARS-CoV-2 Tax:2697049
450 501-507 Disease denotes sepsis MESH:D018805
451 675-681 Disease denotes sepsis MESH:D018805
452 1289-1295 Disease denotes cancer MESH:D009369
453 1352-1364 Disease denotes inflammation MESH:D007249