PMC:7352545 / 7608-8590 JSONTXT

{"project":"LitCovid_Glycan-Motif-Structure","denotations":[{"id":"T23","span":{"begin":190,"end":192},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T24","span":{"begin":199,"end":205},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T25","span":{"begin":267,"end":269},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T26","span":{"begin":341,"end":365},"obj":"https://glytoucan.org/Structures/Glycans/G50850NI"},{"id":"T27","span":{"begin":341,"end":365},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T28","span":{"begin":630,"end":632},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T29","span":{"begin":643,"end":645},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T30","span":{"begin":710,"end":712},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T31","span":{"begin":775,"end":777},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T32","span":{"begin":786,"end":788},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T33","span":{"begin":968,"end":970},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"}],"text":"The 9-carbon SAs are mainly animal-specific with anionic sugars attached to terminal sugars. SAs exist in two forms, NeuGc and NeuAc. NeuGc is a differentially modified form of the parental SA form, Neu5Ac. SAs are structurally diverse. For example, several modified SA forms are known for their structures including neuraminic acid (NeuC), N-acetyl neuraminic acid (NeuAc), N-glycolyl neuraminic acid (NeuGc), N,O-diacetyl neuraminic acid (occurs in horses), N,O-diacetyl neuraminic acid (occurs in bovines) and N-acetyl O-diacetyl neuraminic acid (occurs in bovines) (Figure 2). Sialyltransferases (STs) biosynthesize different SA linkages. SA linkage diversity occurs at the α2-3, α2-6, α2-8 or α2-9 to the SA or Gal residues (Figure 3). For example, in formation of α2,3 SA or α2,6 SA structures, α2,3-ST and α2,6-ST utilize substrates such as Galβ-1,4-GlcNAc (Figure 4). The most frequent modification of SAs is O-acetylation at positions of C4, C7, C8 and C9 of SA (Figure 5)."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T45","span":{"begin":57,"end":63},"obj":"Body_part"},{"id":"T46","span":{"begin":85,"end":91},"obj":"Body_part"},{"id":"T47","span":{"begin":341,"end":365},"obj":"Body_part"}],"attributes":[{"id":"A45","pred":"fma_id","subj":"T45","obj":"http://purl.org/sig/ont/fma/fma82737"},{"id":"A46","pred":"fma_id","subj":"T46","obj":"http://purl.org/sig/ont/fma/fma82737"},{"id":"A47","pred":"fma_id","subj":"T47","obj":"http://purl.org/sig/ont/fma/fma82788"}],"text":"The 9-carbon SAs are mainly animal-specific with anionic sugars attached to terminal sugars. SAs exist in two forms, NeuGc and NeuAc. NeuGc is a differentially modified form of the parental SA form, Neu5Ac. SAs are structurally diverse. For example, several modified SA forms are known for their structures including neuraminic acid (NeuC), N-acetyl neuraminic acid (NeuAc), N-glycolyl neuraminic acid (NeuGc), N,O-diacetyl neuraminic acid (occurs in horses), N,O-diacetyl neuraminic acid (occurs in bovines) and N-acetyl O-diacetyl neuraminic acid (occurs in bovines) (Figure 2). Sialyltransferases (STs) biosynthesize different SA linkages. SA linkage diversity occurs at the α2-3, α2-6, α2-8 or α2-9 to the SA or Gal residues (Figure 3). For example, in formation of α2,3 SA or α2,6 SA structures, α2,3-ST and α2,6-ST utilize substrates such as Galβ-1,4-GlcNAc (Figure 4). The most frequent modification of SAs is O-acetylation at positions of C4, C7, C8 and C9 of SA (Figure 5)."}

