PMC:7352545 / 80056-80835
Annnotations
LitCovid_Glycan-Motif-Structure
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T236 | 26-29 | https://glytoucan.org/Structures/Glycans/G46613JI | denotes | GM1 |
| T237 | 26-29 | https://glytoucan.org/Structures/Glycans/G48558GR | denotes | GM1 |
| T238 | 213-216 | https://glytoucan.org/Structures/Glycans/G46613JI | denotes | GM1 |
| T239 | 213-216 | https://glytoucan.org/Structures/Glycans/G48558GR | denotes | GM1 |
| T240 | 250-253 | https://glytoucan.org/Structures/Glycans/G46613JI | denotes | GM1 |
| T241 | 250-253 | https://glytoucan.org/Structures/Glycans/G48558GR | denotes | GM1 |
| T242 | 370-373 | https://glytoucan.org/Structures/Glycans/G46613JI | denotes | GM1 |
| T243 | 370-373 | https://glytoucan.org/Structures/Glycans/G48558GR | denotes | GM1 |
| T244 | 487-490 | https://glytoucan.org/Structures/Glycans/G46613JI | denotes | GM1 |
| T245 | 487-490 | https://glytoucan.org/Structures/Glycans/G48558GR | denotes | GM1 |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T768 | 30-35 | Body_part | denotes | sugar | http://purl.org/sig/ont/fma/fma82737 |
| T769 | 73-80 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T770 | 120-124 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T771 | 148-155 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T772 | 271-278 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T773 | 599-611 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T774 | 616-628 | Body_part | denotes | gangliosides | http://purl.org/sig/ont/fma/fma82816 |
| T775 | 637-650 | Body_part | denotes | cell surfaces | http://purl.org/sig/ont/fma/fma67653 |
| T776 | 637-641 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T777 | 656-661 | Body_part | denotes | lipid | http://purl.org/sig/ont/fma/fma67264 |
| T778 | 682-686 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T326 | 156-159 | Disease | denotes | NTD | http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075 |
| T328 | 322-325 | Disease | denotes | NTD | http://purl.obolibrary.org/obo/MONDO_0008449|http://purl.obolibrary.org/obo/MONDO_0018075 |
| T330 | 586-594 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1110 | 120-124 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T1111 | 389-390 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T1112 | 517-527 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activities |
| T1113 | 637-641 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T1114 | 682-686 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T1115 | 702-703 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T1116 | 771-778 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T95244 | 26-29 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110 |
| T91399 | 73-80 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T75759 | 148-155 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T66644 | 213-216 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110 |
| T616 | 250-253 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110 |
| T69799 | 271-278 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T620 | 287-291 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T621 | 370-373 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110 |
| T75682 | 375-378 | Chemical | denotes | Asn | http://purl.obolibrary.org/obo/CHEBI_17196|http://purl.obolibrary.org/obo/CHEBI_22653|http://purl.obolibrary.org/obo/CHEBI_50347 |
| T45327 | 391-399 | Chemical | denotes | hydrogen | http://purl.obolibrary.org/obo/CHEBI_49637 |
| T94022 | 414-420 | Chemical | denotes | GalNAc | http://purl.obolibrary.org/obo/CHEBI_28037|http://purl.obolibrary.org/obo/CHEBI_28800 |
| T14276 | 450-453 | Chemical | denotes | Phe | http://purl.obolibrary.org/obo/CHEBI_17295|http://purl.obolibrary.org/obo/CHEBI_29997 |
| T99238 | 472-475 | Chemical | denotes | Glc | http://purl.obolibrary.org/obo/CHEBI_17234 |
| T633 | 487-490 | Chemical | denotes | GM1 | http://purl.obolibrary.org/obo/CHEBI_18216|http://purl.obolibrary.org/obo/CHEBI_61048|http://purl.obolibrary.org/obo/CHEBI_73110 |
| T31697 | 507-516 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
| T48080 | 599-611 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T638 | 616-628 | Chemical | denotes | gangliosides | http://purl.obolibrary.org/obo/CHEBI_28892 |
| T639 | 656-661 | Chemical | denotes | lipid | http://purl.obolibrary.org/obo/CHEBI_18059 |
| T640 | 687-689 | Chemical | denotes | PM | http://purl.obolibrary.org/obo/CHEBI_141444|http://purl.obolibrary.org/obo/CHEBI_16410|http://purl.obolibrary.org/obo/CHEBI_53551 |
| T643 | 752-757 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T770 | 0-141 | Sentence | denotes | As CLQ interacts with the GM1 sugar part, the N-terminal domain of the S protein loses viral attachment capacity to the cell receptors [166]. |
| T771 | 142-374 | Sentence | denotes | The S protein NTD and the CLQ/CLQ-OH maintain the same position during GM1 binding, consequently preventing GM1 binding to the S protein and the drug at the same time, because the NTD and the CLQ/CLQ-OH simultaneously recognize GM1. |
| T772 | 375-491 | Sentence | denotes | Asn-167 forms a hydrogen bond with the GalNAc residue, whereas an aromatic Phe-135 stacks to the Glc residue of GM1. |
| T773 | 492-651 | Sentence | denotes | Therefore, the antiviral activities of CLQ and CLQ-OH is to block the interaction between the SARS-CoV-2 S glycoprotein and gangliosides on host cell surfaces. |
| T774 | 652-779 | Sentence | denotes | The lipid composition of host cell PM can also be a potential target for preventive and therapeutic drugs against such viruses. |
LitCovid-PD-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glyco_epitope_db_id |
|---|---|---|---|---|---|
| T22 | 26-29 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T23 | 213-216 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T24 | 250-253 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T25 | 370-373 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
| T26 | 487-490 | GlycoEpitope | denotes | GM1 | http://www.glycoepitope.jp/epitopes/EP0050 |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32604730-32293710-51944131 | 136-139 | 32293710 | denotes | 166 |
| T9412 | 136-139 | 32293710 | denotes | 166 |