PMC:7352545 / 80056-80835 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7352545","sourcedb":"PMC","sourceid":"7352545","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7352545","text":"As CLQ interacts with the GM1 sugar part, the N-terminal domain of the S protein loses viral attachment capacity to the cell receptors [166]. The S protein NTD and the CLQ/CLQ-OH maintain the same position during GM1 binding, consequently preventing GM1 binding to the S protein and the drug at the same time, because the NTD and the CLQ/CLQ-OH simultaneously recognize GM1. Asn-167 forms a hydrogen bond with the GalNAc residue, whereas an aromatic Phe-135 stacks to the Glc residue of GM1. Therefore, the antiviral activities of CLQ and CLQ-OH is to block the interaction between the SARS-CoV-2 S glycoprotein and gangliosides on host cell surfaces. The lipid composition of host cell PM can also be a potential target for preventive and therapeutic drugs against such viruses.","tracks":[{"project":"LitCovid_Glycan-Motif-Structure","denotations":[{"id":"T236","span":{"begin":26,"end":29},"obj":"https://glytoucan.org/Structures/Glycans/G46613JI"},{"id":"T237","span":{"begin":26,"end":29},"obj":"https://glytoucan.org/Structures/Glycans/G48558GR"},{"id":"T238","span":{"begin":213,"end":216},"obj":"https://glytoucan.org/Structures/Glycans/G46613JI"},{"id":"T239","span":{"begin":213,"end":216},"obj":"https://glytoucan.org/Structures/Glycans/G48558GR"},{"id":"T240","span":{"begin":250,"end":253},"obj":"https://glytoucan.org/Structures/Glycans/G46613JI"},{"id":"T241","span":{"begin":250,"end":253},"obj":"https://glytoucan.org/Structures/Glycans/G48558GR"},{"id":"T242","span":{"begin":370,"end":373},"obj":"https://glytoucan.org/Structures/Glycans/G46613JI"},{"id":"T243","span":{"begin":370,"end":373},"obj":"https://glytoucan.org/Structures/Glycans/G48558GR"},{"id":"T244","span":{"begin":487,"end":490},"obj":"https://glytoucan.org/Structures/Glycans/G46613JI"},{"id":"T245","span":{"begin":487,"end":490},"obj":"https://glytoucan.org/Structures/Glycans/G48558GR"}],"attributes":[{"subj":"T236","pred":"source","obj":"LitCovid_Glycan-Motif-Structure"},{"subj":"T237","pred":"source","obj":"LitCovid_Glycan-Motif-Structure"},{"subj":"T238","pred":"source","obj":"LitCovid_Glycan-Motif-Structure"},{"subj":"T239","pred":"source","obj":"LitCovid_Glycan-Motif-Structure"},{"subj":"T240","pred":"source","obj":"LitCovid_Glycan-Motif-Structure"},{"subj":"T241","pred":"source","obj":"LitCovid_Glycan-Motif-Structure"},{"subj":"T242","pred":"source","obj":"LitCovid_Glycan-Motif-Structure"},{"subj":"T243","pred":"source","obj":"LitCovid_Glycan-Motif-Structure"},{"subj":"T244","pred":"source","obj":"LitCovid_Glycan-Motif-Structure"},{"subj":"T245","pred":"source","obj":"LitCovid_Glycan-Motif-Structure"}]},{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T768","span":{"begin":30,"end":35},"obj":"Body_part"},{"id":"T769","span":{"begin":73,"end":80},"obj":"Body_part"},{"id":"T770","span":{"begin":120,"end":124},"obj":"Body_part"},{"id":"T771","span":{"begin":148,"end":155},"obj":"Body_part"},{"id":"T772","span":{"begin":271,"end":278},"obj":"Body_part"},{"id":"T773","span":{"begin":599,"end":611},"obj":"Body_part"},{"id":"T774","span":{"begin":616,"end":628},"obj":"Body_part"},{"id":"T775","span":{"begin":637,"end":650},"obj":"Body_part"},{"id":"T776","span":{"begin":637,"end":641},"obj":"Body_part"},{"id":"T777","span":{"begin":656,"end":661},"obj":"Body_part"},{"id":"T778","span":{"begin":682,"end":686},"obj":"Body_part"}],"attributes":[{"id":"A768","pred":"fma_id","subj":"T768","obj":"http://purl.org/sig/ont/fma/fma82737"},{"id":"A769","pred":"fma_id","subj":"T769","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A770","pred":"fma_id","subj":"T770","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A771","pred":"fma_id","subj":"T771","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A772","pred":"fma_id","subj