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9-carbon SAs are mainly animal-specific with anionic sugars attached to terminal sugars. SAs exist in two forms, NeuGc and NeuAc. NeuGc is a differentially modified form of the parental SA form, Neu5Ac. SAs are structurally diverse. For example, several modified SA forms are known for their structures including neuraminic acid (NeuC), N-acetyl neuraminic acid (NeuAc), N-glycolyl neuraminic acid (NeuGc), N,O-diacetyl neuraminic acid (occurs in horses), N,O-diacetyl neuraminic acid (occurs in bovines) and N-acetyl O-diacetyl neuraminic acid (occurs in bovines) (Figure 2). Sialyltransferases (STs) biosynthesize different SA linkages. SA linkage diversity occurs at the α2-3, α2-6, α2-8 or α2-9 to the SA or Gal residues (Figure 3). For example, in formation of α2,3 SA or α2,6 SA structures, α2,3-ST and α2,6-ST utilize substrates such as Galβ-1,4-GlcNAc (Figure 4). The most frequent modification of SAs is O-acetylation at positions of C4, C7, C8 and C9 of SA (Figure 5)."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T8","span":{"begin":757,"end":766},"obj":"http://purl.obolibrary.org/obo/GO_0009058"}],"text":"The 9-carbon SAs are mainly animal-specific with anionic sugars attached to terminal sugars. SAs exist in two forms, NeuGc and NeuAc. NeuGc is a differentially modified form of the parental SA form, Neu5Ac. SAs are structurally diverse. For example, several modified SA forms are known for their structures including neuraminic acid (NeuC), N-acetyl neuraminic acid (NeuAc), N-glycolyl neuraminic acid (NeuGc), N,O-diacetyl neuraminic acid (occurs in horses), N,O-diacetyl neuraminic acid (occurs in bovines) and N-acetyl O-diacetyl neuraminic acid (occurs in bovines) (Figure 2). Sialyltransferases (STs) biosynthesize different SA linkages. SA linkage diversity occurs at the α2-3, α2-6, α2-8 or α2-9 to the SA or Gal residues (Figure 3). For example, in formation of α2,3 SA or α2,6 SA structures, α2,3-ST and α2,6-ST utilize substrates such as Galβ-1,4-GlcNAc (Figure 4). The most frequent modification of SAs is O-acetylation at positions of C4, C7, C8 and C9 of SA (Figure 5)."}

{"project":"LitCovid-sentences","denotations":[{"id":"T57","span":{"begin":0,"end":92},"obj":"Sentence"},{"id":"T58","span":{"begin":93,"end":133},"obj":"Sentence"},{"id":"T59","span":{"begin":134,"end":206},"obj":"Sentence"},{"id":"T60","span":{"begin":207,"end":236},"obj":"Sentence"},{"id":"T61","span":{"begin":237,"end":580},"obj":"Sentence"},{"id":"T62","span":{"begin":581,"end":642},"obj":"Sentence"},{"id":"T63","span":{"begin":643,"end":740},"obj":"Sentence"},{"id":"T64","span":{"begin":741,"end":875},"obj":"Sentence"},{"id":"T65","span":{"begin":876,"end":982},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The 9-carbon SAs are mainly animal-specific with anionic sugars attached to terminal sugars. SAs exist in two forms, NeuGc and NeuAc. NeuGc is a differentially modified form of the parental SA form, Neu5Ac. SAs are structurally diverse. For example, several modified SA forms are known for their structures including neuraminic acid (NeuC), N-acetyl neuraminic acid (NeuAc), N-glycolyl neuraminic acid (NeuGc), N,O-diacetyl neuraminic acid (occurs in horses), N,O-diacetyl neuraminic acid (occurs in bovines) and N-acetyl O-diacetyl neuraminic acid (occurs in bovines) (Figure 2). Sialyltransferases (STs) biosynthesize different SA linkages. SA linkage diversity occurs at the α2-3, α2-6, α2-8 or α2-9 to the SA or Gal residues (Figure 3). For example, in formation of α2,3 SA or α2,6 SA structures, α2,3-ST and α2,6-ST utilize substrates such as Galβ-1,4-GlcNAc (Figure 4). The most frequent modification of SAs is O-acetylation at positions of C4, C7, C8 and C9 of SA (Figure 5)."}