":"T772","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A773","pred":"fma_id","subj":"T773","obj":"http://purl.org/sig/ont/fma/fma62925"},{"id":"A774","pred":"fma_id","subj":"T774","obj":"http://purl.org/sig/ont/fma/fma82816"},{"id":"A775","pred":"fma_id","subj":"T775","obj":"http://purl.org/sig/ont/fma/fma67653"},{"id":"A776","pred":"fma_id","subj":"T776","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A777","pred":"fma_id","subj":"T777","obj":"http://purl.org/sig/ont/fma/fma67264"},{"id":"A778","pred":"fma_id","subj":"T778","obj":"http://purl.org/sig/ont/fma/fma68646"},{"subj":"T768","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T769","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T770","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T771","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T772","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T773","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T774","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T775","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T776","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T777","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T778","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T326","span":{"begin":156,"end":159},"obj":"Disease"},{"id":"T328","span":{"begin":322,"end":325},"obj":"Disease"},{"id":"T330","span":{"begin":586,"end":594},"obj":"Disease"}],"attributes":[{"id":"A326","pred":"mondo_id","subj":"T326","obj":"http://purl.obolibrary.org/obo/MONDO_0008449"},{"id":"A327","pred":"mondo_id","subj":"T326","obj":"http://purl.obolibrary.org/obo/MONDO_0018075"},{"id":"A328","pred":"mondo_id","subj":"T328","obj":"http://purl.obolibrary.org/obo/MONDO_0008449"},{"id":"A329","pred":"mondo_id","subj":"T328","obj":"http://purl.obolibrary.org/obo/MONDO_0018075"},{"id":"A330","pred":"mondo_id","subj":"T330","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"subj":"T326","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T328","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T330","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T1110","span":{"begin":120,"end":124},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T1111","span":{"begin":389,"end":390},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T1112","span":{"begin":517,"end":527},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T1113","span":{"begin":637,"end":641},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T1114","span":{"begin":682,"end":686},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T1115","span":{"begin":702,"end":703},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T1116","span":{"begin":771,"end":778},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"}],"attributes":[{"subj":"T1110","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1111","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1112","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1113","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1114","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1115","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T1116","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T95244","span":{"begin":26,"end":29},"obj":"Chemical"},{"id":"T91399","span":{"begin":73,"end":80},"obj":"Chemical"},{"id":"T75759","span":{"begin":148,"end":155},"obj":"Chemical"},{"id":"T66644","span":{"begin":213,"end":216},"obj":"Chemical"},{"id":"T616","span":{"begin":250,"end":253},"obj":"Chemical"},{"id":"T69799","span":{"begin":271,"end":278},"obj":"Chemical"},{"id":"T620","span":{"begin":287,"end":291},"obj":"Chemical"},{"id":"T621","span":{"begin":370,"end":373},"obj":"Chemical"},{"id":"T75682","span":{"begin":375,"end":378},"obj":"Chemical"},{"id":"T45327","span":{"begin":391,"end":399},"obj":"Chemical"},{"id":"T94022","span":{"begin":414,"end":420},"obj":"Chemical"},{"id":"T14276","span":{"begin":450,"end":453},"obj":"Chemical"},{"id":"T99238","span":{"begin":472,"end":475},"obj":"Chemical"},{"id":"T633","span":{"begin":487,"end":490},"obj":"Chemical"},{"id":"T31697","span":{"begin":507,"end":516},"obj":"Chemical"},{"id":"T48080","span":{"begin":599,"end":611},"obj":"Chemical"},{"id":"T638","span":{"begin":616,"end":628},"obj":"Chemical"},{"id":"T639","span":{"begin":656,"end":661},"obj":"Chemical"},{"id":"T640","span":{"begin":687,"end":689},"obj":"Chemical"},{"id":"T643","span":{"begin":752,"end":757},"obj":"Chemical"}],"attributes":[{"id":"A40278","pred":"chebi_id","subj":"T95244","obj":"http://purl.obolibrary.org/obo/CHEBI_18216"},{"id":"A45898","pred":"chebi_id","subj":"T95244","obj":"http://purl.obolibrary.org/obo/CHEBI_61048"},{"id":"A6912","pred":"chebi_id","subj":"T95244","obj":"http://purl.obolibrary.org/obo/CHEBI_73110"},{"id":"A75643","pred":"chebi_id","subj":"T91399","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A61178","pred":"chebi_id","subj":"T75759","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A36034","pred":"chebi_id","subj":"T66644","obj":"http://purl.obolibrary.org/obo/CHEBI_18216"},{"id":"A49567","pred":"chebi_id","subj":"T66644","obj":"http://purl.obolibrary.org/obo/CHEBI_61048"},{"id":"A80906","pred":"chebi_id","subj":"T66644","obj":"http://purl.obolibrary.org/obo/CHEBI_73110"},{"id":"A17854","pred":"chebi_id","subj":"T616","obj":"http://purl.obolibrary.org/obo/CHEBI_18216"},{"id":"A59692","pred":"chebi_id","subj":"T616","obj":"http://purl.obolibrary.org/obo/CHEBI_61048"},{"id":"A78046","pred":"chebi_id","subj":"T616","obj":"http://purl.obolibrary.org/obo/CHEBI_73110"},{"id":"A82919","pred":"chebi_id","subj":"T69799","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A49105","pred":"chebi_id","subj":"T620","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A96396","pred":"chebi_id","subj":"T621","obj":"http://purl.obolibrary.org/obo/CHEBI_18216"},{"id":"A24081","pred":"chebi_id","subj":"T621","obj":"http://purl.obolibrary.org/obo/CHEBI_61048"},{"id":"A54973","pred":"chebi_id","subj":"T621","obj":"http://purl.obolibrary.org/obo/CHEBI_73110"},{"id":"A81947","pred":"chebi_id","subj":"T75682","obj":"http://purl.obolibrary.org/obo/CHEBI_17196"},{"id":"A69537","pred":"chebi_id","subj":"T75682","obj":"http://purl.obolibrary.org/obo/CHEBI_22653"},{"id":"A85523","pred":"chebi_id","subj":"T75682","obj":"http://purl.obolibrary.org/obo/CHEBI_50347"},{"id":"A62030","pred":"chebi_id","subj":"T45327","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A38857","pred":"chebi_id","subj":"T94022","obj":"http://purl.obolibrary.org/obo/CHEBI_28037"},{"id":"A63570","pred":"chebi_id","subj":"T94022","obj":"http://purl.obolibrary.org/obo/CHEBI_28800"},{"id":"A26394","pred":"chebi_id","subj":"T14276","obj":"http://purl.obolibrary.org/obo/CHEBI_17295"},{"id":"A84799","pred":"chebi_id","subj":"T14276","obj":"http://purl.obolibrary.org/obo/CHEBI_29997"},{"id":"A11789","pred":"chebi_id","subj":"T99238","obj":"http://purl.obolibrary.org/obo/CHEBI_17234"},{"id":"A42584","pred":"chebi_id","subj":"T633","obj":"http://purl.obolibrary.org/obo/CHEBI_18216"},{"id":"A63639","pred":"chebi_id","subj":"T633","obj":"http://purl.obolibrary.org/obo/CHEBI_61048"},{"id":"A11382","pred":"chebi_id","subj":"T633","obj":"http://purl.obolibrary.org/obo/CHEBI_73110"},{"id":"A73374","pred":"chebi_id","subj":"T31697","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A48613","pred":"chebi_id","subj":"T48080","obj":"http://purl.obolibrary.org/obo/CHEBI_17089"},{"id":"A9980","pred":"chebi_id","subj":"T638","obj":"http://purl.obolibrary.org/obo/CHEBI_28892"},{"id":"A62133","pred":"chebi_id","subj":"T639","obj":"http://purl.obolibrary.org/obo/CHEBI_18059"},{"id":"A57610","pred":"chebi_id","subj":"T640","obj":"http://purl.obolibrary.org/obo/CHEBI_141444"},{"id":"A97720","pred":"chebi_id","subj":"T640","obj":"http://purl.obolibrary.org/obo/CHEBI_16410"},{"id":"A98821","pred":"chebi_id","subj":"T640","obj":"http://purl.obolibrary.org/obo/CHEBI_53551"},{"id":"A32991","pred":"chebi_id","subj":"T643","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"subj":"T95244","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T91399","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T75759","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T66644","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T616","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T69799","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T620","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T621","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T75682","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T45327","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T94022","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T14276","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T99238","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T633","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T31697","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T48080","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T638","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T639","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T640","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T643","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T770","span":{"begin":0,"end":141},"obj":"Sentence"},{"id":"T771","span":{"begin":142,"end":374},"obj":"Sentence"},{"id":"T772","span":{"begin":375,"end":491},"obj":"Sentence"},{"id":"T773","span":{"begin":492,"end":651},"obj":"Sentence"},{"id":"T774","span":{"begin":652,"end":779},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T770","pred":"source","obj":"LitCovid-sentences"},{"subj":"T771","pred":"source","obj":"LitCovid-sentences"},{"subj":"T772","pred":"source","obj":"LitCovid-sentences"},{"subj":"T773","pred":"source","obj":"LitCovid-sentences"},{"subj":"T774","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PD-GlycoEpitope","denotations":[{"id":"T22","span":{"begin":26,"end":29},"obj":"GlycoEpitope"},{"id":"T23","span":{"begin":213,"end":216},"obj":"GlycoEpitope"},{"id":"T24","span":{"begin":250,"end":253},"obj":"GlycoEpitope"},{"id":"T25","span":{"begin":370,"end":373},"obj":"GlycoEpitope"},{"id":"T26","span":{"begin":487,"end":490},"obj":"GlycoEpitope"}],"attributes":[{"id":"A22","pred":"glyco_epitope_db_id","subj":"T22","obj":"http://www.glycoepitope.jp/epitopes/EP0050"},{"id":"A23","pred":"glyco_epitope_db_id","subj":"T23","obj":"http://www.glycoepitope.jp/epitopes/EP0050"},{"id":"A24","pred":"glyco_epitope_db_id","subj":"T24","obj":"http://www.glycoepitope.jp/epitopes/EP0050"},{"id":"A25","pred":"glyco_epitope_db_id","subj":"T25","obj":"http://www.glycoepitope.jp/epitopes/EP0050"},{"id":"A26","pred":"glyco_epitope_db_id","subj":"T26","obj":"http://www.glycoepitope.jp/epitopes/EP0050"},{"subj":"T22","pred":"source","obj":"LitCovid-PD-GlycoEpitope"},{"subj":"T23","pred":"source","obj":"LitCovid-PD-GlycoEpitope"},{"subj":"T24","pred":"source","obj":"LitCovid-PD-GlycoEpitope"},{"subj":"T25","pred":"source","obj":"LitCovid-PD-GlycoEpitope"},{"subj":"T26","pred":"source","obj":"LitCovid-PD-GlycoEpitope"}]},{"project":"2_test","denotations":[{"id":"32604730-32293710-51944131","span":{"begin":136,"end":139},"obj":"32293710"},{"id":"T9412","span":{"begin":136,"end":139},"obj":"32293710"}],"attributes":[{"subj":"32604730-32293710-51944131","pred":"source","obj":"2_test"},{"subj":"T9412","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid_Glycan-Motif-Structure","color":"#eca093","default":true},{"id":"LitCovid-PD-FMA-UBERON","color":"#93a0ec"},{"id":"LitCovid-PD-MONDO","color":"#baec93"},{"id":"LitCovid-PD-CLO","color":"#ec93d4"},{"id":"LitCovid-PD-CHEBI","color":"#93ecea"},{"id":"LitCovid-sentences","color":"#ecd093"},{"id":"LitCovid-PD-GlycoEpitope","color":"#b693ec"},{"id":"2_test","color":"#93ec9c"}]}]}}